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    Microfluidic device for electrochemically regulating pH of fluid therein and method of regulating pH of fluid using the microfluidic device
    1.
    发明授权
    Microfluidic device for electrochemically regulating pH of fluid therein and method of regulating pH of fluid using the microfluidic device 有权
    用于电化学调节流体pH值的微流体装置和使用微流体装置调节流体pH值的方法

    公开(公告)号：US07771573B2

    公开(公告)日：2010-08-10

    申请号：US11489289

    申请日：2006-07-19

    申请人： Hun-joo Lee ,  Joon-ho Kim ,  Chin-sung Park ,  Young-sun Lee ,  Jong-Suk Chung

    发明人： Hun-joo Lee ,  Joon-ho Kim ,  Chin-sung Park ,  Young-sun Lee ,  Jong-Suk Chung

    IPC分类号： C25B9/00 ,  C02F1/461

    CPC分类号： B01D67/0062 ,  B01D2311/2623

    摘要： Provided is a microfluidic device for electrochemically regulating the pH of a fluid. The microfluidic device includes: an ion-exchange material; an anode chamber having a surface defined by a surface of the ion-exchange material and an anode electrode disposed along an edge of the surface of the anode chamber; and a cathode chamber having a surface defined by a surface of the ion-exchange material and a cathode electrode disposed along an edge of the surface of the cathode chamber, wherein the anode chamber and the cathode chamber are separated by an insulation material.

    摘要翻译： 提供了用于电化学调节流体pH的微流体装置。 微流体装置包括：离子交换材料; 具有由所述离子交换材料的表面限定的表面的阳极室和沿着所述阳极室的表面的边缘设置的阳极电极; 以及阴极室，其具有由离子交换材料的表面限定的表面和沿着阴极室的表面的边缘设置的阴极电极，其中阳极室和阴极室由绝缘材料分隔开。

    Microfluidic device for electrochemically regulating pH of fluid therein and method of regulating pH of fluid using the microfluidic device
    2.
    发明申请
    Microfluidic device for electrochemically regulating pH of fluid therein and method of regulating pH of fluid using the microfluidic device 有权
    用于电化学调节流体pH值的微流体装置和使用微流体装置调节流体pH值的方法

    公开(公告)号：US20070017810A1

    公开(公告)日：2007-01-25

    申请号：US11489289

    申请日：2006-07-19

    申请人： Hun-joo Lee ,  Joon-ho Kim ,  Chin-sung Park ,  Young-sun Lee ,  Jong-Suk Chung

    发明人： Hun-joo Lee ,  Joon-ho Kim ,  Chin-sung Park ,  Young-sun Lee ,  Jong-Suk Chung

    IPC分类号： B01D61/44

    CPC分类号： B01D67/0062 ,  B01D2311/2623

    摘要： Provided is a microfluidic device for electrochemically regulating the pH of a fluid. The microfluidic device includes: an ion-exchange material; an anode chamber having a surface defined by a surface of the ion-exchange material and an anode electrode disposed along an edge of the surface of the anode chamber; and a cathode chamber having a surface defined by a surface of the ion-exchange material and a cathode electrode disposed along an edge of the surface of the cathode chamber, wherein the anode chamber and the cathode chamber are separated by an insulation material.

    摘要翻译： 提供了用于电化学调节流体pH的微流体装置。 微流体装置包括：离子交换材料; 具有由所述离子交换材料的表面限定的表面的阳极室和沿着所述阳极室的表面的边缘设置的阳极电极; 以及阴极室，其具有由离子交换材料的表面限定的表面和沿着阴极室的表面的边缘设置的阴极电极，其中阳极室和阴极室由绝缘材料分隔开。

    MICROFLUIDIC DEVICE AND METHOD OF FABRICATING THE SAME
    3.
    发明申请
    MICROFLUIDIC DEVICE AND METHOD OF FABRICATING THE SAME 审中-公开
    微流体装置及其制造方法

    公开(公告)号：US20090170189A1

    公开(公告)日：2009-07-02

    申请号：US12184317

    申请日：2008-08-01

    申请人： Chin-sung PARK ,  Kak Namkoong ,  Young-sun Lee

    发明人： Chin-sung PARK ,  Kak Namkoong ,  Young-sun Lee

    IPC分类号： C12M1/34 ,  C12M1/00 ,  B32B37/06

    CPC分类号： C12M23/16 ,  B01L2200/12 ,  B01L2300/0816 ,  B01L2300/1827 ,  B29C65/02 ,  B29C65/08 ,  B29C66/1122 ,  B29C66/30223 ,  B29C66/47 ,  B29C66/53461 ,  B29C66/61 ,  B29C66/71 ,  B29C66/7352 ,  B29C66/73921 ,  B29C66/8322 ,  B29K2023/06 ,  B29K2023/12 ,  B29K2033/12 ,  B29K2067/00 ,  B29K2069/00 ,  B29L2031/756 ,  Y10T156/10 ,  B29K2067/003 ,  B29K2023/38

    摘要： Provided are a microfluidic device that performs a biochemical reaction using a small amount of a biochemical fluid and detects the result thereof, and a method of fabricating the same. The microfluidic device includes: a substrate which comprises a chamber that is formed as a concave groove and accommodates a fluid in the bottom surface of the substrate, and is formed of polymer; and a film welded on the bottom surface of the substrate to seal the chamber so that the chamber is not open at the bottom surface of the substrate, and formed of polymer. The method of fabricating a microfluidic device includes: preparing a substrate which comprises a chamber that is formed as a concave groove and accommodates a fluid in the bottom surface of the substrate, and is formed of polymer; and welding a film on a bottom surface of the substrate to seal the chamber so that the chamber is not opened at the bottom surface of the substrate, the film being formed of polymer.

