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1.SUBSTITUTED BENZOFURANS, BENZOTHIOPHENES, BENZOSELENOPHENES AND INDOLES AND THEIR USE AS TUBULIN POLYMERISATION INHIBITORS 有权
标题翻译: 替代苯唑酮,苯并噻唑,苯并噻吩和吲哚,以及其作为管状体聚合抑制剂的用途公开(公告)号:US20100004208A1
公开(公告)日:2010-01-07
申请号:US12162917
申请日:2007-02-02
申请人: Jason Hugh Chaplin , Gurmit Singh Gill , Damian Wojciech Grobelny , Bernard Luke Flynn , Gabriel Kremmidiotis
发明人: Jason Hugh Chaplin , Gurmit Singh Gill , Damian Wojciech Grobelny , Bernard Luke Flynn , Gabriel Kremmidiotis
IPC分类号: A61K31/343 , C07D307/78 , C07D307/82 , C07D405/12 , A61K31/443 , A61K31/496 , A61K31/665 , A61P35/00
CPC分类号: A61K31/343 , A61K31/381 , A61K31/404 , A61K31/41 , A61K31/4178 , A61K31/443 , A61K31/496 , A61K31/665 , A61K39/3955 , A61K45/06 , A61K51/00 , C07D209/12 , C07D307/80 , C07D307/81 , C07D307/82 , C07D307/83 , C07D307/84 , C07D307/85 , C07D307/86 , C07D333/56 , C07D405/06 , C07D405/12 , C07D407/06 , C07D407/12 , C07F9/65517 , C07K16/22
摘要: The present invention relates generally to substituted benzofurans, benzothiophenes, and indoles and their use as tubulin polymerisation inhibitors.
摘要翻译: 本发明一般涉及取代的苯并呋喃,苯并噻吩和吲哚及其作为微管蛋白聚合抑制剂的用途。
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公开(公告)号:US08202513B2
公开(公告)日:2012-06-19
申请号:US12681763
申请日:2008-10-03
申请人: Bernard Luke Flynn , Jonathan Bayldon Baell , Jason Hugh Chaplin , Gurmit Singh Gill , Damian Wojciech Grobelny , Andrew John Harvey , Jorgen Alvar Mould , Dharam Paul
发明人: Bernard Luke Flynn , Jonathan Bayldon Baell , Jason Hugh Chaplin , Gurmit Singh Gill , Damian Wojciech Grobelny , Andrew John Harvey , Jorgen Alvar Mould , Dharam Paul
IPC分类号: A61K38/21 , A61K31/138 , A61K31/4402 , A61K31/5375 , A61K31/4453 , A61K31/40 , A61K31/4965 , A61K31/54 , A61K31/4174 , A61K31/4196 , A61K31/397 , A61K31/198 , A61K39/395 , C07C215/64 , A61P29/00 , A61P3/10 , A61P25/28 , C07D213/54 , C07D265/30 , C07D211/34 , C07D211/74 , C07D207/08 , C07D241/18 , C07D279/12 , C07D233/60 , C07D249/08 , C07D205/04
CPC分类号: C07C217/22 , C07C49/84 , C07C2601/08 , C07D205/04 , C07D205/08 , C07D207/10 , C07D211/38 , C07D211/46 , C07D211/74 , C07D213/30 , C07D233/60 , C07D241/18 , C07D249/08 , C07D265/30 , C07D295/088
摘要: The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.
摘要翻译: 本发明涉及可用于调节细胞中钾通道活性的化合物,特别是在T细胞中发现的Kv1.3通道的活性。 本发明还涉及这些化合物在治疗或预防自身免疫性和炎性疾病,包括多发性硬化症中的用途,含有这些化合物的药物组合物及其制备方法。
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公开(公告)号:US20100292190A1
公开(公告)日:2010-11-18
申请号:US11816209
申请日:2006-02-14
IPC分类号: A61K31/675 , A61K31/67 , A61K31/665 , A61K31/496 , A61K31/443 , A61K31/4192 , A61K31/427 , A61K31/424 , A61K31/422 , A61K31/41 , A61K31/4196 , A61K31/4178 , A61K31/4155 , A61K31/4025 , A61K31/381 , A61K31/343 , C07D405/04 , C07F9/09 , C07D417/04 , C07D498/14 , C07D413/04 , C07D403/04 , C07D409/04 , C07D407/04 , A61P29/00 , A61P35/00 , A61P17/06
CPC分类号: C07D403/04 , C07D307/80 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07F9/65517 , C07F9/65586
摘要: The present invention relates to compounds of general formula (I) as tublin polymerisation inhibitors and methods for preparing such compounds.
