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公开(公告)号：US20110136696A1
公开(公告)日：2011-06-09
申请号：US13029071
申请日：2011-02-16
申请人： David L. Heiner , Aaron C. Jones , Steven P. Fambro , Mark J. Nibbe , Steve R. Burgett , Brett M. Ellman , Michal Lebl
发明人： David L. Heiner , Aaron C. Jones , Steven P. Fambro , Mark J. Nibbe , Steve R. Burgett , Brett M. Ellman , Michal Lebl
IPC分类号： C40B50/00
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00283 , B01J2219/00315 , B01J2219/00326 , B01J2219/0036 , B01J2219/00423 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00612 , B01J2219/00659 , B01J2219/00675 , B01J2219/00693 , B01J2219/00722 , B01J2219/00725 , C40B60/14 , Y10T436/115831 , Y10T436/12
摘要： Described is a system and method for synthesizing polymeric molecules such as oligonucleotides and polypeptides. The system is capable of continuously synthesizing molecules by providing an array of reaction sites and an array of stations for carrying out synthetic manipulations. The reaction sites in the former array can be placed in a fixed order and at fixed intervals relative to each other. Similarly, the stations can be placed in a fixed order and at fixed intervals relative to each other. The two arrays can be moved relative to each other such that the stations carry out desired steps of a reaction scheme at each reaction site. The relative locations of the stations and the schedule for the relative movement can correlate with the order and duration of reaction steps in the reaction scheme such that once a reaction site has completed a cycle of interacting with the full array of stations then the reaction scheme is complete.
摘要翻译： 描述了用于合成聚合物分子如寡核苷酸和多肽的系统和方法。 该系统能够通过提供反应位点阵列和用于进行合成操作的站阵列来连续合成分子。 前一阵列中的反应位点可以相对于彼此以固定的顺序和固定的间隔放置。 类似地，站可以以固定的顺序相对于彼此以固定的间隔放置。 两个阵列可以相对于彼此移动，使得站在每个反应位置进行反应方案的期望步骤。 站的相对位置和相对运动的时间表可以与反应方案中的反应步骤的顺序和持续时间相关联，使得一旦反应位点完成了与整个站阵列相互作用的循环，则反应方案为 完成。
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公开(公告)号：US08731721B2
公开(公告)日：2014-05-20
申请号：US13029071
申请日：2011-02-16
申请人： David L. Heiner , Aaron C. Jones , Steven P. Fambro , Mark J. Nibbe , Steve R. Burgett , Brett M. Ellman , Michal Lebl
发明人： David L. Heiner , Aaron C. Jones , Steven P. Fambro , Mark J. Nibbe , Steve R. Burgett , Brett M. Ellman , Michal Lebl
IPC分类号： G05B21/00
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00283 , B01J2219/00315 , B01J2219/00326 , B01J2219/0036 , B01J2219/00423 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00612 , B01J2219/00659 , B01J2219/00675 , B01J2219/00693 , B01J2219/00722 , B01J2219/00725 , C40B60/14 , Y10T436/115831 , Y10T436/12
摘要： Described is a system and method for synthesizing polymeric molecules such as oligonucleotides and polypeptides. The system is capable of continuously synthesizing molecules by providing an array of reaction sites and an array of stations for carrying out synthetic manipulations. The reaction sites in the former array can be placed in a fixed order and at fixed intervals relative to each other. Similarly, the stations can be placed in a fixed order and at fixed intervals relative to each other. The two arrays can be moved relative to each other such that the stations carry out desired steps of a reaction scheme at each reaction site. The relative locations of the stations and the schedule for the relative movement can correlate with the order and duration of reaction steps in the reaction scheme such that once a reaction site has completed a cycle of interacting with the full array of stations then the reaction scheme is complete.
