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公开(公告)号：US08828320B2
公开(公告)日：2014-09-09
申请号：US11615927
申请日：2006-12-22
申请人： Ron L. Bardell , Aravind Padmanabhan , Peter L. Reutiman , Tom M. Rezachek , James A. Cox , Bernard S. Fritz , Cleopatra Cabuz
发明人： Ron L. Bardell , Aravind Padmanabhan , Peter L. Reutiman , Tom M. Rezachek , James A. Cox , Bernard S. Fritz , Cleopatra Cabuz
IPC分类号： G01N33/00
CPC分类号： G01N35/085 , G01N15/1056 , G01N15/12 , G01N15/1459 , G01N15/1484 , G01N35/00603 , G01N35/00663 , G01N2015/0069 , G01N2015/0073 , G01N2015/008 , G01N2015/0084 , G01N2015/1062 , G01N2015/1486 , G06F19/00
摘要： A system relating to sample analyzers, and more particular, to sample analyzers that are simple to operate and have a reduced risk of providing an erroneous result to a user. In some cases, the sample analyzer may be a portable sample analyzer that includes a disposable fluidic cartridge. The operators of the analyzers need not be trained.
摘要翻译： 与样品分析仪有关的系统，更具体地说，涉及操作简单且降低向用户提供错误结果的风险的样品分析仪。 在一些情况下，样品分析仪可以是便携式样品分析仪，其包括一次性流体盒。 不需要对分析仪的操作员进行培训。
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公开(公告)号：US08383043B2
公开(公告)日：2013-02-26
申请号：US11615884
申请日：2006-12-22
申请人： Aravind Padmanabhan , James A. Cox , Bernard S. Fritz , Tom M. Rezachek , Peter L. Reutiman , Ron L. Bardell , Cleopatra Cabuz
发明人： Aravind Padmanabhan , James A. Cox , Bernard S. Fritz , Tom M. Rezachek , Peter L. Reutiman , Ron L. Bardell , Cleopatra Cabuz
CPC分类号： G01N35/00603 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/502746 , B01L9/527 , B01L2200/027 , B01L2200/04 , B01L2200/0636 , B01L2200/0684 , B01L2200/143 , B01L2200/146 , B01L2300/021 , B01L2300/044 , B01L2300/0627 , B01L2300/0672 , B01L2300/0816 , B01L2300/0877 , B01L2300/14 , B01L2400/0406 , B01L2400/0481 , B01L2400/0487 , G01N15/1404 , G01N15/1459 , G01N15/1484 , G01N21/53 , G01N29/032 , G01N33/5094 , G01N35/00663 , G01N2015/0069 , G01N2015/0073 , G01N2015/008 , G01N2015/0084 , G01N2015/1452 , G01N2015/1486 , G01N2035/00148 , G01N2035/00158 , G01N2035/00247 , G01N2035/1034 , G01N2035/1053 , G01N2291/02433 , G01N2291/02836 , G01N2291/02872
摘要： A system relating to sample analyzers, and more particular, to sample analyzers that are simple to operate and have a reduce risk of providing an erroneous result to a user. In some cases, the sample analyzer may be a portable sample analyzer that includes a disposable fluidic cartridge. The operators of the analyzers need not be trained.
摘要翻译： 与样品分析仪相关的系统，更具体地，涉及操作简单且降低向用户提供错误结果的风险的样品分析仪。 在一些情况下，样品分析仪可以是便携式样品分析仪，其包括一次性流体盒。 不需要对分析仪的操作员进行培训。
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公开(公告)号：US08323564B2
公开(公告)日：2012-12-04
申请号：US11615874
申请日：2006-12-22
申请人： Aravind Padmanabhan , James A. Cox , Bernard S. Fritz , Tom M. Rezachek , Peter L. Reutiman , Ron L. Bardell , Cleopatra Cabuz
发明人： Aravind Padmanabhan , James A. Cox , Bernard S. Fritz , Tom M. Rezachek , Peter L. Reutiman , Ron L. Bardell , Cleopatra Cabuz
CPC分类号： G01N35/00603 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/502746 , B01L9/527 , B01L2200/027 , B01L2200/04 , B01L2200/0636 , B01L2200/0684 , B01L2200/143 , B01L2200/146 , B01L2300/021 , B01L2300/0627 , B01L2300/0672 , B01L2300/0816 , B01L2300/0877 , B01L2300/14 , B01L2400/0487 , G01N15/1404 , G01N15/1459 , G01N15/1484 , G01N21/53 , G01N29/032 , G01N35/00663 , G01N2015/0069 , G01N2015/0073 , G01N2015/008 , G01N2015/0084 , G01N2015/1452 , G01N2015/1486 , G01N2035/00148 , G01N2035/00247 , G01N2035/1034 , G01N2035/1053 , G01N2291/02433 , G01N2291/02836 , G01N2291/02872
摘要： A system relating to sample analyzers, and more particular, to sample analyzers that are simple to operate and have a reduced risk of providing an erroneous result to a user. In some cases, the sample analyzer may be a portable sample analyzer that includes a disposable fluidic cartridge. The operators of the analyzers need not be trained.
