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公开(公告)号:US08622991B2
公开(公告)日:2014-01-07
申请号:US12450246
申请日:2008-03-19
申请人: Benny Pesach , Gabriel Bitton , Ram Weiss , Ron Nagar
发明人: Benny Pesach , Gabriel Bitton , Ram Weiss , Ron Nagar
CPC分类号: A61M5/1723 , A61B18/14 , A61B18/1492 , A61B18/18 , A61F7/007 , A61F7/10 , A61H9/0057 , A61H23/00 , A61M5/14244 , A61M5/158 , A61M5/16831 , A61M37/0092 , A61M2005/1581 , A61M2005/1726 , A61M2205/05 , A61M2205/051 , A61M2205/052 , A61M2205/058 , A61N1/30 , A61N1/406 , A61N2/002 , A61N5/062 , A61N7/00 , A61N2005/0645 , G06F19/00
摘要: Systems, devices and methods for delivery of a chemical substance to the body of the patient are provided. Such embodiments may include an infusion catheter configured to be inserted into tissue, a catheter securing element configured to be adhered to the skin of the patient and further configured to secure the infusion catheter to the skin, a drug delivery pump configured to infuse a drug into the infusion catheter for delivery to a drug infused region on the body of the patient, and a treatment element configured to apply a treatment to the drug infused region to improve pharmacodynamics of the drug during a period of delivery of the drug to the patient.
摘要翻译: 提供了将化学物质递送到患者体内的系统,装置和方法。 这样的实施例可以包括构造成插入组织中的输注导管,导管固定元件,其构造成粘附到患者的皮肤上,并进一步被配置成将输注导管固定到皮肤上;药物输送泵,被配置为将药物注入 用于输送到患者身体上的药物输注区域的输注导管,以及配置成对药物输注区域施加治疗以改善药物递送到患者期间药物的药效学的治疗元件。
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公开(公告)号:US20110288527A1
公开(公告)日:2011-11-24
申请号:US13127823
申请日:2009-11-06
申请人: Benny Pesach , Gabriel Bitton , Ron Nagar , Ram Weiss
发明人: Benny Pesach , Gabriel Bitton , Ron Nagar , Ram Weiss
IPC分类号: A61M37/00
CPC分类号: A61M5/44 , A61B2018/00005 , A61B2090/0803 , A61F7/007 , A61F7/02 , A61F2007/0093 , A61F2007/0096 , A61F2007/0226 , A61M5/003 , A61M5/20 , A61M5/427 , A61M2205/273 , A61M2205/3368 , A61M2205/3653 , A61M2209/00
摘要: A therapeutic treatment device, system and method for improving administration of a temperature sensitive drug into a tissue on the body of a patient at a drug injection site are disclosed. The device includes a treatment element with a controllable heating element in temperature communicative contact with the tissue adjacent to the drug injection site. The controllable heating element is configured to heat the tissue adjacent to the drug injection site to a controllable temperature but does not heat the injected drug above a predetermined limiting temperature, above which degradation of the injected drug may occur.
摘要翻译: 公开了一种治疗装置,系统和方法,用于在药物注射部位改善对患者体内的组织中的感温药物的给药。 该装置包括具有可控加热元件的处理元件,其与邻近药物注射部位的组织温度交互接触。 可控制加热元件被配置为将邻近药物注射部位的组织加热到可控温度,但是不将注射的药物加热到预定的极限温度以上,在该极限温度以上可能发生注射药物的降解。
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公开(公告)号:US20110184342A1
公开(公告)日:2011-07-28
申请号:US12809425
申请日:2008-12-18
申请人: Benny Pesach , Gabriel Bitton , Ron Nagar , Ram Weiss
发明人: Benny Pesach , Gabriel Bitton , Ron Nagar , Ram Weiss
IPC分类号: A61M5/00
CPC分类号: A61M5/1723 , A61M5/14248 , A61M2005/14296 , A61M2005/1726 , A61M2205/3368 , A61M2205/50 , A61M2205/60 , A61M2230/201 , A61M2230/50 , A61M2230/63
摘要: An apparatus and a system for controlling and/or managing administration of a drug to a body of a patient. The apparatus includes a drug infusion device configured to deliver drug at a predetermined location in the body of the patient, at least one sensor disposed in the drug infusion device and configured to measure a. corresponding property related to the patient and selected from the group consisting of physiological properties, biochemical properties, environmental properties and drug-related properties, a controller disposed in the drug infusion device and configured to receive from the at least one sensor data representative of the measured corresponding property and based on the received data, determine a drug delivery rate. The drug delivery device is configured to deliver the drug to the body of the patient based on the determined drug delivery rate.
