公开(公告)号：US06439263B2

公开(公告)日：2002-08-27

申请号：US09741993

申请日：2000-12-22

申请人： Helmut Schwegler ,  Ralph Ittlinger ,  Wolfgang Bueser ,  Martin Maier ,  Lorenz Drutu

发明人： Helmut Schwegler ,  Ralph Ittlinger ,  Wolfgang Bueser ,  Martin Maier ,  Lorenz Drutu

IPC分类号： F16K2110

CPC分类号： G05D16/12 ,  F02M69/54 ,  Y10T137/785 ,  Y10T137/7852 ,  Y10T137/7928

摘要： The pressure regulating valve (2) proposed here can be designed with the aid of the outflow throttle restriction (28) downstream of the valve seat (22) in such a way that the pressure regulating valve (2), as the fluid flow becomes greater, sets or adjusts a smaller pressure difference at the pressure regulating valve (2), as a result of which the line losses that can never be avoided can be compensated for. The pressure regulating valve is suitable in particular for a fuel supply system of a motor vehicle having an internal combustion engine.

摘要翻译： 这里提出的压力调节阀（2）可以借助于阀座（22）下游的流出节气门限制（28）来设计，使得压力调节阀（2）随着流体流量变大 在压力调节阀（2）上设定或调节较小的压力差，结果可以补偿永远不能避免的线路损耗。 压力调节阀特别适用于具有内燃机的机动车辆的燃料供给系统。

公开(公告)号：US06431149B1

公开(公告)日：2002-08-13

申请号：US09622875

申请日：2000-11-09

申请人： Helmut Schwegler ,  Martin Maier

发明人： Helmut Schwegler ,  Martin Maier

IPC分类号： F02M3704

CPC分类号： F02M69/465 ,  F02M55/04 ,  F02M61/166 ,  F02M2200/315 ,  F02M2200/9015

摘要： A fuel supply system of an internal combustion engine that has fuel injection is described. The fuel supply system has a fuel rail, from which injectors are supplied with fuel via valve seats. The damper element has an elastic tubular body arranged in the fuel rail. The tubular body sealingly separating an inner fuel chamber, through which fuel flows, from an outer fuel chamber, through which fuel flows and which is connected to the valve seats. Walls of the tubular body are made of an elastic material. The elastic tubular body is arranged upstream of a pressure regulator.

摘要翻译： 描述了具有燃料喷射的内燃机的燃料供给系统。 燃料供应系统具有燃料轨，通过阀座由喷油器供给燃料。 阻尼元件具有布置在燃料轨道中的弹性管状体。 管状体密封地分离内部燃料室，燃料从燃料流经外部燃料室，燃料通过该内部燃料室流动并与阀座连接。 管状体的壁由弹性材料制成。 弹性管体设置在压力调节器的上游。

公开(公告)号：US06513501B1

公开(公告)日：2003-02-04

申请号：US09787760

申请日：2001-05-11

申请人： Helmut Schwegler ,  Martin Maier

发明人： Helmut Schwegler ,  Martin Maier

IPC分类号： F02M4100

CPC分类号： F02M37/0041 ,  F02M37/0047 ,  F02M55/025 ,  F02M55/04 ,  F02M63/0225 ,  F02M69/465 ,  F02M2200/315 ,  F02M2200/40 ,  F16L55/0331 ,  F16L55/0332

摘要： The invention relates to a flat tubular damper for damping fluid pressure pulsations in fluid lines, in particular fuel pressure pulsations in fuel supply lines of motor vehicles, having at least one elongated chamber whose cross section is small in comparison to its longitudinal span and at least a part of whose chamber wall, being operationally connected with the fluid, can be elastically deformed by the fluid pressure pulsations. The invention provides that the cross section of the chamber changes continuously or discretely along its longitudinal span.

摘要翻译： 本发明涉及一种用于阻止流体管线中的流体压力脉动，特别是机动车辆的燃料供应管线中的燃料压力脉动的扁平管状阻尼器，其具有至少一个细长室，其横截面与其纵向跨度相比较小，并且至少 其室壁的一部分与流体可操作地连接，可以通过流体压力脉动而弹性变形。 本发明提供了室的横截面沿其纵向跨度连续或离散地改变。

公开(公告)号：US09999673B2

公开(公告)日：2018-06-19

申请号：US13979336

申请日：2012-01-11

申请人： Kallanthottathil G. Rajeev ,  Muthiah Manoharan ,  Muthusamy Jayaraman ,  Martin Maier ,  Jayaprakash K. Nair ,  David Butler

发明人： Kallanthottathil G. Rajeev ,  Muthiah Manoharan ,  Muthusamy Jayaraman ,  Martin Maier ,  Jayaprakash K. Nair ,  David Butler

IPC分类号： A61K47/18 ,  C07C235/06 ,  C07C271/16 ,  C07D207/12 ,  C07D307/20 ,  C07D207/14 ,  C07D307/12 ,  C08G65/329 ,  A61K47/48

CPC分类号： A61K47/18 ,  A61K47/6911 ,  C07C235/06 ,  C07C271/16 ,  C07D207/12 ,  C07D207/14 ,  C07D307/12 ,  C07D307/20 ,  C08G65/329 ,  C08L2203/02

摘要： The invention provides poly(ethylene glycol)-lipid conjugates for use in drug delivery.

