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    Hetero compound
    1.
    发明授权
    Hetero compound 有权
    杂环化合物

    公开(公告)号：US07951825B2

    公开(公告)日：2011-05-31

    申请号：US12696327

    申请日：2010-01-29

    申请人： Hironori Harada ,  Kazuyuki Hattori ,  Kazuya Fujita ,  Masataka Morita ,  Sunao Imada ,  Yoshito Abe ,  Hiromichi Itani ,  Tatsuaki Morokata ,  Hideo Tsutsumi

    发明人： Hironori Harada ,  Kazuyuki Hattori ,  Kazuya Fujita ,  Masataka Morita ,  Sunao Imada ,  Yoshito Abe ,  Hiromichi Itani ,  Tatsuaki Morokata ,  Hideo Tsutsumi

    IPC分类号： C07D413/02 ,  C07D413/14 ,  C07D401/02 ,  C07D401/14 ,  A61K31/443

    CPC分类号： C07D413/04 ,  C07D417/04 ,  C07D471/04

    摘要： To provide a useful compound as an active ingredient for a preventing and/or treating agent for rejection in the transplantation of an organ, bone marrow, or a tissue, an autoimmune disease, or the like, which has an excellent S1P1 agonist activity.Since the compound of the invention has an S1P1 agonist activity, it is useful as an active ingredient for a treating or preventing agent for a disease caused by unfavorable lymphocytic infiltration, for example, an autoimmune disease such as graft rejection in the transplantation of an organ, bone marrow, or a tissue, a graft-versus-host disease, rheumatic arthritis, multiple sclerosis, systemic lupus erythematosus, a nephrotic syndrome, encephalomeningitis, myasthenia gravis, pancreatitis, hepatitis, nephritis, diabetes, pulmonary disorder, asthma, atopic dermatitis, inflammatory bowel disease, atherosclerosis, ischemia-reperfusion injury, or an inflammatory disease, and further, a disease caused by the abnormal growth or accumulation of cells such as cancer and leukemia.

    摘要翻译： 为了提供具有优异的S1P1激动剂活性的器官，骨髓或组织，自身免疫疾病等的移植中的预防和/或治疗剂的有效成分的有用化合物。 由于本发明的化合物具有S1P1激动剂活性，因此可用作治疗或预防由不利淋巴细胞浸润引起的疾病的活性成分，例如自体免疫疾病例如器官移植中的移植排斥反应 骨髓或组织，移植物抗宿主病，风湿性关节炎，多发性硬化症，系统性红斑狼疮，肾病综合征，脑炎，重症肌无力，胰腺炎，肝炎，肾炎，糖尿病，肺病，哮喘，特应性皮炎 炎症性肠病，动脉粥样硬化，缺血再灌注损伤或炎性疾病，以及由细胞如癌症和白血病的异常生长或积累引起的疾病。

    Hetero compound
    2.
    发明授权
    Hetero compound 有权
    杂环化合物

    公开(公告)号：US07678820B2

    公开(公告)日：2010-03-16

    申请号：US12244102

    申请日：2008-10-02

    申请人： Hironori Harada ,  Kazuyuki Hattori ,  Kazuya Fujita ,  Masataka Morita ,  Sunao Imada ,  Yoshito Abe ,  Hiromichi Itani ,  Tatsuaki Morokata ,  Hideo Tsutsumi

    发明人： Hironori Harada ,  Kazuyuki Hattori ,  Kazuya Fujita ,  Masataka Morita ,  Sunao Imada ,  Yoshito Abe ,  Hiromichi Itani ,  Tatsuaki Morokata ,  Hideo Tsutsumi

    IPC分类号： A61K31/4245 ,  C07D271/06

    CPC分类号： C07D413/04 ,  C07D417/04 ,  C07D471/04

    摘要： To provide a useful compound as an active ingredient for a preventing and/or treating agent for rejection in the transplantation of an organ, bone marrow, or a tissue, an autoimmune disease, or the like, which has an excellent S1P1 agonist activity. Since the compound of the invention has an S1P1 agonist activity, it is useful as an active ingredient for a treating or preventing agent for a disease caused by unfavorable lymphocytic infiltration, for example, an autoimmune disease such as graft rejection in the transplantation of an organ, bone marrow, or a tissue, a graft-versus-host disease, rheumatic arthritis, multiple sclerosis, systemic lupus erythematosus, a nephrotic syndrome, encephalomeningitis, myasthenia gravis, pancreatitis, hepatitis, nephritis, diabetes, pulmonary disorder, asthma, atopic dermatitis, inflammatory bowel disease, atherosclerosis, ischemia-reperfusion injury, or an inflammatory disease, and further, a disease caused by the abnormal growth or accumulation of cells such as cancer and leukemia.

