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公开(公告)号：US20100105686A1
公开(公告)日：2010-04-29
申请号：US12447151
申请日：2007-10-27
申请人： Gyula Beke , Eva Bozo , Sandor Farkas , Katalin Hornok , Gyorgy Keseru , Eva Schmidt , Eva Szentirmay , Istvan Vago , Monika Vastag
发明人： Gyula Beke , Eva Bozo , Sandor Farkas , Katalin Hornok , Gyorgy Keseru , Eva Schmidt , Eva Szentirmay , Istvan Vago , Monika Vastag
IPC分类号： A61K31/5375 , C07D211/32 , A61K31/445 , C07D241/04 , A61K31/495 , C07C311/01 , A61K31/18 , C07D295/00 , C07C271/02 , A61K31/195 , A61K31/4545 , A61P29/00
CPC分类号： C07C311/21 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D209/08 , C07D211/26 , C07D211/58 , C07D213/40 , C07D213/75 , C07D231/40 , C07D233/54 , C07D233/64 , C07D235/30 , C07D241/08 , C07D261/14 , C07D277/46 , C07D277/62 , C07D277/82 , C07D285/135 , C07D295/13 , C07D295/135 , C07D317/46
摘要： The present invention relates to new sulfonamide derivatives of formula (I) wherein R1-R8 and Z are as defined in the claims, and optical antipodes or racemates and/or salts and/or hydrates and/or solvates thereof, which are selective antagonists of bradykinin B1, to processes for producing these same compounds, pharmacological compositions containing them and to their use in therapy or prevention of painful and inflammatory conditions.
摘要翻译： 本发明涉及式（I）的新的磺酰胺衍生物，其中R 1 -R 8和Z如权利要求中所定义，和光学对映体或外消旋体和/或其盐和/或水合物和/或溶剂化物，其是选择性拮抗剂 缓激肽B1，用于制备这些相同化合物的方法，含有它们的药理学组合物及其在治疗或预防疼痛和炎症病症中的用途。
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2.发明申请公开(公告)号：US20130029991A1
公开(公告)日：2013-01-31
申请号：US13564429
申请日：2012-08-01
申请人： Gyula Beke , Eva Bozo , Sandor Farkas , Katalin Hornok , Gyorgy Keseru , Eva Schmidt , Eva Szentirmay , Istvan Vago , Monika Vastag
发明人： Gyula Beke , Eva Bozo , Sandor Farkas , Katalin Hornok , Gyorgy Keseru , Eva Schmidt , Eva Szentirmay , Istvan Vago , Monika Vastag
IPC分类号： A61K31/445 , C07C303/38 , A61P25/04 , A61P29/00 , C07C311/46 , A61K31/4545 , C07D265/30 , A61K31/5375 , C07D233/64 , A61K31/4174 , C07D401/04 , C07D211/34 , A61K31/18
CPC分类号： C07C311/21 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D209/08 , C07D211/26 , C07D211/58 , C07D213/40 , C07D213/75 , C07D231/40 , C07D233/54 , C07D233/64 , C07D235/30 , C07D241/08 , C07D261/14 , C07D277/46 , C07D277/62 , C07D277/82 , C07D285/135 , C07D295/13 , C07D295/135 , C07D317/46
摘要： The present invention relates to new sulfonamide derivatives of formula (I) wherein R1-R8 and Z are as defined in the claims, and optical antipodes or racemates and/or salts and/or hydrates and/or solvates thereof, which are selective antagonists of bradykinin B1, to processes for producing these same compounds, pharmacological compositions containing them and to their use in therapy or prevention of painful and inflammatory conditions.
