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    Method for Measuring Luminescence at a Luminescence Detection Workstation
    2.
    发明申请
    Method for Measuring Luminescence at a Luminescence Detection Workstation 有权
    发光检测工作站测量发光的方法

    公开(公告)号：US20100248387A1

    公开(公告)日：2010-09-30

    申请号：US12716219

    申请日：2010-03-02

    申请人： Michael R. Gambini ,  John C. Voyta ,  John Atwood ,  Susan A. Atwood-Stone ,  Bruce E. DeSimas, II ,  Edward Lakatos ,  Jeff Levi ,  Israel Metal ,  George Sabak ,  Yongdong Wang

    发明人： Michael R. Gambini ,  John C. Voyta ,  John Atwood ,  Susan A. Atwood-Stone ,  Bruce E. DeSimas, II ,  Edward Lakatos ,  Jeff Levi ,  Israel Metal ,  George Sabak ,  Yongdong Wang

    IPC分类号： G01N21/76

    CPC分类号： G01N21/763 ,  G01N21/15 ,  G01N21/274 ,  G01N21/276 ,  G01N21/31 ,  G01N21/6452 ,  G01N21/6456 ,  G01N21/6486 ,  G01N21/76 ,  G01N33/581 ,  G01N2021/6471 ,  G01N2333/90241 ,  Y10T436/115831

    摘要： A luminescence detecting apparatus and method for analyzing luminescent samples is disclosed. Luminescent samples are placed in a plurality of sample wells in a tray, and the tray is placed in a visible-light impervious chamber containing a charge coupled device camera. The samples may be injected in the wells, and the samples may be injected with buffers and reagents, by an injector. In the chamber, light from the luminescent samples pass through a collimator, a Fresnel field lens, a filter, and a camera lens, whereupon a focused image is created by the optics on the charge-coupled device (CCD) camera. The use of a Fresnel field lens, in combination with a collimator and filter, reduces crosstalk between samples below the level attainable by the prior art. Preferred embodiments of the luminescence detecting apparatus and method disclosed include central processing control of all operations, multiple wavelength filter wheel, and robot handling of samples and reagents. Preferred embodiments of processing software integrated with the invention include elements for mechanical alignment, outlier shaving, edge detection and masking, manipulation of multiple integration times to expand the dynamic range, crosstalk correction, dark subtraction interpolation and drift correction, multi-component analysis applications specifically tailored for luminescence, and uniformity correction.

    摘要翻译： 公开了一种用于分析发光样品的发光检测装置和方法。 将发光样品放置在托盘中的多个样品孔中，并且将托盘放置在包含电荷耦合器件照相机的可见光不透水室中。 样品可以注入孔中，样品可以通过注射器注入缓冲液和试剂。 在室中，来自发光样品的光通过准直仪，菲涅尔场透镜，滤光器和照相机镜头，由此电荷耦合器件（CCD）照相机上的光学器件产生聚焦图像。 使用菲涅耳场透镜与准直器和滤光器结合使得样品之间的串扰降低到现有技术可获得的水平以下。 发光检测装置和方法的优选实施例包括所有操作，多波长滤光轮和样品和试剂的机器人处理的中央处理控制。 与本发明集成的处理软件的优选实施例包括用于机械对准，异常刮削，边缘检测和掩蔽的元件，多次积分时间的操纵以扩大动态范围，串扰校正，暗减法内插和漂移校正，特别是多组分分析应用 适合发光和均匀性校正。

    Thermal cycler for PCR
    5.
    发明申请
    Thermal cycler for PCR 有权

    公开(公告)号：US20050145273A1

    公开(公告)日：2005-07-07

    申请号：US11057960

    申请日：2005-02-15

    申请人： John Atwood ,  Adrian Fawcett ,  Keith Ferrara ,  Paul Hetherington ,  Richard Noreiks ,  Douglas Olsen ,  John Widomski ,  Charles Wittmer

    发明人： John Atwood ,  Adrian Fawcett ,  Keith Ferrara ,  Paul Hetherington ,  Richard Noreiks ,  Douglas Olsen ,  John Widomski ,  Charles Wittmer

    IPC分类号： B01L7/00 ,  G01R27/20 ,  G05D23/19 ,  H01L35/30 ,  H01L37/00 ,  G01K3/00 ,  H01L35/34

    CPC分类号： B01L7/52 ,  B01L3/50853 ,  B01L2300/0829 ,  B01L2300/1822 ,  B01L2300/1827 ,  C12Q1/686 ,  F25B21/04 ,  F25B2321/021 ,  G01R27/205 ,  G05D23/1919 ,  H01L35/30 ,  Y10T137/1516

