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115 条记录 (耗时 0.022 秒)

    3'-substituted nucleoside derivatives
    1.
    发明授权
    3'-substituted nucleoside derivatives 失效
    3'-取代核苷衍生物

    公开(公告)号：US5763418A

    公开(公告)日：1998-06-09

    申请号：US693161

    申请日：1996-08-13

    申请人： Akira Matsuda ,  Sasaki Takuma

    发明人： Akira Matsuda ,  Sasaki Takuma

    IPC分类号： A61K31/7052 ,  A61P35/00 ,  C07H19/04 ,  C07H19/06 ,  C07H19/10 ,  C07H19/16 ,  C07H19/20 ,  A61K31/70

    CPC分类号： C07H19/06 ,  C07H19/04 ,  C07H19/10 ,  C07H19/16 ,  C07H19/20 ,  Y02P20/55

    摘要： The invention relates to a 3'-substituted nucleoside derivative represented by the following general formula (1): ##STR1## wherein B means a nucleic acid base which may have a substituent, Z represents a lower alkynyl or lower alkenyl group which may be substituted by a group represented by the formula: ##STR2## in which R.sup.a, R.sup.b and R.sup.c are individually a lower alkyl group or a phenyl group, or an oxiranyl group which may have at least one lower alkyl group, R.sup.1 and R.sup.2 individually represent H or an ester-forming residue capable of easily leaving in a living body, and R.sup.3 is H, a mono- or polyphosphoric acid residue, or an ester-forming residue capable of easily leaving in a living body, with the proviso that the sugar moiety is ribose, or a pharmaceutically acceptable salt thereof. The 3'-substituted nucleoside derivative according to the invention has an excellent antitumor activity and is hence useful for treatment for and prevention of cancers.

    摘要翻译： PCT No.PCT / JP95 / 02554 Sec。 371日期：1996年8月13日 102（e）日期1996年8月13日PCT 1995年12月13日PCT PCT。 WO96 / 18636 PCT公开号 日期：1996年6月20日本发明涉及由以下通式（1）表示的3'-取代核苷衍生物：其中B表示可具有取代基的核酸碱基，Z表示低级炔基 或低级链烯基，其可以被下式表示的基团取代：其中Ra，Rb和Rc分别是低级烷基或苯基，或可以具有至少一个的环氧乙烷基 低级烷基，R 1和R 2分别表示H或能够容易地在活体中离开的成酯残基，R3是H，单磷酸或多磷酸残基或能容易地离开的酯形成残基 活体，条件是糖部分是核糖，或其药学上可接受的盐。 根据本发明的3'-取代的核苷衍生物具有优异的抗肿瘤活性，因此可用于治疗和预防癌症。

    VIEWING-ANGLE-ENHANCING FILM FOR LIQUID CRYSTAL DISPLAY DEVICE, PROTECTIVE FILM WITH VIEWING-ANGLE-ENHANCING-FUNCTION, AND LIQUID CRYSTAL DISPLAY DEVICE
    3.
    发明申请
    VIEWING-ANGLE-ENHANCING FILM FOR LIQUID CRYSTAL DISPLAY DEVICE, PROTECTIVE FILM WITH VIEWING-ANGLE-ENHANCING-FUNCTION, AND LIQUID CRYSTAL DISPLAY DEVICE 有权
    用于液晶显示装置的观察角增强膜，具有角度增强功能的保护膜和液晶显示装置

    公开(公告)号：US20120176573A1

    公开(公告)日：2012-07-12

    申请号：US13497482

    申请日：2010-10-13

    申请人： Katsuaki Kuze ,  Kenji Kawai ,  Kazumoto Imai ,  Akihumi Yasui ,  Akira Matsuda ,  Masao Kochi

    发明人： Katsuaki Kuze ,  Kenji Kawai ,  Kazumoto Imai ,  Akihumi Yasui ,  Akira Matsuda ,  Masao Kochi

