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    Oxidized phospholipid degrading enzyme and gene thereof
    4.
    发明授权
    Oxidized phospholipid degrading enzyme and gene thereof 失效
    氧化磷脂降解酶及其基因

    公开(公告)号：US5880272A

    公开(公告)日：1999-03-09

    申请号：US961716

    申请日：1997-10-31

    申请人： Hideki Adachi ,  Masafumi Tsujimoto ,  Keizo Inoue ,  Hiroyuki Arai

    发明人： Hideki Adachi ,  Masafumi Tsujimoto ,  Keizo Inoue ,  Hiroyuki Arai

    IPC分类号： C12N9/16 ,  C12N9/18 ,  C12N15/09 ,  C12N15/53 ,  C12N9/20 ,  C12N15/55

    CPC分类号： C12N9/18

    摘要： An oxidized phospholipid degrading enzyme is provided, which plays an important role in the oxygen stress preventive mechanism in organisms. The enzyme hydrolyzes a 1-acyl-2-.omega.-carboxyfatty acid acyl-3-phosphatidylcholine as a substrate at the 2-ester bond thereof to form 1-acyl-2-lyso-3-phosphatidylcholine. The activity of the enzyme is slightly enhanced by 4 mM calcium chloride. The molecular mass of the enzyme is 95.+-.5 kDa (by gel filtration). The enzyme is composed of three subunits whose molecular masses have been found to be 29 kDa, 30 kDa and 45 kDa, respectively, by SDS-polyacrylamide electrophoresis. A gene coding the enzyme is also provided. This gene is important for the synthesis of the enzyme by genetic engineering.

    摘要翻译： 提供氧化磷脂降解酶，在生物体的氧应激预防机制中起重要作用。 该酶水解1-酰基-2-巯基脂肪酸酰基-3-磷脂酰胆碱作为其2-酯键的底物，形成1-酰基-2-溶血-3-磷脂酰胆碱。 该酶的活性由4mM氯化钙稍微增强。 酶的分子量为95 +/- 5kDa（通过凝胶过滤）。 该酶由三个亚基组成，其分子量分别通过SDS-聚丙烯酰胺电泳发现为29kDa，30kDa和45kDa。 还提供了编码酶的基因。 该基因对通过遗传工程合成酶非常重要。

    Novel lipase
    6.
    发明申请
    Novel lipase 审中-公开
    新型脂肪酶

    公开(公告)号：US20070202520A1

    公开(公告)日：2007-08-30

    申请号：US11652080

    申请日：2007-01-11

    申请人： Junken Aoki ,  Hiroyuki Arai ,  Keizo Inoue

    发明人： Junken Aoki ,  Hiroyuki Arai ,  Keizo Inoue

    IPC分类号： C12Q1/68 ,  C12Q1/34 ,  C07H21/04 ,  C12P21/06 ,  C12N9/20

    CPC分类号： C12N9/18 ,  A61K38/00 ,  A61K2039/505 ,  C07K16/40 ,  C12N9/16 ,  C12Q1/44 ,  C12Y301/01032 ,  G01N2333/918 ,  G01N2500/00

    摘要： A novel phospholipase A1 (PLA1) having a substrate specificity to phosphatidic acid (PA); a peptide or a polypeptide originating in the above novel PLA1; a polynucleotide encoding the peptide or polypeptide originating in the novel PLA1; a process for producing the peptide or polypeptide originating in the novel PLA1; an antibody against the peptide or polypeptide originating in the novel PLA1; a method of identifying an inhibitor, an antagonist or an activator of the novel PLA1 by using the same; compounds identified by the above method; and medicinal compositions and diagnostic methods by using the same.

