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公开(公告)号:US20070003443A1
公开(公告)日:2007-01-04
申请号:US11426289
申请日:2006-06-23
申请人: Donald Sandell , Ralph Somack , Ian Harding , Dennis Lehto
发明人: Donald Sandell , Ralph Somack , Ian Harding , Dennis Lehto
IPC分类号: B01L3/02
CPC分类号: B01L3/502 , B01L3/0275 , B01L7/52 , B01L2200/0642 , B01L2300/0809 , B01L2300/0864 , B01L2400/0478 , B01L2400/0487 , B01L2400/0638 , B01L2400/0644 , G01N2035/103 , G01N2035/1032 , G01N2035/1034 , G01N2035/1062
摘要: A pipette tip and system for aspiration of a biological sample, distribution to a plurality of sample chambers, and thermal cycling in the pipette tip.
摘要翻译: 用于抽吸生物样品的移液管尖端和系统,分配到多个样品室,以及移液管尖端中的热循环。
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公开(公告)号:US20070014695A1
公开(公告)日:2007-01-18
申请号:US11380327
申请日:2006-04-26
申请人: Min Yue , David Liu , Yuh-Min Chiang , Joon Mo Yang , Dennis Lehto , Charles Vann , Nigel Beard , Ian Harding , John Van Camp , Alexander Dromaretsky , Sergey Ermakov , Mark Oldham , Joy Roy , Maryam Shariati , Umberto Ulmanella
发明人: Min Yue , David Liu , Yuh-Min Chiang , Joon Mo Yang , Dennis Lehto , Charles Vann , Nigel Beard , Ian Harding , John Van Camp , Alexander Dromaretsky , Sergey Ermakov , Mark Oldham , Joy Roy , Maryam Shariati , Umberto Ulmanella
IPC分类号: B01L3/00
CPC分类号: C12Q1/6806 , B01J2219/00317 , B01J2219/00722 , B01L3/502707 , B01L3/502723 , B01L3/50853 , B01L2200/0684 , B01L2200/0689 , B01L2200/16 , B01L2300/041 , B01L2300/048 , B01L2300/0636 , B01L2300/0816 , B01L2300/0829 , B01L2300/0864 , B01L2300/087 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/0694 , G01N35/028 , Y10T436/2575
摘要: Systems and methods for multiple analyte detection include a system for distribution of a biological sample that includes a substrate, wherein the substrate includes a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber. The system may further include a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate and a sealing instrument configured to be placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber. The substrate can be constructed of detection-compatible and assay-compatible materials.
摘要翻译: 用于多个分析物检测的系统和方法包括用于分配包括基底的生物样品的系统,其中所述基底包括多个样品室,用于每个样品室的样品引入通道和用于每个样品室的排气通道。 该系统可以进一步包括包含在每个样品室中并被配置用于进入基底的生物样品的核酸分析的预加载试剂和被配置为与基底接触以密封每个样品室以便基本上防止 每个样品室中包含的样品从每个样品室流出。 底物可以由检测相容和测定相容的材料构成。
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公开(公告)号:US20050232818A1
公开(公告)日:2005-10-20
申请号:US11086276
申请日:2005-03-22
申请人: Donald Sandell , Albert Carrillo , Adrian Fawcett , Ian Harding , Gary Lim
发明人: Donald Sandell , Albert Carrillo , Adrian Fawcett , Ian Harding , Gary Lim
CPC分类号: G01N35/028 , B01L3/0293 , B01L3/5025 , B01L3/5027 , B01L3/50851 , B01L3/50853 , B01L7/52 , B01L9/523 , B01L9/56 , B01L2200/021 , B01L2200/025 , B01L2200/0605 , B01L2200/0642 , B01L2300/022 , B01L2300/044 , B01L2300/046 , B01L2300/0829 , B01L2300/0851 , B01L2300/0864 , B01L2300/1805 , B01L2400/0406 , B01L2400/0409 , B01L2400/0487 , G01N21/274 , G01N21/6452 , G01N21/648 , G01N2035/00366
摘要: An automated seal applicator for applying a sealing cover to a microplate. The microplate can comprise a plurality of wells for receiving an assay. The automated seal applicator can comprise a housing and a sealing cover cartridge containing a sealing cover releasably carried on a carrier liner. The sealing cover can be at least partially contained within the sealing cover cartridge. A sealing cover drive system can engage the sealing cover and/or the carrier liner and maintain a predetermined alignment of the sealing cover relative to the microplate.
