Dispenser device for and a method of dispensing a substance onto a substrate
    1.
    发明申请
    Dispenser device for and a method of dispensing a substance onto a substrate 审中-公开
    用于将物质分配到基底上的分配器装置和方法

    公开(公告)号:US20100092683A1

    公开(公告)日:2010-04-15

    申请号:US12442471

    申请日:2007-09-24

    IPC分类号: B05D1/02 B05C5/00

    摘要: A dispenser device (100) for dispensing a substance (101) onto a substrate (102), the dispenser device (100) comprising a gripper unit (103) adapted for gripping a container (104) including the substance (101), a first motion mechanism (116, 117) adapted for moving the gripper unit (103) and the substrate (102) relative to each other within a planar region (106), and a second motion mechanism (115, 201 and 209) adapted for moving the gripper unit (103) and the substrate (102) relative to each other in a direction (108) essentially perpendicular to the planar region (106) to thereby dispense the substance (101) to a surface portion (109) of the substrate (102), wherein the first motion mechanism (115) and the second motion mechanism (116, 117) are decoupled from one another.

    摘要翻译: 一种用于将物质(101)分配到基底(102)上的分配器装置(100),所述分配器装置(100)包括适于夹持包括所述物质(101)的容器(104)的夹持器单元(103),第一 适于在平面区域(106)内相对于彼此移动所述夹持单元(103)和所述基板(102)的运动机构(116,117)以及适于移动所述夹持单元 夹持器单元(103)和基板(102)在基本上垂直于平面区域(106)的方向(108)上相对于彼此分配,从而将物质(101)分配到基板(102)的表面部分(109) ),其中所述第一运动机构(115)和所述第二运动机构(116,117)彼此分离。

    Microchip matrix device for duplicating and characterizing nucleic acids
    3.
    发明授权
    Microchip matrix device for duplicating and characterizing nucleic acids 有权
    用于复制和表征核酸的Microchip矩阵器件

    公开(公告)号:US07888074B2

    公开(公告)日:2011-02-15

    申请号:US10038284

    申请日:2002-01-02

    IPC分类号: C12P19/34 C12M1/36 G01N15/06

    摘要: The aim of the invention is to provide a device for duplicating and characterizing nucleic acids almost simultaneously and with a high sample throughput rate. The device consists of a chamber body with a recess whose edge sealingly holds an optically transparent chip. Said chip holds nucleic acids in individual spots on a detection surface. The chamber body is placed on an optically transparent chamber support with a bearing surface, in such a way that a capillary gap, which can be filled with a liquid sample, is formed between the detection surface of the chip facing towards the chamber support and said chamber support. The chamber body is provided with an inlet and an outlet, which are spatially separate from each other, and has a space, which laterally encompasses the chip and which has a gas reservoir. The chamber support is provided with heating elements.

    摘要翻译: 本发明的目的是提供一种用于几乎同时复制和表征核酸并具有高样品通过率的装置。 该装置包括具有凹口的腔体,其边缘密封地保持光学透明的芯片。 所述芯片将核酸保留在检测表面上的各个斑点中。 室体被放置在具有支承表面的光学透明室支撑件上,使得可以在面向腔室支撑件的芯片的检测表面之间形成可填充有液体样品的毛细管间隙,并且所述 室支持。 腔体设置有在空间上彼此分离的入口和出口,并且具有横向包围芯片并且具有气体储存器的空间。 腔室支撑件设有加热元件。

    Miniaturized temperature-zone flow reactor
    5.
    发明授权
    Miniaturized temperature-zone flow reactor 失效
    微型化温度区流量反应器

    公开(公告)号:US06896855B1

    公开(公告)日:2005-05-24

    申请号:US09600694

    申请日:1999-02-10

    摘要: A miniaturized temperature-zone flow reactor, used for thermally controlled biochemical or molecular-biological processes, especially polymerase chain reaction (PCR) enables more efficient reactions by providing at least one closed flow path which is divided into three partial paths (A1 . . . An; B1 . . . Bn and BB1 . . . BBn−1; C1 . . . Cn) with the reactor having three substrate chips (A; B; C) which are made of a material having a high heat conductivity, and which have defined channel sections that are spaced apart relative to each other, and are connected by a connecting chip (V) made of a poor heat-conductive material. The substrate chips (A; B; C) are maintained at different temperatures by various means, including the use of controlling heating elements in contact with the chips.

