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">1.发明授权Tylosin 20-imino-20-deoxo-4"-acyl derivatives, pharmaceutical compositions and method of use 失效泰乐菌素20-亚氨基-20-脱氧-4'-酰基衍生物，药物组合物和使用方法
公开(公告)号：US4435388A
公开(公告)日：1984-03-06
申请号：US386834
申请日：1982-06-10
申请人： Ashit K. Ganguly , Allan K. Mallams , Yi-Tsung Liu
发明人： Ashit K. Ganguly , Allan K. Mallams , Yi-Tsung Liu
CPC分类号： C07H17/08
摘要： There are disclosed 20-imino-20-deoxo-4"-acyl derivatives of the antibiotic tylosin which have higher serum levels and better absorption than the parent tylosins. Methods of preparation of the compounds are also disclosed.
摘要翻译： 公开了抗生素泰乐菌素的20-亚氨基-20-脱氧-4'-酰基衍生物，其具有比母体泰乐菌素更高的血清水平和更好的吸收。 还公开了化合物的制备方法。
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公开(公告)号：USRE43298E1
公开(公告)日：2012-04-03
申请号：US13068159
申请日：2011-04-22
申请人： Anil K. Saksena , Viyyoor Moopil Girijavallabhan , Raymond G. Lovey , Edwin Jao , Frank Bennett , Jinping L. McCormick , Haiyan Wang , Russell E. Pike , Stephane L. Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. George Njoroge , Ashok Arasappan , Tejal Parekh , Ashit K. Ganguly , Kevin X. Chen , Srikanth Venkatraman , Henry M. Vaccaro , Patrick A. Pinto , Bama Santhanam , Scott Jeffrey Kemp , Odile Esther Levy , Marguerita Lim-Wilby , Susan Y. Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang
发明人： Anil K. Saksena , Viyyoor Moopil Girijavallabhan , Raymond G. Lovey , Edwin Jao , Frank Bennett , Jinping L. McCormick , Haiyan Wang , Russell E. Pike , Stephane L. Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. George Njoroge , Ashok Arasappan , Tejal Parekh , Ashit K. Ganguly , Kevin X. Chen , Srikanth Venkatraman , Henry M. Vaccaro , Patrick A. Pinto , Bama Santhanam , Scott Jeffrey Kemp , Odile Esther Levy , Marguerita Lim-Wilby , Susan Y. Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang
IPC分类号： A61K38/00 , A01N37/18 , A61P1/16 , A61P31/12 , A61K39/12 , G01N33/53 , A61K38/07 , A61K38/06 , C07K5/08 , C07K5/10
CPC分类号： C07K5/0202 , A61K38/00 , C07K5/0812 , C07K5/0827 , C07K7/02
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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3.发明申请NOVEL PEPTIDES AS NS3-SERINE PROTEASE INHIBITORS OF HEPATITIS C VIRUS 审中-公开新型肽作为丙型肝炎病毒的NS3-丝氨酸蛋白酶抑制剂公开(公告)号：US20110117057A1
公开(公告)日：2011-05-19
申请号：US12973020
申请日：2010-12-20
申请人： Anil K. Saksena , Viyyoor Moopil Girijavallabhan , Raymond G. Lovey , Edwin Jao , Frank Bennett , Jinping L. McCormick , Haiyan Wang , Russell E. Pike , Stephane L. Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. George Njoroge , Ashok Arasappan , Tejal Parekh , Ashit K. Ganguly , Kevin X. Chen , Srikanth Venkatraman , Henry A. Vaccaro , Patrick A. Pinto , Bama Santhanam , Scott Jeffrey Kemp , Odile Esther Levy , Marguerita Lim-Wilby , Susan Y. Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang
发明人： Anil K. Saksena , Viyyoor Moopil Girijavallabhan , Raymond G. Lovey , Edwin Jao , Frank Bennett , Jinping L. McCormick , Haiyan Wang , Russell E. Pike , Stephane L. Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. George Njoroge , Ashok Arasappan , Tejal Parekh , Ashit K. Ganguly , Kevin X. Chen , Srikanth Venkatraman , Henry A. Vaccaro , Patrick A. Pinto , Bama Santhanam , Scott Jeffrey Kemp , Odile Esther Levy , Marguerita Lim-Wilby , Susan Y. Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang
IPC分类号： A61K38/06 , C07D207/16 , C07D403/10 , C07K5/083 , C07D209/42 , C07K5/107 , C07D215/48 , A61K38/05 , A61K38/07 , A61K38/21 , A61P31/14
CPC分类号： C07K5/0202 , A61K38/00 , C07K5/0812 , C07K5/0827 , C07K7/02
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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4.发明授权
公开(公告)号：US5403937A
公开(公告)日：1995-04-04
申请号：US55268
申请日：1993-04-30
申请人： Anil K. Saksena , Viyyoor M. Girijavallabhan , Russell E. Pike , Haiyan Wang , Raymond G. Lovey , Yi-Tsung Liu , Ashit K. Ganguly , William B. Morgan , Aleksey Zaks