摘要翻译： 描述了用于合成聚合物分子如寡核苷酸和多肽的系统和方法。 该系统能够通过提供反应位点阵列和用于进行合成操作的站阵列来连续合成分子。 前一阵列中的反应位点可以相对于彼此以固定的顺序并且以固定的间隔放置。 类似地，站可以以固定的顺序相对于彼此以固定的间隔放置。 两个阵列可以相对于彼此移动，使得站在每个反应位置进行反应方案的期望步骤。 站的相对位置和相对运动的时间表可以与反应方案中的反应步骤的顺序和持续时间相关联，使得一旦反应位点完成了与整个站阵列相互作用的循环，则反应方案为 完成。
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公开(公告)号：US07914739B2
公开(公告)日：2011-03-29
申请号：US11521573
申请日：2006-09-13
申请人： David L. Heiner , Aaron C. Jones , Steven P. Fambro , Mark J. Nibbe , Steve R. Burgett , Brett M. Ellman , Michal Lebl
发明人： David L. Heiner , Aaron C. Jones , Steven P. Fambro , Mark J. Nibbe , Steve R. Burgett , Brett M. Ellman , Michal Lebl
IPC分类号： G01N21/00
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00283 , B01J2219/00315 , B01J2219/00326 , B01J2219/0036 , B01J2219/00423 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00612 , B01J2219/00659 , B01J2219/00675 , B01J2219/00693 , B01J2219/00722 , B01J2219/00725 , C40B60/14 , Y10T436/115831 , Y10T436/12
摘要： Described is a system and method for synthesizing polymeric molecules such as oligonucleotides and polypeptides. The system is capable of continuously synthesizing molecules by providing an array of reaction sites and an array of stations for carrying out synthetic manipulations. The reaction sites in the former array can be placed in a fixed order and at fixed intervals relative to each other. Similarly, the stations can be placed in a fixed order and at fixed intervals relative to each other. The two arrays can be moved relative to each other such that the stations carry out desired steps of a reaction scheme at each reaction site. The relative locations of the stations and the schedule for the relative movement can correlate with the order and duration of reaction steps in the reaction scheme such that once a reaction site has completed a cycle of interacting with the full array of stations then the reaction scheme is complete.
摘要翻译： 描述了用于合成聚合物分子如寡核苷酸和多肽的系统和方法。 该系统能够通过提供反应位点阵列和用于进行合成操作的站阵列来连续合成分子。 前一阵列中的反应位点可以相对于彼此以固定的顺序和固定的间隔放置。 类似地，站可以以固定的顺序相对于彼此以固定的间隔放置。 两个阵列可以相对于彼此移动，使得站在每个反应位置进行反应方案的期望步骤。 站的相对位置和相对运动的时间表可以与反应方案中的反应步骤的顺序和持续时间相关联，使得一旦反应位点完成了与整个站阵列相互作用的循环，则反应方案为 完成。
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公开(公告)号：US09073033B2
公开(公告)日：2015-07-07
申请号：US13008317
申请日：2011-01-18
申请人： Michal Lebl , Michel Perbost , Chad F. DeRosier , Mark J. Nibbe , Steve R. Burgett , David L. Heiner
发明人： Michal Lebl , Michel Perbost , Chad F. DeRosier , Mark J. Nibbe , Steve R. Burgett , David L. Heiner
CPC分类号： B01J19/22 , B01J14/005 , B01J19/0046 , B01J2219/00306 , B01J2219/00324 , B01J2219/00351 , B01J2219/0036 , B01J2219/00378 , B01J2219/0038 , B01J2219/00495 , B01J2219/00518 , B01J2219/00533 , B01J2219/00585 , B01J2219/00596 , B01J2219/00644 , B01J2219/00686 , B01J2219/00693 , B01J2219/00722 , B01L3/50851 , B01L7/5255 , B01L2300/069 , B01L2300/0812 , B01L2300/0829 , B01L2300/123
摘要： Disclosed herein are compositions, methods and systems for the processing of chemical reactions, such as the synthesis of polymers.