公开(公告)号：US09810189B2

公开(公告)日：2017-11-07

申请号：US13609694

申请日：2012-09-11

申请人： Martin Maier ,  Martin Goehner ,  Markus Feigl ,  Helmut Schneider ,  Nikolaus Hautmann ,  Dietmar Uhlenbrock ,  Holger Uhrig

发明人： Martin Maier ,  Martin Goehner ,  Markus Feigl ,  Helmut Schneider ,  Nikolaus Hautmann ,  Dietmar Uhlenbrock ,  Holger Uhrig

IPC分类号： F02M69/50 ,  F02M55/02

CPC分类号： F02M69/50 ,  F02M55/025 ,  F02M2200/25 ,  F02M2200/26 ,  F02M2200/315 ,  F02M2200/857

摘要： A fuel distributor, which is used, in particular, for fuel injection systems of mixture-compressing, internal combustion engines having externally supplied ignition, includes a distributor pipe, a first holder and at least one second holder. The distributor pipe has a longitudinal axis. In this connection, the first holder and the second holder are situated at the distributor pipe so as to be axially set apart from one another with respect to the longitudinal axis. The distributor pipe is designed to allow axial length compensation. It is also possible for at least one holder to be designed to allow axial length compensation.

公开(公告)号：US09325165B2

公开(公告)日：2016-04-26

申请号：US14344985

申请日：2011-09-16

申请人： Klaus Behringer ,  Martin Maier ,  Klaus Pfitzner ,  Bernhard Rösch

发明人： Klaus Behringer ,  Martin Maier ,  Klaus Pfitzner ,  Bernhard Rösch

IPC分类号： H02H5/04 ,  H02P29/00 ,  H02P29/02 ,  G01K7/01 ,  G01R19/165 ,  H02H7/085 ,  H02H3/08

CPC分类号： H02H5/047 ,  G01K7/01 ,  G01R19/16571 ,  H02H3/085 ,  H02H7/0852 ,  H02P29/027 ,  H02P29/68

摘要： A device is disclosed for protecting a consumer, with a first current path having two lines, and a monitoring arrangement for detecting an imminent overload of the electrical consumer. In order to enable the detection of an imminent overload of a consumer, it is proposed that the monitoring arrangement includes a first temperature measuring unit, an evaluation unit and a first measuring element, which establishes an electrically conductive connection between the two lines of the first current path. The first temperature measuring unit is electrically isolated from the first measuring element and includes a first and a second temperature sensor. The first and second temperature sensor of the first temperature measuring unit are configured to simultaneously record a temperature of the first measuring element and the evaluation unit is configured to detect an imminent overload of the consumer based upon the recorded temperatures of the first temperature measuring unit.

摘要翻译： 公开了一种用于保护消费者的装置，其中具有两条线路的第一电流路径以及用于检测电消费者即将发生的过载的监视装置。 为了能够检测到消费者即将发生的过载，建议监视装置包括第一温度测量单元，评估单元和第一测量元件，该第一测量单元，第一测量单元在第一和第二测量单元的两条线之间建立导电连接 当前路径。 第一温度测量单元与第一测量元件电隔离并且包括第一和第二温度传感器。 第一温度测量单元的第一温度传感器和第二温度传感器被配置为同时记录第一测量元件的温度，并且评估单元被配置为基于第一温度测量单元的记录温度来检测消费者即将发生的过载。

公开(公告)号：US08999351B2

公开(公告)日：2015-04-07

申请号：US13128287

申请日：2009-11-10

申请人： Muthiah Manoharan ,  Kallanthottathil G. Rajeev ,  Muthusamy Jayaraman ,  David Butler ,  Jayaprakash K. Narayanannair ,  Martin Maier ,  Laxman Eltepu

发明人： Muthiah Manoharan ,  Kallanthottathil G. Rajeev ,  Muthusamy Jayaraman ,  David Butler ,  Jayaprakash K. Narayanannair ,  Martin Maier ,  Laxman Eltepu

