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1.发明申请ORF2 PROTEIN OF PCV2 SUBTYPE A (PCV2A) FOR USE IN CROSS-PROTECTION 审中-公开用于交叉保护的PCV2亚型A（PCV2A）的ORF2蛋白质公开(公告)号：US20140322267A1
公开(公告)日：2014-10-30
申请号：US14263193
申请日：2014-04-28
申请人： Gregory HAIWICK , Luis HERNANDEZ , Wesley Scott JOHNSON , Christine Margaret MUEHLENTHALER , Eric Martin VAUGHN
发明人： Gregory HAIWICK , Luis HERNANDEZ , Wesley Scott JOHNSON , Christine Margaret MUEHLENTHALER , Eric Martin VAUGHN
IPC分类号： A61K39/12 , A61K39/108 , A61K39/08 , A61K39/02 , A61K39/215 , A61K39/145 , A61K39/04 , A61K39/085 , A61K39/09 , A61K39/23 , A61K39/245 , A61K39/05 , A61K39/235
CPC分类号： A61K39/12 , A61K39/0208 , A61K39/0258 , A61K39/04 , A61K39/05 , A61K39/08 , A61K39/085 , A61K39/092 , A61K39/145 , A61K39/215 , A61K39/23 , A61K39/235 , A61K39/245 , A61K2039/545 , A61K2039/552 , A61K2039/55555 , A61K2039/70 , C12N7/00 , C12N2750/10022 , C12N2750/10034
摘要： Vaccination methods to control PCV2 infection with different PCV2 subtypes are disclosed. Specifically, a PCV2 subtype a (PCV2a) ORF2 proteins or immunogenic compositions comprising a PCV2a ORF2 protein are used in a method for the treatment or prevention of an infection with PCV2 of a different subtype, the reduction, prevention or treatment of clinical signs caused by an infection with PCV2 of a different subtype, or the prevention or treatment of a disease caused by an infection with PCV2 of a different subtype.
摘要翻译： 公开了用不同PCV2亚型控制PCV2感染的疫苗接种方法。 具体地说，将PCV2亚型（PCV2a）ORF2蛋白质或包含PCV2a ORF2蛋白质的免疫原性组合物用于治疗或预防不同亚型的PCV2感染的方法，减少，预防或治疗由 不同亚型的PCV2的感染，或预防或治疗由不同亚型的PCV2的感染引起的疾病。
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公开(公告)号：US20150056248A1
公开(公告)日：2015-02-26
申请号：US14464132
申请日：2014-08-20
申请人： Gregory HAIWICK , Marc Allan EICHMEYER , Luis Alejandro HERNANDEZ , Wesley Scott JOHNSON , Christine Margaret MUEHLENTHALER , Eric Martin VAUGHN
发明人： Gregory HAIWICK , Marc Allan EICHMEYER , Luis Alejandro HERNANDEZ , Wesley Scott JOHNSON , Christine Margaret MUEHLENTHALER , Eric Martin VAUGHN
IPC分类号： A61K39/12
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/5256 , A61K2039/55 , A61K2039/552 , A61K2039/55516 , A61K2039/55566 , A61K2039/58 , C12N7/00 , C12N2710/14043 , C12N2750/10034
摘要： Vaccination methods to control PCV2 infection with different PCV2 subtypes are disclosed. Specifically, a PCV2 subtype b (PCV2b) ORF2 proteins or immunogenic compositions comprising a PCV2b ORF2 protein are used in a method for the treatment or prevention of an infection with PCV2 of a different subtype, the reduction, prevention or treatment of clinical signs caused by an infection with PCV2 of a different subtype, or the prevention or treatment of a disease caused by an infection with PCV2 of a different subtype.
