公开(公告)号：US6051221A

公开(公告)日：2000-04-18

申请号：US591474

申请日：1996-06-10

申请人： Barry Austin Gusterson ,  Mark Roger Crompton ,  Philip John Mitchell ,  Karen Tracey Barker ,  Taherah Kamalati ,  Martin John Page ,  Paul Spence

发明人： Barry Austin Gusterson ,  Mark Roger Crompton ,  Philip John Mitchell ,  Karen Tracey Barker ,  Taherah Kamalati ,  Martin John Page ,  Paul Spence

IPC分类号： A61K31/275 ,  A61K31/35 ,  A61K31/55 ,  A61K31/70 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  A61K47/48 ,  A61K48/00 ,  A61P35/00 ,  C07H21/04 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/12 ,  C12N15/09 ,  C12N15/12 ,  C12N15/54 ,  C12Q1/48 ,  C12Q1/68 ,  C12R1/91 ,  G01N33/573 ,  A61K38/43 ,  C12N15/11

CPC分类号： A61K31/70 ,  A61K31/275 ,  A61K31/35 ,  A61K31/55 ,  A61K47/48238 ,  C12N9/1205 ,  C12Q1/48 ,  C12Q1/6886 ,  G01N33/573 ,  A61K38/00 ,  C12Q2600/136 ,  C12Q2600/158

摘要： The invention relates to a novel tyrosine kinase designated brk and the use of this tyrosine kinase in the development of diagnostic and therapeutic approaches to cancer. The novel tyrosine kinase was isolated from a human metastatic breast tumor using a PCR based differential screening approach and has the deduced amino acid sequence shown in SEQ ID NO:2.

摘要翻译： PCT No.PCT / GB94 / 01479 Sec。 371日期1996年6月10日 102（e）1996年6月10日PCT 1994年7月8日PCT公布。 第WO95 / 02057号公报 日期1995年1月19日本发明涉及一种新的酪氨酸激酶，指定为brk，以及该酪氨酸激酶在癌症诊断和治疗方法开发中的应用。 使用基于PCR的差异筛选方法从人转移性乳腺肿瘤中分离出新的酪氨酸激酶，并且具有SEQ ID NO：2所示的推导的氨基酸序列。

公开(公告)号：US20070282158A1

公开(公告)日：2007-12-06

申请号：US11841244

申请日：2007-08-20

申请人： Paul Spence

发明人： Paul Spence

IPC分类号： A61M1/12

CPC分类号： A61M1/1005 ,  A61M1/1008 ,  A61M1/1037 ,  A61M1/1044 ,  A61M1/1055 ,  A61M1/106 ,  A61M1/107 ,  A61M1/1086 ,  A61M1/122 ,  A61M1/127 ,  A61M2205/8243

摘要： Counterpulsation methods and systems for assisting the heart of a patient involve, for example, coordinating the operation of a pulsatile pump to suction blood from an artery through a first conduit while the heart is in systole and expel the blood into the first conduit and the artery while the heart is in diastole.

摘要翻译： 用于辅助患者心脏的反脉冲方法和系统涉及例如协调脉搏泵的操作，以在心脏收缩期间从动脉抽吸血液，并将血液排出到第一导管和动脉 而心脏处于舒缓期。

公开(公告)号：US20070080188A1

公开(公告)日：2007-04-12

申请号：US11425731

申请日：2006-06-22

申请人： Paul Spence ,  Mark Maguire ,  Matthew Murphy ,  Ed McNamara ,  Michael Sansoucy

发明人： Paul Spence ,  Mark Maguire ,  Matthew Murphy ,  Ed McNamara ,  Michael Sansoucy

IPC分类号： A61B17/068 ,  A61F2/24

CPC分类号： A61F2/2451 ,  A61B17/0401 ,  A61B17/0469 ,  A61B17/0482 ,  A61B17/0487 ,  A61B17/064 ,  A61B2017/00398 ,  A61B2017/00862 ,  A61B2017/00867 ,  A61B2017/00876 ,  A61B2017/0406 ,  A61B2017/0409 ,  A61B2017/0417 ,  A61B2017/0419 ,  A61B2017/0454 ,  A61B2017/0464 ,  A61B2017/0496 ,  A61B2017/0641 ,  A61B2017/0647 ,  A61B2090/3954 ,  A61F2/2445 ,  A61F2/2466 ,  A61F2002/30079 ,  A61F2210/009

摘要： Systems and methods for securing tissue including the annulus of a mitral valve. The systems and methods may employ catheter based techniques and devices to plicate tissue and perform an annuloplasty. Magnets may be used for guidance in deploying fasteners from a catheter. The fasteners are cinched with a flexible tensile member.