    摘要翻译： 为了提供具有优异的S1P1激动剂活性的器官，骨髓或组织，自身免疫疾病等的移植中的预防和/或治疗剂的有效成分的有用化合物。 由于本发明的化合物具有S1P1激动剂活性，因此可用作治疗或预防由不利淋巴细胞浸润引起的疾病的活性成分，例如自体免疫疾病例如器官移植中的移植排斥反应 骨髓或组织，移植物抗宿主病，风湿性关节炎，多发性硬化症，系统性红斑狼疮，肾病综合征，脑炎，重症肌无力，胰腺炎，肝炎，肾炎，糖尿病，肺病，哮喘，特应性皮炎 炎症性肠病，动脉粥样硬化，缺血再灌注损伤或炎性疾病，以及由细胞如癌症和白血病的异常生长或积累引起的疾病。

    HETERO COMPOUND
    3.
    发明申请
    HETERO COMPOUND 有权
    HETERO化合物

    公开(公告)号：US20100168159A1

    公开(公告)日：2010-07-01

    申请号：US12696327

    申请日：2010-01-29

    申请人： Hironori Harada ,  Kazuyuki Hattori ,  Kazuya Fujita ,  Masataka Morita ,  Sunao Imada ,  Yoshito Abe ,  Hiromichi Itani ,  Tatsuaki Morokata ,  Hideo Tsutsumi

    发明人： Hironori Harada ,  Kazuyuki Hattori ,  Kazuya Fujita ,  Masataka Morita ,  Sunao Imada ,  Yoshito Abe ,  Hiromichi Itani ,  Tatsuaki Morokata ,  Hideo Tsutsumi

    IPC分类号： A61K31/4439 ,  A61K31/4709 ,  C07D471/04 ,  C07D413/14 ,  A61P35/02 ,  A61P37/06 ,  A61P29/00 ,  A61P9/10 ,  A61P35/00

    CPC分类号： C07D413/04 ,  C07D417/04 ,  C07D471/04

    摘要： [Problems]To provide a useful compound as an active ingredient for a preventing and/or treating agent for rejection in the transplantation of an organ, bone marrow, or a tissue, an autoimmune disease, or the like, which has an excellent S1P1 agonist activity.[Means for solving]Since the compound of the invention has an S1P1 agonist activity, it is useful as an active ingredient for a treating or preventing agent for a disease caused by unfavorable lymphocytic infiltration, for example, an autoimmune disease such as graft rejection in the transplantation of an organ, bone marrow, or a tissue, a graft-versus-host disease, rheumatic arthritis, multiple sclerosis, systemic lupus erythematosus, a nephrotic syndrome, encephalomeningitis, myasthenia gravis, pancreatitis, hepatitis, nephritis, diabetes, pulmonary disorder, asthma, atopic dermatitis, inflammatory bowel disease, atherosclerosis, ischemia-reperfusion injury, or an inflammatory disease, and further, a disease caused by the abnormal growth or accumulation of cells such as cancer and leukemia.

    摘要翻译： [问题]提供一种有用的化合物作为活性成分，用于预防和/或治疗移植器官，骨髓或组织，自身免疫疾病等中的排斥反应，其具有优异的S1P1激动剂 活动。 [解决方法]由于本发明的化合物具有S1P1激动剂活性，因此可用作由不利的淋巴细胞浸润引起的疾病的治疗或预防剂的活性成分，例如自身免疫性疾病如移植排斥反应 器官移植，骨髓或组织，移植物抗宿主病，风湿性关节炎，多发性硬化，系统性红斑狼疮，肾病综合征，脑炎，重症肌无力，胰腺炎，肝炎，肾炎，糖尿病，肺功能障碍 哮喘，特应性皮炎，炎症性肠病，动脉粥样硬化，局部缺血再灌注损伤，炎症性疾病等疾病，以及癌症，白血病等细胞异常生长或积累引起的疾病。

    2H-chromene compound and derivative thereof
    5.
    发明授权
    2H-chromene compound and derivative thereof 有权
    2H-色烯化合物及其衍生物

    公开(公告)号：US08193378B2

    公开(公告)日：2012-06-05

    申请号：US13131343

    申请日：2009-12-04

    申请人： Hironori Harada ,  Kazuyuki Hattori ,  Kazuya Fujita ,  Sunao Imada ,  Tatsuaki Morokata

    发明人： Hironori Harada ,  Kazuyuki Hattori ,  Kazuya Fujita ,  Sunao Imada ,  Tatsuaki Morokata

