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公开(公告)号：US07585645B2
公开(公告)日：2009-09-08
申请号：US09897898
申请日：2001-07-05
申请人： Harm M. Deckers , Gijs van Rooijen , Joseph Boothe , Janis Goll , Maurice M. Moloney , Bipin K. Dalmia
发明人： Harm M. Deckers , Gijs van Rooijen , Joseph Boothe , Janis Goll , Maurice M. Moloney , Bipin K. Dalmia
IPC分类号： C12P21/04 , A23J1/00 , C12N15/00 , C12N5/00 , A61K38/00 , C07H21/04 , C07K1/00 , C12N5/04 , C12N9/00
CPC分类号： A23D7/001 , A23D7/003 , A23G3/343 , A23G3/346 , A23G3/40 , A23G3/48 , A23G4/066 , A23G4/068 , A23G9/327 , A23G9/42 , A23G2200/08 , A23G2200/14 , A23K20/168 , A23K50/80 , A23L9/10 , A23L23/00 , A23L27/18 , A23L27/60 , A23P20/10 , A61K8/06 , A61K8/66 , A61K8/922 , A61K9/0014 , A61K36/00 , A61K36/31 , A61K47/44 , A61Q1/02 , A61Q1/06 , A61Q1/08 , A61Q1/10 , A61Q5/00 , A61Q11/00 , A61Q13/00 , A61Q17/04 , A61Q19/00 , A61Q19/10 , C09D5/022 , C11B1/10 , Y02A40/818 , A61K2300/00
摘要： The present invention provides novel emulsion formulations which comprise oil bodies. The invention also provides a method for preparing the emulsions and the use of the emulsions in a variety of products including food products, personal care products and pharmaceutical products. In a preferred embodiment the emulsions comprise thioredoxin and/or thioredoxin reductase.
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公开(公告)号：US06596287B2
公开(公告)日：2003-07-22
申请号：US09983540
申请日：2001-10-24
IPC分类号： A61K742
CPC分类号： C11B1/10 , A23D7/001 , A23D7/003 , A23G3/343 , A23G3/346 , A23G3/40 , A23G3/48 , A23G4/066 , A23G4/068 , A23G9/327 , A23G9/42 , A23G2200/08 , A23G2200/14 , A23K20/168 , A23K50/80 , A23L9/10 , A23L23/00 , A23L27/18 , A23L27/60 , A23P20/10 , A61K8/06 , A61K8/66 , A61K8/922 , A61K9/0014 , A61K36/00 , A61K36/31 , A61K47/44 , A61Q1/02 , A61Q1/06 , A61Q1/08 , A61Q1/10 , A61Q5/00 , A61Q11/00 , A61Q13/00 , A61Q17/04 , A61Q19/00 , A61Q19/10 , C09D5/022 , Y02A40/818 , Y10S514/828 , Y10S514/845 , Y10S514/846 , Y10S514/847 , Y10S514/848 , Y10S514/865 , Y10S514/882 , Y10S514/887 , Y10S514/937 , A61K2300/00
摘要： The present invention provides novel emulsion formulations which comprise oil bodies. The invention also provides a method for preparing the emulsions and the use of the emulsions in products for topical application to the skin. The products are very mild to the skin and may be easily formulated into a wide variety of personal care and dermatological products.
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公开(公告)号：US06183762B2
公开(公告)日：2001-02-06
申请号：US09448600
申请日：1999-11-24
IPC分类号： A61K700
CPC分类号： A23D7/001 , A23D7/003 , A23D7/0053 , A23D7/0056 , A23G3/343 , A23G3/346 , A23G3/40 , A23G3/48 , A23G4/066 , A23G4/068 , A23G9/327 , A23G9/42 , A23G2200/08 , A23G2200/14 , A23K20/168 , A23K20/184 , A23K50/80 , A23L9/10 , A23L23/00 , A23L27/18 , A23L27/60 , A23P20/10 , A61K8/06 , A61K8/922 , A61K9/0014 , A61K9/107 , A61K36/00 , A61K36/185 , A61K36/23 , A61K36/28 , A61K36/286 , A61K36/31 , A61K36/42 , A61K36/47 , A61K36/48 , A61K36/889 , A61K36/899 , A61K47/44 , A61Q1/02 , A61Q1/06 , A61Q1/08 , A61Q1/10 , A61Q5/00 , A61Q11/00 , A61Q13/00 , A61Q17/04 , A61Q19/00 , A61Q19/10 , C09D5/022 , C11B1/10 , Y02A40/818 , Y10S426/805 , Y10S514/937 , A61K2300/00
摘要： The present invention provides novel emulsion formulations which comprise oil bodies. The invention also provides a method for preparing the emulsions and the use of the emulsions in various domestic and industrial compositions. The emulsions are especially suited for the preparation of food products, personal care products, pharmaceutical products and industrial products.