摘要翻译： 本文公开了用于处理化学反应的组合物，方法和系统，例如聚合物的合成。
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公开(公告)号：US20110178285A1
公开(公告)日：2011-07-21
申请号：US13008317
申请日：2011-01-18
申请人： Michal Lebl , Michel Perbost , Chad F. DeRosier , Mark J. Nibbe , Steve R. Burgett , David L. Heiner
发明人： Michal Lebl , Michel Perbost , Chad F. DeRosier , Mark J. Nibbe , Steve R. Burgett , David L. Heiner
CPC分类号： B01J19/22 , B01J14/005 , B01J19/0046 , B01J2219/00306 , B01J2219/00324 , B01J2219/00351 , B01J2219/0036 , B01J2219/00378 , B01J2219/0038 , B01J2219/00495 , B01J2219/00518 , B01J2219/00533 , B01J2219/00585 , B01J2219/00596 , B01J2219/00644 , B01J2219/00686 , B01J2219/00693 , B01J2219/00722 , B01L3/50851 , B01L7/5255 , B01L2300/069 , B01L2300/0812 , B01L2300/0829 , B01L2300/123
摘要： Disclosed herein are compositions, methods and systems for the processing of chemical reactions, such as the synthesis of polymers.
摘要翻译： 本文公开了用于处理化学反应的组合物，方法和系统，例如聚合物的合成。
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公开(公告)号：US20110143965A1
公开(公告)日：2011-06-16
申请号：US13023406
申请日：2011-02-08
申请人： Michal Lebl , Mark S. Chee , Steven M. Barnard , David L. Heiner , Vit Pokorny , Mark J. Nibbe , Aaron Christopher Jones
发明人： Michal Lebl , Mark S. Chee , Steven M. Barnard , David L. Heiner , Vit Pokorny , Mark J. Nibbe , Aaron Christopher Jones
CPC分类号： B01J19/0046 , B01J2219/00283 , B01J2219/00286 , B01J2219/00295 , B01J2219/00308 , B01J2219/00315 , B01J2219/00326 , B01J2219/00328 , B01J2219/00369 , B01J2219/00389 , B01J2219/00412 , B01J2219/00421 , B01J2219/00423 , B01J2219/00454 , B01J2219/0049 , B01J2219/005 , B01J2219/00585 , B01J2219/0059 , B01J2219/00689 , B01J2219/0072 , B01J2219/00722 , C40B40/06 , C40B50/14 , C40B60/14 , G01N35/025 , G01N35/028 , G01N35/1067 , G01N2035/00504 , G01N2035/1037 , G01N2035/1069 , Y10T436/111666 , Y10T436/12 , Y10T436/2575
摘要： An apparatus for high-throughput combinatorial synthesis of organic molecules including a reaction vessel for containing a combinatorial chemistry synthetic reaction, a liquid dispenser for dispensing the liquid, a liquid aspirator and an adjustment mechanism. The reaction vessel includes an ingress aperture allowing a liquid to enter into an interior of the vessel and an egress aperture for aspirating the liquid from the vessel. The liquid dispenser dispenses liquid through the ingress aperture. The liquid aspirator aspirates liquid through the egress aperture and includes a rotor for carrying the vessel and orbiting the vessel about an axis of rotation. The rotor is oriented generally in a horizontal plane and includes an adjustment mechanism for adjusting the angle of the vessel relative to the horizontal plane in response to the centrifugal force generated by orbiting the vessel about the axis or rotation. A method of combinatorial synthesis of organic molecules is also disclosed.