摘要翻译： 用于固定包括二尖瓣环的组织的系统和方法。 该系统和方法可以采用基于导管的技术和装置来剔除组织并执行瓣环成形术。 磁铁可用于从导管部署紧固件的引导。 紧固件用柔性抗拉构件束紧。

公开(公告)号：US20050258378A1

公开(公告)日：2005-11-24

申请号：US11007821

申请日：2004-12-08

申请人： Drew Speer ,  Paul Spence ,  Gregory McDonald ,  Timothy Dennison ,  Gregory Grossman ,  Csaba Kiss ,  Jason Verrett ,  Charles Zende

发明人： Drew Speer ,  Paul Spence ,  Gregory McDonald ,  Timothy Dennison ,  Gregory Grossman ,  Csaba Kiss ,  Jason Verrett ,  Charles Zende

IPC分类号： B65D85/50 ,  B01J19/12 ,  B65B55/08 ,  C08K3/00 ,  C08K5/00 ,  C06B23/00

CPC分类号： B65B55/08 ,  C08K5/0008 ,  C08K2201/012

摘要： The invention is a method, triggering unit, and system for activating an oxygen scavenging composition at high speeds. The triggering unit includes a plurality of UV lamps that can operate at increased temperatures and have high output intensites from about 10 to 35 mW/cm2. The triggering unit can activate films at speeds from about 20 to 100 fps. Mercury amalgam lamps are useful in the practice of the invention. The invention also includes a UV dose management system and film tensioning system that facilitates triggering at high film speeds. The UV dose management system controls the amount of UV exposure that the film receives so that the oxygen scavenging rate of the activated composition can be controlled.

摘要翻译： 本发明是一种高速激活氧气清除组合物的方法，触发单元和系统。 触发单元包括多个可在增加的温度下操作并具有约10至35mW / cm 2的高输出强度的UV灯。 触发单元可以以大约20至100fps的速度激活胶片。 汞合金灯在本发明的实践中是有用的。 本发明还包括一种UV剂量管理系统和薄膜张紧系统，其有助于以高胶片速度触发。 UV剂量管理系统控制膜接收的UV暴露量，从而可以控制活化组合物的除氧速率。

公开(公告)号：US6083355A

公开(公告)日：2000-07-04

申请号：US947714

申请日：1997-10-09

申请人： Paul Spence

发明人： Paul Spence

IPC分类号： B29C59/14 ,  C23C16/40 ,  C23C16/509 ,  C23C16/54 ,  H01J37/32 ,  H05F3/00

CPC分类号： H01J37/32082 ,  B29C59/14 ,  C23C16/402 ,  C23C16/509 ,  C23C16/545 ,  H01J37/32541 ,  H01J37/3277 ,  B01J2219/0894

摘要： Continuous-feed plasma treater systems are designed to treat continuous substrates, such as webs or films, by continuously feeding the substrates through an enclosure having a plasma discharge that alters the substrate's surface properties in some desirable fashion. The plasma discharges are generated by one or more electrode assemblies housed within the enclosure. In general, the plasma treater systems of the present invention have one or more cylinder-sleeve electrode assemblies and/or one or more cylindrical cavity electrode assemblies. A cylinder-sleeve electrode assembly comprises a cylinder electrode and a sleeve electrode positioned with its concave face facing and substantially parallel to the cylinder electrode to form an annular gap between the outer surface of the cylinder electrode and the inner surface of the sleeve electrode. The electrode assembly is adapted to be excited to generate a plasma within the annular gap to form a primary plasma discharge zone for exposure of the plasma to a substrate. A cylindrical cavity electrode assembly comprises (1) a cavity electrode, having a cylindrical bore and a wall slot running parallel to the cylindrical bore and exposing the cylindrical bore; (2) a cylinder electrode coaxially positioned within the cylindrical bore of the cavity electrode to form an annular gap between the outer surface of the cylinder electrode and the surface of the cylindrical bore, the annular gap forming a primary plasma discharge zone; and (3) a treater drum positioned adjacent to the wall slot of the cavity electrode. During operations, the substrate is translated past the wall slot by the treater drum and exposed to plasma species that are convected from the primary plasma discharge zone to the wall slot. Plasma treater systems of the present invention can be used (a) to treat substrates in an efficient cost-effective manner and (b) to produce treated substrates having superior surface properties as compared to those generated using prior-art systems, such as corona-type discharge systems.

公开(公告)号：US20110230432A1

公开(公告)日：2011-09-22

申请号：US13116484

申请日：2011-05-26

申请人： Jack Nguyen ,  Gregory T. Went ,  Paul Spence ,  Timothy J. Fultz ,  David Chernoff

发明人： Jack Nguyen ,  Gregory T. Went ,  Paul Spence ,  Timothy J. Fultz ,  David Chernoff

IPC分类号： A61K31/7056 ,  A61P31/16

CPC分类号： A61K31/454 ,  A61K31/7056 ,  A61K2300/00

摘要： Compositions, kits and methods are provided for the treatment or prophylaxis of influenza.

