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公开(公告)号：US08182767B2
公开(公告)日：2012-05-22
申请号：US11306399
申请日：2005-12-27
IPC分类号： A61B5/00
CPC分类号： G01N35/1079 , B01L3/502715 , B01L3/502746 , B01L9/527 , B01L2200/027 , B01L2200/143 , B01L2300/0627 , B01L2300/0672 , B01L2300/0816 , B01L2400/0481 , B01L2400/0487 , G01N35/1095 , G01N2035/00158
摘要： Instrument-cartridge interfaces for fluidic analyzers that have an instrument and a removable cartridge are disclosed. For example, and in one illustrative embodiment, the instrument may include a needle that is adapted to penetrate a septum on a removable cartridge. In another illustrative embodiment, the instrument may include a plunger that is adapted to deform a deformable membrane on a removable cartridge. In yet another illustrative embodiment, the instrument may include a nozzle that is adapted to mate and seal with a flow channel on a removable cartridge. Techniques for detecting the flow rate in a flow channel on a removable cartridge, as well as the position of fluid in a flow channel of a removable cartridge, are also disclosed.
摘要翻译： 公开了具有仪器和可移除盒的流体分析仪的盒式磁带接口。 例如，在一个说明性实施例中，仪器可以包括适于穿透可移除盒的隔膜的针。 在另一说明性实施例中，仪器可以包括适于使可移除盒上的可变形膜变形的柱塞。 在另一个说明性实施例中，仪器可以包括适于与可移除盒上的流动通道配合和密封的喷嘴。 还公开了用于检测可移除盒上的流动通道中的流速以及可移除盒的流动通道中的流体位置的技术。
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公开(公告)号：US08518328B2
公开(公告)日：2013-08-27
申请号：US11306402
申请日：2005-12-27
IPC分类号： G01N21/00
CPC分类号： G01N33/80 , B01L3/502715 , B01L3/502746 , B01L2200/027 , B01L2200/143 , B01L2200/147 , B01L2300/044 , B01L2300/0645 , B01L2400/0481 , B01L2400/0487 , B01L2400/0605 , G01N35/00029 , G01N35/025
摘要： Instrument-cartridge interfaces for fluidic analyzers that have an instrument and a removable cartridge are disclosed. For example, and in one illustrative embodiment, the instrument may include a needle that is adapted to penetrate a septum on a removable cartridge. In another illustrative embodiment, the instrument may include a plunger that is adapted to deform a deformable membrane on a removable cartridge. In yet another illustrative embodiment, the instrument may include a nozzle that is adapted to mate and seal with a flow channel on a removable cartridge. Techniques for detecting the flow rate in a flow channel on a removable cartridge, as well as the position of fluid in a flow channel of a removable cartridge, are also disclosed.
摘要翻译： 公开了具有仪器和可移除盒的流体分析仪的盒式磁带接口。 例如，在一个说明性实施例中，仪器可以包括适于穿透可移除盒的隔膜的针。 在另一说明性实施例中，仪器可以包括适于使可移除盒上的可变形膜变形的柱塞。 在另一个说明性实施例中，仪器可以包括适于与可移除盒上的流动通道配合和密封的喷嘴。 还公开了用于检测可移除盒上的流动通道中的流速以及可移除盒的流动通道中的流体位置的技术。
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公开(公告)号：US07485153B2
公开(公告)日：2009-02-03
申请号：US11306401
申请日：2005-12-27
IPC分类号： G01D21/00
CPC分类号： B01L9/527 , B01L3/502715 , B01L3/502746 , B01L2200/027 , B01L2300/0809 , B01L2300/0877 , B01L2300/123 , B01L2400/0481 , F04C2/18 , F04C13/001 , G01N33/18 , G01N2035/00158
摘要： Instrument-cartridge interfaces for fluidic analyzers that have an instrument and a removable cartridge are disclosed. For example, and in one illustrative embodiment, the instrument may include a needle that is adapted to penetrate a septum on a removable cartridge. In another illustrative embodiment, the instrument may include a plunger that is adapted to deform a deformable membrane on a removable cartridge. In yet another illustrative embodiment, the instrument may include a nozzle that is adapted to mate and seal with a flow channel on a removable cartridge. Techniques for detecting the flow rate in a flow channel on a removable cartridge, as well as the position of fluid in a flow channel of a removable cartridge, are also disclosed.
