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公开(公告)号:US4873232A
公开(公告)日:1989-10-10
申请号:US924246
申请日:1986-10-29
申请人: Alexander Krantz , John M. Young
发明人: Alexander Krantz , John M. Young
IPC分类号: A61K31/19
CPC分类号: A61K31/19
摘要: Novel alkoxycarbonylamino benzoates and related copounds (carbamoyl benzoates) are disclosed for treatment of auto-immune disease states, such as arthritis.
摘要翻译: 公开了新型烷氧基羰基氨基苯甲酸酯和相关的助剂(氨基甲酰苯甲酸酯)用于治疗自身免疫疾病状态,例如关节炎。
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公开(公告)号:US06765322B2
公开(公告)日:2004-07-20
申请号:US09682182
申请日:2001-08-01
申请人: John M. Young , Martin van Duyn
发明人: John M. Young , Martin van Duyn
IPC分类号: H02K524
CPC分类号: H02K3/527
摘要: A method for facilitating damping torsional or ring vibrations of a dynamoelectric machine including a rotor assembly with a first amortisseur bar and a second amortisseur bar extending therefrom and terminating at an endring is provided. The method includes providing a damping assembly, and positioning the damping between the first amortisseur bar and the second amortisseur bar such that the damping assembly contacts the first and second amortisseur bars, and is substantially proximate the endring or alternatively the damping assembly is positioned only over one amortisseur bar.
摘要翻译: 提供了一种用于促进电动机的扭转或环振动的阻尼方法,该电动机包括具有从其延伸并终止于端部的第一阻尼杆和第二平滑杆的转子组件。 该方法包括提供阻尼组件,以及将阻尼定位在第一静止塞杆和第二静止塞杆之间,使得阻尼组件接触第一和第二减震塞杆,并且基本上靠近端部,或者可选地,阻尼组件仅定位在 一个amortisseur酒吧。
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公开(公告)号:US6004933A
公开(公告)日:1999-12-21
申请号:US065258
申请日:1998-04-23
申请人: Lyle W. Spruce , Albert C. Gyorkos , John C. Cheronis , Val S. Goodfellow , Axel H. Leimer , John M. Young , James Ivan Gerrity
发明人: Lyle W. Spruce , Albert C. Gyorkos , John C. Cheronis , Val S. Goodfellow , Axel H. Leimer , John M. Young , James Ivan Gerrity
IPC分类号: A61K38/00 , C07K5/06 , C07K5/062 , C07K5/087 , C07K5/093 , A61K38/03 , C07D215/02 , C07D237/30 , C07D239/70 , C07D241/36 , C07D253/10
CPC分类号: C07K5/06078 , C07K5/06043 , C07K5/06052 , C07K5/0812 , C07K5/0819 , A61K38/00
摘要: The present invention relates to cysteine protease inhibitors of the general formula (I): ##STR1## wherein Z is a cysteine protease binding moiety; X and Y are S, O or optionally substituted N; and R.sub.1 is optionally substituted alkyl or aryl.