摘要翻译： 提供组合物，试剂盒和方法用于治疗或预防流行性感冒。

公开(公告)号：US20100160431A1

公开(公告)日：2010-06-24

申请号：US12545007

申请日：2009-08-20

申请人： Gregory Went ,  David Chernoff ,  Paul Spence ,  Terry Burkoth ,  Timothy Fultz

发明人： Gregory Went ,  David Chernoff ,  Paul Spence ,  Terry Burkoth ,  Timothy Fultz

IPC分类号： A61K31/215 ,  A61K31/13 ,  A61P31/16

CPC分类号： A61K45/06 ,  A61K9/2009 ,  A61K9/2054 ,  A61K9/2846 ,  A61K9/5026 ,  A61K9/5047 ,  A61K9/5073 ,  A61K9/5084 ,  A61K31/13 ,  A61K2300/00

摘要： Compositions for treating flu comprise an M2 inhibitor, and optionally a neuraminidase inhibitor, wherein at least one of said M2 inhibitor or said neuraminidase inhibitor is provided in an extended release dosage form.

摘要翻译： 用于治疗流感的组合物包含M2抑制剂和任选的神经氨酸酶抑制剂，其中所述M2抑制剂或所述神经氨酸酶抑制剂中的至少一种以延长释放剂型形式提供。

公开(公告)号：US20050184122A1

公开(公告)日：2005-08-25

申请号：US11111044

申请日：2005-04-21

申请人： Edwin Hlavka ,  Paul Spence

发明人： Edwin Hlavka ,  Paul Spence

IPC分类号： A61B17/00 ,  A61B17/04 ,  A61B17/064 ,  A61B17/068 ,  A61B19/00 ,  A61F2/24 ,  A61M20060101

CPC分类号： A61B17/00234 ,  A61B17/0469 ,  A61B17/0487 ,  A61B17/0643 ,  A61B17/0644 ,  A61B2017/00243 ,  A61B2017/00349 ,  A61B2017/00867 ,  A61B2017/0417 ,  A61B2017/0462 ,  A61B2017/0464 ,  A61B2017/0472 ,  A61B2017/0496 ,  A61B2017/0649

摘要： A minimally invasive method of performing annuloplasty. According to one aspect, a method for performing annuloplasty includes creating a first plication in the tissue near a mitral valve of a heart, using at least a first plication element, and creating a second plication in the tissue near the mitral valve such that the second plication is substantially coupled to the first plication.

摘要翻译： 进行瓣膜成形术的微创方法。 根据一个方面，一种用于进行瓣膜成形术的方法包括使用至少第一pl裂元件在心脏的二尖瓣附近的组织中产生第一脓肿，并在二尖瓣附近的组织中产生第二脓肿，使得第二 折叠基本上与第一塌陷相耦合。

公开(公告)号：US20050148825A1

公开(公告)日：2005-07-07

申请号：US11063478

申请日：2005-02-23

申请人： Paul Spence ,  Warren Williamson

发明人： Paul Spence ,  Warren Williamson

IPC分类号： A61B17/02 ,  A61B17/30 ,  A61B1/32

CPC分类号： A61B17/02 ,  A61B17/0206 ,  A61B17/0218 ,  A61B2017/0243 ,  A61B2017/306 ,  A61B2017/308

摘要： A heart retractor links lifting of the heart and regional immobilization which stops one part of the heart from moving to allow expeditious suturing while permitting other parts of the heart to continue to function whereby coronary surgery can be performed on a beating heart while maintaining cardiac output unabated and uninterrupted. Circumflex coronary artery surgery can be performed using the heart retractor of the present invention. The retractor includes a plurality of flexible arms and a plurality of rigid arms as well as a surgery target immobilizing element. One form of the retractor can be used in minimally invasive surgery, while other forms of the retractor can accommodate variations in heart size and paracardial spacing.

公开(公告)号：US20050119734A1

公开(公告)日：2005-06-02

申请号：US10948923

申请日：2004-09-24

申请人： Paul Spence ,  Ed McNamara ,  Mark Maguire

发明人： Paul Spence ,  Ed McNamara ,  Mark Maguire

IPC分类号： A61F2/24

CPC分类号： A61F2/2451 ,  A61B17/0401 ,  A61B17/0487 ,  A61B2017/00243 ,  A61B2017/00783 ,  A61B2017/00876 ,  A61B2017/0409 ,  A61B2017/0414 ,  A61B2017/0417 ,  A61B2017/0419 ,  A61B2017/0464 ,  A61B2017/0496 ,  A61F2/2466 ,  A61F2210/009 ,  A61F2220/0016 ,  A61F2220/0075

摘要： Catheter based systems and methods for securing tissue including the annulus of a mitral valve. The systems and methods employ catheter based techniques and devices to plicate tissue and perform an annuloplasty.