    摘要： An instrument for performing highly accurate PCR employing an assembly, a heated cover and an internal computer. The assembly is made up of a sample block, a number of Peltier thermal electric devices and heat sink, clamped together. The sample block temperature is changed exclusively by the thermoelectric devices controlled by the computer. The sample block is of low thermal mass and is constructed of silver. The Peltier devices are designed to provide fast temperature excursions over a wide range. The heat sink has a perimeter trench to minimize edge losses and is adjacent to a continuously variable fan. A perimeter heater is used to improve the thermal uniformity across the sample block to approximately ±0.2° C. A heated platen pushes down onto the tube caps to apply a minimum acceptable force for seating the tubes into the block, ensuring good thermal contact with the block. The force is applied about the periphery of the tube caps to prevent distortion of the caps during thermal cycling. The platen is heated to provided thermal isolation from ambient conditions and to prevent evaporation from the surface of the sample into the upper portion of the sample tube. A control algorithm manipulates the current supplied to the thermoelectric coolers such that the dynamic thermal performance of the block can be controlled so that pre-defined thermal profiles for the sample temperature can be executed. The sample temperature is calculated instead of measured using a design specific model and equations. The control software includes calibration diagnostics which permit variation in the performance of thermoelectric coolers from instrument to instrument to be compensated for such that all instruments perform identically. The block/heat sink assembly can be changed to another of the same or different design. The assembly carries the necessary information required to characterize its own performance in an on-board memory device, allowing the assembly to be interchangeable among instruments while retaining its precision operating characteristics. The instrument has a graphical user interface. The instrument monitors the thermoelectric devices and warns of changes in resistance that may result in failure.

    Opaque quarantine and device discovery
    6.
    发明授权
    Opaque quarantine and device discovery 有权
    不透明的隔离和设备发现

    公开(公告)号：US08621574B2

    公开(公告)日：2013-12-31

    申请号：US12476966

    申请日：2009-06-02

    申请人： Juan V. Esteve Balducci ,  John Atwood ,  Zhike Kong ,  Ying Zhang ,  Sergey B. Plakhotnyuk

    发明人： Juan V. Esteve Balducci ,  John Atwood ,  Zhike Kong ,  Ying Zhang ,  Sergey B. Plakhotnyuk

    IPC分类号： G06F21/00

    CPC分类号： H04L63/105 ,  G06F21/62

    摘要： Embodiments described herein provide communication control features and functionality, but are not so limited. In an embodiment, a computing environment includes an access control component that can use a number of access states to control access to computing data and/or services. In one embodiment, a server computer can control access to data and/or services using a number of access states including, but not limited to: an allowed state, a blocked state, a device discovery state, and/or a quarantined state. Other embodiments are available.

    摘要翻译： 本文描述的实施例提供通信控制特征和功能，但不限于此。 在一个实施例中，计算环境包括访问控制组件，其可以使用多个访问状态来控制对计算数据和/或服务的访问。 在一个实施例中，服务器计算机可以使用多个访问状态来控制对数据和/或服务的访问，包括但不限于：允许状态，阻止状态，设备发现状态和/或隔离状态。 其他实施例是可用的。

    Thermal cycler for PCR
    8.
    发明申请
    Thermal cycler for PCR 有权

    公开(公告)号：US20070113880A1

    公开(公告)日：2007-05-24

    申请号：US11654239

    申请日：2007-01-17

    申请人： John Atwood ,  Adrian Fawcett ,  Keith Ferrara ,  Paul Hetherington ,  Richard Noreiks ,  Douglas Olsen ,  John Widomski ,  Charles Wittmer

    发明人： John Atwood ,  Adrian Fawcett ,  Keith Ferrara ,  Paul Hetherington ,  Richard Noreiks ,  Douglas Olsen ,  John Widomski ,  Charles Wittmer

    IPC分类号： H01L35/28

    CPC分类号： B01L7/52 ,  B01L3/50853 ,  B01L2300/0829 ,  B01L2300/1822 ,  B01L2300/1827 ,  C12Q1/686 ,  F25B21/04 ,  F25B2321/021 ,  G01R27/205 ,  G05D23/1919 ,  H01L35/30 ,  Y10T137/1516