摘要翻译： 公开了具有仪器和可移除盒的流体分析仪的盒式磁带接口。 例如，在一个说明性实施例中，仪器可以包括适于穿透可移除盒的隔膜的针。 在另一说明性实施例中，仪器可以包括适于使可移除盒上的可变形膜变形的柱塞。 在另一个说明性实施例中，仪器可以包括适于与可移除盒上的流动通道配合和密封的喷嘴。 还公开了用于检测可移除盒上的流动通道中的流速以及可移除盒的流动通道中的流体位置的技术。
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公开(公告)号：US08323564B2
公开(公告)日：2012-12-04
申请号：US11615874
申请日：2006-12-22
申请人： Aravind Padmanabhan , James A. Cox , Bernard S. Fritz , Tom M. Rezachek , Peter L. Reutiman , Ron L. Bardell , Cleopatra Cabuz
发明人： Aravind Padmanabhan , James A. Cox , Bernard S. Fritz , Tom M. Rezachek , Peter L. Reutiman , Ron L. Bardell , Cleopatra Cabuz
CPC分类号： G01N35/00603 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/502746 , B01L9/527 , B01L2200/027 , B01L2200/04 , B01L2200/0636 , B01L2200/0684 , B01L2200/143 , B01L2200/146 , B01L2300/021 , B01L2300/0627 , B01L2300/0672 , B01L2300/0816 , B01L2300/0877 , B01L2300/14 , B01L2400/0487 , G01N15/1404 , G01N15/1459 , G01N15/1484 , G01N21/53 , G01N29/032 , G01N35/00663 , G01N2015/0069 , G01N2015/0073 , G01N2015/008 , G01N2015/0084 , G01N2015/1452 , G01N2015/1486 , G01N2035/00148 , G01N2035/00247 , G01N2035/1034 , G01N2035/1053 , G01N2291/02433 , G01N2291/02836 , G01N2291/02872
摘要： A system relating to sample analyzers, and more particular, to sample analyzers that are simple to operate and have a reduced risk of providing an erroneous result to a user. In some cases, the sample analyzer may be a portable sample analyzer that includes a disposable fluidic cartridge. The operators of the analyzers need not be trained.
摘要翻译： 与样品分析仪有关的系统，更具体地说，涉及操作简单且降低向用户提供错误结果的风险的样品分析仪。 在一些情况下，样品分析仪可以是便携式样品分析仪，其包括一次性流体盒。 不需要对分析仪的操作员进行培训。
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公开(公告)号：US08034296B2
公开(公告)日：2011-10-11
申请号：US11428289
申请日：2006-06-30
IPC分类号： G01N33/00
CPC分类号： G01N15/1459 , B01L3/502723 , B01L3/502746 , B01L3/502761 , B01L3/502776 , B01L2200/0636 , B01L2200/0684 , B01L2200/10 , B01L2300/0816 , B01L2300/0887 , B01L2400/0406 , B01L2400/0415 , B01L2400/0427 , B01L2400/0487 , B01L2400/086 , G01N15/1404 , G01N15/1484 , G01N2015/0073 , G01N2015/1006 , G01N2015/1486 , G01N2015/149
摘要： A microfluidic circuit cartridge for a complete blood count, including analyses of red blood cells. Various parameters of the red blood cells may be attained. The cartridge may have sphering mechanism which has a channel or loop with a configuration for reducing or eliminating cell settling. The channel or loop may incorporate a combination of straight and curve paths in the context of gravity. The channel may alternatively have a hydrophilic or hydrophobic inside surface. Again alternatively, the channel may have an electro-wettable inside surface. Or, the channel may be subject to an electric or magnetic field. There may also be a mechanism for reducing or eliminating clumping of a sample.