摘要翻译: 一种用于将密封盖施加到微孔板的自动密封施加器。 微孔板可以包括用于接收测定的多个孔。 自动密封施加器可以包括壳体和密封盖盒,所述密封盖盒可释放地承载在载体衬里上的密封盖。 密封盖可以至少部分地容纳在密封盖盒内。 密封盖驱动系统可以接合密封盖和/或载体衬里并且保持密封盖相对于微板的预定对准。
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公开(公告)号:US20050226780A1
公开(公告)日:2005-10-13
申请号:US11087105
申请日:2005-03-22
申请人: Donald Sandell , Albert Carrillo , Adrian Fawcett , Ian Harding , Gary Lim
发明人: Donald Sandell , Albert Carrillo , Adrian Fawcett , Ian Harding , Gary Lim
IPC分类号: B01L3/00 , B01L7/00 , B01L9/00 , B01L99/00 , C12M1/34 , C12P19/34 , C12Q1/68 , G01N1/10 , G01N21/03 , G01N21/27 , G01N21/64 , G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10
CPC分类号: G01N35/028 , B01L3/0293 , B01L3/5025 , B01L3/5027 , B01L3/502723 , B01L3/50851 , B01L3/50853 , B01L7/52 , B01L9/523 , B01L9/56 , B01L2200/021 , B01L2200/025 , B01L2200/0605 , B01L2200/0642 , B01L2300/022 , B01L2300/044 , B01L2300/046 , B01L2300/0829 , B01L2300/0851 , B01L2300/0864 , B01L2300/1805 , B01L2400/0406 , B01L2400/0409 , B01L2400/0487 , G01N21/274 , G01N21/6452 , G01N21/648 , G01N2035/00148 , G01N2035/00356 , G01N2035/0405 , G01N2035/0425 , G01N2035/1037
摘要: An seal applicator for applying a sealing cover to a microplate. The microplate can comprise a plurality of wells for receiving an assay. The seal applicator can comprise a housing containing a sealing cover roll. The sealing cover roll can comprise an elongated carrier liner and a plurality of individual sealing covers releasably carried on the elongated carrier liner. The seal applicator can further comprise a plane assembly supporting the elongated carrier liner and a drive roller assembly engaging the elongated carrier liner. The drive roller assembly can selectively drive the carrier liner.