摘要翻译： 与样品分析仪有关的系统，更具体地说，涉及操作简单且降低向用户提供错误结果的风险的样品分析仪。 在一些情况下，样品分析仪可以是便携式样品分析仪，其包括一次性流体盒。 不需要对分析仪的操作员进行培训。
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公开(公告)号：US07641856B2
公开(公告)日：2010-01-05
申请号：US10908461
申请日：2005-05-12
CPC分类号： G01N15/1404 , G01N2015/1413 , G01N2015/1486 , Y10T436/101666
摘要： A sample analyzer with a removable and/or disposable cartridge for use at the point of care of a patient such as in a doctor's office, in the home, or elsewhere in the field. By providing a removable and/or disposable cartridge with all of the needed reagents and/or fluids, the sample analyzer can be reliably used outside of the laboratory environment, with little or no specialized training.
摘要翻译： 具有可拆卸和/或一次性药筒的样品分析器，用于患者的护理点，例如在医生的办公室，家庭或现场的其他地方。 通过提供具有所有需要的试剂和/或流体的可拆卸和/或一次性的筒，样品分析仪可以在实验室环境之外被可靠地使用，很少或没有专门的培训。
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公开(公告)号：US07333197B2
公开(公告)日：2008-02-19
申请号：US10991001
申请日：2004-11-17
IPC分类号： G01N21/00
CPC分类号： G01N21/658 , G01N15/147
摘要： A method and apparatus for enabling chemical identification of individual particles, cells of molecules by obtaining a Raman spectrum of a particle, cell or molecule as it flows past a sensing point in a flow cytometer. The particles, which may be cells or molecules, are associated with a suitable noble metal colloid or colloidal aggregate. Cellular particles may be associated with gold or silver colloidal particles by ultra-sonic sonification while in a sample preparation reservoir containing the gold or silver colloidal suspension. The colloid associated particles are then hydrodynamically focused into a single file by a fluid control module. The surface-enhance Raman Spectrum of individual particles are obtained by illuminating the particle with a laser as the particle flows past a sensing point and gathering the light that is non-elastically scattered (Raman scattered) by the particle. The surface-enhanced Raman spectrum is then analyzed to identify the particle.
摘要翻译： 一种方法和装置，用于通过在流式细胞计数器中流过感测点时获得粒子，细胞或分子的拉曼光谱，从而能够化学鉴定单个颗粒，分子细胞。 可以是细胞或分子的颗粒与合适的贵金属胶体或胶体聚集体相关联。 在含有金或银胶体悬浮液的样品制备储存器中，细胞颗粒可以通过超声波超声处理与金或银胶体颗粒结合。 然后通过流体控制模块将胶体相关颗粒流体动力聚焦成单个文件。 当颗粒流过感测点并通过颗粒收集非弹性散射（拉曼散射）的光时，通过用激光照射颗粒来获得单个颗粒的表面增强拉曼光谱。 然后分析表面增强拉曼光谱以鉴定颗粒。
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公开(公告)号：US07978329B2
公开(公告)日：2011-07-12
申请号：US10304773
申请日：2002-11-26
IPC分类号： G01N21/00
CPC分类号： G01N15/147 , A61B5/150022 , A61B5/150213 , A61B5/150221 , A61B5/150343 , A61B5/150351 , A61B5/157 , A61B5/417 , B01L3/5027 , G01N15/1404 , G01N15/1484 , G01N2015/0088 , G01N2015/1075 , G01N2015/1486 , G01N2035/00891
摘要： An apparatus having scattering and multi-color fluorescence detecting, analyzing and identification capabilities of blood or other fluids of interest. The sample to be tested may be entered in a disposable microfluidic cartridge which in turn is insertable in a hand-holdable or implantable miniaturized and portable cytometer instrument. This cytometer has significant application in biological warfare agent detection, hematology and other clinical and research fields.