摘要翻译: 本发明涉及作为都柏林聚合抑制剂的通式(I)化合物及其制备方法。
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公开(公告)号:US09023848B2
公开(公告)日:2015-05-05
申请号:US14002243
申请日:2012-03-02
申请人: Bernard Luke Flynn , Dharam Paul , Andrew John Harvey , Damian Wojciech Grobelny , Sue O'Connor , Jonathan Bayldon Baell , Brad Sleebs , Ian Phillip Street
发明人: Bernard Luke Flynn , Dharam Paul , Andrew John Harvey , Damian Wojciech Grobelny , Sue O'Connor , Jonathan Bayldon Baell , Brad Sleebs , Ian Phillip Street
IPC分类号: C07D215/54 , C07D215/38 , C07D401/04 , C07D413/04 , C07D491/107
CPC分类号: C07D215/54 , C07D215/38 , C07D401/04 , C07D413/04 , C07D491/107
摘要: The present invention provides compounds of formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful in treating central nervous system disorders, such as anxiety disorders or depression.
摘要翻译: 本发明提供式(I)化合物,其药学上可接受的盐及其药物组合物。 本发明的化合物可用于治疗中枢神经系统疾病,例如焦虑障碍或抑郁症。
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5.Furo[2,3-d]pyrimidines and related compounds and methods for treating disease states by inhibiting tubulin polymerization 有权
标题翻译: 呋喃并[2,3-d]嘧啶及其相关化合物和通过抑制微管蛋白聚合来治疗疾病状态的方法公开(公告)号:US08466163B2
公开(公告)日:2013-06-18
申请号:US12448146
申请日:2007-12-11
IPC分类号: A61K31/519 , A61P35/00
CPC分类号: C07D491/04 , C07D495/04
摘要: The present invention relates generally to chemical compounds and methods for their use and preparation. In particular, the invention relates to chemical compounds which may possess useful therapeutic activity, use of these compounds in methods of therapy and the manufacture of medicaments as well as compositions containing these compounds.
摘要翻译: 本发明一般涉及化合物及其使用和制备方法。 特别地,本发明涉及可能具有有用的治疗活性的化合物,这些化合物在治疗和药物制造方法中的应用以及含有这些化合物的组合物。
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公开(公告)号:US20100048591A1
公开(公告)日:2010-02-25
申请号:US12448146
申请日:2007-12-11
IPC分类号: A61K31/519 , A61K31/4355 , C07D491/048
CPC分类号: C07D491/04 , C07D495/04
摘要: The present invention relates generally to chemical compounds and methods for their use and preparation. In particular, the invention relates to chemical compounds which may possess useful therapeutic activity, use of these compounds in methods of therapy and the manufacture of medicaments as well as compositions containing these compounds.
摘要翻译: 本发明一般涉及化合物及其使用和制备方法。 特别地,本发明涉及可能具有有用的治疗活性的化合物,这些化合物在治疗和药物制造方法中的应用以及含有这些化合物的组合物。
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公开(公告)号:US6071895A
公开(公告)日:2000-06-06
申请号:US255551
申请日:1999-02-22
IPC分类号: A61K38/00 , C07C243/18 , C07C243/28 , C07C243/32 , C07C243/34 , C07C251/80 , C07C255/13 , C07C255/24 , C07C271/20 , C07C271/22 , C07C281/02 , C07C323/60 , C07D207/14 , C07D207/40 , C07D207/416 , C07D209/48 , C07D211/28 , C07D211/58 , C07D211/72 , C07D213/30 , C07D213/40 , C07D213/56 , C07D213/75 , C07D213/80 , C07D213/81 , C07D215/14 , C07D215/48 , C07D231/04 , C07D231/54 , C07D237/04 , C07D237/30 , C07D237/32 , C07D239/04 , C07D243/10 , C07D245/02 , C07D255/02 , C07D257/04 , C07D265/06 , C07D265/30 , C07D295/13 , C07D295/26 , C07D303/36 , C07D307/12 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/08 , C07D491/04 , C07D495/04 , C07D498/08 , C07D521/00 , C07F9/09 , C07F9/141 , C07F9/553 , C07F9/572 , C07F9/58 , C07F9/60 , C07F9/62 , C07F9/6506 , C07F9/6509 , C07F9/6558 , C07F9/6561 , C07F9/6574 , C07K5/06 , C07K5/078 , A61K31/65 , A61K31/27 , C07C323/57
CPC分类号: C07K5/06139 , C07C243/18 , C07C243/28 , C07C243/32 , C07C243/34 , C07C251/80 , C07C255/13 , C07C255/24 , C07C271/20 , C07C271/22 , C07C281/02 , C07C323/60 , C07D207/14 , C07D207/416 , C07D209/48 , C07D211/28 , C07D211/58 , C07D211/72 , C07D213/30 , C07D213/40 , C07D213/56 , C07D213/75 , C07D213/80 , C07D213/81 , C07D215/14 , C07D215/48 , C07D231/04 , C07D231/12 , C07D231/54 , C07D233/56 , C07D237/04 , C07D237/30 , C07D237/32 , C07D239/04 , C07D243/10 , C07D245/02 , C07D249/08 , C07D255/02 , C07D257/04 , C07D265/06 , C07D265/30 , C07D295/13 , C07D295/26 , C07D303/36 , C07D307/12 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/08 , C07D491/04 , C07D495/04 , C07F9/091 , C07F9/093 , C07F9/1411 , C07F9/1412 , C07F9/5532 , C07F9/5721 , C07F9/588 , C07F9/60 , C07F9/62 , C07F9/65067 , C07F9/650994 , C07F9/65583 , C07F9/65586 , C07F9/6561 , C07F9/65742 , C07F9/65744 , C07K5/06191 , A61K38/00 , C07C2101/14 , C07C2101/16 , C07C2102/10 , C07C2103/24
摘要: The present invention discloses the compounds of general formula (1) ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 are optionally substituted carbonyl and amide derivatives which are useful as inhibitors of retroviral proteases, and are effective in treating conditions characterized by unwanted activity of these enzymes, such as acquired immume deficiency syndrome.