摘要翻译: 一种用于将密封盖施加到微板的密封件。 微孔板可以包括用于接收测定的多个孔。 密封件施加器可以包括容纳密封盖辊的壳体。 密封盖辊可以包括细长的载体衬里和可释放地承载在细长载体衬套上的多个单独的密封盖。 密封件施加器还可以包括支撑细长载体衬套的平面组件和接合细长载体衬套的驱动辊组件。 驱动辊组件可以选择性地驱动载体衬套。
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公开(公告)号:US20060011305A1
公开(公告)日:2006-01-19
申请号:US11086263
申请日:2005-03-22
申请人: Donald Sandell , Albert Carrillo , Adrian Fawcett , Ian Harding , Gary Lim
发明人: Donald Sandell , Albert Carrillo , Adrian Fawcett , Ian Harding , Gary Lim
CPC分类号: G01N35/028 , B01L3/0293 , B01L3/5025 , B01L3/5027 , B01L3/50851 , B01L3/50853 , B01L7/52 , B01L9/50 , B01L9/523 , B01L2200/021 , B01L2200/025 , B01L2200/0605 , B01L2200/0642 , B01L2300/022 , B01L2300/044 , B01L2300/046 , B01L2300/0829 , B01L2300/0851 , B01L2300/0864 , B01L2300/1805 , B01L2400/0406 , B01L2400/0409 , B01L2400/0487 , B32B33/00 , B32B38/10 , B32B2038/047 , G01N21/274 , G01N21/553 , G01N21/6452 , G01N35/04 , G01N2035/00366 , G01N2035/0405 , Y10T156/171 , Y10T156/1744
摘要: An automated seal applicator for applying a sealing cover to a microplate. The microplate can comprise a plurality of wells for receiving an assay. The automated seal applicator can comprise a housing and a removable sealing cover cassette containing a sealing cover roll. The sealing cover roll can comprise an elongated carrier liner and a plurality of individual sealing covers releasably carried on the elongated carrier liner. The sealing cover cassette can be selectively engagable with the housing. A sealing cover drive system can engage the sealing cover roll and maintain a predetermined alignment of each of the plurality of individual sealing covers relative to the microplate.
摘要翻译: 一种用于将密封盖施加到微孔板的自动密封施加器。 微孔板可以包括用于接收测定的多个孔。 自动密封施加器可以包括容纳密封盖辊的壳体和可移除的密封盖盒。 密封盖辊可以包括细长的载体衬里和可释放地承载在细长载体衬垫上的多个单独的密封盖。 密封盖盒可以选择性地与壳体接合。 密封盖驱动系统可以接合密封盖辊并且保持多个单个密封盖中的每一个相对于微板的预定对准。
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公开(公告)号:US20060013984A1
公开(公告)日:2006-01-19
申请号:US11086264
申请日:2005-03-22
申请人: Donald Sandell , Albert Carrillo , Ian Harding , Gary Lim
发明人: Donald Sandell , Albert Carrillo , Ian Harding , Gary Lim
CPC分类号: G01N35/028 , B01L3/0293 , B01L3/5025 , B01L3/5027 , B01L3/50851 , B01L3/50853 , B01L7/52 , B01L9/50 , B01L9/523 , B01L2200/021 , B01L2200/025 , B01L2200/0605 , B01L2200/0642 , B01L2300/022 , B01L2300/044 , B01L2300/046 , B01L2300/0829 , B01L2300/0851 , B01L2300/0864 , B01L2300/1805 , B01L2400/0406 , B01L2400/0409 , B01L2400/0487 , B32B33/00 , B32B38/10 , B32B2038/047 , G01N21/274 , G01N21/6452 , G01N21/648 , G01N2035/00366 , Y10T156/1052 , Y10T428/14 , Y10T428/1476
摘要: A sealing cover roll for use in sealing a microplate comprising an elongated carrier liner having a first surface and a second surface. A plurality of sealing covers are releasably carried on the first surface of the elongated carrier liner. Each of the plurality of sealing covers comprises a base stock and an adhesive. The adhesive is operable to retain the base stock to the elongated carrier liner and permit release of the base stock and the adhesive from the elongated carrier liner. A roll core supports a rolled configuration of the elongated carrier liner such that the first surface of the elongated carrier liner faces toward the roll core when rolled.