摘要翻译： 一种具有散射和多色荧光检测，分析和识别血液或其他感兴趣液体的能力的装置。 要测试的样品可以输入一次性微流控盒中，该滤芯又可插入手持式或可植入式的小型化便携式血细胞仪器中。 该细胞仪在生物战剂检测，血液学等临床和研究领域具有重要应用。
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公开(公告)号：US07277166B2
公开(公告)日：2007-10-02
申请号：US10908543
申请日：2005-05-16
申请人： Aravind Padmanabhan , Jay G. Schwichtenberg , Bernard S. Fritz , Cleopatra Cabuz , Ernest A. Satren
发明人： Aravind Padmanabhan , Jay G. Schwichtenberg , Bernard S. Fritz , Cleopatra Cabuz , Ernest A. Satren
CPC分类号： G01N15/1459 , B01L3/502715 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/0636 , B01L2200/0689 , B01L2300/0645 , B01L2300/0654 , B01L2400/0487 , B01L2400/0633 , G01N15/1456 , G01N15/1484 , G01N2015/008 , G01N2015/1452 , G01N2015/1486
摘要： A medium having microfluidic circuitry for sampling and analyses. The medium may be a cartridge having a window countersunk into it and containing a flow channel. The flow channel may have items of interest flowing through it. Analyses of these items may be optical involving one or more light sources emanating light to and one or more light detectors receiving light from the channel. There are various configurations so that source and detector light cones may reach the flow channel without obscuration or interference of the light to and from the flow channel in the window.
摘要翻译： 具有用于取样和分析的微流体电路的介质。 该介质可以是具有一个窗口沉入其中并包含流动通道的盒。 流动通道可以具有流过其的兴趣物品。 这些项目的分析可以是光学的，涉及发射光的一个或多个光源和从该通道接收光的一个或多个光检测器。 存在各种配置，使得源和检测器光锥可以到达流动通道而不会使光在窗口中的流动通道的光线不受干扰或干扰。
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公开(公告)号：US08071051B2
公开(公告)日：2011-12-06
申请号：US10908460
申请日：2005-05-12
CPC分类号： B01L3/502715 , B01L9/527 , B01L2200/027 , B01L2200/04 , B01L2200/0636 , B01L2200/146 , B01L2300/0672 , B01L2300/0816 , B01L2300/0877 , B01L2300/14 , B01L2400/0487 , G01N15/1484 , G01N35/00722 , G01N2015/0073 , G01N2015/0084 , G01N2015/0088 , G01N2015/1413 , G01N2015/1486 , G01N2035/00891
摘要： A sample analyzer cartridge for use at a point of care of a patient such as in a doctor's office, in the home, or elsewhere in the field. By providing a removable and/or disposable cartridge with all of the needed reagents and/or fluids, the sample analyzer can be reliably used outside of the laboratory environment, with little or no specialized training.
摘要翻译： 在患者的护理点使用的样品分析器盒，例如在医生的办公室，家庭或现场的其他地方。 通过提供具有所有需要的试剂和/或流体的可拆卸和/或一次性的筒，样品分析仪可以在实验室环境之外被可靠地使用，很少或没有专门的培训。
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公开(公告)号：US20120003730A1
公开(公告)日：2012-01-05
申请号：US13220449
申请日：2011-08-29
IPC分类号： C12M1/34
CPC分类号： B01L3/502715 , B01L9/527 , B01L2200/027 , B01L2200/04 , B01L2200/0636 , B01L2200/146 , B01L2300/0672 , B01L2300/0816 , B01L2300/0877 , B01L2300/14 , B01L2400/0487 , G01N15/1484 , G01N35/00722 , G01N2015/0073 , G01N2015/0084 , G01N2015/0088 , G01N2015/1413 , G01N2015/1486 , G01N2035/00891
摘要： A sample analyzer cartridge for use at a point of care of a patient such as in a doctor's office, in the home, or elsewhere in the field. By providing a removable and/or disposable cartridge with all of the needed reagents and/or fluids, the sample analyzer can be reliably used outside of the laboratory environment, with little or no specialized training.
摘要翻译： 在患者的护理点使用的样品分析器盒，例如在医生的办公室，家庭或现场的其他地方。 通过提供具有所有需要的试剂和/或流体的可拆卸和/或一次性的筒，样品分析仪可以在实验室环境之外被可靠地使用，很少或没有专门的培训。
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公开(公告)号：US08540946B2
公开(公告)日：2013-09-24
申请号：US13220449
申请日：2011-08-29
IPC分类号： B01L3/00
CPC分类号： B01L3/502715 , B01L9/527 , B01L2200/027 , B01L2200/04 , B01L2200/0636 , B01L2200/146 , B01L2300/0672 , B01L2300/0816 , B01L2300/0877 , B01L2300/14 , B01L2400/0487 , G01N15/1484 , G01N35/00722 , G01N2015/0073 , G01N2015/0084 , G01N2015/0088 , G01N2015/1413 , G01N2015/1486 , G01N2035/00891
摘要： A sample analyzer cartridge for use at a point of care of a patient such as in a doctor's office, in the home, or elsewhere in the field. By providing a removable and/or disposable cartridge with all of the needed reagents and/or fluids, the sample analyzer can be reliably used outside of the laboratory environment, with little or no specialized training.
摘要翻译： 在患者的护理点使用的样品分析器盒，例如在医生的办公室，家庭或现场的其他地方。 通过提供具有所有需要的试剂和/或流体的可拆卸和/或一次性的筒，样品分析仪可以在实验室环境之外被可靠地使用，很少或没有专门的培训。
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