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    Chemical Temperature Control
    3.
    发明申请
    Chemical Temperature Control 审中-公开
    化学温度控制

    公开(公告)号：US20140154786A1

    公开(公告)日：2014-06-05

    申请号：US13874060

    申请日：2013-04-30

    申请人： Program For Appropriate Technology In Health

    发明人： Paul Donald Labarre ,  Jay Lewis Gerlach ,  Bernhard Hans Weigl ,  Gonzalo Jose Domingo-Villegas

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/686 ,  B01L3/5027 ,  B01L3/50273 ,  B01L7/00 ,  B01L7/525 ,  B01L2300/0663 ,  B01L2300/0816 ,  B01L2300/088 ,  B01L2300/1855 ,  B01L2300/1877 ,  B01L2400/0406 ,  B01L2400/0442 ,  B01L2400/0445 ,  B01L2400/0478 ,  B01L2400/0487

    摘要： Exothermic and/or endothermic chemical reactions in combination with phase change materials can produce output temperature(s) within strict tolerances without requiring expensive and complicated external equipment to generate and maintain an output temperature. Similarly, an exothermic phase change material, which generates heat as a consequence of crystallizing a supercooled liquid, can generate heat at a constant temperature, without requiring expensive and complicated external equipment, as a consequence of the liquid form of the exothermic phase change material being in equilibrium with the solid form of the exothermic phase change material. Numerous biological and chemical processes and/or diagnostic devices require a constant temperature or temperatures for set periods of time. An example completely non-instrumented diagnostic platform based on nucleic acid amplification is described, which is particularly suited for use in developing countries that may not have access to expensive and complicated external equipment.

    摘要翻译： 与相变材料相结合的放热和/或吸热化学反应可以在严格的公差范围内产生输出温度，而不需要昂贵和复杂的外部设备来产生和保持输出温度。 类似地，作为结晶过冷液体的结果产生热量的放热相变材料可以在恒定温度下产生热量，而不需要昂贵且复杂的外部设备，因为放热相变材料的液体形式是 与固体形式的放热相变材料平衡。 许多生物和化学过程和/或诊断装置需要恒定的温度或温度来设定一段时间。 描述了基于核酸扩增的完全非仪器化诊断平台的示例，其特别适用于可能无法访问昂贵且复杂的外部设备的发展中国家。

    THERMAL CYCLER
    4.
    发明申请
    THERMAL CYCLER 有权
    热循环

    公开(公告)号：US20130330818A1

    公开(公告)日：2013-12-12

    申请号：US13910462

    申请日：2013-06-05

    申请人： Seiko Epson Corporation

    发明人： Hiroshi KOEDA ,  Toshiro MURAYAMA

    IPC分类号： C12M1/34

    CPC分类号： C12M41/12 ,  B01L7/525 ,  B01L7/5255 ,  B01L7/54 ,  B01L2300/1827 ,  B01L2400/0445 ,  B01L2400/0457 ,  B01L2400/0469

    摘要： A thermal cycler includes: a first mounting unit and a second mounting unit which are cylindrical; a temperature gradient forming unit which forms a temperature gradient along mounting directions of the first mounting unit and the second mounting unit; and a driving mechanism which rotates the first mounting unit, the second mounting unit, and the temperature gradient forming unit around a rotating shaft having a component perpendicular to a direction in which gravity is applied and a component intersecting the mounting directions of the first mounting unit and the second mounting unit, wherein the first mounting unit and the second mounting unit are disposed on opposite sides to each other with the rotating shaft interposed therebetween, the mounting direction of the first mounting unit and the mounting direction of the second mounting unit are in the same direction.

    摘要翻译： 热循环仪包括：圆柱形的第一安装单元和第二安装单元; 温度梯度形成单元，其沿着第一安装单元和第二安装单元的安装方向形成温度梯度; 以及驱动机构，其使第一安装单元，第二安装单元和温度梯度形成单元围绕具有与重力施加的方向垂直的分量的旋转轴旋转，并且与第一安装单元的安装方向相交的部件 和第二安装单元，其中第一安装单元和第二安装单元彼此相对设置，其中转轴插入其间，第一安装单元的安装方向和第二安装单元的安装方向在 方向相同

    CHANNELS WITH CROSS-SECTIONAL THERMAL GRADIENTS
    5.
    发明申请
    CHANNELS WITH CROSS-SECTIONAL THERMAL GRADIENTS 有权
    具有跨部分热梯度的通道