    IPC分类号： G02F1/1335 ,  G02B1/10 ,  B29D11/00 ,  G02B5/02

    CPC分类号： G02B5/045 ,  G02B5/0231 ,  G02B5/0257 ,  G02B5/0273 ,  G02B6/0053 ,  G02F1/133504

    摘要： To provide a viewing-angle-enhancing film which is set in a liquid crystal display device at a position nearer to an observer than the position of a liquid crystal layer in the device, and which attains, at a high level, the compatibility of being enhanced in viewing angle with a decrease in the darkening of images at the time of observing the screen from the front thereof. A viewing-angle-enhancing film which is set in a liquid crystal display device at a position nearer to an observer than the position of a liquid crystal layer in the device, and simultaneously satisfies the following requirements (1) to (3): (1) the film has a parallel ray transmittance of 5 to 90%; (2) the film has a diffusivity (A) of 1 to 20 degrees in its main diffusion direction; and (3) the film has a diffusivity ratio of 0.25 to 15% in the main diffusion direction.

    摘要翻译： 为了提供一种视角增强膜，其设置在液晶显示装置中比装置中的液晶层的位置更靠近观察者的位置，并且高水平地实现了 在从其前方观察屏幕时图像的变暗减小而观看角度增强。 在液晶显示装置中，在比装置中的液晶层位置更靠近观察者的位置设置可视角增强膜，同时满足以下要求（1）〜（3）：（ 1）膜的平行光线透射率为5〜90％; （2）膜的主扩散方向的扩散度（A）为1〜20度; （3）膜的主扩散方向的扩散率为0.25〜15％。

    Heavy duty pneumatic tire
    7.
    发明授权
    Heavy duty pneumatic tire 失效
    重型充气轮胎

    公开(公告)号：US06602943B2

    公开(公告)日：2003-08-05

    申请号：US09249443

    申请日：1999-02-12

    申请人： Tomohiro Kusano ,  Akira Matsuda

    发明人： Tomohiro Kusano ,  Akira Matsuda

    IPC分类号： C08K334

    CPC分类号： C08K3/04 ,  B60C1/0016 ,  C08K3/36 ,  C08L21/00

    摘要： In a heavy duty pneumatic tire comprising a tread, the tread is made of a rubber composition comprising 20-67 parts by weight of carbon black and 3-20 parts by weight of silica based on 100 parts by weight of diene based rubber, wherein the carbon black has a ratio of a dibutyl phthalate (DBP) absorption to a 24M4 DBP absorption (DBP absorption/24M4 DBP absorption) of not less than 1.20 and a ratio of the DBP absorption to a nitrogen adsorption specific area (N2SA) of not less than 0.8.

    摘要翻译： 在包含胎面的重型充气轮胎中，胎面由基于100重量份二烯基橡胶的20-67重量份炭黑和3-20重量份二氧化硅的橡胶组合物制成，其中， 炭黑的邻苯二甲酸二丁酯（DBP）吸收与24M4 DBP吸收（DBP吸收/ 24M4 DBP吸收）的比例不小于1.20，DBP吸收与氮吸附比面积（N2SA）的比例不小于 大于0.8。

    Process for preparing synthetic intermediates of 2-alkynyladenosines and 2-alkynyladenosines
    9.
    发明授权
    Process for preparing synthetic intermediates of 2-alkynyladenosines and 2-alkynyladenosines 失效
    制备2-炔基腺苷和2-炔基腺苷合成中间体的方法

    公开(公告)号：US5459254A

    公开(公告)日：1995-10-17

    申请号：US149943

    申请日：1993-11-10

    申请人： Toyofumi Yamaguchi ,  Takanori Miyashita ,  Shinji Sakata ,  Toichi Abiru ,  Akira Matsuda ,  Tohru Ueda ,  Kentaro Kogi

    发明人： Toyofumi Yamaguchi ,  Takanori Miyashita ,  Shinji Sakata ,  Toichi Abiru ,  Akira Matsuda ,  Tohru Ueda ,  Kentaro Kogi

    IPC分类号： C07H19/16 ,  C07H19/067

    CPC分类号： C07H19/16 ,  Y02P20/55

    摘要： The present invention relates to a novel compound represented by the following formula [I] which is useful as a synthetic intermediate of a 2-alkynyladenosine.The present invention also relates to a process for producing the compound and a process for producing a 2-alkynyladenosine [IV] by way of the compound.Further, the present invention relates to a 2-alkynyladenosine derivative represented by the following formula [V] having excellent storage stability and, to a method of storing the 2-alkynyladenosine in the form of that derivative. ##STR1## [I] A=a leaving group, [II] A=NH.sub.2,[V] A=NHR.sup.4,wherein R.sup.1 through R.sup.4 represent a hydrogen atom or a protective group, and n denotes an integer of 1 to 15, provided that R.sup.1 through R.sup.4 do not represent a hydrogen atom simultaneously.