摘要翻译: 一种用于控制和/或管理药物对患者体内的药物的装置和系统。 该装置包括药物输注装置,其配置成在患者体内的预定位置输送药物,至少一个传感器设置在药物输注装置中并且被配置为测量a。 与患者相关的并且选自生理特性,生物化学性质,环境特性和药物相关性质的对应性质,设置在药物输注装置中并被配置为从所述至少一个传感器接收表示所测量的数据的数据 相应的财产,并根据收到的数据,确定药物递送率。 药物递送装置被配置为基于确定的药物递送速率将药物递送到患者的身体。
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公开(公告)号:US20100292557A1
公开(公告)日:2010-11-18
申请号:US12450250
申请日:2008-03-19
申请人: Benny Pesach , Gabriel Bitton , Ram Weiss , Ron Nagar
发明人: Benny Pesach , Gabriel Bitton , Ram Weiss , Ron Nagar
IPC分类号: A61B5/00
CPC分类号: A61B5/1495 , A61B5/14532 , A61B5/14865 , A61B5/1491
摘要: Embodiments of the present disclosure present systems, devices and methods for ISF glucose monitoring that more accurately reflects the blood glucose levels by introducing a treatment element allowing stable and accurate prediction of blood glucose levels based measured glucose levels from interstitial fluid.
摘要翻译: 本公开的实施例提供了用于ISF葡萄糖监测的系统,装置和方法,其通过引入治疗元件更准确地反映血糖水平,所述治疗元件允许基于来自间质液的测量的葡萄糖水平来稳定和准确地预测血糖水平。
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公开(公告)号:US09220837B2
公开(公告)日:2015-12-29
申请号:US11821230
申请日:2007-06-21
申请人: Benny Pesach , Ron Nagar , Gabriel Bitton , Ram Weiss
发明人: Benny Pesach , Ron Nagar , Gabriel Bitton , Ram Weiss
IPC分类号: A61M5/142 , A61M5/158 , A61M5/168 , A61M5/172 , A61M5/20 , A61B18/14 , A61B18/18 , A61F7/00 , A61M5/14 , A61M39/10 , A61N1/30 , A61N7/00 , A61N5/06 , A61M5/42 , A61B18/08 , A61B18/20
CPC分类号: A61M5/14244 , A61B18/08 , A61B18/14 , A61B18/1477 , A61B18/1492 , A61B18/18 , A61B18/20 , A61B2018/1425 , A61F7/007 , A61M5/1413 , A61M5/158 , A61M5/16831 , A61M5/1723 , A61M5/20 , A61M5/422 , A61M2005/1581 , A61M2005/1726 , A61M2039/1022 , A61M2205/05 , A61M2205/051 , A61M2205/052 , A61M2205/058 , A61M2205/8206 , A61N1/30 , A61N7/00 , A61N2005/0645
摘要: A method and a device for a delivery of a chemical substance to the body of the patient are provided. The device includes an infusion catheter configured to be inserted into a tissue, a catheter securing element configured to be adhered to the skin of the patient and further configured to secure the infusion catheter to the skin, a drug delivery pump configured to infuse a drug into the infusion catheter for delivery to a drug infused region on the body of the patient, and a treatment element configured to apply a treatment to the drug infused region to improve pharmacodynamics of the drug during a period of delivery of the drug to the patient.