    公开(公告)号：US20130183717A1

    公开(公告)日：2013-07-18

    申请号：US13724503

    申请日：2012-12-21

    申请人： Herbert A. Marble ,  Thomas Laffler

    发明人： Herbert A. Marble ,  Thomas Laffler

    IPC分类号： C12P19/34

    CPC分类号： B01L7/54 ,  B01L3/502784 ,  B01L7/525 ,  B01L2400/0415 ,  B01L2400/0433 ,  B01L2400/0445 ,  B01L2400/086 ,  C07H21/00 ,  C12P19/34 ,  C12Q1/686 ,  C12Q2527/15 ,  C12Q2563/159 ,  C12Q2565/629

    摘要： Provided herein are systems, devices, and methods for generating thermal gradients in channels and uses thereof. In particular, provided herein are system, methods, and devices employing first and second thermal layers positioned around a channel in order to create a thermal gradient across a cross-section of the channel having, for example, a nucleic acid denaturation zone, a nucleic acid annealing zone, and a nucleic acid polymerization zone. Such devices find use in, for example, nucleic acid amplification procedures, including digital polymerase chain reaction (dPCR) to temperature cycle droplets for amplification of nucleic acid templates within the droplets.

    摘要翻译： 本文提供了用于在通道中产生热梯度的系统，装置和方法及其用途。 特别地，本文提供了使用位于通道周围的第一和第二热层的系统，方法和装置，以便跨越具有例如核酸变性区的通道的横截面产生热梯度，核酸 酸退火区和核酸聚合区。 这样的装置可用于例如核酸扩增程序，包括数字聚合酶链反应（dPCR）到温度循环液滴，用于扩散液滴内的核酸模板。

    NATURAL CONVECTION-DRIVEN PCR APPARATUS AND METHOD USING DISPOSABLE POLYMER CHIP
    6.
    发明申请
    NATURAL CONVECTION-DRIVEN PCR APPARATUS AND METHOD USING DISPOSABLE POLYMER CHIP 有权
    自然对流驱动PCR装置和使用可分散聚合物芯片的方法

    公开(公告)号：US20080131956A1

    公开(公告)日：2008-06-05

    申请号：US11866979

    申请日：2007-10-03

    申请人： Kwang-Hyo CHUNG ,  Dae-Sik Lee ,  Hyeon-Bong Pyo ,  Seon-Hee Park

    发明人： Kwang-Hyo CHUNG ,  Dae-Sik Lee ,  Hyeon-Bong Pyo ,  Seon-Hee Park

    IPC分类号： C12M1/36

    CPC分类号： C12Q1/686 ,  B01L3/5027 ,  B01L3/50273 ,  B01L7/52 ,  B01L7/525 ,  B01L2300/088 ,  B01L2300/1827 ,  B01L2400/0445 ,  B01L2400/0472 ,  B01L2400/0688 ,  B33Y80/00 ,  C12Q1/6844

    摘要： Provided is a natural convection-driven polymerase chain reaction (PCR) apparatus and method, which can periodically change temperature of a sample to make a natural convection-driven flow in a loop-shaped channel on a disposable polymer chip and contacting heating metal members maintained at different temperatures with channels. The natural convection-driven PCR apparatus includes: a polymer chip having a plurality of channels connected together to form a loop-shaped microchannel, a sample being filled inside the channels; a plurality of heating metal members contacting the loop-shaped microchannel of the polymer chip and transferring heat; a temperature controller connected to the heating metal members to maintain the heating metal members at different temperatures; a plurality of heaters connected to the heating metal members and the temperature controller to supply heat to the heating metal members; and temperature sensors connected to the heating metal members and the temperature controller.

    摘要翻译： 提供了一种自然对流驱动的聚合酶链反应（PCR）装置和方法，其可以周期性地改变样品的温度以在一次性聚合物芯片上的环形通道中进行自然对流驱动的流动，并且接触保持的加热金属构件 在不同的温度与通道。 自然对流驱动PCR装置包括：聚合物芯片，具有连接在一起形成环形微通道的多个通道，样品填充在通道内; 与聚合物芯片的环形微通道接触并传递热量的多个加热金属构件; 连接到所述加热金属部件以将所述加热金属部件保持在不同温度的温度控制器; 连接到加热金属部件的多个加热器和温度控制器，以向加热金属部件供热; 温度传感器连接到加热金属部件和温度控制器。