摘要翻译: 一种用于密封微板的密封盖辊,包括具有第一表面和第二表面的细长载体衬垫。 多个密封盖可释放地承载在细长载体衬里的第一表面上。 多个密封盖中的每一个包括基础材料和粘合剂。 粘合剂可操作以将基础材料保持在细长的载体衬里上,并且允许基材和粘合剂从细长的载体衬里释放。 辊芯支撑细长载体衬套的卷绕构型,使得细长载体衬套的第一表面在滚动时面向辊芯。
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公开(公告)号:US20050233363A1
公开(公告)日:2005-10-20
申请号:US11096282
申请日:2005-03-31
申请人: Ian Harding , Donald Sandell , Kevin Bodner , Tim Woudenberg , Mark Oldham , H. Kao , Gary Lim , John Bodeau , Adrian Fawcett , Robert Jones
发明人: Ian Harding , Donald Sandell , Kevin Bodner , Tim Woudenberg , Mark Oldham , H. Kao , Gary Lim , John Bodeau , Adrian Fawcett , Robert Jones
CPC分类号: C12N15/1072 , B01L3/50851 , B01L3/50853 , B01L7/52 , B01L2200/0689 , B01L2300/021 , B01L2300/041 , B01L2300/0829 , B01L2300/12 , B01L2300/1805
摘要: A method for simultaneously determining a genetic expression profile for an individual member of a species relative to an entire standard genome for the species. The method can comprise distributing a liquid sample into an array of reaction chambers of a substrate. The array can comprise a primer set and a probe for each polynucleotide target along the entire standard genome. The liquid sample can comprise substantially all genetic material of the member. Each of the reaction chambers can comprise the primer set and the probe for at least one of the polynucleotide targets and a polymerase. The method can further comprise amplifying the liquid sample in the array, detecting a signal emitted by at least one of the probes, and identifying the genetic expression profile in response to the signal.
摘要翻译: 一种相对于物种的整个标准基因组同时测定物种的个体成员的遗传表达谱的方法。 该方法可以包括将液体样品分配到基底的反应室的阵列中。 该阵列可以包含沿着整个标准基因组的每个多核苷酸靶的引物组和探针。 液体样品可以包括构件的基本上所有的遗传物质。 每个反应室可以包含用于至少一个多核苷酸靶标和聚合酶的引物组和探针。 该方法还可以包括放大阵列中的液体样品,检测由至少一个探针发射的信号,以及响应于该信号鉴定遗传表达谱。
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公开(公告)号:US20050225751A1
公开(公告)日:2005-10-13
申请号:US11087101
申请日:2005-03-22
申请人: Donald Sandell , Ian Harding , Robin Li , Gary Lim
发明人: Donald Sandell , Ian Harding , Robin Li , Gary Lim
IPC分类号: B01L3/00 , B01L7/00 , B01L9/00 , B01L99/00 , C12M1/34 , C12P19/34 , C12Q1/68 , G01N1/10 , G01N21/03 , G01N21/27 , G01N21/64 , G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10
CPC分类号: G01N35/028 , B01L3/0293 , B01L3/5025 , B01L3/5027 , B01L3/502723 , B01L3/50851 , B01L3/50853 , B01L7/52 , B01L9/523 , B01L9/56 , B01L2200/021 , B01L2200/025 , B01L2200/0605 , B01L2200/0642 , B01L2300/022 , B01L2300/044 , B01L2300/046 , B01L2300/0829 , B01L2300/0851 , B01L2300/0864 , B01L2300/1805 , B01L2400/0406 , B01L2400/0409 , B01L2400/0487 , G01N21/274 , G01N21/6452 , G01N21/648 , G01N2035/00148 , G01N2035/00356 , G01N2035/0405 , G01N2035/0425 , G01N2035/1037
摘要: A microplate comprising a main body portion having a first surface and an opposing second surface. A plurality of wells are formed in the first surface, each of the plurality of wells being sized to receive an assay therein. A cap portion, formed separate from the main body portion and comprising an integrated identification feature, is connectable with the main body portion.