摘要翻译： 用于完整血细胞计数的微流体电路盒，包括红细胞分析。 可以获得红细胞的各种参数。 盒可以具有球形机构，其具有通道或环，其具有用于减少或消除细胞沉降的构造。 通道或环路可以在重力的上下文中包含直线和曲线路径的组合。 通道也可以具有亲水或疏水的内表面。 或者，通道可以具有电润湿的内表面。 或者，通道可能受到电场或磁场的影响。 还可以存在减少或消除样品团块的机理。
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公开(公告)号：US08273294B2
公开(公告)日：2012-09-25
申请号：US11428370
申请日：2006-06-30
CPC分类号： G01N15/1484 , B01L3/502715 , B01L3/502776 , B01L2200/0621 , B01L2200/0636 , B01L2200/12 , B01L2300/087 , B01L2300/0877 , G01N15/1404 , G01N2015/008 , G01N2015/1486 , Y10T436/117497 , Y10T436/2575
摘要： A microfluidic circuit cartridge having 3-D hydrodynamic focusing. The cartridge may be fabricated with injection-molded or other molded layers providing a 3-D structure. A flow channel on the card may have a sample core flowing in a fluid of a flow channel for analysis. The sample core may be adjustable in position within the channel with one or more jets or channels of fluid being injected into the flow channel. The jets may also adjust the size of the sample core. There may be a hemoglobin measurement mechanism or card with a cuvette.
摘要翻译： 具有3-D流体动力学聚焦的微流体电路盒。 盒可以用提供3-D结构的注射成型或其它模制层制造。 卡上的流动通道可以具有在流动通道的流体中流动的样本核心用于分析。 样品芯可以在通道内的位置可调节，其中一个或多个喷射流体或通道的流体被注入到流动通道中。 射流也可以调节样品芯的尺寸。 可能有一个血红蛋白测量机制或一个有比色皿的卡。
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公开(公告)号：US08828320B2
公开(公告)日：2014-09-09
申请号：US11615927
申请日：2006-12-22
申请人： Ron L. Bardell , Aravind Padmanabhan , Peter L. Reutiman , Tom M. Rezachek , James A. Cox , Bernard S. Fritz , Cleopatra Cabuz
发明人： Ron L. Bardell , Aravind Padmanabhan , Peter L. Reutiman , Tom M. Rezachek , James A. Cox , Bernard S. Fritz , Cleopatra Cabuz
IPC分类号： G01N33/00
CPC分类号： G01N35/085 , G01N15/1056 , G01N15/12 , G01N15/1459 , G01N15/1484 , G01N35/00603 , G01N35/00663 , G01N2015/0069 , G01N2015/0073 , G01N2015/008 , G01N2015/0084 , G01N2015/1062 , G01N2015/1486 , G06F19/00
摘要： A system relating to sample analyzers, and more particular, to sample analyzers that are simple to operate and have a reduced risk of providing an erroneous result to a user. In some cases, the sample analyzer may be a portable sample analyzer that includes a disposable fluidic cartridge. The operators of the analyzers need not be trained.
摘要翻译： 与样品分析仪有关的系统，更具体地说，涉及操作简单且降低向用户提供错误结果的风险的样品分析仪。 在一些情况下，样品分析仪可以是便携式样品分析仪，其包括一次性流体盒。 不需要对分析仪的操作员进行培训。
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公开(公告)号：US08383043B2
公开(公告)日：2013-02-26
申请号：US11615884
申请日：2006-12-22
申请人： Aravind Padmanabhan , James A. Cox , Bernard S. Fritz , Tom M. Rezachek , Peter L. Reutiman , Ron L. Bardell , Cleopatra Cabuz
发明人： Aravind Padmanabhan , James A. Cox , Bernard S. Fritz , Tom M. Rezachek , Peter L. Reutiman , Ron L. Bardell , Cleopatra Cabuz
CPC分类号： G01N35/00603 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/502746 , B01L9/527 , B01L2200/027 , B01L2200/04 , B01L2200/0636 , B01L2200/0684 , B01L2200/143 , B01L2200/146 , B01L2300/021 , B01L2300/044 , B01L2300/0627 , B01L2300/0672 , B01L2300/0816 , B01L2300/0877 , B01L2300/14 , B01L2400/0406 , B01L2400/0481 , B01L2400/0487 , G01N15/1404 , G01N15/1459 , G01N15/1484 , G01N21/53 , G01N29/032 , G01N33/5094 , G01N35/00663 , G01N2015/0069 , G01N2015/0073 , G01N2015/008 , G01N2015/0084 , G01N2015/1452 , G01N2015/1486 , G01N2035/00148 , G01N2035/00158 , G01N2035/00247 , G01N2035/1034 , G01N2035/1053 , G01N2291/02433 , G01N2291/02836 , G01N2291/02872
摘要： A system relating to sample analyzers, and more particular, to sample analyzers that are simple to operate and have a reduce risk of providing an erroneous result to a user. In some cases, the sample analyzer may be a portable sample analyzer that includes a disposable fluidic cartridge. The operators of the analyzers need not be trained.
