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公开(公告)号：US08360753B2
公开(公告)日：2013-01-29
申请号：US12517602
申请日：2007-12-04
申请人： Dae-Sik Lee , Sung-Lyul Maeng , Jack Luo , Bill Milne
发明人： Dae-Sik Lee , Sung-Lyul Maeng , Jack Luo , Bill Milne
IPC分类号： F04B17/00
CPC分类号： F04B19/006 , B01L3/502707 , B01L3/50273 , B01L2300/0816 , B01L2400/0439 , B01L2400/0496 , F04F7/00 , Y10T29/42 , Y10T137/86027
摘要： Provided is a micro fluidic transportation device capable of controlling discontinuous transportation of micro droplets using surface acoustic wave (SAW), and a method for manufacturing the same. The micro fluidic transportation device which includes: a substrate; a piezoelectric layer formed on the substrate; an inter digitated transducer (IDT) electrode formed on the piezoelectric layer for energy conversion by generating a surface acoustic wave (SAW); and a fluid passage formed on the piezoelectric thin layer.
摘要翻译： 提供一种能够使用表面声波（SAW）控制微滴的不连续输送的微流体输送装置及其制造方法。 微流体输送装置，包括：基板; 形成在基板上的压电层; 通过产生声表面波（SAW）形成在压电层上用于能量转换的数字间传感器（IDT）电极; 以及形成在压电薄层上的流体通道。
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公开(公告)号：US20100018596A1
公开(公告)日：2010-01-28
申请号：US12517602
申请日：2007-12-04
申请人： Dae-Sik Lee , Sung-Lyul Maeng , Jack Luo , Bill Milne
发明人： Dae-Sik Lee , Sung-Lyul Maeng , Jack Luo , Bill Milne
CPC分类号： F04B19/006 , B01L3/502707 , B01L3/50273 , B01L2300/0816 , B01L2400/0439 , B01L2400/0496 , F04F7/00 , Y10T29/42 , Y10T137/86027
摘要： Provided is a micro fluidic transportation device capable of controlling discontinuous transportation of micro droplets using surface acoustic wave (SAW), and a method for manufacturing the same. The micro fluidic transportation device which includes: a substrate; a piezoelectric layer formed on the substrate; an inter digitated transducer (IDT) electrode formed on the piezoelectric layer for energy conversion by generating a surface acoustic wave (SAW); and a fluid passage formed on the piezoelectric thin layer.
摘要翻译： 提供一种能够使用表面声波（SAW）控制微滴的不连续输送的微流体输送装置及其制造方法。 微流体输送装置，包括：基板; 形成在基板上的压电层; 通过产生声表面波（SAW）形成在压电层上用于能量转换的数字间传感器（IDT）电极; 以及形成在压电薄层上的流体通道。
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3.发明申请PLASTIC-BASED MICROFABRICATED THERMAL DEVICE, MANUFACTURING METHOD THEREOF, DNA AMPLIFICATION CHIP USING THE PLASTIC-BASED MICROFABRICATED THERMAL DEVICE, AND METHOD FOR MANUFACTURING THE DNA AMPLIFICATION CHIP 审中-公开基于塑料的微晶热装置，其制造方法，使用基于塑料的微晶热装置的DNA扩增芯片，以及用于制造DNA扩增芯片的方法公开(公告)号：US20080064086A1
公开(公告)日：2008-03-13
申请号：US11854401
申请日：2007-09-12
申请人： Dae-Sik Lee , Se-Ho Park , Kwang-Hyo Chung , Hyeon-Bong Pyo
发明人： Dae-Sik Lee , Se-Ho Park , Kwang-Hyo Chung , Hyeon-Bong Pyo
CPC分类号： H05B3/267 , B01J2219/00317 , B01J2219/00662 , B01J2219/00722 , B01L3/50851 , B01L3/50853 , B01L7/52 , B01L2200/12 , B01L2200/147 , B01L2300/0645 , B01L2300/12 , B01L2300/1827 , G01N2035/00158
摘要： Provided are a microfabricated thermal device using a thin plastic substrate, a manufacturing method thereof, a silicon micro-chamber, a double-stranded deoxyribonucleic acid (DNA) amplification chip employing the microfabricated thermal device and the silicon micro-chamber, and a manufacturing method thereof, and a DNA amplification chip array, and a method for manufacturing the DNA amplification chip array. The microfabricated thermal device using a thin plastic substrate can be used for DNA amplification, i.e., a polymerase chain reaction (PCR), which is essential to DNA related diagnosis and analysis. The plastic-based microfabricated thermal device, includes: a plastic substrate; a heating unit disposed on the top surface of the plastic substrate to supply heat to the plastic substrate; a sensing unit disposed on the top surface of the plastic substrate to detect heat; and a diffusing unit disposed on the bottom surface of the plastic substrate to diffuse heat to the plastic substrate.