摘要翻译: 本发明涉及通式(I)的半胱氨酸蛋白酶抑制剂:其中Z是半胱氨酸蛋白酶结合部分; X和Y是S,O或任选取代的N; 并且R 1是任选取代的烷基或芳基。
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公开(公告)号:US4593120A
公开(公告)日:1986-06-03
申请号:US564155
申请日:1983-12-22
IPC分类号: A61K31/215 , A61K31/22 , A61K31/235 , A61K31/265 , A61K31/275 , A61P17/00 , A61P29/00 , C07C45/63 , C07C46/00 , C07C46/02 , C07C50/24 , C07C50/32 , C07C67/00 , C07C69/017 , C07C69/76 , C07C69/78 , C07C205/48 , C07C213/00 , C07C219/34 , C07C253/00 , C07C255/55 , C07C313/00 , C07C317/22 , C07C323/20 , C07C323/38 , C07D213/70 , C07D213/71 , C07D213/89 , C07D521/00
CPC分类号: C07D213/70 , C07C205/48 , C07C255/00 , C07C317/00 , C07C323/00 , C07C45/63 , C07C46/00 , C07C46/02 , C07C50/24 , C07C50/32 , C07D213/89
摘要: Psoriasis in mammals is relieved by topically administering naphthalenes of the formula: ##STR1## wherein: R.sup.1 and R.sup.2 are the same and are lower alkoxy, lower alkylthio, optionally substituted phenoxy or optionally substituted phenylthio,R.sup.3 is lower alkyl, lower alkoxy, or halo and m is 0, 1 or 2 or R.sup.3 is optionally substituted phenyl, optionally substituted phenyl lower alkyl, optionally substituted phenyl lower alkoxy, amino, lower alkylamino, lower dialkylamino, cyano, or S(O).sub.n R wherein R is lower alkyl; optionally substituted phenyl; optionally substituted phenyl lower alkyl; or optionally substituted heterocyclic aryl of three to nine ring atoms containing one or two heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, and the pharmaceutically acceptable acid addition salts thereof; and m is 1 and n is 0, 1 or 2; andW is alkyl of one to seven carbon atoms, optionally substituted phenyl or optionally substituted benzyl.
摘要翻译: 哺乳动物的银屑病通过局部施用下式的萘来减轻:其中:R1和R2相同,为低级烷氧基,低级烷硫基,任选取代的苯氧基或任选取代的苯硫基,R 3为低级烷基,低级烷氧基 或卤素,m为0,1或2或R3为任选取代的苯基,任选取代的苯基低级烷基,任选取代的苯基低级烷氧基,氨基,低级烷基氨基,低级二烷基氨基,氰基或S(O)n R其中R为 低级烷基 任选取代的苯基; 任选取代的苯基低级烷基; 或含有一个或两个选自氮,氧和硫的杂原子的三至九个环原子的任选取代的杂环芳基及其药学上可接受的酸加成盐; m为1,n为0,1或2; 且W为1至7个碳原子的烷基,任选取代的苯基或任选取代的苄基。
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公开(公告)号:US5155132A
公开(公告)日:1992-10-13
申请号:US170490
申请日:1988-03-21
申请人: Michael C. Venuti , John M. Young
发明人: Michael C. Venuti , John M. Young
摘要: Psoriasis in mammals is relieved by topically administering naphthalenes of the formula: ##STR1## wherein: R.sup.1 is lower alkoxy or optionally substituted phenoxy;R.sup.2 is hydrogen, lower alkyl, optionally substituted phenyl or optionally substituted phenylalkyl;R.sup.3 is hydrogen, lower alkyl, lower alkoxy, halo, optionally substituted phenyl, optionally substituted phenyl-lower-alkyl or optionally substituted phenyl-lower-alkoxy, and m is 1 or 2;X and Y are different and are either R.sup.4 or --C(O)W whereinR.sup.4 is lower alkyl or optionally substituted phenyl-lower-alkyl;W is --OR.sup.5 or --NR.sup.6 R.sup.7,whereinR.sup.5 is alkyl, optionally substituted phenyl or optionally substituted benzyl; and R.sup.6 and R.sup.7 are independently hydrogen, lower alkyl, cycloalkyl or optionally substituted phenyl.The compounds of this invention are also useful for the treatment of disease-states caused by lipoxygenase activity in mammals, particularly 5-lipoxygenase activity, when administered systemically.