摘要翻译： 与样品分析仪相关的系统，更具体地，涉及操作简单且降低向用户提供错误结果的风险的样品分析仪。 在一些情况下，样品分析仪可以是便携式样品分析仪，其包括一次性流体盒。 不需要对分析仪的操作员进行培训。
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公开(公告)号：US08282576B2
公开(公告)日：2012-10-09
申请号：US10574242
申请日：2004-09-29
申请人： Travis Marsot , Paul Lum , Don Alden , James Ross , Ron L. Bardell , Bernhard Weigl
发明人： Travis Marsot , Paul Lum , Don Alden , James Ross , Ron L. Bardell , Bernhard Weigl
CPC分类号： A61B5/14865 , A61B5/1411 , A61B5/14532 , A61B5/150022 , A61B5/150152 , A61B5/150167 , A61B5/150358 , A61B5/150427 , A61B5/150503 , A61B5/150572 , A61B5/15107 , A61B5/15121 , A61B5/15146 , A61B5/15153 , A61B5/15161 , A61B5/15176 , A61B5/157 , A61B5/6848 , A61B2560/0223
摘要： A body fluid sampling device is provided. A mesh may be used to guide blood or fluid to travel directly from the wound to an analyte detecting port on the cartridge. Thus the volume of blood or body fluid produced at the wound site irregardless of its droplet geometry can be reliable and substantially completely transported to the analyte detecting member for measurement.
摘要翻译： 提供体液取样装置。 可以使用网格来引导血液或流体直接从伤口行进到药筒上的分析物检测端口。 因此，在伤口部位产生的血液或体液的体积无论其液滴几何形状如何都可以是可靠的并且基本上完全输送到分析物检测构件以进行测量。
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公开(公告)号：US20120259186A1
公开(公告)日：2012-10-11
申请号：US13526882
申请日：2012-06-19
申请人： Travis Marsot , Paul Lum , Don Alden , James Ross , Ron L. Bardell , Bernhard Hans Weigl
发明人： Travis Marsot , Paul Lum , Don Alden , James Ross , Ron L. Bardell , Bernhard Hans Weigl
CPC分类号： A61B5/14865 , A61B5/1411 , A61B5/14532 , A61B5/150022 , A61B5/150152 , A61B5/150167 , A61B5/150358 , A61B5/150427 , A61B5/150503 , A61B5/150572 , A61B5/15107 , A61B5/15121 , A61B5/15146 , A61B5/15153 , A61B5/15161 , A61B5/15176 , A61B5/157 , A61B5/6848 , A61B2560/0223
摘要： A body fluid sampling device is provided. A mesh (120) may be used to guide blood or fluid to travel directly form the wound to an analyte detecting port on the cartridge (121). Theus the volume of blood or body fluid produced at the wound site irregardless of its droplet geometry can be reliable and substantially completely transported to the analyte detecting member (150) for measurement.
摘要翻译： 提供体液取样装置。 可以使用网眼（120）来引导血液或流体直接从伤口移动到药筒（121）上的分析物检测端口。 在伤口部位产生的血液或体液的体积不管其液滴几何形状是否可靠且基本上完全输送到分析物检测构件（150）以进行测量。
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