发明人： Anil K. Saksena , Viyyoor M. Girijavallabhan , Russell E. Pike , Haiyan Wang , Raymond G. Lovey , Yi-Tsung Liu , Ashit K. Ganguly , William B. Morgan , Aleksey Zaks
IPC分类号： C07C69/63 , C07C69/65 , C07D263/26 , C07D307/12 , C07D405/06 , C07D413/06 , C07D417/06 , C07D521/00 , C12P7/04 , C12P7/62 , C12P41/00 , C07D249/08
CPC分类号： C07D249/08 , C07C69/63 , C07C69/65 , C07D231/12 , C07D233/56 , C07D263/26 , C07D307/12 , C07D405/06 , C07D413/06 , C07D417/06 , C12P41/004 , C12P7/62 , Y02P20/55
摘要： Disclosed is a process for preparing chiral compounds of the formula (I) ##STR1## wherein: X.sup.1 and X.sup.2 are independently F or Cl; and E is --SO.sub.2 R.sup.2, wherein R.sup.2 is C.sub.1 -C.sub.6 alkyl, --C.sub.6 H.sub.4 CH.sub.3 or --CF.sub.3 ; its enantiomer and racemates thereof, useful in the synthesis of tetrahydrofuran azole antifungals. Novel compounds of the formula ##STR2## wherein: X.sup.1 and X.sup.2 are independently F or Cl; B represents --C(O)Q* or --CH.sub.2 OR"; Q* represents a chiral auxiliary group; R" represents a hydroxy protecting group selected from --CH.sub.2 C.sub.6 H.sub.5, or --C(O)R.sup.1, wherein R.sup.1 is C.sub.1 -C.sub.6 alkyl; and A represents Cl, Br, I or triazolyl; are also disclosed.
摘要翻译： 公开了制备式（I）的手性化合物（I）的方法，其中：X 1和X 2独立地是F或Cl; 并且E是-SO 2 R 2，其中R 2是C 1 -C 6烷基，-C 6 H 4 CH 3或-CF 3; 其对映体和外消旋体，可用于四氢呋喃唑类抗真菌剂的合成。 新颖的式（III）化合物或其成分：其中：X 1和X 2独立地为F或Cl; B表示-C（O）Q *或-CH 2 OR“; Q *表示手性辅助基团; R“表示选自-CH 2 C 6 H 5或-C（O）R 1的羟基保护基，其中R 1是C 1 -C 6烷基; A表示Cl，Br，I或三唑基; 也被披露。
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公开(公告)号：US07244721B2
公开(公告)日：2007-07-17
申请号：US10052386
申请日：2002-01-18
申请人： Anil K. Saksena , Viyyoor Moopil Girijavallabhan , Raymond G. Lovey , Edwin Jao , Frank Bennett , Jinping L. Mc Cormick , Haiyan Wang , Russell E. Pike , Stephane L. Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. George Njoroge , Ashok Arasappan , Tejal Parekh , Ashit K. Ganguly , Kevin X. Chen , Srikanth Venkatraman , Henry A. Vaccaro , Patrick A. Pinto , Bama Santhanam , Scott Jeffrey Kemp , Odile Esther Levy , Marguerita Lim-Wilby , Susan Y. Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang , Jesse K. Wong , Latha G. Nair
发明人： Anil K. Saksena , Viyyoor Moopil Girijavallabhan , Raymond G. Lovey , Edwin Jao , Frank Bennett , Jinping L. Mc Cormick , Haiyan Wang , Russell E. Pike , Stephane L. Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. George Njoroge , Ashok Arasappan , Tejal Parekh , Ashit K. Ganguly , Kevin X. Chen , Srikanth Venkatraman , Henry A. Vaccaro , Patrick A. Pinto , Bama Santhanam , Scott Jeffrey Kemp , Odile Esther Levy , Marguerita Lim-Wilby , Susan Y. Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang , Jesse K. Wong , Latha G. Nair
IPC分类号： A61K31/497 , A61K31/407 , A61K31/454 , A61K31/4025
CPC分类号： C07K5/0804 , A61K38/00 , C07K5/0202 , C07K5/0812 , C07K5/0827 , C07K7/02
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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公开(公告)号：US5710154A
公开(公告)日：1998-01-20
申请号：US459225
申请日：1995-06-02
申请人： Anil K. Saksena , Viyyoor M. Girijavallabhan , Raymond G. Lovey , Russell E. Pike , Haiyan Wang , Yi-Tsung Liu , Ashit K. Ganguly , Frank Bennett
发明人： Anil K. Saksena , Viyyoor M. Girijavallabhan , Raymond G. Lovey , Russell E. Pike , Haiyan Wang , Yi-Tsung Liu , Ashit K. Ganguly , Frank Bennett
IPC分类号： C07D405/14 , A61K31/41 , A61K31/495 , A61K31/675 , A61P31/00 , A61P31/10 , C07D521/00 , C07F9/6558 , C07D413/14 , C07F9/6518
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07F9/65586
摘要： A compound represented by the formula I ##STR1## wherein X is independently both F or both Cl or one X is independently F and the other is independently Cl; R.sub.1 is a straight or branched chain (C.sub.3 to C.sub.8) alkyl group substituted by one or two groups convertible in vivo into hydroxy moieties, (e.g., a polyether ester, amino acid ester or phosphate ester) thereof or a pharmaceutically acceptable salt thereof and pharmaceutical compositions thereof useful for treating and/or preventing fungal infections are disclosed.