    摘要翻译： 本发明涉及可用作2-炔基腺苷合成中间体的下式[I]表示的新型化合物。 本发明还涉及该化合物的制备方法和通过该化合物制备2-炔基腺苷[Ⅳ]的方法。 此外，本发明涉及具有优异的储存稳定性的由下式[V]表示的2-炔基腺苷衍生物，以及以该衍生物的形式存储2-炔基腺苷的方法。 [I] A =离去基团，[II] A = NH 2，[V] A = NHR 4，其中R 1至R 4表示氢原子或保护基，n表示1至15的整数， R1至R4同时不表示氢原子。

    Electric contact material and electric contact using said material
    10.
    发明授权
    Electric contact material and electric contact using said material 失效
    使用所述材料的电接触材料和电接触

    公开(公告)号：US5338618A

    公开(公告)日：1994-08-16

    申请号：US951587

    申请日：1992-09-25

    申请人： Satoshi Suzuki ,  Nobuyuki Shibata ,  Ryotomo Shirakawa ,  Akira Matsuda

    发明人： Satoshi Suzuki ,  Nobuyuki Shibata ,  Ryotomo Shirakawa ,  Akira Matsuda

    IPC分类号： C22C1/10 ,  C22C5/06 ,  H01H1/023 ,  H01H1/0237 ,  H01H11/04 ,  H01R39/20 ,  H01H1/02

    CPC分类号： H01H1/0237 ,  Y10T428/12486 ,  Y10T428/12882 ,  Y10T428/12896 ,  Y10T428/12903

    摘要： An electric contact material containing Li oxide of 0.01 to 2.0% by weight when represented in terms of the amount of Li, oxide of at least one rare earth element of 0.05 to 0.18% by weight when represented in terms of the amount of the rare earth element, and Ag or Ag alloy as the remaining portion; an electric contact material containing Li oxide of 0.01 to 2.0% by weight when represented in terms of the amount of Li, at least one rare earth element of 0.05 to 0.18% by weight when represented in terms of the amount of the rare earth element, at least one element selected from a group consisting of In, Sn, Zn, Mn, Pd, Sb, Cu, Mg, Pb, Cd, Cr and Bi by an amount of 0.1 to 1.0% by weight (however, in the case of Zn and Mn, the amount is set less than 0.5% by weight), and/or at least one element selected from a group consisting of Fe, Ni and Co by an amount of 0.03 to 0.6% by weight, and Ag as the remaining portion; and an electric contact formed by using the above material. It is excellent in the arc resistance, wear resistance an lubricity in a small current region and is suitable as the material for a slide contact and rotary slide contact.

    摘要翻译： 当以稀土量表示的至少一种稀土元素的Li的氧化物为0.05〜0.18重量％表示时，含有0.01〜2.0重量％的Li氧化物的电接触材料 元素，Ag或Ag合金作为剩余部分; 当以Li的量表示，含有0.01〜2.0重量％的Li氧化物的电接触材料，当以稀土元素的量表示时，至少一种稀土元素为0.05〜0.18重量％ 选自由In，Sn，Zn，Mn，Pd，Sb，Cu，Mg，Pb，Cd，Cr和Bi组成的组中的至少一种元素，其量为0.1至1.0重量％（然而，在 Zn和Mn，其含量设定为小于0.5重量％），和/或至少一种选自Fe，Ni和Co的元素的量为0.03至0.6重量％，Ag为剩余量 一部分; 以及通过使用上述材料形成的电接触。 电弧电阻优良，耐磨性小，在小电流区域具有润滑性，适用于滑动接触和旋转滑动接触的材料。