摘要翻译: 哺乳动物的银屑病通过局部施用下式的萘来缓解:其中:R1是低级烷氧基或任意取代的苯氧基; R 2是氢,低级烷基,任选取代的苯基或任选取代的苯基烷基; R 3是氢,低级烷基,低级烷氧基,卤素,任选取代的苯基,任选取代的苯基 - 低级烷基或任选取代的苯基 - 低级烷氧基,m是1或2; X和Y不同,为R 4或-C(O)W,其中R 4为低级烷基或任选取代的苯基 - 低级 - 烷基; W是-OR 5或-NR 6 R 7,其中R 5是烷基,任选取代的苯基或任选取代的苄基; 且R 6和R 7独立地为氢,低级烷基,环烷基或任选取代的苯基。 当系统给药时,本发明的化合物也可用于治疗由哺乳动物的脂氧合酶活性引起的疾病状态,特别是5-脂氧合酶活性。
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公开(公告)号:US4792556A
公开(公告)日:1988-12-20
申请号:US856929
申请日:1986-04-28
IPC分类号: A61K31/22 , C07C50/32 , C07C67/08 , C07C67/297 , C07C69/157 , C07C69/16 , C07C69/63 , C07C69/635 , C07C205/45 , A61K31/275 , A61K31/415 , A61K31/44
CPC分类号: A61K31/22 , C07C50/32 , C07C67/08 , C07C67/11 , C07C67/29 , C07C69/017 , C07C69/16 , C07C69/28 , C07C69/63 , C07C69/635
摘要: Psoriasis in mammals is relieved by topically administering naphthalenes of the formula: ##STR1## wherein: R.sup.1 and R.sup.2 are the same and are lower alkoxy or optionally substituted phenoxy,R.sup.3 is lower alkyl, lower alkoxy, or halo and m is 0, 1 or 2 or R.sup.3 is optionally substituted phenyl, optionally substituted phenyl lower alkyl, optionally substituted phenyl lower alkoxy, amino, lower alkylamino, lower dialkylamino, cyano, or S(O).sub.n R wherein R is lower alkyl; optionally substituted phenyl; optionally substituted phenyl lower alkyl; or optionally substituted heterocyclic aryl of three to nine ring atoms containing one or two heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, and the pharmaceutically acceptable acid addition salts thereof; and m is 1 and n is 0, 1 or 2;at least one of X or Y is C(O)W and the other X or Y is different and is hydrogen, C(O)W or R.sup.4whereinW is alkyl of one to seven carbon atoms, optionally substituted phenyl or optionally substituted benzyl; andR.sup.4 is lower alkyl or optionally substituted phenyl-lower-alkyl.
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公开(公告)号:US4350537A
公开(公告)日:1982-09-21
申请号:US195688
申请日:1980-10-09
申请人: John M. Young , Peter D. Scovell
发明人: John M. Young , Peter D. Scovell
IPC分类号: H01L21/265 , H01L21/324 , H01L21/26
CPC分类号: H01L21/26513 , H01L21/324 , Y10S148/09
摘要: A process for annealing crystal damage in ion implanted semiconductor devices in which the device is rapidly heated to a temperature between 450.degree. and 900.degree. C. and allowed to cool. It has been found that such heating of the device to these relatively low temperatures results in rapid annealing. In one application the device (17) may be heated on a graphite element (14) mounted between electrodes (15) in an inert atmosphere in a chamber (11). The process may be enhanced by the application of optical radiation from a Xenon lamp (19).
摘要翻译: 一种离子注入半导体器件中退火晶体损伤的方法,其中将器件快速加热至450°至900°C的温度并使其冷却。 已经发现,将器件加热到这些相对低的温度导致快速退火。 在一个应用中,可以在室(11)中的惰性气氛中的装置(17)上加热安装在电极(15)之间的石墨元件(14)。 可以通过施加来自氙灯(19)的光辐射来增强该过程。
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公开(公告)号:US4063119A
公开(公告)日:1977-12-13
申请号:US725209
申请日:1976-09-22
IPC分类号: H03K3/3565 , H04Q3/52 , H03K3/286 , H03K3/295 , H03K3/353
CPC分类号: H04Q3/521 , H03K3/3565
摘要: This invention relates to a Schmitt trigger circuit, and particularly to a Schmitt trigger circuit comprising MOS transistors.The all MOS transistor Schmitt trigger circuit has a first MOS input inverting amplifier regeneratively coupled with a further MOS transistor to provide the requisite positive feedback voltage, and a second MOS input inverting amplifier, not in the feedback loop but having the feedback voltage also applied thereto, the output being taken from the second inverter.Separation of output from the feedback loop gives flexible control of input triggering points and output characteristics.This circuit is intended for use in a MOS IC telephone switching cross-point switch.
