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    AUTOMATIC SLIDE LOADING DEVICE FOR MICRO ARRAY SCANNER AND ITS METHODS OF USE
    1.
    发明申请
    AUTOMATIC SLIDE LOADING DEVICE FOR MICRO ARRAY SCANNER AND ITS METHODS OF USE 审中-公开
    用于微阵列扫描仪的自动幻灯片加载装置及其使用方法

    公开(公告)号：US20130203611A1

    公开(公告)日：2013-08-08

    申请号：US13814196

    申请日：2011-08-05

    申请人： Hang Li ,  Huihui Teng ,  Danyang Mei ,  Wenjun Wang ,  Gang Li ,  Xiaokun Qin ,  Zhengde Feng ,  Dong Wang ,  Jing Cheng

    发明人： Hang Li ,  Huihui Teng ,  Danyang Mei ,  Wenjun Wang ,  Gang Li ,  Xiaokun Qin ,  Zhengde Feng ,  Dong Wang ,  Jing Cheng

    IPC分类号： G01N21/64 ,  B25J11/00

    CPC分类号： G01N21/6486 ,  B25J11/00 ,  G01N21/6452 ,  G01N35/04 ,  G01N2035/00039 ,  G01N2035/00138 ,  G02B21/34

    摘要： An automatic slide loading device for microarray scanner comprises slide holders (1), a carrier device (2) and a positioning chamber (3), wherein the slide holder (1) can hold microarray slides (6) and the slide holder (1) is placed out of the scanning platform of the microarray scanner when the microarray scanner is in off work state, wherein the carrier device (2) is connected to the positioning chamber (3) and the carrier device (2) can load the slide holder (1) into the positioning chamber (3), wherein the positioning chamber (3) is placed above the scanning platform of the microarray scanner and is used to precisely locate the working surface of the microarray slides (6) in the slide holder (1).

    摘要翻译： 一种用于微阵列扫描器的自动滑块装载装置，包括滑动架（1），载体装置（2）和定位室（3），其中滑动架（1）可以容纳微阵列滑块（6）和滑动架（1） 当微阵列扫描仪处于关闭状态时，放置在微阵列扫描仪的扫描平台之外，其中载体装置（2）连接到定位室（3），并且载体装置（2）可以装载滑动架（ 1）进入定位室（3），其中定位室（3）放置在微阵列扫描仪的扫描平台上方，并用于精确地定位载玻片保持器（1）中的微阵列滑块（6）的工作表面， 。

    Method and apparatus for washing solid substrate with ultrasonic wave after hybridization reaction
    3.
    发明申请
    Method and apparatus for washing solid substrate with ultrasonic wave after hybridization reaction 审中-公开
    杂交反应后用超声波洗涤固体底物的方法和装置

    公开(公告)号：US20060124152A1

    公开(公告)日：2006-06-15

    申请号：US10524903

    申请日：2002-12-10

    申请人： Gang Li ,  Wanli Xing ,  Ruige Wu ,  Min Guo ,  Jing Cheng

    发明人： Gang Li ,  Wanli Xing ,  Ruige Wu ,  Min Guo ,  Jing Cheng

    IPC分类号： B08B3/10

    CPC分类号： B08B3/12 ,  C12Q1/6813 ,  C12Q2523/301

    摘要： A method and apparatus for washing solid substrate with ultrasonic wave after hybridization reaction are provided. The method includes (1) putting the solid substrate into a container having a washing solution, on which the hybridization reaction has been completed, (2) using an ultrasonic generator to produce a certain strength of ultrasonic wave and transmit it into the washing solution, (3) washing the substrate by means of the cavitation effect being produced in the washing solution by the ultrasonic wave. Since the cavitation bubbles in the washing solution can produce intensive efflux and local microslipstream against the solid surface, evidently reducing the liquid surface tension and friction and enhance the liquid flow, non-specific adsorbate and deposit bound weakly on the solid substrate can be washed down rapidly.