    摘要翻译: 用于热控生物化学或分子生物学过程,特别是聚合酶链式反应(PCR)的小型化温度 - 区域流动反应器通过提供至少一个闭合流动路径来实现更有效的反应,其被分成三个部分路径(A 1。 (A; B; C)的反应器,由具有高热量的材料制成的反应器(A; B; C); B 1 ... Bn和BB 1 ... BBn-1; C 1 ... Cn) 导电性,并且具有相对于彼此间隔开的限定的通道部分,并且由由差的导热材料制成的连接芯片(V)连接。 衬底芯片(A; B; C)通过各种方式保持在不同的温度,包括使用控制与芯片接触的加热元件。

    Miniaturized multi-chamber thermocycler
    6.
    发明授权
    Miniaturized multi-chamber thermocycler 失效
    小型多室热循环仪

    公开(公告)号:US5939312A

    公开(公告)日:1999-08-17

    申请号:US765649

    申请日:1996-12-26

    摘要: A miniaturized multi-chamber thermocycler provides a thermocycler which is easy to handle, and permits the treatment of a great number of samples of small sample volumes at high temperature changing rates and at low heating powers. A sample receptacle body manufactured in micro-system technics provides a plurality of sample chambers which are embodied such that at least one of the sample chamber walls of the sample chamber which constitutes the sample chamber base is an efficient heat conductor and also of low mass. Said sample chambers are coupled to a coupling body, serving as heat sink, established via at least one poor heat conducting bridge which, with respect to its dimensioning and/or material selection is such that its specific heat conductance .lambda. is smaller 5 W/K.degree..multidot.m. The sample chambers are provided with at least one heating element which is constructed to effect, in connection with a sample chamber wall serving as heat balancing layer which simultaneously can be the sample chamber base, a substantially homogeneous temperature distribution in a fluid insertable into the sample chambers.

    摘要翻译: PCT No.PCT / EP96 / 02111 Sec。 371日期1996年12月26日第 102(e)日期1996年12月26日PCT提交1996年5月17日PCT公布。 WO96 / 37303 PCT出版物 日期:1996年11月28日小型化多腔热循环仪提供了一种易于处理的热循环仪,并允许以高温变化率和低加热功率处理大量样品体积小样品。 以微系统技术制造的样品容器体提供多个样品室,其被构造为使得构成样品室基底的样品室的样品室壁中的至少一个是有效的热导体并且也是低质量的。 所述样品室耦合到用作散热器的耦合体,所述耦合体经由至少一个差的导热桥构成,其相对于其尺寸和/或材料选择使其比热导数λ小于5W / K DEG xm。 样品室设置有至少一个加热元件,其被构造成与用作同时可以是样品室基底的热平衡层的样品室壁相关联,在可插入样品中的流体中基本均匀的温度分布 房间。

    Miniaturized flow thermocycler
    7.
    发明授权
    Miniaturized flow thermocycler 失效
    微型流动热循环仪

    公开(公告)号:US5716842A

    公开(公告)日:1998-02-10

    申请号:US649632

    申请日:1996-05-23

    摘要: A miniaturized thermocycler is provided for carrying out thermally controlled biochemical or biological melecular processes, in particular polymerase chain reactions. The aim of the invention is to provide a miniaturized thermocycler which enables such reactions to be carried out more effectively, avoids the problem of parasitic heat absorbers and can be manufactured inexpensively in series. This aim is achieved by virtue of the fact that the sample holder (1) is designed as a series of meanders winding in a plane, the sample holder (1) has a groove in a wall and closed over by a cover, the groove passing alternately through comparable heating zones (2) and cooling zones (3), located at intervals along the groove, as it meanders.

    摘要翻译: PCT No.PCT / EP95 / 03580第 371日期:1996年5月23日 102(e)日期1996年5月23日PCT提交1995年9月12日PCT公布。 出版物WO96 / 10456 日期1996年04月11日提供了一种小型化热循环仪,用于进行热控生物化学或生物分子过程,特别是聚合酶链反应。 本发明的目的是提供一种能够更有效地进行这种反应的小型化的热循环仪,避免寄生吸热体的问题,并且可以廉价地串联制造。 该目的是通过将样品架(1)设计成一系列在平面内缠绕的蜿蜒的方式实现的,样品保持器(1)在壁中具有凹槽并被盖封闭,凹槽通过 交替地通过可比较的加热区域(2)和冷却区域(3),沿着凹槽间隔开,当它蜿蜒时。