摘要翻译： 提供使用薄塑料基板的微制造热装置，其制造方法，硅微室，采用微制造热装置和硅微室的双链脱氧核糖核酸（DNA）扩增芯片，以及制造方法 以及DNA扩增芯片阵列，以及DNA扩增芯片阵列的制造方法。 使用薄塑料底物的微制造热装置可以用于DNA扩增，即聚合酶链式反应（PCR），这对DNA相关的诊断和分析至关重要。 基于塑料的微制造热装置，包括：塑料基板; 加热单元，设置在所述塑料基板的顶表面上以向所述塑料基板供应热量; 感测单元，设置在所述塑料基板的顶表面上以检测热量; 以及设置在塑料基板的底表面上以将热量扩散到塑料基板的漫射单元。
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4.发明授权Natural convection-driven PCR apparatus and method using disposable polymer chip 有权自然对流驱动PCR装置及使用一次性聚合物芯片的方法公开(公告)号：US08735103B2
公开(公告)日：2014-05-27
申请号：US11866979
申请日：2007-10-03
申请人： Kwang-Hyo Chung , Dae-Sik Lee , Hyeon-Bong Pyo , Seon-Hee Park
发明人： Kwang-Hyo Chung , Dae-Sik Lee , Hyeon-Bong Pyo , Seon-Hee Park
CPC分类号： C12Q1/686 , B01L3/5027 , B01L3/50273 , B01L7/52 , B01L7/525 , B01L2300/088 , B01L2300/1827 , B01L2400/0445 , B01L2400/0472 , B01L2400/0688 , B33Y80/00 , C12Q1/6844
摘要： Provided is a natural convection-driven polymerase chain reaction (PCR) apparatus and method, which can periodically change temperature of a sample to make a natural convection-driven flow in a loop-shaped channel on a disposable polymer chip and contacting heating metal members maintained at different temperatures with channels. The natural convection-driven PCR apparatus includes: a polymer chip having a plurality of channels connected together to form a loop-shaped microchannel, a sample being filled inside the channels; a plurality of heating metal members contacting the loop-shaped microchannel of the polymer chip and transferring heat; a temperature controller connected to the heating metal members to maintain the heating metal members at different temperatures; a plurality of heaters connected to the heating metal members and the temperature controller to supply heat to the heating metal members; and temperature sensors connected to the heating metal members and the temperature controller.
摘要翻译： 提供了一种自然对流驱动的聚合酶链反应（PCR）装置和方法，其可以周期性地改变样品的温度以在一次性聚合物芯片上的环形通道中进行自然对流驱动的流动，并且接触保持的加热金属构件 在不同的温度与通道。 自然对流驱动PCR装置包括：聚合物芯片，具有连接在一起形成环形微通道的多个通道，样品填充在通道内; 与聚合物芯片的环形微通道接触并传递热量的多个加热金属构件; 连接到所述加热金属部件以将所述加热金属部件保持在不同温度的温度控制器; 连接到加热金属部件的多个加热器和温度控制器，以向加热金属部件供热; 温度传感器连接到加热金属部件和温度控制器。
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5.发明申请公开(公告)号：US20080286153A1
公开(公告)日：2008-11-20
申请号：US12094980
申请日：2006-11-27
CPC分类号： G01N30/6095 , B01L3/5027
摘要： An affinity chromatography microdevice includes a top board and a bottom board. The top board includes an inlet and an outlet through which microfluid flows, and a reaction chamber for limiting the flow of the microfluid for reaction. The bottom board includes a microelectrode for independently controlling a micro-temperature, and a thermosensitive polymer matrix formed on the microelectrode. The thermosensitive polymer matrix is contracted or expanded according to temperature change.
摘要翻译： 亲和层析微装置包括顶板和底板。 顶板包括微流体流过的入口和出口，以及用于限制用于反应的微流体流动的反应室。 底板包括用于独立控制微温度的微电极和形成在微电极上的热敏聚合物基体。 热敏聚合物基体根据温度变化而收缩或膨胀。
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公开(公告)号：US06415954B1
公开(公告)日：2002-07-09
申请号：US09546617
申请日：2000-04-10
申请人： Dae-Sik Lee
发明人： Dae-Sik Lee
IPC分类号： B65H350
CPC分类号： A47F1/087
摘要： A round-shaped article dispensing device, including a dispensing barrel and a guide member. The dispensing barrel is provided with a discharge hole that is selectively opened and closed by a door. The guide member is disposed in the dispensing barrel and is provided with a guide slit that is slanted and extended from the interior of the dispensing barrel to the discharge hole. The guide slit may be spirally formed along the wall of the guide member.