摘要翻译： 一种用于高通量组合合成有机分子的装置，包括用于包含组合化学合成反应的反应容器，用于分配液体的液体分配器，液体抽吸器和调节机构。 反应容器包括允许液体进入容器内部的入口孔和用于从容器吸出液体的出口孔。 液体分配器通过入口孔分配液体。 液体吸入器通过出口孔吸出液体，并且包括用于承载容器并绕容器围绕旋转轴线运动的转子。 转子通常在水平面定向，并且包括调节机构，用于响应于通过围绕轴线或旋转绕过容器而产生的离心力来调节容器相对于水平面的角度。 还公开了组合合成有机分子的方法。
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公开(公告)号：US06663832B2
公开(公告)日：2003-12-16
申请号：US09738473
申请日：2000-12-13
申请人： Michal Lebl , Mark S. Chee , Steven M. Barnard , David L. Heiner , Vit Pokorny , Mark J. Nibbe , Aaron Christopher Jones
发明人： Michal Lebl , Mark S. Chee , Steven M. Barnard , David L. Heiner , Vit Pokorny , Mark J. Nibbe , Aaron Christopher Jones
IPC分类号： G01N2100
CPC分类号： C40B50/14 , B01J19/0046 , B01J2219/00283 , B01J2219/00286 , B01J2219/00295 , B01J2219/00308 , B01J2219/00315 , B01J2219/00326 , B01J2219/00328 , B01J2219/00369 , B01J2219/00389 , B01J2219/00412 , B01J2219/00421 , B01J2219/00423 , B01J2219/00454 , B01J2219/0049 , B01J2219/005 , B01J2219/00585 , B01J2219/0059 , B01J2219/00689 , B01J2219/0072 , B01J2219/00722 , C40B40/06 , C40B60/14 , G01N35/025 , G01N35/028 , G01N35/1067 , G01N2035/00504 , G01N2035/1037 , G01N2035/1069 , Y10T436/11 , Y10T436/111666 , Y10T436/113332 , Y10T436/2575
摘要： An apparatus for high-throughput combinatorial syntheses of organic molecules including a reaction vessel for containing a combinatorial-chemistry synthetic reaction, a liquid dispenser for dispensing the liquid, a liquid aspirator and an adjustment mechanism. The reaction vessel includes an ingress aperture allowing a liquid to enter into an interior of the vessel and an egress aperture for aspirating the liquid from the vessel. The liquid dispenser dispenses liquid through the ingress aperture. The liquid aspirator aspirates liquid through the egress aperture and includes a rotor for carrying the vessel and orbiting the vessel about an axis of rotation. The rotor is oriented generally in a horizontal plane and includes an adjustment mechanism for adjusting the angle of the vessel relative to the horizontal plane in response to the centrifugal force generated by orbiting the vessel about the axis of rotation. A method of combinatorial synthesis of organic molecules is also disclosed.
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公开(公告)号：US08465694B2
公开(公告)日：2013-06-18
申请号：US13023406
申请日：2011-02-08
申请人： Michal Lebl , Mark S. Chee , Steven M. Barnard , David L. Heiner , Vit Pokorny , Mark J. Nibbe , Aaron Christopher Jones
发明人： Michal Lebl , Mark S. Chee , Steven M. Barnard , David L. Heiner , Vit Pokorny , Mark J. Nibbe , Aaron Christopher Jones
IPC分类号： G01N33/00
CPC分类号： B01J19/0046 , B01J2219/00283 , B01J2219/00286 , B01J2219/00295 , B01J2219/00308 , B01J2219/00315 , B01J2219/00326 , B01J2219/00328 , B01J2219/00369 , B01J2219/00389 , B01J2219/00412 , B01J2219/00421 , B01J2219/00423 , B01J2219/00454 , B01J2219/0049 , B01J2219/005 , B01J2219/00585 , B01J2219/0059 , B01J2219/00689 , B01J2219/0072 , B01J2219/00722 , C40B40/06 , C40B50/14 , C40B60/14 , G01N35/025 , G01N35/028 , G01N35/1067 , G01N2035/00504 , G01N2035/1037 , G01N2035/1069 , Y10T436/111666 , Y10T436/12 , Y10T436/2575
摘要： An apparatus for high-throughput combinatorial synthesis of organic molecules including a reaction vessel for containing a combinatorial chemistry synthetic reaction, a liquid dispenser for dispensing the liquid, a liquid aspirator and an adjustment mechanism. The reaction vessel includes an ingress aperture allowing a liquid to enter into an interior of the vessel and an egress aperture for aspirating the liquid from the vessel. The liquid dispenser dispenses liquid through the ingress aperture. The liquid aspirator aspirates liquid through the egress aperture and includes a rotor for carrying the vessel and orbiting the vessel about an axis of rotation. The rotor is oriented generally in a horizontal plane and includes an adjustment mechanism for adjusting the angle of the vessel relative to the horizontal plane in response to the centrifugal force generated by orbiting the vessel about the axis or rotation. A method of combinatorial synthesis of organic molecules is also disclosed.