摘要翻译: 提供了一种将化学物质输送到患者体内的方法和装置。 该装置包括构造成插入到组织中的输注导管,导管固定元件,其构造成粘附到患者的皮肤上,并进一步构造成将输注导管固定到皮肤上;药物输送泵,被配置为将药物注入 用于输送到患者身体上的药物输注区域的输注导管,以及配置成对药物输注区域施加治疗以改善药物递送到患者期间药物的药效学的治疗元件。
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公开(公告)号:US08409133B2
公开(公告)日:2013-04-02
申请号:US12809425
申请日:2008-12-18
申请人: Benny Pesach , Gabriel Bitton , Ron Nagar , Ram Weiss
发明人: Benny Pesach , Gabriel Bitton , Ron Nagar , Ram Weiss
IPC分类号: A61N1/08
CPC分类号: A61M5/1723 , A61M5/14248 , A61M2005/14296 , A61M2005/1726 , A61M2205/3368 , A61M2205/50 , A61M2205/60 , A61M2230/201 , A61M2230/50 , A61M2230/63
摘要: An apparatus and a system for controlling and/or managing administration of a drug to a body of a patient. The apparatus includes a drug infusion device configured to deliver drug at a predetermined location in the body of the patient, at least one sensor disposed in the drug infusion device and configured to measure a. corresponding property related to the patient and selected from the group consisting of physiological properties, biochemical properties, environmental properties and drug-related properties, a controller disposed in the drug infusion device and configured to receive from the at least one sensor data representative of the measured corresponding property and based on the received data, determine a drug delivery rate. The drug delivery device is configured to deliver the drug to the body of the patient based on the determined drug delivery rate.
摘要翻译: 一种用于控制和/或管理药物对患者体内的药物的装置和系统。 该装置包括药物输注装置,其配置成在患者体内的预定位置输送药物,至少一个传感器设置在药物输注装置中并且被配置为测量a。 与患者相关的并且选自生理特性,生物化学性质,环境特性和药物相关性质的对应性质,设置在药物输注装置中并被配置为从所述至少一个传感器接收表示所测量的数据的数据 相应的财产,并根据收到的数据,确定药物递送率。 药物递送装置被配置为基于确定的药物递送速率将药物递送到患者的身体。
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公开(公告)号:US08827979B2
公开(公告)日:2014-09-09
申请号:US12450251
申请日:2008-03-19
申请人: Benny Pesach , Gabriel Bitton , Ram Weiss , Ron Nagar
发明人: Benny Pesach , Gabriel Bitton , Ram Weiss , Ron Nagar
CPC分类号: A61M5/31 , A61B18/08 , A61B18/14 , A61B18/1477 , A61B18/18 , A61B18/20 , A61B2018/1425 , A61F7/007 , A61M5/14244 , A61M5/158 , A61M5/16831 , A61M5/1723 , A61M5/19 , A61M5/20 , A61M5/2448 , A61M5/422 , A61M2005/1581 , A61M2005/1726 , A61M2205/05 , A61M2205/051 , A61M2205/052 , A61M2205/054 , A61M2205/057 , A61M2205/058 , A61N1/30 , A61N7/00 , A61N2005/0645
摘要: The present disclosure presents systems, devices and methods for injection of drugs, substances and/or chemicals to a patient and for improving their effectiveness once they are injected are disclosed. Additional treatment can be applied to a tissue region on the patient into which a drug (e.g., insulin) is injected, to expose the tissue region to various forms of energy or a substance to improve the drug's pharmacokinetic and/or pharmacodynamic profile.
摘要翻译: 本公开内容公开了向患者注射药物,物质和/或化学物质并且一旦注射后提高其效力的系统,装置和方法。 可以对注射药物(例如胰岛素)的患者的组织区域施加额外的治疗,以将组织区域暴露于各种形式的能量或物质以改善药物的药代动力学和/或药效学特征。
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公开(公告)号:US20100286467A1
公开(公告)日:2010-11-11
申请号:US12450249
申请日:2008-03-19
申请人: Benny Pesach , Gabriel Bitton , Ron Nagar , Ram Weiss
发明人: Benny Pesach , Gabriel Bitton , Ron Nagar , Ram Weiss
CPC分类号: A61M5/158 , A61M5/16836 , A61M2005/1581 , A61M2005/1587
摘要: Embodiments of the present invention are directed to systems, apparatuses, devices and methods for improving, modifying and/or stabilizing pharmacokinetic and/or pharmacodynamic profile of a drug infused into the tissue by a catheter and absorbed into the blood or lymphatic system. In some embodiments, infusion sets provide fluid and electrical connection between a catheter assembly/treatment element and at least one of a fluid source and a second source.