摘要翻译： 本发明提供了包含油体的新型乳液制剂。 本发明还提供了制备乳液的方法以及乳液在各种家用和工业组合物中的用途。 该乳液特别适用于制备食品，个人护理产品，药品和工业产品。
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公开(公告)号：US06599513B2
公开(公告)日：2003-07-29
申请号：US09983546
申请日：2001-10-24
IPC分类号： A61K742
CPC分类号： A23D7/001 , A23D7/003 , A23G3/343 , A23G3/346 , A23G3/40 , A23G3/48 , A23G4/066 , A23G4/068 , A23G9/327 , A23G9/42 , A23G2200/08 , A23G2200/14 , A23K20/168 , A23K50/80 , A23L9/10 , A23L23/00 , A23L27/18 , A23L27/60 , A23P20/10 , A61K8/06 , A61K8/66 , A61K8/922 , A61K9/0014 , A61K36/00 , A61K36/31 , A61K47/44 , A61Q1/02 , A61Q1/06 , A61Q1/08 , A61Q1/10 , A61Q5/00 , A61Q11/00 , A61Q13/00 , A61Q17/04 , A61Q19/00 , A61Q19/10 , C09D5/022 , C11B1/10 , Y02A40/818 , Y10S514/828 , Y10S514/845 , Y10S514/846 , Y10S514/847 , Y10S514/848 , Y10S514/882 , Y10S514/887 , A61K2300/00
摘要： The present invention provides novel emulsion formulations which comprise oil bodies. The invention also provides a method for preparing the emulsions and the use of the emulsions in products for topical application to the skin. The products are very mild to the skin and may be easily formulated into a wide variety of personal care and dermatological products.
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公开(公告)号：US06582710B2
公开(公告)日：2003-06-24
申请号：US10058125
申请日：2002-01-29
IPC分类号： A61K742
CPC分类号： C11B1/10 , A23D7/001 , A23D7/003 , A23G3/343 , A23G3/346 , A23G3/40 , A23G3/48 , A23G4/066 , A23G4/068 , A23G9/327 , A23G9/42 , A23G2200/08 , A23G2200/14 , A23K20/168 , A23K50/80 , A23L9/10 , A23L23/00 , A23L27/18 , A23L27/60 , A23P20/10 , A61K8/06 , A61K8/66 , A61K8/922 , A61K9/0014 , A61K36/00 , A61K36/31 , A61K47/44 , A61Q1/02 , A61Q1/06 , A61Q1/08 , A61Q1/10 , A61Q5/00 , A61Q11/00 , A61Q13/00 , A61Q17/04 , A61Q19/00 , A61Q19/10 , C09D5/022 , Y02A40/818 , Y10S514/828 , Y10S514/845 , Y10S514/846 , Y10S514/847 , Y10S514/848 , Y10S514/865 , Y10S514/882 , Y10S514/887 , Y10S514/937 , A61K2300/00
摘要： The present invention provides novel emulsion formulations which comprise oil bodies. The invention also provides a method for preparing the emulsions and the use of the emulsions in products for topical application to the skin. The products are very mild to the skin and may be easily formulated into a wide variety of personal care and dermatological products.
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公开(公告)号：US06761914B2
公开(公告)日：2004-07-13
申请号：US09880901
申请日：2001-06-15
申请人： Harm M. Deckers , Gijs van Rooijen , Joseph Boothe , Janis Goll , Maurice M. Moloney , Anthony B. Schryvers , Joenel Alcantara , Wendy A. Hutchins
发明人： Harm M. Deckers , Gijs van Rooijen , Joseph Boothe , Janis Goll , Maurice M. Moloney , Anthony B. Schryvers , Joenel Alcantara , Wendy A. Hutchins
IPC分类号： A61K4500
CPC分类号： C11B1/10 , A23D7/001 , A23D7/003 , A23G3/343 , A23G3/346 , A23G3/40 , A23G3/48 , A23G4/066 , A23G4/068 , A23G9/327 , A23G9/42 , A23G2200/08 , A23G2200/14 , A23K20/168 , A23K50/80 , A23L9/10 , A23L23/00 , A23L27/18 , A23L27/60 , A23P20/10 , A61K8/06 , A61K8/922 , A61K9/0014 , A61K9/0019 , A61K36/00 , A61K39/39 , A61K47/44 , A61K2039/54 , A61K2039/55566 , A61K2039/55588 , A61Q1/02 , A61Q1/06 , A61Q1/08 , A61Q1/10 , A61Q5/00 , A61Q11/00 , A61Q13/00 , A61Q17/04 , A61Q19/00 , A61Q19/10 , C07K14/415 , C07K2319/00 , C09D5/022 , Y02A40/818 , Y10S424/812 , Y10S514/885
摘要： The present invention provides novel adjuvants which comprise oil bodies. The invention also provides vaccine formulations comprising oil bodies and an antigen and methods for preparing the vaccines and the use of the vaccines to elicit an immune response.