摘要翻译: 本发明公开了通式(1)的化合物,其中R 1,R 2,R 3为任选取代的羰基和酰胺衍生物,其可用作逆转录病毒蛋白酶的抑制剂,并且有效治疗以这些酶为不期望的活性为特征的病症,例如 获得性缺血综合征。
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8.Substituted benzofurans, benzothiophenes, benzoselenophenes and indoles and their use as tubulin polymerisation inhibitors 有权
标题翻译: 取代的苯并呋喃,苯并噻吩,苯并硒吩和吲哚及其作为微管蛋白聚合抑制剂的用途公开(公告)号:US08716335B2
公开(公告)日:2014-05-06
申请号:US13461213
申请日:2012-05-01
申请人: Jason Hugh Chaplin , Gurmit Singh Gill , Damian Wojciech Grobelny , Bernard Luke Flynn , Gabriel Kremmidiotis
发明人: Jason Hugh Chaplin , Gurmit Singh Gill , Damian Wojciech Grobelny , Bernard Luke Flynn , Gabriel Kremmidiotis
IPC分类号: A61K31/343 , C07D307/80
CPC分类号: A61K31/343 , A61K31/381 , A61K31/404 , A61K31/41 , A61K31/4178 , A61K31/443 , A61K31/496 , A61K31/665 , A61K39/3955 , A61K45/06 , A61K51/00 , C07D209/12 , C07D307/80 , C07D307/81 , C07D307/82 , C07D307/83 , C07D307/84 , C07D307/85 , C07D307/86 , C07D333/56 , C07D405/06 , C07D405/12 , C07D407/06 , C07D407/12 , C07F9/65517 , C07K16/22
摘要: The present invention relates generally to substituted benzofurans, benzothiophenes, and indoles and their use as tubulin polymerization inhibitors.
摘要翻译: 本发明一般涉及取代的苯并呋喃,苯并噻吩和吲哚及其作为微管蛋白聚合抑制剂的用途。
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公开(公告)号:US08278290B2
公开(公告)日:2012-10-02
申请号:US11816209
申请日:2006-02-14
IPC分类号: A61K31/38 , A61K31/675 , A01N57/00 , C07D405/00
CPC分类号: C07D403/04 , C07D307/80 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07F9/65517 , C07F9/65586
摘要: The present invention relates to compounds of general formula (I) as tublin polymerization inhibitors and methods for preparing such compounds.
摘要翻译: 本发明涉及作为都柏林聚合抑制剂的通式(I)化合物及其制备方法。
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公开(公告)号:US06258806B1
公开(公告)日:2001-07-10
申请号:US09321043
申请日:1999-05-27
IPC分类号: C07D21548
CPC分类号: C07C271/20 , C07C281/02 , C07C323/60 , C07C2601/14 , C07D213/30 , C07D213/81 , C07D215/48 , C07D231/54 , C07D237/04 , C07D237/30 , C07D401/12
摘要: The present invention discloses the compounds of general formula (1) wherein R1, R2, R3 are optionally substituted carbonyl and amide derivatives which are useful as inhibitors of retroviral proteases, and are effective in treating conditions characterized by unwanted activity of these enzymes, such as acquired immune deficiency syndrome.
摘要翻译: 本发明公开了通式(1)的化合物,其中R 1,R 2,R 3为任选取代的羰基和酰胺衍生物,其可用作逆转录病毒蛋白酶的抑制剂,并且有效治疗以这些酶为不期望的活性为特征的病症,例如 获得性免疫缺陷综合征。
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