摘要翻译: 本发明涉及施密特触发电路,特别涉及包括MOS晶体管的施密特触发电路。
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公开(公告)号:US5091558A
公开(公告)日:1992-02-25
申请号:US23089
申请日:1987-03-06
IPC分类号: C07C46/00 , C07C50/10 , C07C50/14 , C07C50/24 , C07C50/32 , C07C69/00 , C07D213/64 , C07D213/89 , C07D239/38 , C07D333/64
CPC分类号: C07D213/89 , C07C255/00 , C07C317/00 , C07C323/00 , C07C46/00 , C07C50/10 , C07C50/14 , C07C50/24 , C07C50/32 , C07D213/64 , C07D239/38 , C07D333/64
摘要: Psoriasis in mammals is relieved by topically administering naphthalenes of the formula: ##STR1## wherein: R.sup.1 is alkoxy, alkylthio, optionally substituted phenoxy or optionally substituted phenylthio;R.sup.2 is hydrogen, lower alkyl, optionally substituted phenyl or optionally substituted phenylalkyl;R.sup.3 is lower alkyl, lower alkoxy, or halo and m is 0, 1 or 2, or R.sup.3 is optionally substituted phenyl, optionally substituted phenyl lower alkyl, optionally substituted phenyl lower alkoxy, amino, lower alkylamino, lower dialkylamino, cyano, or S(0).sub.n R wherein R is lower alkyl; optionally substituted phenyl; optionally substituted phenyl lower alkyl; or optionally substituted heterocyclic aryl of three to nine ring atoms containing one or two heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, and the pharmaceutically acceptable acid addition salts thereof; and m is 1 and n is 0, 1 or 2; andW is alkyl of one to seven carbon atoms, optionally substituted phenyl or optionally substituted benzyl.
摘要翻译: 哺乳动物中的牛皮癣通过局部施用下式的萘来减轻:其中:R1是烷氧基,烷硫基,任选取代的苯氧基或任选取代的苯硫基; R 2是氢,低级烷基,任选取代的苯基或任选取代的苯基烷基; R3是低级烷基,低级烷氧基或卤素,m是0,1或2,或R3是任选取代的苯基,任选取代的苯基低级烷基,任选取代的苯基低级烷氧基,氨基,低级烷基氨基,低级二烷基氨基,氰基或S (O)n R其中R是低级烷基; 任选取代的苯基; 任选取代的苯基低级烷基; 或含有一个或两个选自氮,氧和硫的杂原子的三至九个环原子的任选取代的杂环芳基及其药学上可接受的酸加成盐; m为1,n为0,1或2; 且W为1至7个碳原子的烷基,任选取代的苯基或任选取代的苄基。
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公开(公告)号:US4269487A
公开(公告)日:1981-05-26
申请号:US139369
申请日:1980-04-11
申请人: John M. Young
发明人: John M. Young
CPC分类号: G02C13/005 , G02C7/086 , G02C9/00
摘要: Over refraction of an aphakic patient with a temporary lens clipped into an empty eye wire of a spectacles frame to be subsequently permanently glazed and worn by the patient. With the temporary lens set at proper vertex distance from the cornea, centered with the eye and correct face fitting adjustment of the frame, over-refraction is undertaken for determination of permanent lens refractive requirements.
摘要翻译: 过度折射无晶状体患者,将临时镜头夹在眼镜架的空眼线中,随后由患者永久釉面磨损。 将临时透镜设置在与角膜正确的顶点距离处,以眼睛为中心并且正确地调整框架的面部调整,进行过度折射以确定永久性镜片折射要求。
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