摘要翻译： 本发明提供了包含油体的新型佐剂。 本发明还提供包含油体和抗原的疫苗制剂以及用于制备疫苗的方法和疫苗引起免疫应答的用途。
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公开(公告)号：US06372234B1
公开(公告)日：2002-04-16
申请号：US09577147
申请日：2000-05-24
IPC分类号： A61K700
CPC分类号： C11B1/10 , A23D7/001 , A23D7/003 , A23G3/343 , A23G3/346 , A23G3/40 , A23G3/48 , A23G4/066 , A23G4/068 , A23G9/327 , A23G9/42 , A23G2200/08 , A23G2200/14 , A23K20/168 , A23K50/80 , A23L9/10 , A23L23/00 , A23L27/18 , A23L27/60 , A23P20/10 , A61K8/06 , A61K8/66 , A61K8/922 , A61K9/0014 , A61K36/00 , A61K36/31 , A61K47/44 , A61Q1/02 , A61Q1/06 , A61Q1/08 , A61Q1/10 , A61Q5/00 , A61Q11/00 , A61Q13/00 , A61Q17/04 , A61Q19/00 , A61Q19/10 , C09D5/022 , Y02A40/818 , Y10S514/828 , Y10S514/845 , Y10S514/846 , Y10S514/847 , Y10S514/848 , Y10S514/865 , Y10S514/882 , Y10S514/887 , Y10S514/937 , A61K2300/00
摘要： The present invention provide novel emulsion formulations which comprise oil bodies. The invention also provides a method for preparing the emulsions and the use of the emulsions in products for topical application to the skin. The products are very mild to the skin and may be easily formulated into a wide variety of personal care and dermatological products.
摘要翻译： 本发明提供了包含油体的新型乳液制剂。 本发明还提供了一种制备乳液的方法以及在产品中使用乳剂以局部施用于皮肤。 产品对皮肤非常温和，可以很容易地配制成各种个人护理和皮肤病学产品。
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公开(公告)号：US06210742B1
公开(公告)日：2001-04-03
申请号：US09610855
申请日：2000-07-05
申请人： Harm M Deckers , Gijs van Rooijen , Joseph Boothe , Janis Goll , Soheil Mahmoud , Maurice M. Moloney
发明人： Harm M Deckers , Gijs van Rooijen , Joseph Boothe , Janis Goll , Soheil Mahmoud , Maurice M. Moloney
IPC分类号： A23L120
CPC分类号： A23G3/48 , A23D7/001 , A23D7/003 , A23G3/343 , A23G3/346 , A23G3/40 , A23G4/066 , A23G4/068 , A23G9/327 , A23G9/42 , A23G2200/08 , A23G2200/14 , A23K20/168 , A23K20/184 , A23K50/80 , A23L9/10 , A23L23/00 , A23L27/18 , A23L27/60 , A23P20/10 , A61K8/06 , A61K8/922 , A61K9/0014 , A61K9/107 , A61K36/00 , A61K36/185 , A61K36/23 , A61K36/28 , A61K36/286 , A61K36/31 , A61K36/42 , A61K36/47 , A61K36/48 , A61K36/889 , A61K36/899 , A61K47/44 , A61Q1/02 , A61Q1/06 , A61Q1/08 , A61Q1/10 , A61Q5/00 , A61Q11/00 , A61Q13/00 , A61Q17/04 , A61Q19/00 , A61Q19/10 , C09D5/022 , C11B1/10 , Y02A40/818 , Y10S426/805 , Y10S514/937 , A61K2300/00
摘要： The present invention provides novel emulsion formulations which comprise oil bodies. The invention also provides a method for preparing the emulsions and the use of the emulsions in various domestic and industrial compositions. The emulsions are especially suited for the preparation of food products, personal care products, pharmaceutical products and industrial products.