摘要翻译： 公开了用不同PCV2亚型控制PCV2感染的疫苗接种方法。 具体地说，将PCV2亚型b（PCV2b）ORF2蛋白质或包含PCV2b ORF2蛋白质的免疫原性组合物用于治疗或预防不同亚型的PCV2感染的方法，减少，预防或治疗由 不同亚型的PCV2的感染，或预防或治疗由不同亚型的PCV2的感染引起的疾病。
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公开(公告)号：US20150093404A1
公开(公告)日：2015-04-02
申请号：US14504839
申请日：2014-10-02
申请人： Luis Alejandro HERNANDEZ , Christine Margaret MUEHLENTHALER , Eric Martin VAUGHN , Gregory HAIWICK
发明人： Luis Alejandro HERNANDEZ , Christine Margaret MUEHLENTHALER , Eric Martin VAUGHN , Gregory HAIWICK
IPC分类号： C07K14/005 , C12N7/00
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , C12N7/00 , C12N2710/14043 , C12N2750/10022 , C12N2750/10023 , C12N2750/10034 , C12N2750/10051 , C12N2799/026 , C12P21/02
摘要： Vaccination methods to control PCV2 infection with different PCV2 subtypes are disclosed. Specifically, a PCV2 subtype b (PCV2b) ORF2 proteins or immunogenic compositions comprising a PCV2b ORF2 protein are used in a method for the treatment or prevention of an infection with PCV2 of the same PCV2b and/or different subtype; the reduction, prevention or treatment of clinical signs caused by an infection with PCV2 of the same PCV2b or a different subtype; and/or the prevention or treatment of a disease caused by an infection with PCV2 of the same PCV2b and/or a different subtype. The present invention in particular relates to PCV2 subtype b (PCV2b) ORF2 proteins characterized in that they contain at least one mutation in the BC loop that such that the expressed protein is preferably expressed in a higher amount compared to a PCV2 ORF2 protein that does not contain such mutation.
摘要翻译： 公开了用不同PCV2亚型控制PCV2感染的疫苗接种方法。 具体地说，在用于治疗或预防相同PCV2b和/或不同亚型的PCV2的感染的方法中使用包含PCV2b ORF2蛋白的PCV2亚型b（PCV2b）ORF2蛋白或免疫原性组合物; 减少，预防或治疗由相同PCV2b或不同亚型的PCV2感染引起的临床症状; 和/或预防或治疗由相同PCV2b和/或不同亚型的PCV2感染引起的疾病。 本发明特别涉及PCV2亚型b（PCV2b）ORF2蛋白，其特征在于它们在BC环中含有至少一个突变，使得与不携带的PCV2 ORF2蛋白相比，表达的蛋白优选以更高的量表达 含有这种突变。
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公开(公告)号：US20140255442A1
公开(公告)日：2014-09-11
申请号：US14281287
申请日：2014-05-19
申请人： Kim BURGARD , Jeremy KROLL , Sarah M. LAYTON , Volker OHLINGER , Francois-Xavier ORVEILLON , Stefan PESCH , Michael Dennis PIONTKOWSKI , Michael B. ROOF , Philip UTLEY , Eric Martin VAUGHN
发明人： Kim BURGARD , Jeremy KROLL , Sarah M. LAYTON , Volker OHLINGER , Francois-Xavier ORVEILLON , Stefan PESCH , Michael Dennis PIONTKOWSKI , Michael B. ROOF , Philip UTLEY , Eric Martin VAUGHN
IPC分类号： C12N7/00
CPC分类号： A61K39/12 , A61K2039/5254 , A61K2039/53 , A61K2039/552 , A61K2039/575 , C12N7/00 , C12N2770/10021 , C12N2770/10034 , C12N2770/10064 , C12N2770/10071
摘要： The present invention is related to improved modified live PRRS vaccines containing new PRRSV European strains of PRRSV and methods of use and manufacture of such vaccines.
摘要翻译： 本发明涉及包含新的PRRSV欧洲PRRSV菌株的改良的活的PRRS疫苗，以及使用和制造这种疫苗的方法。
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公开(公告)号：US20140234354A1
公开(公告)日：2014-08-21
申请号：US13800413
申请日：2013-03-13
申请人： Arun V. IYER , Dianna M. Murphy JORDAN , Abby Rae PATTERSON , Michael B. ROOF , Eric Martin VAUGHN , Joseph Gilbert VICTORIA , Callie Ann VISEK
发明人： Arun V. IYER , Dianna M. Murphy JORDAN , Abby Rae PATTERSON , Michael B. ROOF , Eric Martin VAUGHN , Joseph Gilbert VICTORIA , Callie Ann VISEK
IPC分类号： C12N7/00
CPC分类号： A61K39/23 , A61K2039/53 , C07K14/005 , C12N7/00 , C12N2750/14321 , C12N2750/14322 , C12N2750/14334 , G01N33/56983 , G01N2333/015 , G01N2469/10
摘要： The present invention provides novel nucleotides sequences, protein sequences, immunogenic compositions, vaccines, and methods that relate to making and using new porcine parvovirus 5B (PPV5B) that infects, inter alia, domestic swine. The compositions and methods provide for the detection of infections by said new virus, monitoring genetic changes in the viral sequences in wild and domestic animals and herds, and making and using novel vaccines for protecting animals from infection by the virus.
