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公开(公告)号：US20110060128A1
公开(公告)日：2011-03-10
申请号：US12945829
申请日：2010-11-12
申请人： Jörg Peters , Torsten Minuth , Hans-Georg Dellweg
发明人： Jörg Peters , Torsten Minuth , Hans-Georg Dellweg
IPC分类号： C07K14/54
CPC分类号： G01N33/6869 , C07K14/5406 , G01N2333/5406
摘要： This invention relates generally to a method for purifying Interleukin-4 or related variants from an Escherichia coli culture medium, where Interleukin-4 and its derivatives are expressed as insoluble protein aggregates, so-called inclusion bodies.
摘要翻译： 本发明一般涉及从大肠杆菌培养基中纯化白介素-4或相关变体的方法，其中白细胞介素-4及其衍生物被表达为不溶性蛋白质聚集体，即所谓的包涵体。
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公开(公告)号：US20060134690A1
公开(公告)日：2006-06-22
申请号：US10520883
申请日：2003-07-02
申请人： Jorg Peters , Torsten Minuth , Hans-Georg Dellweg
发明人： Jorg Peters , Torsten Minuth , Hans-Georg Dellweg
IPC分类号： G01N33/53
CPC分类号： G01N33/6869 , C07K14/5406 , G01N2333/5406
摘要： This invention relates generally to a method for purifying Interleukin-4 or related variants from an Escherichia coli culture medium, where Interleukin-4 and its derivatives are expressed as insoluble protein aggregates, so-called inclusion bodies.
摘要翻译： 本发明一般涉及从大肠杆菌培养基中纯化白介素-4或相关变体的方法，其中白细胞介素-4及其衍生物被表达为不溶性蛋白质聚集体，即所谓的包涵体。
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公开(公告)号：US5223517A
公开(公告)日：1993-06-29
申请号：US749018
申请日：1991-08-23
IPC分类号： A61K31/40 , A61K31/403 , A61K31/44 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/635 , A61P7/02 , A61P9/08 , A61P9/10 , A61P11/00 , A61P37/08 , C07D209/86 , C07D209/88 , C07D213/24 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D405/06 , C07D409/06 , C07D417/06
CPC分类号： C07D401/06 , C07D209/86 , C07D401/12 , C07D403/06
摘要： Heterocyclically substituted cycloalkano[b]-indolesulphonamides can be prepared by reaction of appropriate N-unsubstituted indoles with acrylonitrile, followed by hydrolysis, esterification or amidation, or by reaction of heterocyclically substituted hydrazines with cycloalkanones or by subsequent introduction of the heterocyclic group into appropriate indole derivatives. The heterocyclically substituted cycloalkano[b]-indolesulphonamides can be employed for the treatment of thromboembolic disorders, ischaemias, arteriosclerosis, asthma, allergies and for the prophylaxis of myocardial infarcts.
摘要翻译： 杂环取代的环烷基[b] - 吲哚磺酰胺可以通过合适的N-未取代的吲哚与丙烯腈的反应制备，然后水解，酯化或酰胺化，或通过杂环取代的肼与环烷酮的反应或随后将杂环基引入适当的吲哚 衍生品 杂环取代的环烷基[b] - 吲哚磺酰胺可用于治疗血栓栓塞障碍，局部缺血，动脉硬化，哮喘，过敏和预防心肌梗死。
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公开(公告)号：US5089487A
公开(公告)日：1992-02-18
申请号：US528667
申请日：1990-05-24
申请人： Klaus Frobel , Jan-Bernd Lenfers , Peter Fey , Andreas Knorr , Johannes-Peter Stasch , Hartwig Muller , Erwin Bischoff , Hans-Georg Dellweg
发明人： Klaus Frobel , Jan-Bernd Lenfers , Peter Fey , Andreas Knorr , Johannes-Peter Stasch , Hartwig Muller , Erwin Bischoff , Hans-Georg Dellweg
IPC分类号： C12N1/14 , A61K31/335 , A61K31/35 , A61K31/357 , A61K31/365 , A61K31/38 , A61K31/40 , A61K31/425 , A61K31/44 , A61K31/443 , A61K31/4433 , A61P3/00 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/12 , C07D321/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/04 , C07D407/12 , C07D409/04 , C07D417/04 , C07D493/14 , C07H9/04 , C07H15/26 , C12P17/08 , C12P17/16 , C12R1/80
CPC分类号： C07D405/12 , C07D321/12 , C07D407/04 , C07D407/12 , C07D493/14 , C07H15/26 , C12P17/08 , C12P17/16 , C12R1/80
摘要： Cardioactive compounds of the formula ##STR1## in which R.sup.1 and R.sup.8 and R.sup.14 and R.sup.15 can be hydrogen or various organic radicals.