IPC分类号： A61K39/12 ,  A61K9/127 ,  A61K39/00 ,  C12N15/11

CPC分类号： A61K47/44 ,  A61K9/1272 ,  A61K31/7088 ,  A61K31/713 ,  A61K39/00 ,  A61K39/39 ,  A61K47/10 ,  A61K47/18 ,  A61K47/20 ,  A61K47/28 ,  A61K2039/55555 ,  A61K2039/55561 ,  C07C229/08 ,  C07C229/30 ,  C07C237/16 ,  C07C251/38 ,  C07C251/78 ,  C07C271/12 ,  C07C271/20 ,  C07C323/25 ,  C07D203/10 ,  C07D317/28 ,  C07D317/44 ,  C07D317/46 ,  C07D317/72 ,  C07D319/06 ,  C07D405/12 ,  C07D491/056 ,  C07D491/113 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/3515 ,  C12N2320/32 ,  Y02A50/464

摘要： The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structure (I) wherein R1 and R2 are each independently for each occurrence optionally substituted C10-C30 alkyl, optionally substituted C10-C30 alkenyl, optionally substituted C10-C30 alkynyl, optionally substituted C10-C30 acyl, or -linker-ligand; R3 is H, optionally substituted C1-C10 alkyl, optionally substituted C2-C10 alkenyl, optionally substituted C2-C10 alkynyl, alkylhetrocycle, alkylphosphate, alkylphosphorothioate, alkylphosphorodithioate, alkylphosphonates, alkylamines, hydroxyalkyls, ω-aminoalkyls, ω-(substituted)aminoalkyls, ω-phosphoalkyls, ω-thiophosphoalkyls, optionally substituted polyethylene glycol (PEG, mw 100-40K), optionally substituted mPEG (mw 120-40K), heteroaryl, heterocycle, or linker-ligand; E is O, S, N(Q), C(O), N(Q)C(O), C(O)N(Q), (Q)N(CO)O, O(CO)N(Q), S(O), NS(O)2N(Q), S(O)2, N(Q)S(O)2, SS, O═N, aryl, heteroaryl, cyclic or heterocycle; and, Q is H, alkyl, ω-aminoalkyl, ω-(substituted)aminoalky, ω-phosphoalkyl or ω-thiophosphoalkyl.

摘要翻译： 本发明提供有利地用于脂质颗粒以用于体内递送治疗剂至细胞的脂质。 特别地，本发明提供具有以下结构（I）的脂质，其中R1和R2各自独立地为任何取代的C 10 -C 30烷基，任选取代的C 10 -C 30烯基，任选取代的C 10 -C 30炔基，任选取代的C 10 -C 30 酰基或 - 连接子 - 配体; R 3为H，任选取代的C 1 -C 10烷基，任选取代的C 2 -C 10烯基，任选取代的C 2 -C 10炔基，烷基硫代烷基磷酸酯，烷基硫代磷酸酯，烷基二硫代磷酸酯，烷基膦酸酯，烷基胺，羟基烷基，ω-氨基烷基，ω-（取代的）氨基烷基， ω-磷酸烷基酯，ω-硫代磷酰基烷基酯，任选取代的聚乙二醇（PEG，mw 100-40K），任选取代的mPEG（mw 120-40K），杂芳基，杂环或连接基 - 配体; E是O，S，N（Q），C（O），N（Q）C（O），C（O）N（Q），（Q） ），S（O），NS（O）2N（Q），S（O）2，N（Q）S（O）2，SS，O = N，芳基，杂芳基，环状或杂环; Q为H，烷基，ω-氨基烷基，ω-（取代）氨基烷基，ω-磷酸烷基或ω-硫代磷酰基烷基。

公开(公告)号：US20140375301A1

公开(公告)日：2014-12-25

申请号：US14344985

申请日：2011-09-16

申请人： Klaus Behringer ,  Martin Maier ,  Klaus Pfitzner ,  Bernhard Rösch

发明人： Klaus Behringer ,  Martin Maier ,  Klaus Pfitzner ,  Bernhard Rösch

IPC分类号： H02H5/04 ,  G01K7/01 ,  G01R19/165

CPC分类号： H02H5/047 ,  G01K7/01 ,  G01R19/16571 ,  H02H3/085 ,  H02H7/0852 ,  H02P29/027 ,  H02P29/68

摘要： A device is disclosed for protecting a consumer, with a first current path having two lines, and a monitoring arrangement for detecting an imminent overload of the electrical consumer. In order to enable the detection of an imminent overload of a consumer, it is proposed that the monitoring arrangement includes a first temperature measuring unit, an evaluation unit and a first measuring element, which establishes an electrically conductive connection between the two lines of the first current path. The first temperature measuring unit is electrically isolated from the first measuring element and includes a first and a second temperature sensor. The first and second temperature sensor of the first temperature measuring unit are configured to simultaneously record a temperature of the first measuring element and the evaluation unit is configured to detect an imminent overload of the consumer based upon the recorded temperatures of the first temperature measuring unit.

