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149 条记录 (耗时 0.046 秒)

    Certain 2-pyridinyl-phenylsulfinyl-benzoxazoles, the corresponding benzothiazoles or benzimidazoles having anti-inflammatory or gastric acid secretion inhibition activity
    2.
    发明授权
    Certain 2-pyridinyl-phenylsulfinyl-benzoxazoles, the corresponding benzothiazoles or benzimidazoles having anti-inflammatory or gastric acid secretion inhibition activity 失效
    某些2-吡啶基 - 苯基亚磺酰基 - 苯并恶唑，具有抗炎或胃酸分泌抑制活性的相应的苯并噻唑或苯并咪唑

    公开(公告)号：US4851419A

    公开(公告)日：1989-07-25

    申请号：US918832

    申请日：1986-10-14

    申请人： David Cox ,  David E. Hall ,  Anthony H. Ingall ,  John L. Suschitzky

    发明人： David Cox ,  David E. Hall ,  Anthony H. Ingall ,  John L. Suschitzky

    IPC分类号： C07D235/28 ,  C07D401/12 ,  C07D413/12 ,  C07D417/12

    CPC分类号： C07D401/12 ,  C07D235/28 ,  C07D413/12 ,  C07D417/12

    摘要： There are described compounds of formula I, ##STR1## in which A is a benzene or heterocyclic ring, y is 0 or 1,L is a group containing 1 or 2 carbon atoms, or is a single bond,R.sub.9 and R.sub.10 have a variety of significances, e.g.R.sub.10 may form part of a double bond with L, orthe group --NR.sub.9 R.sub.10 forms a ring carrying substituents R.sub.1 and R.sub.8, orwhen L is a single bond --NR.sub.10 and R.sub.8 may form a ring carrying substituents R.sub.16 to R.sub.25, orthe group --LNR.sub.9 R.sub.10 forms a heterocyclic ring carrying substituents R.sub.26 to R.sub.33,R.sub.1 to R.sub.8 and R.sub.16 to R.sub.33 have a variety of significancesn is 0, 1 or 2,x is 3, 4 or 5,X is S, O or NR.sub.15,R.sub.15 is hydrogen, --COR, --COOR or alkyl optionally substituted by --OCOR,and certain provisos.Processes for making the compounds and pharmaceutical formulations containing them, e.g. for the treatment of conditions involving excess gastric acid secretion, are also described.

    摘要翻译： 描述了式I化合物，其中A是苯或杂环，y是0或1，L是含有1或2个碳原子的基团，或是单键，R 9和R 10具有 各种意义，例如 R 10可以与L形成双键的一部分，或者-NR 9 R 10基团形成携带取代基R 1和R 8的环，或者当L是单键-NR 10时，R 8可以形成携带取代基R 16〜R 25的环， LNR9R10形成携带取代基R26至R33的杂环，R1至R8和R16至R33具有各种含义，n为0,1或2，x为3,4或5，X为S，O或NR15，R15为氢 ，-COR，-COOR或任选被-OCOR取代的烷基，以及某些条件。 制备化合物和含有它们的药物制剂的方法，例如 也描述了治疗涉及过多胃酸分泌的病症。

    Pyranoquinolinones and analogs thereof
    3.
    发明授权
    Pyranoquinolinones and analogs thereof 失效
    吡喃喹啉酮及其类似物

    公开(公告)号：US4419352A

    公开(公告)日：1983-12-06

    申请号：US236329

    申请日：1981-02-20

    申请人： David Cox ,  Hugh Cairns ,  Nigel Chadwick ,  John L. Suschitzky

    发明人： David Cox ,  Hugh Cairns ,  Nigel Chadwick ,  John L. Suschitzky

    IPC分类号： A61K31/435 ,  A61K31/495 ,  A61P11/06 ,  A61P37/08 ,  C07D215/00 ,  C07D215/48 ,  C07D239/72 ,  C07D239/90 ,  C07D311/24 ,  C07D335/06 ,  C07D491/04 ,  C07D491/052 ,  C07D495/04 ,  A61K31/47 ,  A61K31/535 ,  C07D413/14

    CPC分类号： C07D491/04 ,  C07D215/48 ,  C07D239/90 ,  C07D311/24 ,  C07D335/06 ,  C07D495/04 ,  Y10S514/826 ,  Y10S514/914 ,  Y10S514/925 ,  Y10S514/926 ,  Y10S514/927 ,  Y10S514/934

    摘要： There are described compounds of formula I, ##STR1## in which an adjacent pair of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a chain --CZC(G.sub.1).dbd.(G.sub.2)--Z--,R.sub.4, R.sub.9 and the remainder of R.sub.5, R.sub.6, R.sub.7 and R.sub.8, which may be the same or different, each represent hydrogen, alkyl, halogen, alkenyl, --NO.sub.2, --NR.sub.1 R.sub.2, --OR.sub.3, --S(O).sub.n R.sub.3 ; or alkyl substituted by hydroxy, amino, alkoxy or carbonyl oxygen,n is 0, 1 or 2,R.sub.1 and R.sub.2, which may be the same or different, each represent hydrogen, alkyl, --CONHR.sub.3, phenyl or phenyl substituted by alkyl or halogen, or R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached form a 5 or 6 membered heterocyclic ring,R.sub.3 represents hydrogen, alkyl, alkenyl or phenyl,one of G.sub.1 and G.sub.2 is hydrogen and the other is a group E,each E, which may be the same or different, is --COOH, a 5-tetrazolyl group, or a carboxamidotetrazole group,each Z, which may be the same or different, is oxygen or sulphur, andone or two of the atoms, a, b, c and d are nitrogen atoms and the remainder are carbon atoms, R.sup.9 having no significance when two of a, b, c and d are nitrogen,(with certain exclusions)and pharmaceutically acceptable derivatives thereof.There are also described methods for making the compounds and pharmaceutical, e.g. anti-allergic, compositions and mixtures containing them.