摘要翻译： 本发明涉及式（I）的新的磺酰胺衍生物，其中R 1 -R 8和Z如权利要求中所定义，和光学对映体或外消旋体和/或其盐和/或水合物和/或溶剂化物，其是选择性拮抗剂 缓激肽B1，用于制备这些相同化合物的方法，含有它们的药理学组合物及其在治疗或预防疼痛和炎症病症中的用途。
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公开(公告)号：US20100298299A1
公开(公告)日：2010-11-25
申请号：US12739868
申请日：2007-10-27
申请人： Istvan Vago , Sandor Farkas , Katalin Hornok , Gyula Beke , Eva Bozo , Monika Vastag , Eva Szentirmay , Gyorgy Keseru , Eva Schmidt
发明人： Istvan Vago , Sandor Farkas , Katalin Hornok , Gyula Beke , Eva Bozo , Monika Vastag , Eva Szentirmay , Gyorgy Keseru , Eva Schmidt
IPC分类号： A61K31/55 , C07D401/06 , A61K31/454 , A61P29/00 , C07D295/192 , A61K31/495 , C07D403/06 , A61K31/496 , C07D413/06 , A61K31/5377 , C07D401/02 , A61K31/4545 , A61K31/40 , C07D207/06 , C07D295/18 , A61K31/5375 , A61K31/54 , C07D223/04
CPC分类号： C07C311/21 , C07D207/36 , C07D211/22 , C07D211/26 , C07D211/46 , C07D211/58 , C07D211/60 , C07D211/74 , C07D241/08 , C07D295/096 , C07D295/185
摘要： The present invention relates to new non-peptide derivatives of formula (I), wherein R1-R5, Q and Z are as defined in the claims, and optical antipodes or racemates and/or salts and/or hydrates and/or solvates thereof, which are selective antagonists of bradykinin B1, to processes for producing these compounds, to pharmacological compositions containing them and to their use in therapy or prevention of painful and inflammatory conditions.
摘要翻译： 本发明涉及新的式（I）的非肽衍生物，其中R 1 -R 5，Q和Z如权利要求中所定义，和光学对映体或外消旋物和/或其盐和/或其水合物和/或溶剂合物， 其是缓激肽B1的选择性拮抗剂，用于制备这些化合物的方法，含有它们的药理学组合物及其在治疗或预防疼痛和炎症病症中的用途。
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公开(公告)号：US08481527B2
公开(公告)日：2013-07-09
申请号：US12447157
申请日：2007-10-27
申请人： Istvan Vago , Gyula Beke , Eva Bozo , Sandor Farkas , Katalin Hornok , Gyorgy Keseru , Eva Schmidt , Eva Szentirmay , Monika Vastag
发明人： Istvan Vago , Gyula Beke , Eva Bozo , Sandor Farkas , Katalin Hornok , Gyorgy Keseru , Eva Schmidt , Eva Szentirmay , Monika Vastag
IPC分类号： C07D207/08 , C07D211/18 , C07D211/44 , C07D211/22 , C07D211/58 , C07D211/26 , C07D211/62 , C07D207/26 , C07D211/34 , C07D211/68 , A61K31/18 , A61P29/00
CPC分类号： C07D295/185 , C07D207/08 , C07D207/26 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/26 , C07D211/34 , C07D211/38 , C07D211/44 , C07D211/58 , C07D211/62 , C07D211/68 , C07D211/76 , C07D219/06 , C07D223/10 , C07D239/42 , C07D241/06 , C07D241/20 , C07D243/08 , C07D279/12 , C07D295/20 , C07D295/26 , C07D307/14 , C07D307/24 , C07D307/68 , C07D401/06 , C07D487/08
摘要： The present invention relates to new phenylsulfamoyl benzamide derivatives of formula (I) wherein R1-R5 and Z are as defined in the claims, and optical antipodes or racemates and/or salts and/or hydrates and/or solvates thereof, which are selective antagonists of bradykinin B1, to processes for producing these compounds, to pharmacological compositions containing them and to their use in therapy or prevention of painful and inflammatory conditions.
摘要翻译： 本发明涉及式（I）的新的苯基氨磺酰基苯甲酰胺衍生物，其中R 1 -R 5和Z如权利要求中所定义，和作为选择性拮抗剂的光学对映体或外消旋物和/或其盐和/或水合物和/或溶剂合物 缓激肽B1，制备这些化合物的方法，含有它们的药物组合物及其在治疗或预防疼痛和炎症病症中的用途。
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5.发明申请公开(公告)号：US20120295910A1
公开(公告)日：2012-11-22
申请号：US13564360
申请日：2012-08-01
申请人： Gyula Beke , Eva Bozo , Sandor Farkas , Katalin Hornok , Gyorgy Keseru , Eva Schmidt , Eva Szentirmay , Istvan Vago , Monika Vastag
发明人： Gyula Beke , Eva Bozo , Sandor Farkas , Katalin Hornok , Gyorgy Keseru , Eva Schmidt , Eva Szentirmay , Istvan Vago , Monika Vastag
IPC分类号： A61K31/535 , A61K31/4965 , A61K31/4545 , A61K31/445 , A61K31/4164 , C07D207/50 , C07D265/30 , C07D401/02 , C07D241/04 , C07D401/04 , C07D211/56 , C07D233/88 , A61K31/497 , A61K31/40
CPC分类号： C07C311/21 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D209/08 , C07D211/26 , C07D211/58 , C07D213/40 , C07D213/75 , C07D231/40 , C07D233/54 , C07D233/64 , C07D235/30 , C07D241/08 , C07D261/14 , C07D277/46 , C07D277/62 , C07D277/82 , C07D285/135 , C07D295/13 , C07D295/135 , C07D317/46
摘要： The present invention relates to new sulfonamide derivatives of formula (I), wherein R1-R8 and Z are as defined in the claims, and optical antipodes or racemates and/or salts and/or hydrates and/or solvates thereof, which are selective antagonists of bradykinin B1, to processes for producing these same compounds, pharmacological compositions containing them and to their use in therapy or prevention of painful and inflammatory conditions.