摘要翻译： 由式I表示的化合物其中X独立地为F或两者为Cl或一个X独立地为F，另一个独立地为Cl; R1是被体内转化成羟基的一个或两个基团（例如，其聚醚酯，氨基酸酯或磷酸酯）或其药学上可接受的盐和药学上可接受的盐取代的直链或支链（C3至C8）烷基 公开了可用于治疗和/或预防真菌感染的组合物。
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公开(公告)号：US4617300A
公开(公告)日：1986-10-14
申请号：US652707
申请日：1984-09-21
IPC分类号： C07D519/06 , A61K31/425 , A61P31/04 , C07D499/88 , C07D499/897 , C07D521/00 , C07F9/568 , C07F9/6561 , C07D499/00
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D499/88 , C07F9/5683
摘要： There are disclosed 2(N-heterocyclyl) penems and their pharmaceutically acceptable salts and esters and their use as anti-bacterials.
摘要翻译： 公开了2种（N-杂环基）青霉烯及其药学上可接受的盐和酯及其作为抗菌剂的用途。
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公开(公告)号：US07012066B2
公开(公告)日：2006-03-14
申请号：US09908955
申请日：2001-07-19
申请人： Anil K. Saksena , Viyyoor Moopil Girijavallabhan , Raymond G. Lovey , Edwin Jao , Frank Bennett , Jinping L. Mc Cormick , Haiyan Wang , Russell E. Pike , Stephane L. Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. George Njoroge , Ashok Arasappan , Tejal Parekh , Ashit K. Ganguly , Kevin X. Chen , Srikanth Venkatraman , Henry A. Vaccaro , Patrick A. Pinto , Bama Santhanam , Scott Jeffrey Kemp , Odile Esther Levy , Marguerita Lim-Wilby , Susan Y. Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang
发明人： Anil K. Saksena , Viyyoor Moopil Girijavallabhan , Raymond G. Lovey , Edwin Jao , Frank Bennett , Jinping L. Mc Cormick , Haiyan Wang , Russell E. Pike , Stephane L. Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. George Njoroge , Ashok Arasappan , Tejal Parekh , Ashit K. Ganguly , Kevin X. Chen , Srikanth Venkatraman , Henry A. Vaccaro , Patrick A. Pinto , Bama Santhanam , Scott Jeffrey Kemp , Odile Esther Levy , Marguerita Lim-Wilby , Susan Y. Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang
CPC分类号： C07K5/0202 , A61K38/00 , C07K5/0812 , C07K5/0827 , C07K7/02
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
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公开(公告)号：US4373095A
公开(公告)日：1983-02-08
申请号：US244541
申请日：1981-03-17
申请人： Ashit K. Ganguly , Olga Sarre , Yi-Tsung Liu
发明人： Ashit K. Ganguly , Olga Sarre , Yi-Tsung Liu
摘要： Desmycinosyl derivatives of 12,13-desepoxy-12,13-dehydro antibiotic AR-5 component 1 and 12,13-desepoxy-12,13-dehydro antibiotic AR-5 component 2 are useful antibacterial agents and may be converted to other such agents by processes analogous to those generally known in the art.
摘要翻译： 12,13-去环氧-12,13-脱氢抗菌素AR-5组分1和12,13-去环氧-12,13-脱氢抗生素AR-5组分2的去霉霉素衍生物是有用的抗菌剂，并且可以转化成其它这样的试剂 通过与本领域中通常已知的方法类似的方法。
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公开(公告)号：US4279896A
公开(公告)日：1981-07-21
申请号：US161947
申请日：1980-06-23
申请人： Ashit K. Ganguly , Yi-Tsung Liu
发明人： Ashit K. Ganguly , Yi-Tsung Liu
IPC分类号： A61K31/70 , A61K31/7042 , A61K31/7048 , A61P31/04 , C07H17/08 , A61K31/71
CPC分类号： C07H17/08
摘要： Rosaramicin and 12,13-desepoxy-12,13-dehydrorosaramicin form novel 20-imino-20-deoxy derivatives having substantial antibacterial activity. Methods for preparing such compounds are also disclosed.
摘要翻译： 异恶唑烷酮和12,13-去环氧-12,13-脱氢罗丹霉素形成具有显着抗菌活性的新型20-亚氨基-20-脱氧衍生物。 还公开了制备这些化合物的方法。
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