    摘要翻译： 提供了一种用于在杂交反应之后用超声波洗涤固体底物的方法和装置。 该方法包括：（1）将固体基质置于具有杂交反应完成的洗涤液的容器中，（2）使用超声波发生器产生一定强度的超声波并将其输送到洗涤液中， （3）通过超声波在洗涤液中产生的空化作用洗涤基板。 由于洗涤液中的气穴气泡能够对固体表面产生强烈的流出和局部微滑流，明显降低了液面张力和摩擦力，增强了液体流动，固体基质上弱结合的非特异性吸附物和沉积物可以被冲洗掉 迅速

    Device for washing and hybridization of biochips
    4.
    发明授权
    Device for washing and hybridization of biochips 有权
    用于生物芯片的洗涤和杂交的装置

    公开(公告)号：US08137622B2

    公开(公告)日：2012-03-20

    申请号：US12527184

    申请日：2007-10-09

    申请人： Hang Li ,  Jianxin Ye ,  Xingling Al ,  Xianhua Wang ,  Liang Zhang ,  Jing Cheng

    发明人： Hang Li ,  Jianxin Ye ,  Xingling Al ,  Xianhua Wang ,  Liang Zhang ,  Jing Cheng

    IPC分类号： B01F11/00 ,  B01F11/04

    CPC分类号： B08B3/044 ,  B01F11/0028 ,  B01J2219/00326 ,  B01J2219/00328 ,  B01J2219/00527 ,  B01J2219/00659 ,  B01L7/00 ,  B01L2300/0819 ,  B08B11/02 ,  Y10S435/809

    摘要： A device for biochip hybridization or washing is provided, which comprises a carousel (12), a translational movement controller, a revolving movement controller, and optionally a heating chamber (13). The revolving movement controller controls the revolving movement of the carousel and allows it to move in a wobbling fashion, allowing liquid movement of the hybridization or washing boxes (11) during hybridization and/or washing of biochips on the carousel. The translational movement controller brings the carousel back to horizontal position once the revolving movement controller stops, thereby ensures that the liquid do not spill out. The heating chamber circulates hot air within the device, thereby ensures that the hybridization and washing in a thermostatic condition.

    摘要翻译： 提供了用于生物芯片杂交或洗涤的装置，其包括圆盘传送带（12），平移运动控制器，旋转运动控制器和可选的加热室（13）。 旋转运动控制器控制圆盘传送带的旋转运动，并允许其以摆动的方式移动，允许杂交或洗涤盒（11）在传送带上的生物芯片的杂交和/或洗涤期间的液体移动。 一旦旋转运动控制器停止，平移运动控制器将转盘回到水平位置，从而确保液体不会溢出。 加热室在装置内循环热空气，从而确保在恒温条件下进行杂交和洗涤。

    DEVICE FOR WASHING AND HYBRIDIZATION OF BIOCHIPS
    5.
    发明申请
    DEVICE FOR WASHING AND HYBRIDIZATION OF BIOCHIPS 有权
    BIOCHIPS洗涤和杂交装置

    公开(公告)号：US20100190663A1

    公开(公告)日：2010-07-29

    申请号：US12527184

    申请日：2007-10-09

    申请人： Hang Li ,  Jianxin Ye ,  Xingling Al ,  Xianhua Wang ,  Liang Zhang ,  Jing Cheng

    发明人： Hang Li ,  Jianxin Ye ,  Xingling Al ,  Xianhua Wang ,  Liang Zhang ,  Jing Cheng

    IPC分类号： C40B60/00

    CPC分类号： B08B3/044 ,  B01F11/0028 ,  B01J2219/00326 ,  B01J2219/00328 ,  B01J2219/00527 ,  B01J2219/00659 ,  B01L7/00 ,  B01L2300/0819 ,  B08B11/02 ,  Y10S435/809

    摘要： A device for biochip hybridization or washing is provided, which comprises a carousel (12), a translational movement controller, a revolving movement controller, and optionally a heating chamber (13). The revolving movement controller controls the revolving movement of the carousel and allows it to move in a wobbling fashion, allowing liquid movement of the hybridization or washing boxes (11) during hybridization and/or washing of biochips on the carousel. The translational movement controller brings the carousel back to horizontal position once the revolving movement controller stops, thereby ensures that the liquid do not spill out. The heating chamber circulates hot air within the device, thereby ensures that the hybridization and washing in a thermostatic condition.

    摘要翻译： 提供了用于生物芯片杂交或洗涤的装置，其包括圆盘传送带（12），平移运动控制器，旋转运动控制器和可选的加热室（13）。 旋转运动控制器控制圆盘传送带的旋转运动，并允许其以摆动的方式移动，允许杂交或洗涤盒（11）在传送带上的生物芯片的杂交和/或洗涤期间的液体移动。 一旦旋转运动控制器停止，平移运动控制器将转盘回到水平位置，从而确保液体不会溢出。 加热室在装置内循环热空气，从而确保在恒温条件下进行杂交和洗涤。

    Micro-Volume Liquid Ejection System
    7.
    发明申请
    Micro-Volume Liquid Ejection System 有权
    微量液体喷射系统