摘要翻译： 本发明涉及新的式（I）磺酰胺衍生物，其中R 1 -R 8和Z如权利要求中所定义，和光学对映体或外消旋体和/或其盐和/或其水合物和/或溶剂化物，它们是选择性拮抗剂 缓激肽B1的制备方法，制备这些相同化合物的方法，含有它们的药物组合物及其在治疗或预防疼痛和炎症病症中的用途。
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公开(公告)号：US20100087423A1
公开(公告)日：2010-04-08
申请号：US12447157
申请日：2007-10-27
申请人： Istvan Vago , Gyula Beke , Eva Bozo , Sandor Farkas , Katalin Hornok , Gyorgy Keseru , Eva Schmidt , Eva Szentirmay , Monika Vastag
发明人： Istvan Vago , Gyula Beke , Eva Bozo , Sandor Farkas , Katalin Hornok , Gyorgy Keseru , Eva Schmidt , Eva Szentirmay , Monika Vastag
IPC分类号： A61K31/496 , C07D403/02 , A61K31/551 , A61P25/00 , A61P29/00
CPC分类号： C07D295/185 , C07D207/08 , C07D207/26 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/26 , C07D211/34 , C07D211/38 , C07D211/44 , C07D211/58 , C07D211/62 , C07D211/68 , C07D211/76 , C07D219/06 , C07D223/10 , C07D239/42 , C07D241/06 , C07D241/20 , C07D243/08 , C07D279/12 , C07D295/20 , C07D295/26 , C07D307/14 , C07D307/24 , C07D307/68 , C07D401/06 , C07D487/08
摘要： The present invention relates to new phenylsulfamoyl benzamide derivatives of formula (I) wherein R1-R5 and Z are as defined in the claims, and optical antipodes or racemates and/or salts and/or hydrates and/or solvates thereof, which are selective antagonists of bradykinin B1, to processes for producing these compounds, to pharmacological compositions containing them and to their use in therapy or prevention of painful and inflammatory conditions.
摘要翻译： 本发明涉及式（I）的新的苯基氨磺酰基苯甲酰胺衍生物，其中R 1 -R 5和Z如权利要求中所定义，和作为选择性拮抗剂的光学对映体或外消旋物和/或其盐和/或水合物和/或溶剂合物 缓激肽B1，制备这些化合物的方法，含有它们的药物组合物及其在治疗或预防疼痛和炎症病症中的用途。
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公开(公告)号：US20100075978A1
公开(公告)日：2010-03-25
申请号：US12447132
申请日：2007-10-27
申请人： Eva Bozo , Gyula Beke , Janos Eles , Sandor Farkas , Katalin Hornok , Gyorgy Keseru , Eva Schmidt , Eva Szentirmay , Istvan Vago , Monika Vastag
发明人： Eva Bozo , Gyula Beke , Janos Eles , Sandor Farkas , Katalin Hornok , Gyorgy Keseru , Eva Schmidt , Eva Szentirmay , Istvan Vago , Monika Vastag
IPC分类号： A61K31/496 , C07D401/04 , A61P25/00 , A61P29/00
CPC分类号： C07C311/21 , C07D207/26 , C07D211/26 , C07D211/34 , C07D211/56 , C07D211/62 , C07D211/76 , C07D213/38 , C07D213/74 , C07D213/75 , C07D233/54 , C07D239/04 , C07D239/42 , C07D241/20 , C07D243/08 , C07D295/12 , C07D295/20 , C07D401/04 , C07D401/06 , C07D401/12
摘要： The present invention relates to new sulfonamide derivatives of formula (I) wherein R1-R5 and Z are as defined in the claims, and optical antipodes or racemates and/or salts and/or hydrates and/or solvates thereof, which are selective antagonists of bradykinin B1, to processes for producing these compounds, pharmacological compositions containing them and to their use in therapy or prevention of painful and inflammatory conditions.