    IPC分类号： C07D311/00

    CPC分类号： C07D403/12 ,  C07D405/06 ,  C07D405/14 ,  C07D409/06 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

    摘要： Provided is a compound which has an excellent S1P1 agonist action, and is useful particularly as an active ingredient for an agent for preventing and/or treating a disease induced by undesirable lymphocyte infiltration or a disease induced by abnormal proliferation or accumulation of cells. According to the present invention, a 2H-chromene compound or a derivative thereof which has an excellent S1P1 agonist action, and is useful particularly as an active ingredient of an agent for preventing and/or treating a disease induced by undesirable lymphocyte infiltration or a disease induced by abnormal proliferation or accumulation of cells can be provided. The 2H-chromene compound and a derivative thereof which are the compounds of the present invention have an S1P1 agonist action, and can be used particularly for prevention and/or treatment of a disease induced by undesirable lymphocyte infiltration or a disease induced by abnormal proliferation or accumulation of cells.

    摘要翻译： 本发明提供了具有优异的S1P1激动剂作用的化合物，特别是用于预防和/或治疗由不希望的淋巴细胞浸润引起的疾病或由细胞的异常增殖或积聚引起的疾病的活性成分。 根据本发明，具有优异的S1P1激动剂作用的2H-色烯化合物或其衍生物，并且特别用作预防和/或治疗由不想要的淋巴细胞浸润或疾病引起的疾病的药剂的活性成分 可以提供异常增殖或细胞积聚诱导的细胞。 作为本发明化合物的2H-色烯化合物及其衍生物具有S1P1激动剂作用，可以特别用于预防和/或治疗由不想要的淋巴细胞浸润引起的疾病或由异常增殖诱导的疾病或 细胞积聚。

    2H-CHROMENE COMPOUND AND DERIVATIVE THEREOF
    6.
    发明申请
    2H-CHROMENE COMPOUND AND DERIVATIVE THEREOF 有权
    2H-氯化合物及其衍生物

    公开(公告)号：US20110230463A1

    公开(公告)日：2011-09-22

    申请号：US13131343

    申请日：2009-12-04

    申请人： Hironori Harada ,  Kazuyuki Hattori ,  Kazuya Fujita ,  Sunao Imada ,  Tatsuaki Morokata

    发明人： Hironori Harada ,  Kazuyuki Hattori ,  Kazuya Fujita ,  Sunao Imada ,  Tatsuaki Morokata

    IPC分类号： A61K31/397 ,  C07D405/06 ,  A61K31/4025 ,  C07D417/14 ,  A61K31/428 ,  A61K31/453 ,  C07D405/14 ,  A61K31/404 ,  C07D409/14 ,  A61K31/427 ,  A61K31/4155 ,  A61K31/4433 ,  C07D311/58 ,  A61K31/352 ,  A61P29/00 ,  A61P37/06 ,  A61P25/28

    CPC分类号： C07D403/12 ,  C07D405/06 ,  C07D405/14 ,  C07D409/06 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

    摘要： [Object] Provided is a compound which has an excellent S1P1 agonist action, and is useful particularly as an active ingredient for an agent for preventing and/or treating a disease induced by undesirable lymphocyte infiltration or a disease induced by abnormal proliferation or accumulation of cells.[Means for Solution] According to the present invention, a 2H-chromene compound or a derivative thereof which has an excellent S1P1 agonist action, and is useful particularly as an active ingredient of an agent for preventing and/or treating a disease induced by undesirable lymphocyte infiltration or a disease induced by abnormal proliferation or accumulation of cells can be provided. The 2H-chromene compound and a derivative thereof which are the compounds of the present invention have an S1P1 agonist action, and can be used particularly for prevention and/or treatment of a disease induced by undesirable lymphocyte infiltration or a disease induced by abnormal proliferation or accumulation of cells.

    摘要翻译： 本发明提供具有优异的S1P1激动剂作用的化合物，特别是用于预防和/或治疗由不希望的淋巴细胞浸润引起的疾病或由细胞的异常增殖或积聚引起的疾病的活性成分 。 [解决方案]根据本发明，具有优异的S1P1激动剂作用的2H-色烯化合物或其衍生物，特别是作为用于预防和/或治疗由不希望的 可以提供淋巴细胞浸润或由细胞的异常增殖或积聚诱导的疾病。 作为本发明化合物的2H-色烯化合物及其衍生物具有S1P1激动剂作用，可以特别用于预防和/或治疗由不想要的淋巴细胞浸润引起的疾病或由异常增殖诱导的疾病或 细胞积聚。