    摘要翻译： 提供了使用少量生物化学流体进行生化反应并检测其结果的微流体装置及其制造方法。 微流体装置包括：基板，其包括形成为凹槽并容纳基板的底表面中的流体的腔室，并且由聚合物形成; 以及焊接在基板的底表面上的膜以密封室，使得室不在基板的底表面处开口，并且由聚合物形成。 制造微流体装置的方法包括：制备基板，其包括形成为凹槽的腔室，并且在基底的底表面容纳流体，并且由聚合物形成; 并且在所述基板的底表面上焊接膜以密封所述室，使得所述室在所述基板的底表面处不被打开，所述膜由聚合物形成。

    METHOD OF REDUCING TEMPERATURE DIFFERENCE BETWEEN A PAIR OF SUBSTRATES AND FLUID REACTION DEVICE USING THE SAME
    6.
    发明申请
    METHOD OF REDUCING TEMPERATURE DIFFERENCE BETWEEN A PAIR OF SUBSTRATES AND FLUID REACTION DEVICE USING THE SAME 有权
    降低基板对流与使用其的流体反应装置之间的温度差异的方法

    公开(公告)号：US20080053647A1

    公开(公告)日：2008-03-06

    申请号：US11689640

    申请日：2007-03-22

    申请人： Kak Namkoong ,  Su-hyeon Kim ,  Jin-tae Kim ,  Chin-sung Park ,  Young-sun Lee

    发明人： Kak Namkoong ,  Su-hyeon Kim ,  Jin-tae Kim ,  Chin-sung Park ,  Young-sun Lee

    IPC分类号： F28F7/00

    CPC分类号： B81B3/0081 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/00873 ,  B01L3/5027 ,  B01L7/5255 ,  B01L2200/14 ,  B01L2200/147 ,  B01L2300/1805 ,  B01L2300/1827 ,  B81B2201/051 ,  F28F21/02 ,  F28F2013/006

    摘要： A method of reducing a temperature difference between a high-temperature and a low-temperature substrate includes interposing a heat transfer facilitating layer which has a higher thermal conductivity than air and can hold particles between the substrates, and maintaining close contact between the high-temperature substrate, the heat transfer facilitating layer, and the low-temperature substrate, wherein formation of an air layer can be at least substantially prevented between the high-temperature substrate and the heat transfer facilitating layer, and between the low-temperature substrate and the heat transfer facilitating layer. A fluid reaction device includes a microfluidic reaction chip which accommodates a fluid, a heater, and a heat transfer facilitating layer which is interposed between the microfluidic reaction chip and the heater, the heat transfer facilitating layer has a higher thermal conductivity than air and can hold particles, wherein formation of an air layer can be prevented.

    摘要翻译： 降低高温和低温基板之间的温度差的方法包括：介于热传导率高于空气的传热促进层，并且可以在基板之间保持颗粒，并且保持高温 基板，传热促进层和低温基板，其中至少可以在高温基板和传热促进层之间以及在低温基板和热量之间基本上防止空气层的形成 转移促进层。 流体反应装置包括容纳流体的微流体反应芯片，加热器和介于微流体反应芯片和加热器之间的传热促进层，传热促进层具有比空气更高的导热性并且可以保持 颗粒，其中可以防止空气层的形成。

    Apparatus for regulating salt concentration using electrodialysis, lab-on-a-chip including the same, and method of regulating salt concentration using the apparatus
    8.
    发明授权
    Apparatus for regulating salt concentration using electrodialysis, lab-on-a-chip including the same, and method of regulating salt concentration using the apparatus 有权
    使用电渗析法调节盐浓度的装置，包括该盐浓度的实验室的方法以及使用该装置调节盐浓度的方法

    公开(公告)号：US07722751B2

    公开(公告)日：2010-05-25

    申请号：US11440872

    申请日：2006-05-25

    申请人： Jung-im Han ,  Young-sun Lee ,  Joon-ho Kim

    发明人： Jung-im Han ,  Young-sun Lee ,  Joon-ho Kim

    IPC分类号： B01D61/48

    CPC分类号： B01D61/422 ,  B01D61/46 ,  B01L3/5027 ,  G01N2001/4011

    摘要： An apparatus for regulating salt concentration, a lab-on-a-chip including the same and a method of regulating salt concentration using the apparatus are provided. The apparatus includes: a reaction chamber that is defined by a cation exchange membrane and an anion exchange membrane and is selected from the group consisting of a biomolecule extraction chamber, an amplification chamber, a hybridization chamber, and a detection chamber; a first electrode chamber that is defined by the anion exchange membrane and a first electrode and includes an ion exchange medium; and a second electrode chamber that is defined by the cation exchange membrane and a second electrode and includes an ion exchange medium. Even without injecting solutions with different salt concentrations into the reaction chamber by operating pumps and valves for each operation stage, the salt concentration can be reversibly regulated in situ by adjusting the polarity, intensity and application time of a voltage.

    摘要翻译： 提供了一种调节盐浓度的装置，包括该盐浓度的实验室，以及使用该装置调节盐浓度的方法。 该装置包括：由阳离子交换膜和阴离子交换膜限定的反应室，其选自生物分子提取室，扩增室，杂交室和检测室; 由阴离子交换膜和第一电极限定并包括离子交换介质的第一电极室; 以及由阳离子交换膜和第二电极限定并包括离子交换介质的第二电极室。 即使在每个操作阶段通过操作泵和阀都不会将具有不同盐浓度的溶液注入反应室中，可以通过调节电压的极性，强度和施加时间来原位调节盐浓度。