摘要翻译： 本发明提供新颖的核苷酸序列，蛋白质序列，免疫原性组合物，疫苗和涉及制造和使用感染尤其是家猪的新型猪细小病毒5B（PPV5B）的方法。 组合物和方法提供了用于检测所述新病毒的感染，监测野生和家畜和猪群中的病毒序列的遗传变化，以及制备和使用新型疫苗以保护动物免受病毒感染。
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6.发明申请NOVEL H5 PROTEINS, NUCLEIC ACID MOLECULES AND VECTORS ENCODING FOR THOSE, AND THEIR MEDICINAL USE 审中-公开新型H5蛋白，核酸分子和编码的载体及其药物使用公开(公告)号：US20140050755A1
公开(公告)日：2014-02-20
申请号：US14061249
申请日：2013-10-23
IPC分类号： A61K39/145 , C07K14/005
CPC分类号： A61K39/145 , A61K39/00 , A61K39/12 , A61K2039/53 , A61K2039/55555 , A61K2039/55566 , C07K14/005 , C12N2760/16122 , C12N2760/16134
摘要： The present invention relates to novel hemagglutinin H5 proteins, nucleic acids and vectors encoding for those as well as vaccines comprising any of such H5 proteins, nucleic acids or vectors encoding for those H5 proteins. Moreover, the present invention also relates to the medicinal use of any of such compositions in humans and animals.
摘要翻译： 本发明涉及新的血凝素H5蛋白，核酸和编码这些蛋白的载体以及包含任何这样的H5蛋白，核酸或编码这些H5蛋白的载体的疫苗。 此外，本发明还涉及任何这样的组合物在人和动物中的药物用途。
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7.发明申请PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS, COMPOSITIONS, VACCINE AND METHODS OF USE 有权PORCINE生殖和呼吸道综合症病毒，组合物，疫苗和使用方法公开(公告)号：US20140271698A1
公开(公告)日：2014-09-18
申请号：US14206283
申请日：2014-03-12
申请人： Dianna M. Murphy JORDAN , Brian Thomas MARTINSON , Michael B. ROOF , Eric Martin VAUGHN , Joseph Gilbert VICTORIA
发明人： Dianna M. Murphy JORDAN , Brian Thomas MARTINSON , Michael B. ROOF , Eric Martin VAUGHN , Joseph Gilbert VICTORIA
IPC分类号： A61K39/12 , C07K14/005 , C07K16/10
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/5254 , A61K2039/552 , C07K14/005 , C07K16/10 , C12N7/00 , C12N2770/10021 , C12N2770/10022 , C12N2770/10034 , C12N2770/10064
摘要： The present invention relates to Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) mutant strains having increased stability; compositions containing the strains or antigens derived therefrom; vaccines containing the strains, including killed, attenuated or subunit vaccines; nucleic acids encoding PRRSV polypeptides, polypeptides encoded by the nucleic acids, including antigenic fragments thereof; antibodies which specifically bind to said polypeptides, and methods making and using thereof.