摘要翻译： 本发明涉及式（I）的新的磺酰胺衍生物，其中R 1 -R 5和Z如权利要求中所定义，和光学对映体或外消旋体和/或其盐和/或水合物和/或溶剂合物，其是选择性拮抗剂 缓激肽B1，用于制备这些化合物的方法，含有它们的药物组合物及其在治疗或预防疼痛和炎症病症中的用途。
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公开(公告)号：US08034827B2
公开(公告)日：2011-10-11
申请号：US12158606
申请日：2006-12-19
申请人： Gyula Beke , Eva Bozo , Gabor Czira , Janos Eles , Sandor Farkas , Katalin Hornok , Eva Schmidt , Eva Szentirmay , Istvan Vago , Monika Vastag
发明人： Gyula Beke , Eva Bozo , Gabor Czira , Janos Eles , Sandor Farkas , Katalin Hornok , Eva Schmidt , Eva Szentirmay , Istvan Vago , Monika Vastag
IPC分类号： A61K31/44 , C07D211/68
CPC分类号： C07D401/12 , C07D213/74 , C07D221/12 , C07D295/135 , C07D401/10 , C07D401/14
摘要： The present invention relates to new phenanthridine derivatives of formula (I), wherein the variables are as defined in the specification, to processes for producing the same, to pharmacological compositions containing the same and to their use in therapy or prevention of painful and inflammatory processes.
摘要翻译： 本发明涉及式（I）的新的菲啶衍生物，其中变量如本说明书中所定义，其制备方法，含有其的药物组合物及其在治疗或预防疼痛和炎症过程中的用途 。
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公开(公告)号：US20090270411A1
公开(公告)日：2009-10-29
申请号：US12158606
申请日：2006-12-19
申请人： Gyula Beke , Eva Bozo , Gabor Czira , Janos Eles , Sandor Farkas , Katalin Hornok , Eva Schmidt , Eva Szentirmay , Istvan Vago , Monika Vastag
发明人： Gyula Beke , Eva Bozo , Gabor Czira , Janos Eles , Sandor Farkas , Katalin Hornok , Eva Schmidt , Eva Szentirmay , Istvan Vago , Monika Vastag
IPC分类号： A61K31/496 , A61K31/506 , A61K31/473 , C07D401/04 , C07D401/14 , C07D403/12
CPC分类号： C07D401/12 , C07D213/74 , C07D221/12 , C07D295/135 , C07D401/10 , C07D401/14
摘要： The present invention relates to new phenanthridine derivatives of formula (I), wherein the variables are as defined in the specification, to processes for producing the same, to pharmacological compositions containing the same and to their use in therapy or prevention of painful and inflammatory processes.
摘要翻译： 本发明涉及式（I）的新的菲啶衍生物，其中变量如本说明书中所定义，其制备方法，含有其的药物组合物及其在治疗或预防疼痛和炎症过程中的用途 。
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公开(公告)号：US08802672B2
公开(公告)日：2014-08-12
申请号：US12979439
申请日：2010-12-28
申请人： Gizella Bartane Szalai , Eva Againe Csongor , Gyorgy Domany , Istvan Gyertyan , Bela Kiss , Judit Laszy , Katalin Saghy , Eva Schmidt , Sandor Farkas , Zsolt Komlodi
发明人： Gizella Bartane Szalai , Eva Againe Csongor , Gyorgy Domany , Istvan Gyertyan , Bela Kiss , Judit Laszy , Katalin Saghy , Eva Schmidt , Sandor Farkas , Zsolt Komlodi
IPC分类号： A61K31/506
CPC分类号： C07D239/48
摘要： The present invention relates to new dopamine D3 and D2 ligands of formula (I): wherein R1, R2 and Q are as described herein, and/or geometric isomers and/or stereoisomers and/or diastereomers and/or salts and/or hydrates and/or solvates and/or polymorphs thereof. The invention also relates to processes for preparing the same, to compositions containing the same and to their use in the treatment and/or prevention of conditions which requires modulation of dopamine receptors.
摘要翻译： 本发明涉及式（I）的新的多巴胺D3和D2配体：其中R1，R2和Q如本文所述，和/或几何异构体和/或立体异构体和/或非对映异构体和/或盐和/或水合物和 /或其溶剂合物和/或其多晶型物。 本发明还涉及其制备方法，含有该组合物的组合物及其在治疗和/或预防需要调节多巴胺受体的病症中的用途。
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