    摘要： An instrument for performing highly accurate PCR employing an assembly, a heated cover and an internal computer. The assembly is made up of a sample block, a number of Peltier thermal electric devices and heat sink, clamped together. The sample block temperature is changed exclusively by the thermoelectric devices controlled by the computer. The sample block is of low thermal mass and is constructed of silver. The Peltier devices are designed to provide fast temperature excursions over a wide range. The heat sink has a perimeter trench to minimize edge losses and is adjacent to a continuously variable fan. A perimeter heater is used to improve the thermal uniformity across the sample block to approximately ±0.2° C. A heated platen pushes down onto the tube caps to apply a minimum acceptable force for seating the tubes into the block, ensuring good thermal contact with the block. The force is applied about the periphery of the tube caps to prevent distortion of the caps during thermal cycling. The platen is heated to provided thermal isolation from ambient conditions and to prevent evaporation from the surface of the sample into the upper portion of the sample tube. A control algorithm manipulates the current supplied to the thermoelectric coolers such that the dynamic thermal performance of the block can be controlled so that pre-defined thermal profiles for the sample temperature can be executed. The sample temperature is calculated instead of measured using a design specific model and equations. The control software includes calibration diagnostics which permit variation in the performance of thermoelectric coolers from instrument to instrument to be compensated for such that all instruments perform identically. The block/heat sink assembly can be changed to another of the same or different design. The assembly carries the necessary information required to characterize its own performance in an on-board memory device, allowing the assembly to be interchangeable among instruments while retaining its precision operating characteristics. The instrument has a graphical user interface. The instrument monitors the thermoelectric devices and warns of changes in resistance that may result in failure.

    Enforcing device settings for mobile devices
    9.
    发明申请
    Enforcing device settings for mobile devices 有权
    执行移动设备的设备设置

    公开(公告)号：US20070006289A1

    公开(公告)日：2007-01-04

    申请号：US11171850

    申请日：2005-06-30

    申请人： David Limont ,  John Atwood ,  Massimiliano Ciccotosto ,  Omar Aftab ,  Patrick Tousignant ,  Selvaraj Nalliah ,  Zhidong Yang

    发明人： David Limont ,  John Atwood ,  Massimiliano Ciccotosto ,  Omar Aftab ,  Patrick Tousignant ,  Selvaraj Nalliah ,  Zhidong Yang

    IPC分类号： H04L9/32

    CPC分类号： H04W8/22 ,  H04L63/205 ,  H04W12/06 ,  H04W12/08

    摘要： The present invention extends to methods, systems, and computer program products for enforcing device settings for mobile devices. Generally, a computer system enforces appropriate mobile device settings (e.g., policy and/or configuration settings) prior to permitting a mobile device to access maintained data. The computer system receives a request from a mobile device. The computer system determines that current mobile device settings are not appropriate for accessing the maintained data. The computer system sends device settings, representing a new mobile device configuration that is appropriate accessing the maintained data, to the mobile device. The computer system receives an indication that the mobile device is configured in accordance with the device settings. The computer system permits the mobile device to access the maintained data in response to receiving the indication that the mobile device is configured in accordance with the device settings.

    摘要翻译： 本发明扩展到用于实施移动设备的设备设置的方法，系统和计算机程序产品。 通常，在允许移动设备访问维护的数据之前，计算机系统实施适当的移动设备设置（例如策略和/或配置设置）。 计算机系统从移动设备接收请求。 计算机系统确定当前的移动设备设置不适合于访问维护的数据。 计算机系统向移动设备发送表示适合访问维护的数据的新的移动设备配置的设备设置。 计算机系统接收根据设备设置配置移动设备的指示。 响应于接收到根据设备设置配置移动设备的指示，计算机系统允许移动设备访问维护的数据。

    Electronic stimulating device
    10.
    发明授权
    Electronic stimulating device 失效

    公开(公告)号：US4994016A

    公开(公告)日：1991-02-19

    申请号：US385717

    申请日：1989-07-27

    申请人： John Atwood

    发明人： John Atwood

    IPC分类号： A61N1/36 ,  A61N1/40 ,  A61N2/02

    CPC分类号： A61N1/40 ,  A61N1/36014 ,  A61N2/02

    摘要： The invention relates to an electronic stimulating device which produces low frequency pulsating signals generated by a relaxation oscillator. The electronic circuit board is mounted within a lightweight portable housing to enable a user to conveniently carry the device at all times, if desired.