摘要翻译: 一种微板,包括具有第一表面和相对的第二表面的主体部分。 在第一表面中形成多个孔,多个孔中的每一个的大小适于接收其中的测定。 与主体部分分离并且包括集成识别特征的盖部分可与主体部分连接。
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公开(公告)号:US08758582B2
公开(公告)日:2014-06-24
申请号:US12176648
申请日:2008-07-21
申请人: Ian Harding , Sridhar Iyengar
发明人: Ian Harding , Sridhar Iyengar
IPC分类号: G01N33/487 , G01N27/327
CPC分类号: G01N27/3272 , C12Q1/001
摘要: An electrochemical test strip is formed from a first insulating substrate layer, a second substrate layer, and an intervening insulating spacer layer. An opening in the insulating spacer layer defines a test cell which is in contact with the inner surface of the first substrate on one side and the inner surface of the second substrate on the other side. The size of the test cell is determined by the area of substrate exposed and the thickness of the spacer layer. Working and counter electrodes appropriate for the analyte to be detected are disposed on the first insulating substrate in a location within the test cell. The working and counter electrodes are associated with conductive leads that allow The second substrate is conductive at least in a region facing the working and counter electrodes. No functional connection of this conductive surface of the second substrate to the meter is required. When a potential difference is applied between the working and counter electrodes, because of the presence of the conductive surface on the second substrate, the relevant diffusion length is not dependent on the distance between working and counter electrodes, but is instead dependent on the distance between the first and second substrates (i.e., on the thickness of the spacer layer). This means that shorter measurement times can be achieved without having to reduce the spacing of the working and counter electrodes.
摘要翻译: 电化学测试条由第一绝缘衬底层,第二衬底层和中间绝缘间隔层形成。 绝缘间隔层中的开口限定了与第一基板的内表面和另一侧的第二基板的内表面接触的测试单元。 测试电池的尺寸由衬底暴露的面积和间隔层的厚度决定。 适于待检测分析物的工作和对电极在测试电池内的一个位置设置在第一绝缘衬底上。 工作电极和对电极与导电引线相关联,允许第二衬底至少在面向工作电极和对电极的区域中导电。 不需要将第二基板的该导电表面与仪表的功能连接。 当在工作电极和对电极之间施加电位差时,由于第二衬底上存在导电表面,相关的扩散长度不依赖于工作电极和对电极之间的距离,而是取决于 第一和第二基板(即,在间隔层的厚度上)。 这意味着可以实现更短的测量时间,而不必减小工作电极和对电极的间隔。
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公开(公告)号:US20130146478A1
公开(公告)日:2013-06-13
申请号:US13808736
申请日:2011-06-30
申请人: Sridhar Iyengar , Ian Harding , Charles Boiteau , Colin Butters
发明人: Sridhar Iyengar , Ian Harding , Charles Boiteau , Colin Butters
IPC分类号: G01N21/25
CPC分类号: G01N27/3272 , G01J1/42 , G01N21/255 , G01N21/7703 , G01N21/8483 , G01N27/327 , G01N27/3273 , G01N33/48707 , G01N33/48771 , G01N2201/08
摘要: A test strip with an incorporated optical waveguide and deflectors punched through the optical waveguide allows light to exit through a layer of the test strip and be detected by a photo detector. Using light and a photodetector, these uniquely coded strips are identified. The waveguide can be constructed by sandwiching two layers of the test strip around a light transmissible layer. This configuration allows light to be transmitted through the test strip and out the other end, as well as allowing some light to escape the deflector. This light is detected by a photodetector mounted in the analyte test meter. The deflectors may be placed in patterns such that detection of this light indicates certain characteristics of the strip, such as non-counterfeit, regional identification, type of analyte tested, and coding information.
摘要翻译: 具有结合的光波导的测试条和穿过光波导穿过的偏转器允许光通过测试条的层离开并由光电检测器检测。 使用光和光电检测器,识别这些唯一编码的条带。 波导可以通过将两条测试条夹在透光层周围来构造。 这种配置允许光线通过测试条传输,并将光线从另一端传输,并允许一些光线从偏转器中逸出。 该光被安装在分析物测试仪中的光检测器检测。 偏转器可以被放置成图案,使得该光的检测指示条带的某些特性,例如非假冒,区域识别,被测试分析物的类型和编码信息。
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