摘要翻译： 一种用于高通量组合合成有机分子的装置，包括用于包含组合化学合成反应的反应容器，用于分配液体的液体分配器，液体抽吸器和调节机构。 反应容器包括允许液体进入容器内部的入口孔和用于从容器吸出液体的出口孔。 液体分配器通过入口孔分配液体。 液体吸入器通过出口孔吸出液体，并且包括用于承载容器并绕容器围绕旋转轴线运动的转子。 转子通常在水平面定向，并且包括调节机构，用于响应于通过围绕轴线或旋转绕过容器而产生的离心力来调节容器相对于水平面的角度。 还公开了组合合成有机分子的方法。
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公开(公告)号：US20090023605A1
公开(公告)日：2009-01-22
申请号：US12140940
申请日：2008-06-17
申请人： Michal Lebl , Mark S. Chee , Steven M. Barnard , David L. Heiner , Vit Pokorny , Mark J. Nibbe , Aaron Christopher Jones
发明人： Michal Lebl , Mark S. Chee , Steven M. Barnard , David L. Heiner , Vit Pokorny , Mark J. Nibbe , Aaron Christopher Jones
CPC分类号： B01J19/0046 , B01J2219/00283 , B01J2219/00286 , B01J2219/00295 , B01J2219/00308 , B01J2219/00315 , B01J2219/00326 , B01J2219/00328 , B01J2219/00369 , B01J2219/00389 , B01J2219/00412 , B01J2219/00421 , B01J2219/00423 , B01J2219/00454 , B01J2219/0049 , B01J2219/005 , B01J2219/00585 , B01J2219/0059 , B01J2219/00689 , B01J2219/0072 , B01J2219/00722 , C40B40/06 , C40B50/14 , C40B60/14 , G01N35/025 , G01N35/028 , G01N35/1067 , G01N2035/00504 , G01N2035/1037 , G01N2035/1069 , Y10T436/111666 , Y10T436/12 , Y10T436/2575
摘要： An apparatus for high-throughput combinatorial synthesis of organic molecules including a reaction vessel for containing a combinatorial chemistry synthetic reaction, a liquid dispenser for dispensing the liquid, a liquid aspirator and an adjustment mechanism. The reaction vessel includes an ingress aperture allowing a liquid to enter into an interior of the vessel and an egress aperture for aspirating the liquid from the vessel. The liquid dispenser dispenses liquid through the ingress aperture. The liquid aspirator aspirates liquid through the egress aperture and includes a rotor for carrying the vessel and orbiting the vessel about an axis of rotation. The rotor is oriented generally in a horizontal plane and includes an adjustment mechanism for adjusting the angle of the vessel relative to the horizontal plane in response to the centrifugal force generated by orbiting the vessel about the axis or rotation. A method of combinatorial synthesis of organic molecules is also disclosed.
摘要翻译： 一种用于高通量组合合成有机分子的装置，包括用于包含组合化学合成反应的反应容器，用于分配液体的液体分配器，液体抽吸器和调节机构。 反应容器包括允许液体进入容器内部的入口孔和用于从容器吸出液体的出口孔。 液体分配器通过入口孔分配液体。 液体吸入器通过出口孔吸出液体，并且包括用于承载容器并绕容器围绕旋转轴线运动的转子。 转子通常在水平面定向，并且包括调节机构，用于响应于通过围绕轴线或旋转绕过容器而产生的离心力来调节容器相对于水平面的角度。 还公开了组合合成有机分子的方法。
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公开(公告)号：US08592214B2
公开(公告)日：2013-11-26
申请号：US13026086
申请日：2011-02-11
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00315 , B01J2219/00317 , B01J2219/0036 , B01J2219/00414 , B01J2219/00421 , B01J2219/00423 , B01J2219/00585 , B01J2219/00587 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00693 , B01J2219/00698 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14 , Y10T436/115831
摘要： Disclosed herein are systems for monitoring chemical reactions. The systems can comprise a lighting device, a camera device for obtaining an image of the chemical reaction mixtures and an analyzer program to process data obtained from the image. Also disclosed are methods of monitoring the progress of chemical reactions using these systems.
摘要翻译： 本文公开了用于监测化学反应的系统。 该系统可以包括照明装置，用于获得化学反应混合物的图像的相机装置和用于处理从图像获得的数据的分析器程序。 还公开了使用这些系统监测化学反应进程的方法。
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