摘要翻译： 本发明提供了包含油体的新型乳液制剂。 本发明还提供了制备乳液的方法以及乳液在各种家用和工业组合物中的用途。 该乳液特别适用于制备食品，个人护理产品，药品和工业产品。
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公开(公告)号：US06146645A
公开(公告)日：2000-11-14
申请号：US84777
申请日：1998-05-27
申请人： Harm M Deckers , Gijs van Rooijen , Joseph Boothe , Janis Goll , Soheil Mahmoud , Maurice M. Moloney
发明人： Harm M Deckers , Gijs van Rooijen , Joseph Boothe , Janis Goll , Soheil Mahmoud , Maurice M. Moloney
IPC分类号： A23K1/16 , A23D7/00 , A23D7/02 , A23G3/00 , A23G3/34 , A23G3/40 , A23G3/48 , A23G4/00 , A23G4/06 , A23G9/32 , A23G9/42 , A23K1/165 , A23K1/18 , A23L1/00 , A23L1/035 , A23L1/187 , A23L1/20 , A23L1/225 , A23L1/24 , A23L1/39 , A23P1/08 , A61K8/00 , A61K8/06 , A61K8/18 , A61K8/64 , A61K8/73 , A61K8/92 , A61K8/96 , A61K8/97 , A61K9/00 , A61K9/107 , A61K36/00 , A61K36/185 , A61K36/23 , A61K36/28 , A61K36/286 , A61K36/31 , A61K36/42 , A61K36/47 , A61K36/48 , A61K36/889 , A61K36/899 , A61K38/27 , A61K45/00 , A61K47/44 , A61K49/00 , A61Q1/00 , A61Q1/02 , A61Q1/04 , A61Q1/06 , A61Q1/08 , A61Q1/10 , A61Q1/12 , A61Q5/00 , A61Q11/00 , A61Q13/00 , A61Q17/04 , A61Q19/00 , A61Q19/10 , B01F17/00 , C09D5/02 , C11B1/00 , C11B1/04 , C11B1/10 , C11B3/00 , C11B3/16 , C11B5/00 , C11C3/00 , D01F13/00 , A61K7/00 , A23D1/00 , A23K1/00
CPC分类号： A23G3/48 , A23D7/001 , A23D7/003 , A23G3/343 , A23G3/346 , A23G3/40 , A23G4/066 , A23G4/068 , A23G9/327 , A23G9/42 , A23K20/168 , A23K50/80 , A23L23/00 , A23L27/18 , A23L27/60 , A23L9/10 , A23P20/10 , A61K36/00 , A61K36/185 , A61K36/23 , A61K36/28 , A61K36/286 , A61K36/31 , A61K36/42 , A61K36/47 , A61K36/48 , A61K36/889 , A61K36/899 , A61K47/44 , A61K8/06 , A61K8/922 , A61K9/0014 , A61K9/107 , A61Q1/02 , A61Q1/06 , A61Q1/08 , A61Q1/10 , A61Q11/00 , A61Q13/00 , A61Q17/04 , A61Q19/00 , A61Q19/10 , A61Q5/00 , C09D5/022 , C11B1/10 , A23G2200/08 , A23G2200/14 , Y10S426/805 , Y10S514/937
摘要： The present invention provides novel emulsion formulations which comprise oil bodies. The invention also provides a method for preparing the emulsions and the use of the emulsions in various domestic and industrial compositions. The emulsions are especially suited for the preparation of food products, personal care products, pharmaceutical products and industrial products.
摘要翻译： 本发明提供了包含油体的新型乳液制剂。 本发明还提供了制备乳液的方法以及乳液在各种家用和工业组合物中的用途。 该乳液特别适用于制备食品，个人护理产品，药品和工业产品。
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公开(公告)号：US07547821B2
公开(公告)日：2009-06-16
申请号：US10869040
申请日：2004-06-17
CPC分类号： C07K14/62 , C12N15/8257
摘要： Commercial production of human insulin can be affected via transgenic expression in plant seeds. Thus, levels of insulin accumulation exceeding 0.1% of total cellular protein can be achieved recombinantly, through expression of the insulin with a single-chain antibody as a fusion partner. Production in seeds offers flexibility in storage and shipment of insulin as a raw material, and insulin retains its activity upon extraction from stored seed. Further, the amount of biomass subjected to extraction is limited, due to the relatively low water content of plant seeds.
摘要翻译： 人类胰岛素的商业生产可以通过植物种子中的转基因表达来影响。 因此，通过以单链抗体作为融合配偶体的胰岛素的表达，可以重组地实现超过总细胞蛋白质的0.1％的胰岛素积聚的水平。 种子生产提供了作为原料的胰岛素储存和运输的灵活性，胰岛素从储存的种子提取时保留其活性。 此外，由于植物种子的含水量相对较低，所以提取的生物质的量受到限制。
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