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    Protein having antithrombotic activity and method for producing the same
    2.
    发明授权
    Protein having antithrombotic activity and method for producing the same 失效
    具有抗血栓形成活性的蛋白质及其制造方法

    公开(公告)号：US06710031B2

    公开(公告)日：2004-03-23

    申请号：US09969763

    申请日：2001-10-04

    申请人： Naoyuki Fukuchi ,  Morikazu Kito ,  Takashi Kayahara ,  Fumie Futaki ,  Kohki Ishikawa ,  Eiichiro Suzuki ,  Keiko Gondoh ,  Nobuhisa Shimba ,  Naoyuki Yamada

    发明人： Naoyuki Fukuchi ,  Morikazu Kito ,  Takashi Kayahara ,  Fumie Futaki ,  Kohki Ishikawa ,  Eiichiro Suzuki ,  Keiko Gondoh ,  Nobuhisa Shimba ,  Naoyuki Yamada

    IPC分类号： A61K3846

    CPC分类号： C07K14/46 ,  C07K14/745

    摘要： A method for producing a protein having an antithrombotic activity, which comprises replacing, in a protein that has an amino acid sequence having a homology of not less than 30% to the amino acid sequence of SEQ ID NO: 1 and forms a higher order structure composed of a first &bgr; strand (&bgr;1), a first &agr; helix (&agr;1), a second &agr; helix (&agr;2), a second &bgr; strand (&bgr;2), a loop, a third &bgr; strand (&bgr;3), a fourth &bgr; strand (&bgr;4) and a fifth &bgr; strand (&bgr;5) in this order from the amino terminus, at least one amino acid residue in a region from &agr;2 to &bgr;2 and/or a region from &bgr;3 to &bgr;4 so that electric charge of the amino acid residue is changed towards positive direction.

    摘要翻译： 一种具有抗血栓形成活性的蛋白质的制造方法，其特征在于，具有与SEQ ID NO：1的氨基酸序列具有不小于30％的同源性的氨基酸序列的蛋白质，并形成高级结构 由第一β链（β1），第一α螺旋（alpha1），第二α螺旋（α2），第二β链（β2），环，第三β链（β3），第四条β链 β4）和第五个β链（β5），从氨基末端起始，α2至β2区域和/或β3至β4区域中的至少一个氨基酸残基，使得氨基酸残基的电荷为 转向正向。

    Seasoning material
    4.
    发明授权
    Seasoning material 失效
    调味料

    公开(公告)号：US5932267A

    公开(公告)日：1999-08-03

    申请号：US904101

    申请日：1997-07-31

    申请人： Keigo Shima ,  Tsutomu Harada ,  Eiichiro Suzuki ,  Yutaka Honda

    发明人： Keigo Shima ,  Tsutomu Harada ,  Eiichiro Suzuki ,  Yutaka Honda

    IPC分类号： A23L27/00 ,  A23L27/10 ,  A23L27/20 ,  A23L27/21 ,  A23L27/22 ,  C07C229/16 ,  C07C279/14 ,  C07D233/88 ,  A23L1/22

    CPC分类号： C07D233/88 ,  A23L27/2054 ,  A23L27/21 ,  A23L27/82 ,  C07C279/14

    摘要： Compounds of the formula (1) ##STR1## wherein X and Y are each N or NH, Z is O or OH, (1) when X=N and Y=NH, Z=O, and *1 and *3 are double bonds, (2) when X=NH and Y=N, Z=O, and *2 and *3 are double bonds, (3) when X=N and Y=N, Z=OH, and *2 and *4 are double bonds, and R is a side chain derived from an amino acid; for example, the amino acid is glycine with R=H, alanine with R=CH.sub.3, glutamic acid with R=CH.sub.2 CH.sub.2 COOH, lysine with R=CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 NH.sub.2, or leucine with R=CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3, and/or an analogues thereof are useful for imparting a "thick, sour" taste to foods.

    摘要翻译： 式（1）的化合物其中X和Y各自为N或NH，Z为O或OH，（1）当X = N和Y = NH时，Z = O和* 1和* 3为双键， 2）当X = NH和Y = N时，Z = O，* 2和* 3是双键，（3）当X = N和Y = N时，Z = OH，* 2和* 4是双键 ，R为源自氨基酸的侧链; 例如，氨基酸是具有R = H的甘氨酸，具有R = CH 3的丙氨酸，具有R = CH 2 CH 2 COOH的谷氨酸，具有R = CH 2 CH 2 CH 2 CH 2 NH 2的赖氨酸或具有R = CH 2 CH 2 CH 2 CH 3的亮氨酸，和/或其类似物可用于赋予 “厚，酸”味道到食物。

    Protein structure analysis method, protein structure analyzing instrument, program and recording medium
    7.
    发明申请
    Protein structure analysis method, protein structure analyzing instrument, program and recording medium 审中-公开
    蛋白质结构分析方法，蛋白质结构分析仪器，程序和记录介质

    公开(公告)号：US20090319234A1

    公开(公告)日：2009-12-24

    申请号：US10973096

    申请日：2004-10-26

    申请人： Naoyuki Yamada ,  Eiichiro Suzuki ,  Kazuo Hirayama ,  Hideaki Umeyama

    发明人： Naoyuki Yamada ,  Eiichiro Suzuki ,  Kazuo Hirayama ,  Hideaki Umeyama

    IPC分类号： G06F17/50

    CPC分类号： G01N33/6848 ,  C07K1/00 ,  G01N33/68 ,  G01N33/6851

    摘要： This invention fragments ions ionized by an electro-spray ionization method or the like for a target protein whose three-dimensional structure is to be predicted, to fragment ions by a hexapole CID method or the like, and measures a fragmentation spectrum. The present invention determines fragment ion assignment information on an amino acid sequence of the target protein based on the measured fragmentation spectrum. The present invention specifies a region of the amino acid sequence of the target protein in which region the ions are dissociated to the fragment ions according to the determined fragment ion assignment information, and determines easily cleavable domain information on the amino acid sequence of the target protein according to the specified region. The present invention predicts the three-dimensional structure of the target protein. The present invention outputs predicted three-dimensional structure prediction data and the determined easily cleavable domain information while making them correspond to each other.

    摘要翻译： 本发明通过电喷雾离子化法等离子化对于要预测其三维结构的靶蛋白进行离子化离子化，通过六极CID法等分离离子，测定碎裂光谱。 本发明基于测定的断裂谱，确定靶蛋白的氨基酸序列的片段离子分配信息。 本发明根据确定的片段离子分配信息指定靶蛋白的氨基酸序列的区域，其中离子被离解为片段离子，并且确定易于切割的关于靶蛋白的氨基酸序列的结构域信息 根据指定区域。 本发明预测了靶蛋白的三维结构。 本发明输出预测的三维结构预测数据和确定的容易切割的域信息，同时使它们彼此对应。