摘要翻译： 一种圆形物品分配装置，包括分配桶和引导构件。 分配桶设置有由门选择性地打开和关闭的排出孔。 引导构件设置在分配筒中并且设置有从分配筒的内部倾斜并延伸到排出孔的引导狭缝。 引导狭缝可以沿着引导构件的壁螺旋形地形成。
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公开(公告)号：USD647621S1
公开(公告)日：2011-10-25
申请号：US29361124
申请日：2010-05-05
申请人： Dae-Sik Lee , Seon-Hee Park , Moon Youn Jung
设计人： Dae-Sik Lee , Seon-Hee Park , Moon Youn Jung
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公开(公告)号：US20100159576A1
公开(公告)日：2010-06-24
申请号：US12643969
申请日：2009-12-21
申请人： Hyun Woo SONG , Dae-Sik Lee , Hyeon-Bong Pyo , Kwang Hyo Chung , Moon Youn Jung
发明人： Hyun Woo SONG , Dae-Sik Lee , Hyeon-Bong Pyo , Kwang Hyo Chung , Moon Youn Jung
CPC分类号： G01N21/648 , B01J2219/00527 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00702 , B01L3/502715
摘要： Provided are a biochip and a biomaterial detection apparatus. The biochip includes a substrate, a metal layer, and a dielectric layer. The substrate includes a surface having a plurality of acute parts which are formed by first and second inclined planes. The metal layer is formed on at least one of the first and second inclined planes. The dielectric layer is formed on the metal layer, and capture molecules specifically binding to target molecules which are marked with a fluorescent substance are immobilized to a surface of the dielectric layer.
摘要翻译： 提供了生物芯片和生物材料检测装置。 生物芯片包括衬底，金属层和电介质层。 基板包括具有由第一和第二倾斜平面形成的多个锐角部分的表面。 金属层形成在第一和第二倾斜平面中的至少一个上。 电介质层形成在金属层上，捕获与荧光物质标记的靶分子特异结合的捕获分子被固定在电介质层的表面。
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公开(公告)号：US20100158761A1
公开(公告)日：2010-06-24
申请号：US12542627
申请日：2009-08-17
申请人： Kwang Hyo Chung , Dae-Sik Lee , Hyun Woo Song , Yo Han Choi
发明人： Kwang Hyo Chung , Dae-Sik Lee , Hyun Woo Song , Yo Han Choi
CPC分类号： B01J19/0093 , B01J2219/00373 , B01J2219/00376 , B01J2219/00891 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L2300/044 , B01L2300/0816 , B01L2300/0867 , B01L2400/0457 , B01L2400/0487 , B01L2400/06 , Y10T29/494 , Y10T29/49826
摘要： Provided is a microfluidic control apparatus that includes at least one control means and a microfluidic control chip. When the microfluidic control chip is loaded to the control means, a needle provided to the control means is inserted into a reaction solution storage chamber of the microfluidic control chip, in which the reaction solution storage chamber is sealed with a sealing tape. Thus, fluid connection is easily formed between the microfluidic control chip and the control means without leakage.
摘要翻译： 提供了一种微流控制装置，其包括至少一个控制装置和微流控制芯片。 当将微流控制芯片装载到控制装置时，将提供给控制装置的针插入到微流控制芯片的反应溶液储存室中，其中反应溶液储存室用密封胶带密封。 因此，在微流控制芯片和控制装置之间容易形成流体连接而没有泄漏。
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公开(公告)号：US20100143194A1
公开(公告)日：2010-06-10
申请号：US12493092
申请日：2009-06-26
申请人： Dae-Sik Lee , Yo Han Choi , Kwang Hyo Chung , JuHyun Jeon , Hyun Woo Song , Moon Youn Jung , Seon Hee Park
发明人： Dae-Sik Lee , Yo Han Choi , Kwang Hyo Chung , JuHyun Jeon , Hyun Woo Song , Moon Youn Jung , Seon Hee Park
IPC分类号： B01J19/00
CPC分类号： F04B19/006 , B01L3/50273 , B01L9/52 , B01L13/02 , B01L2300/0681 , B01L2300/0816 , B01L2300/1827 , B01L2400/0406 , B01L2400/046 , B01L2400/0677
摘要： Provided is a microfluidic device. The microfluidic device includes a sample storage chamber storing sample fluid therein, a detection chamber connected to the sample storage chamber and detecting a specific material of the sample fluid, a cleaning liquid storage chamber connected to the detection chamber and storing cleaning liquid therein, a plurality of fluid passages interconnecting the chambers, and a micropump transferring the cleaning liquid. The microfluidic device precisely inspects a sample fluid although a small amount of the sample fluid flows.
摘要翻译： 提供了一种微流体装置。 微流体装置包括在其中容纳样品流体的样品储存室，连接到样品储存室并检测样品流体的特定材料的检测室，连接到检测室并在其中储存清洗液体的清洗液储存室，多个 连接腔室的流体通道和传送清洗液体的微型泵。 微流体装置精确检查样品流体，尽管少量样品流体流动。
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