摘要翻译： 本发明涉及具有增加的稳定性的猪繁殖与呼吸综合征病毒（PRRSV）突变株; 含有源自其的菌株或抗原的组合物; 含有菌株的疫苗，包括杀死，减毒或亚单位疫苗; 编码PRRSV多肽的核酸，由核酸编码的多肽，包括其抗原性片段; 特异性结合所述多肽的抗体及其制备和使用方法。
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公开(公告)号：US20140248603A1
公开(公告)日：2014-09-04
申请号：US14194380
申请日：2014-02-28
申请人： Marc Allan EICHMEYER , Michael B. ROOF , Merrill Lynn SCHAEFFER , Eric Martin VAUGHN , Kun YANG , Jeremy Richard RUSH , Daniel John MURFIN
发明人： Marc Allan EICHMEYER , Michael B. ROOF , Merrill Lynn SCHAEFFER , Eric Martin VAUGHN , Kun YANG , Jeremy Richard RUSH , Daniel John MURFIN
IPC分类号： C12Q1/37 , G01N33/569 , C07K14/005 , C07K7/08 , C07K7/06
CPC分类号： C12Q1/37 , C07K7/06 , C07K7/08 , C07K14/001 , C07K14/005 , G01N33/56983 , G01N33/6848 , G01N2333/01
摘要： The invention provides methods and mass-labeled peptides for use in said methods for quantifying the presence of a one or more viral proteins in a sample of a preparation containing agents which bind to said viral protein, using mass-spectroscopic analyses of the sample and standards containing known amounts of labeled and unlabeled signature peptides, in particular wherein said viral proteins are antigens in a vaccine for porcine circovirus.
摘要翻译： 本发明提供了用于所述方法的方法和质量标记的肽，用于定量含有与所述病毒蛋白结合的试剂的制剂的样品中一种或多种病毒蛋白的存在，使用样品和标准品的质谱分析 含有已知量的标记和未标记的特征肽，特别是其中所述病毒蛋白是猪圆环病毒疫苗中的抗原。
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公开(公告)号：US20140170180A1
公开(公告)日：2014-06-19
申请号：US13796621
申请日：2013-03-12
申请人： Arun V. IYER , Dianna M. Murphy JORDAN , Abby Rae PATTERSON , Michael B. ROOF , Eric Martin VAUGHN , Joseph Gilbert VICTORIA , Callie Ann VISEK
发明人： Arun V. IYER , Dianna M. Murphy JORDAN , Abby Rae PATTERSON , Michael B. ROOF , Eric Martin VAUGHN , Joseph Gilbert VICTORIA , Callie Ann VISEK
CPC分类号： A61K39/23 , A61K2039/5252 , A61K2039/5254 , A61K2039/552 , C07K14/005 , C12N7/00 , C12N2750/14021 , C12N2750/14022 , C12N2750/14034 , G01N33/6893
摘要： The present invention provides novel nucleotides sequences, protein sequences, immunogenic compositions, vaccines, and methods that relate to making and using new porcine parvovirus 5A (PPV5A) that infects, inter alia, domestic swine. The compositions and methods provide for the detection of infections by said new virus, monitoring genetic changes in the viral sequences in wild and domestic animals and herds, and making and using novel vaccines for protecting animals from infection by the virus.
摘要翻译： 本发明提供新颖的核苷酸序列，蛋白质序列，免疫原性组合物，疫苗以及涉及制造和使用感染尤其是家猪的新型猪细小病毒5A（PPV5A）的方法。 组合物和方法提供了用于检测所述新病毒的感染，监测野生和家畜和猪群中的病毒序列的遗传变化，以及制备和使用新型疫苗以保护动物免受病毒感染。
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公开(公告)号：US20120213810A1
公开(公告)日：2012-08-23
申请号：US13396298
申请日：2012-02-14
申请人： Kim BURGARD , Jeremy KROLL , Sarah M. LAYTON , Volker OHLINGER , Francois-Xavier ORVEILLON , Stefan PESCH , Michael Dennis PIONTKOWSKI , Michael B. ROOF , Philip UTLEY , Eric Martin VAUGHN
发明人： Kim BURGARD , Jeremy KROLL , Sarah M. LAYTON , Volker OHLINGER , Francois-Xavier ORVEILLON , Stefan PESCH , Michael Dennis PIONTKOWSKI , Michael B. ROOF , Philip UTLEY , Eric Martin VAUGHN
CPC分类号： A61K39/12 , A61K2039/5254 , A61K2039/53 , A61K2039/552 , A61K2039/575 , C12N7/00 , C12N2770/10021 , C12N2770/10034 , C12N2770/10064 , C12N2770/10071
摘要： The present invention is related to improved modified live PRRS vaccines containing new PRRSV European strains of PRRSV and methods of use and manufacture of such vaccines.
摘要翻译： 本发明涉及包含新的PRRSV欧洲PRRSV菌株的改良的活的PRRS疫苗，以及使用和制造这种疫苗的方法。
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