    摘要翻译： 对磷脂酸（PA）具有底物特异性的新型磷脂酶A 1 N（PLA 1 N 2） 源自上述新型PLA 1的肽或多肽; 编码源自新PLA 1的肽或多肽的多核苷酸; 用于产生源自新PLA 1的肽或多肽的方法; 针对源自新PLA 1的肽或多肽的抗体; 通过使用该方法鉴定新型PLA 1的抑制剂，拮抗剂或活化剂的方法; 通过上述方法鉴定的化合物; 以及使用该药物组合物和诊断方法。

    Polycyclic ester containing cyano group and lactone skeleton
    7.
    发明授权
    Polycyclic ester containing cyano group and lactone skeleton 有权

    公开(公告)号：US07834114B2

    公开(公告)日：2010-11-16

    申请号：US12628874

    申请日：2009-12-01

    申请人： Keizo Inoue ,  Takahiro Iwahama ,  Masamichi Nishimura ,  Kiyoharu Tsutsumi

    发明人： Keizo Inoue ,  Takahiro Iwahama ,  Masamichi Nishimura ,  Kiyoharu Tsutsumi

    IPC分类号： C08F24/00 ,  C08F34/02

    CPC分类号： C07D307/93 ,  C08F220/36

    摘要： Disclosed is a polycyclic ester containing a cyano group and a lactone skeleton, represented by following Formula (1): wherein Ra represents, for example, a hydrogen atom or an alkyl group having one to six carbon atoms which may have a halogen atom; R1s each represent, for example, a halogen atom or an alkyl or haloalkyl group having one to six carbon atoms; “m” is the number of R1s; “n” is the number of cyano groups; and CH2═C(Ra)COO— group may have either of an endo conformation and an exo conformation. Accordingly, there is provided a novel polycyclic ester containing a cyano group and a lactone skeleton which is useful typically as a monomeric component for highly functional polymers. A polymer, for example, derived from this compound is highly soluble in an organic solvent while remaining stable typically to chemicals and exhibits improved hydrolyzability and/or improved solubility in water after hydrolysis.

    Process for producing vinyl ether compounds
    8.
    发明授权
    Process for producing vinyl ether compounds 失效
    制备乙烯基醚化合物的方法

    公开(公告)号：US07074970B2

    公开(公告)日：2006-07-11

    申请号：US10231115

    申请日：2002-08-30

    申请人： Yasutaka Ishii ,  Tatsuya Nakano ,  Keizo Inoue

    发明人： Yasutaka Ishii ,  Tatsuya Nakano ,  Keizo Inoue

    IPC分类号： C07C43/00

    CPC分类号： C07D313/10 ,  C07C41/16 ,  C07C43/162 ,  C07C49/753 ,  C07C69/757 ,  C07C2601/14 ,  C07C2603/74 ,  C07C2603/86 ,  C07D307/33 ,  C07D307/93 ,  Y02P20/55 ,  C07C43/16 ,  C07C43/168 ,  C07C43/178 ,  C07C43/188 ,  C07C43/215

    摘要： A process produces vinyl ether compounds and includes allowing a vinyl ester compound represented by following Formula (1): wherein R1, R2, R3 and R4 are the same or different and are each a hydrogen atom or an organic group, to react with a hydroxy compound represented by following Formula (2): R5OH  (2) wherein R5 is an organic group, in the presence of at least one transition element compound to thereby yield a vinyl ether compound represented by following Formula (3): wherein R2, R3, R4 and R5 have the same meanings as defined above. Such transition element compounds include iridium compounds and other compounds containing Group VIII elements.

    摘要翻译： 一种方法制备乙烯基醚化合物，包括使下式（1）表示的乙烯基酯化合物：其中R 1，R 2，R 3， >和R 4相同或不同，并且各自为氢原子或有机基团，与下式（2）表示的羟基化合物反应：<？在线式描述= “在线公式”end =“lead”？> 5 OH（2）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中R 在至少一种过渡元素化合物的存在下，有机基团是有机基团，从而得到下式（3）表示的乙烯基醚化合物：其中R 2，R R 4，R 4和R 5具有与上述相同的含义。 这种过渡元素化合物包括铱化合物和含有VIII族元素的其它化合物。