公开(公告)号：US20170225161A1

公开(公告)日：2017-08-10

申请号：US15504283

申请日：2015-08-14

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Stefano BEGOLO ,  Dmitriy V. ZHUKOV ,  Daan WITTERS ,  Erik B. JUE ,  Rustem F. ISMAGILOV

IPC: B01L3/00 ,  C12Q1/68

CPC classification number: B01L3/50273 ,  B01L3/502715 ,  B01L3/502746 ,  B01L3/502776 ,  B01L3/502784 ,  B01L2200/025 ,  B01L2300/041 ,  B01L2300/046 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0883 ,  B01L2300/14 ,  B01L2400/0475 ,  B01L2400/0478 ,  B01L2400/0487 ,  C12Q1/686

Abstract: Provided herein are devices and methods for generating positive and negative pressures. The devices and methods are suited for the generation of pressures; in particular, the pressures generated can be useful for controlling the flow of fluids, such as in fluidic device.

公开(公告)号：US20180274020A1

公开(公告)日：2018-09-27

申请号：US15524449

申请日：2015-11-05

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  SLIPCHIP CORPORATION

Inventor： Rustem F. ISMAGILOV ,  Eugenia KHOROSHEVA ,  Travis S. SCHLAPPI ,  Matthew S. CURTIS ,  Nathan G. SCHOEPP ,  Hedia MAAMAR ,  Feng SHEN ,  Erik B. JUE

IPC: C12Q1/6851 ,  C12Q1/686 ,  C12Q1/689 ,  C12Q1/18 ,  B01L7/00 ,  B01L3/00

CPC classification number: C12Q1/6851 ,  B01L3/502715 ,  B01L7/00 ,  B01L2300/0861 ,  C12Q1/18 ,  C12Q1/6809 ,  C12Q1/686 ,  C12Q1/689 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2537/165 ,  C12Q2545/114 ,  C12Q2565/629

Abstract: Disclosed herein are methods and devices for rapid assessment of whether a microorganism present in a sample is susceptible or resistant to a treatment.

公开(公告)号：US20180321137A1

公开(公告)日：2018-11-08

申请号：US15774004

申请日：2016-11-04

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Rustem F. ISMAGILOV ,  Jesus Rodriguez MANZANO ,  Mikhail KARYMOV ,  David A. SELCK ,  Stefano BEGOLO ,  Erik B. JUE ,  Dmitriy V. ZHUKOV

IPC: G01N21/25 ,  G06K9/00 ,  G06T7/90 ,  G01J3/50 ,  G01J3/02 ,  C12Q1/6844

CPC classification number: G01N21/253 ,  C12Q1/6844 ,  G01J3/0272 ,  G01J3/46 ,  G01J3/50 ,  G01N2201/0221 ,  G06K9/00134 ,  G06T7/00 ,  G06T7/90 ,  G06T2207/10024 ,  G06T2207/30024 ,  C12Q2527/101 ,  C12Q2537/165 ,  C12Q2563/159

Abstract: The present invention relates to methods, computer readable medium and systems for detecting and counting single nucleic acid molecules confined in nanoliter volumes using an unmodified camera, such as a cell phone camera. In particular, it identifies colorimetric amplification-indicator dyes that are compatible with the spectral sensitivity of standard mobile phones. The invention further provides an optimal ratiometric image-process for a selected dye to achieve a readout that is robust to lighting conditions and camera hardware and provides unambiguous quantitative results, even for colorblind users.