    摘要翻译： 描述了式I，其中相邻的一对R 5，R 6，R 7和R 8形成链-CZC（G1）=（G2）-Z-，R4，R9和R5的其余部分的式I化合物， R 6，R 7和R 8可以相同或不同，各自表示氢，烷基，卤素，烯基，-NO 2，-NR 1 R 2，-OR 3，-S（O）n R 3; 或被羟基，氨基，烷氧基或羰基氧取代的烷基，n为0,1或2，可以相同或不同的R 1和R 2各自表示氢，烷基，-CONHR 3，苯基或被烷基或卤素取代的苯基 ，或R1和R2与它们所连接的氮原子一起形成5或6元杂环，R 3表示氢，烷基，链烯基或苯基，G1和G2之一是氢，另一个是基团E，每个 E可以相同或不同，为-COOH，5-四唑基或羧酰胺基四唑基，各Z可以相同或不同，为氧或硫，一个或两个原子为 b，c和d为氮原子，其余为碳原子，当a，b，c和d中的两个为氮时，R 9为无意义（具有某些排除）及其药学上可接受的衍生物。 还描述了制备化合物和药物的方法。 抗过敏剂，组合物和含有它们的混合物。

    Fastener
    4.
    发明授权
    Fastener 有权

    公开(公告)号：US11466795B2

    公开(公告)日：2022-10-11

    申请号：US17248790

    申请日：2021-02-08

    申请人： David Cox

    发明人： David Cox

    IPC分类号： F16L3/04 ,  F16B15/00

    摘要： A fastener for fastening pipes or electrical conduit can be installed with the optional use of nails or screws. The fastener includes sharp teeth or spikes which can be hammered into an external surface, such as wood or masonry. The teeth or spikes are positioned, oriented, and otherwise configured to best suit the intended application. Installation can be accomplished using only the fastener itself and force exceeding a minimal threshold.

    Internal combustion engines
    9.
    发明授权
    Internal combustion engines 有权
    内燃机

    公开(公告)号：US08499726B2

    公开(公告)日：2013-08-06

    申请号：US12663519

    申请日：2008-05-28

    申请人： David Cox

    发明人： David Cox

    IPC分类号： F01B7/12 ,  F02B25/08 ,  F02B75/28

    CPC分类号： F01B9/023 ,  F01B1/08 ,  F01B7/04 ,  F01B7/10 ,  F02B25/08 ,  F02B75/24 ,  F02B75/28 ,  F02B2075/025 ,  F02B2075/1808 ,  F02B2275/40 ,  F02F1/22 ,  F02F3/0015 ,  Y02T10/125

    摘要： The invention provides a 2-stroke internal combustion engine comprising two opposed cylinders, each cylinder housing two opposed pistons and having at least one exhaust port and at least one intake port, and a crankshaft having asymmetrically arranged journals and scotch-yoke mechanisms for driving the journals from the pistons. The pistons in each cylinder operate to open its exhaust port or ports before its intake port or ports and to close its exhaust port or ports before its intake port or ports.

    摘要翻译： 本发明提供一种二冲程内燃机，其包括两个相对的气缸，每个气缸容纳两个相对的活塞并且具有至少一个排气口和至少一个进气口，以及具有不对称排列的轴颈和用于驱动 来自活塞的期刊。 每个气缸中的活塞在其进气口或端口之前操作以打开其排气端口，并在其进气口或端口之前关闭其排气口或端口。

    METHOD AND SYSTEM FOR AUTHORIZATION OF PRESENCE INFORMATION
    10.
    发明申请
    METHOD AND SYSTEM FOR AUTHORIZATION OF PRESENCE INFORMATION 有权
    用于授权存在信息的方法和系统

    公开(公告)号：US20120304252A1

    公开(公告)日：2012-11-29

    申请号：US13574696

    申请日：2010-01-27

    申请人： Christer Boberg ,  Mikael Klein ,  Anders Lindgren ,  Sofie Lassborn ,  David Cox

    发明人： Christer Boberg ,  Mikael Klein ,  Anders Lindgren ,  Sofie Lassborn ,  David Cox

    IPC分类号： G06F21/00

    CPC分类号： H04L67/24 ,  H04L63/105

    摘要： Embodiments of the present invention include a system and method for implementing a presence system. According to an embodiment of the present invention, responsive to receiving a request for presence information associated with a presentity from a watcher, the presence system receives instructions indicating that an authorization instance other than the presentity shall be given an opportunity to change or verify an authorization rule associated with the request for presence information. As a consequence, the presence system notifies the authorization instance of the request for presence information, thereby enabling the authorization instance to change or verify the authorization rule. The presence system also makes a final decision on the authorization rule on the basis of the instructions and a notification indicating a change or verification of the authorization rule.

    摘要翻译： 本发明的实施例包括用于实现存在系统的系统和方法。 根据本发明的实施例，响应于从观察者接收到与呈现体相关联的存在信息的请求，存在系统接收指示，指示除了呈现体之外的授权实例有机会改变或验证授权 与存在信息请求相关联的规则。 因此，存在系统通知授权实例对存在信息的请求，从而使授权实例能够改变或验证授权规则。 存在系统还根据指令和指示更改或验证授权规则的通知对授权规则作出最终决定。