摘要翻译: 本发明的实施方案涉及用于改善,改变和/或稳定通过导管注入组织并被吸收到血液或淋巴系统中的药物的药代动力学和/或药效学曲线的系统,装置,装置和方法。 在一些实施例中,输注组提供导管组件/处理元件与流体源和第二源中的至少一个之间的流体和电连接。
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公开(公告)号:US08961458B2
公开(公告)日:2015-02-24
申请号:US13127823
申请日:2009-11-06
申请人: Benny Pesach , Gabriel Bitton , Ron Nagar , Ram Weiss
发明人: Benny Pesach , Gabriel Bitton , Ron Nagar , Ram Weiss
IPC分类号: A61F7/12 , A61M31/00 , A61F7/02 , A61M5/00 , A61M5/42 , A61B18/00 , A61B19/00 , A61F7/00 , A61M5/20
CPC分类号: A61M5/44 , A61B2018/00005 , A61B2090/0803 , A61F7/007 , A61F7/02 , A61F2007/0093 , A61F2007/0096 , A61F2007/0226 , A61M5/003 , A61M5/20 , A61M5/427 , A61M2205/273 , A61M2205/3368 , A61M2205/3653 , A61M2209/00
摘要: A therapeutic treatment device, system and method for improving administration of a temperature sensitive drug into a tissue on the body of a patient at a drug injection site are disclosed. The device includes a treatment element with a controllable heating element in temperature communicative contact with the tissue adjacent to the drug injection site. The controllable heating element is configured to heat the tissue adjacent to the drug injection site to a controllable temperature but does not heat the injected drug above a predetermined limiting temperature, above which degradation of the injected drug may occur.
摘要翻译: 公开了一种治疗装置,系统和方法,用于在药物注射部位改善对患者体内的组织中的感温药物的给药。 该装置包括具有可控加热元件的处理元件,其与邻近药物注射部位的组织温度交互接触。 可控制加热元件被配置为将邻近药物注射部位的组织加热到可控温度,但是不将注射的药物加热到预定的极限温度以上,在该极限温度以上可能发生注射药物的降解。
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公开(公告)号:US20100152644A1
公开(公告)日:2010-06-17
申请号:US12450246
申请日:2008-03-19
申请人: Benny Pesach , Gabriel Bitton , Ram Weiss , Ron Nagar
发明人: Benny Pesach , Gabriel Bitton , Ram Weiss , Ron Nagar
CPC分类号: A61M5/1723 , A61B18/14 , A61B18/1492 , A61B18/18 , A61F7/007 , A61F7/10 , A61H9/0057 , A61H23/00 , A61M5/14244 , A61M5/158 , A61M5/16831 , A61M37/0092 , A61M2005/1581 , A61M2005/1726 , A61M2205/05 , A61M2205/051 , A61M2205/052 , A61M2205/058 , A61N1/30 , A61N1/406 , A61N2/002 , A61N5/062 , A61N7/00 , A61N2005/0645 , G06F19/00
摘要: Systems, devices and methods for delivery of a chemical substance to the body of the patient are provided. Such embodiments may include an infusion catheter configured to be inserted into tissue, a catheter securing element configured to be adhered to the skin of the patient and further configured to secure the infusion catheter to the skin, a drug delivery pump configured to infuse a drug into the infusion catheter for delivery to a drug infused region on the body of the patient, and a treatment element configured to apply a treatment to the drug infused region to improve pharmacodynamics of the drug during a period of delivery of the drug to the patient.
摘要翻译: 提供了将化学物质递送到患者体内的系统,装置和方法。 这样的实施例可以包括构造成插入组织中的输注导管,导管固定元件,其构造成粘附到患者的皮肤上,并进一步被配置成将输注导管固定到皮肤上;药物输送泵,被配置为将药物注入 用于输送到患者身体上的药物输注区域的输注导管,以及配置成对药物输注区域施加治疗以改善药物递送到患者期间药物的药效学的治疗元件。
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