摘要翻译： 公开了一种用于保护消费者的装置，其中具有两条线路的第一电流路径以及用于检测电消费者即将发生的过载的监视装置。 为了能够检测到消费者即将发生的过载，建议监视装置包括第一温度测量单元，评估单元和第一测量元件，该第一测量单元，第一测量单元在第一和第二测量单元的两条线之间建立导电连接 当前路径。 第一温度测量单元与第一测量元件电隔离并且包括第一和第二温度传感器。 第一温度测量单元的第一温度传感器和第二温度传感器被配置为同时记录第一测量元件的温度，并且评估单元被配置为基于第一温度测量单元的记录温度来检测消费者即将发生的过载。

公开(公告)号：US20130017223A1

公开(公告)日：2013-01-17

申请号：US13516335

申请日：2010-12-17

申请人： Michael J Hope ,  Thomas D. Madden ,  Pieter R. Cullis ,  Martin Maier ,  Muthusamy Jayaraman ,  Kallanthottathil G. Rajeev ,  Akin Akinc ,  Muthiah Manoharan

发明人： Michael J Hope ,  Thomas D. Madden ,  Pieter R. Cullis ,  Martin Maier ,  Muthusamy Jayaraman ,  Kallanthottathil G. Rajeev ,  Akin Akinc ,  Muthiah Manoharan

IPC分类号： A61K47/24 ,  A61K47/28 ,  A61P37/04 ,  A61K31/713 ,  C12N5/071 ,  C12N15/85 ,  A61K31/7088 ,  A61K31/7105

CPC分类号： A61K47/543 ,  A61K9/1272 ,  A61K47/6911 ,  C12N15/88

摘要： A lipid particle can include a plurality of cationic lipids, such as a first cationic lipid and a second cationic lipid. The first cationic lipid can be selected on the basis of a first property and the second cationic can be selected on the basis of a second property. The first and second properties are complementary. The attributes of the lipid particle can reflect the selected properties of the cationic lipids, and the complementary nature of those properties.

摘要翻译： 脂质颗粒可以包括多个阳离子脂质，例如第一阳离子脂质和第二阳离子脂质。 可以基于第一性质选择第一阳离子脂质，并且可以基于第二性质选择第二阳离子脂质。 第一和第二属性是互补的。 脂质颗粒的属性可以反映阳离子脂质的选择性质，以及这些性质的互补性质。

公开(公告)号：US20120325939A1

公开(公告)日：2012-12-27

申请号：US13517447

申请日：2010-12-01

申请人： Juergen Graner ,  Martin Maier ,  Juergen Lander ,  Jochen Rager

发明人： Juergen Graner ,  Martin Maier ,  Juergen Lander ,  Jochen Rager

IPC分类号： F02M51/06 ,  B21D51/16 ,  B21K1/20 ,  F02M61/16

CPC分类号： F02M51/0682 ,  B22F3/225 ,  B22F5/10 ,  B22F7/06 ,  B29C45/14 ,  F02M61/166 ,  F02M61/168 ,  Y10T29/49412

摘要： An injector having a valve opening, a cylindrical pipe, a valve opening, a valve needle situated inside the pipe in the radial direction and guided to allow axial displacement; a solenoid coil situated outside the pipe in the radial direction; a solenoid core disposed inside the pipe in the radial direction; and a magnetic armature situated inside the pipe, opposite the solenoid core in the radial direction, the magnetic armature being disposed on the valve needle. The pipe is a magnetic first material in a first pipe region and a third pipe region, the first region facing the valve opening in the axial direction, and the third pipe region facing away from the valve opening in the axial direction. The pipe is a non-magnetic second material in a second pipe region, the second pipe region being between the first pipe region and the third pipe region in the axial direction.

摘要翻译： 一种具有阀开口的喷射器，一个圆柱形管，一个阀开口，一个阀芯，位于该管内径向并被引导以允许轴向位移; 位于管径向外的螺线管线圈; 在径向上配置在管内的电磁铁芯; 以及位于所述管内的磁性衔铁，所述磁性衔铁位于所述螺线管芯的径向方向上，所述磁性衔铁设置在所述阀针上。 管是在第一管区域和第三管区域中的磁性第一材料，第一区域在轴向方向上面对阀开口，第三管区域在轴向方向上背离阀开口。 管是第二管区中的非磁性第二材料，第二管区在轴向上位于第一管区和第三管区之间。