    公开(公告)号：US20080267828A1

    公开(公告)日：2008-10-30

    申请号：US11666032

    申请日：2004-11-22

    申请人： Dong Wang ,  Kun Zou ,  Jianxing Ye ,  Yelei Sun ,  Hui Zhu ,  Xianhua Wang ,  Jing Cheng

    发明人： Dong Wang ,  Kun Zou ,  Jianxing Ye ,  Yelei Sun ,  Hui Zhu ,  Xianhua Wang ,  Jing Cheng

    IPC分类号： B65D83/00

    CPC分类号： B01L3/0265 ,  B01L2400/0487 ,  B01L2400/0666 ,  Y10T436/2575

    摘要： The present invention relates to a micro-volume liquid ejection system, including an air pressure module, a micro-ejection unit which is connected with the air pressure module by means of pipes, and a control circuit which is connected with the air pressure module and the micro-ejection unit respectively. In the present invention, due to air is used as the pressure medium, on one hand, as the sample does not contact with the pressure regulating module, the efficiency of cleaning process is improved, on the other hand, the volume of the sample needed in the sample ejecting process is only equal to the cavity-dimension of the micro-ejection unit by not need to fill the whole pipe with liquid. During the sample ejecting process, it is not need to regulate the pressure. After the sample ejecting is finished, the sample can be put into its original place, so as to greatly save the sample. The present invention is connected with the manipulator, so as to sample from the sample plate, eject sample and clean the pipes automatically, and it can also dispense a multiplicity of samples to micro-array substrate conveniently. The present invention can be used for transferring or dispensing the micro volume liquid of nL grade and L grade widely, and all kinds of the micro-volume liquid including biological liquid.

    摘要翻译： 微体积液体喷射系统技术领域本发明涉及一种微体积液体喷射系统，包括空气压力模块，通过管道与空气压力模块连接的微型喷射单元，以及与气压模块连接的控制电路和 微型喷射单元。 在本发明中，由于空气被用作压力介质，一方面由于样品不与压力调节模块接触，因此提高了清洗过程的效率，另一方面，样品的体积需要 在样品喷射过程中，仅通过不需要用整个管道填充液体就等于微喷射单元的腔体尺寸。 在样品喷射过程中，不需要调节压力。 样品喷射完成后，样品可以放在原来的位置，大大节省样品。 本发明与机械手连接，从样品板上取样，自动排出样品并清洗管道，方便地将多个样品分配给微阵列基板。 本发明可广泛用于转移或分配nL级和L级微量液体，以及各种微体积液体，包括生物液体。

    Microvalve Controlled Precision Fluid Dispensing Apparatus with a Self-Purging Feature and Method for use
    10.
    发明申请
    Microvalve Controlled Precision Fluid Dispensing Apparatus with a Self-Purging Feature and Method for use 有权
    具有自清洗特征的微型阀控精密液体分配装置及其使用方法

    公开(公告)号：US20090301231A1

    公开(公告)日：2009-12-10

    申请号：US11991723

    申请日：2006-01-13

    申请人： Dong Wang ,  Kun Zou ,  Jing Cheng

    发明人： Dong Wang ,  Kun Zou ,  Jing Cheng

    IPC分类号： G01N1/14 ,  G01N35/10 ,  G01F11/28

    CPC分类号： B41J2/17596 ,  B01J2219/0036 ,  B01J2219/00364 ,  B01L3/0265 ,  B01L2400/0478 ,  B01L2400/0622 ,  B41J2/175 ,  G01N2035/00247 ,  G01N2035/1041 ,  Y10T436/2575

    摘要： An apparatus and methods for the precise, repeatable dispensing of small, sample fluid volumes, especially as related to the printing of microarrays for biological and/or chemical testing. A pressure tuning module meters fluid volumes for aspiration and dispensation and builds pressure for fluid dispensation, in conjunction with a microvalve that precisely controls the volume of the fluid dispensed under the built pressure. A pressure source can be switched in line to efficiently purge the apparatus of residual sample fluid. A working fluid can be optionally aspirated into the system, prior to aspirating the sample fluid, in order to maximize sample fluid recovery.

    摘要翻译： 用于精确，可重复分配小的样品流体体积的装置和方法，特别是与用于生物和/或化学测试的微阵列的印刷相关。 压力调节模块计量用于抽吸和分配的流体体积，并建立用于流体分配的压力，以及精确控制在内置压力下分配的流体的体积的微型阀。 压力源可以排成一行，以有效地吹扫残留样品液的装置。 在抽吸样品流体之前，可以将工作流体任选地吸入系统，以使样品液体回收最大化。