    HETERO COMPOUND
    7.
    发明申请
    HETERO COMPOUND 有权
    HETERO化合物

    公开(公告)号：US20090076070A1

    公开(公告)日：2009-03-19

    申请号：US12244102

    申请日：2008-10-02

    申请人： Hironori HARADA ,  Kazuyuki Hattori ,  Kazuya Fujita ,  Masataka Morita ,  Sunao Imada ,  Yoshito Abe ,  Hiromichi Itani ,  Tatsuaki Morokata ,  Hideo Tsutsumi

    发明人： Hironori HARADA ,  Kazuyuki Hattori ,  Kazuya Fujita ,  Masataka Morita ,  Sunao Imada ,  Yoshito Abe ,  Hiromichi Itani ,  Tatsuaki Morokata ,  Hideo Tsutsumi

    IPC分类号： A61K31/4245 ,  C07D413/14 ,  A61K31/437 ,  A61P35/02 ,  A61P19/02 ,  A61P1/00 ,  A61P9/10 ,  A61P37/06 ,  A61P35/00 ,  A61K31/4709

    CPC分类号： C07D413/04 ,  C07D417/04 ,  C07D471/04

    摘要： [Problems] To provide a useful compound as an active ingredient for a preventing and/or treating agent for rejection in the transplantation of an organ, bone marrow, or a tissue, an autoimmune disease, or the like, which has an excellent S1P1 agonist activity.[Means for Solving] Since the compound of the invention has an S1P1 agonist activity, it is useful as an active ingredient for a treating or preventing agent for a disease caused by unfavorable lymphocytic infiltration, for example, an autoimmune disease such as graft rejection in the transplantation of an organ, bone marrow, or a tissue, a graft-versus-host disease, rheumatic arthritis, multiple sclerosis, systemic lupus erythematosus, a nephrotic syndrome, encephalomeningitis, myasthenia gravis, pancreatitis, hepatitis, nephritis, diabetes, pulmonary disorder, asthma, atopic dermatitis, inflammatory bowel disease, atherosclerosis, ischemia-reperfusion injury, or an inflammatory disease, and further, a disease caused by the abnormal growth or accumulation of cells such as cancer and leukemia.

    摘要翻译： [问题]提供一种有用的化合物作为活性成分，用于预防和/或治疗移植器官，骨髓或组织，自身免疫疾病等中的排斥反应，其具有优异的S1P1激动剂 活动。 [解决手段]由于本发明的化合物具有S1P1激动剂活性，因此可用作由不利的淋巴细胞浸润引起的疾病的治疗或预防剂的活性成分，例如自身免疫性疾病例如移植排斥反应 器官移植，骨髓或组织，移植物抗宿主病，风湿性关节炎，多发性硬化，系统性红斑狼疮，肾病综合征，脑炎，重症肌无力，胰腺炎，肝炎，肾炎，糖尿病，肺功能障碍 哮喘，特应性皮炎，炎症性肠病，动脉粥样硬化，局部缺血再灌注损伤，炎症性疾病等疾病，以及癌症，白血病等细胞异常生长或积累引起的疾病。

    Vehicle component and sealing member
    9.
    发明授权
    Vehicle component and sealing member 有权
    车辆部件和密封件

    公开(公告)号：US08720908B2

    公开(公告)日：2014-05-13

    申请号：US11727007

    申请日：2007-03-23

    申请人： Yoshikazu Machida ,  Masahiro Natsume ,  Katsumi Sakamoto ,  Kazuya Fujita

    发明人： Yoshikazu Machida ,  Masahiro Natsume ,  Katsumi Sakamoto ,  Kazuya Fujita

    IPC分类号： F16J15/02

    CPC分类号： B60Q1/0466 ,  B60Q1/2626 ,  B60Q1/2653 ,  B60R13/06 ,  F21V31/005

    摘要： A vehicle component includes a sealing member that is sandwiched between the vehicle component and a vehicle body to seal a gap between the vehicle component and the vehicle body. The sealing member includes an adhering/separating member that is adhereable to and separable from a wall of the vehicle body, and an elastic compressing member that is elastically compressible and stacked on the adhering/separating member. The adhering/separating member adheres to the wall of the vehicle body when the sealing member is present between the vehicle component and the vehicle body.

    摘要翻译： 车辆部件包括夹在车辆部件和车体之间的密封部件，以密封车辆部件与车身之间的间隙。 密封构件包括粘附/分离构件，其粘附到车体的壁上并可与其分离;以及弹性压缩构件，其弹性压缩并堆叠在粘合/分离构件上。 当密封构件存在于车辆部件和车身之间时，粘附/分离部件粘附到车体的壁上。