摘要翻译： 其中R 1和R 8以及R 14和R 15可以是氢或各种有机基团的式（Ⅰ）的心脏活性化合物。
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5.发明授权Cycloalkano(b)dihydroindoles and -indolesulphonamides substituted by heterocycles 失效环己烷（B）二异氰酸酯和异烟肼取代的二羟基苯甲酸酯
公开(公告)号：US5204374A
公开(公告)日：1993-04-20
申请号：US679710
申请日：1991-04-03
申请人： Ulrich E. Muller , Ulrich Rosentreter , Ulrich Niewohner , Elisabeth Perzborn , Erwin Bischoff , Hans-Georg Dellweg , Peter Norman , Nigel J. Cuthbert , Hilary P. Francis
发明人： Ulrich E. Muller , Ulrich Rosentreter , Ulrich Niewohner , Elisabeth Perzborn , Erwin Bischoff , Hans-Georg Dellweg , Peter Norman , Nigel J. Cuthbert , Hilary P. Francis
IPC分类号： A61K31/40 , A61K31/403 , A61P7/02 , A61P11/00 , A61P37/08 , C07D209/86 , C07D209/94 , C07D401/12 , C07D409/12 , C07D417/12
CPC分类号： C07D401/12 , C07D409/12 , C07D417/12
摘要： New cycloalkano[b]dihydroindoles and -indolesulphonamides, substituted by heterocycles, of the formula (I) ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are identical or different andrepresent hydrogen, nitro, cyano, halogen, trifluoromethyl, carboxyl, hydroxyl or trifluoromethoxy, orrepresent a group of the formula --S(O).sub.w R.sup.5, in whichR.sup.5 denotes alkyl or optionally substituted aryl,w denotes the number 0, 1 or 2, orrepresents alkoxy or alkoxycarbonyl, or benzyloxy, orrepresents a group of the formula --NR.sup.6 R.sup.7, in whichR.sup.6 and R.sup.7 are identical or different anddenote hydrogen, alkyl or acyl ordenote aryl, ordenote a group of the formula --S(O).sub.w R.sup.5, in which R.sup.5 and w have the abovementioned meaning,represent cycloalkyl orrepresent optionally substituted alkyl or alkenyl,m represents the number 1, 2, 3 or 4,n represents the number 0, 1 or 2,z represents the number 1, 2, 3 or 4,A represents a bond or the --NH group,X represents an optionally substituted heterocycle,Y represents hydroxyl, alkoxy, phenoxy or a group of the formula --NR.sup.6 R.sup.7, in whichR.sup.6 and R.sup.7 have the abovementioned meaning, an isomeric form thereof or salts thereof are useful to treat thromboembolisms, ischaemias, asthma and allergies. Processes of making and chemical intermediates are also disclosed.
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6.发明授权Phenylsulphonamide substituted pyridinealkene- and aminooxyalkanecarboxylic acid derivatives 失效苯基膦酰胺取代的吡嗪基和氨基氧基甲酰氧基酸衍生物
公开(公告)号：US5155121A
公开(公告)日：1992-10-13
申请号：US739747
申请日：1991-08-02
IPC分类号： A61K31/44 , A61K31/4406 , A61K31/4418 , A61P7/02 , A61P43/00 , C07D213/44 , C07D213/50 , C07D213/53 , C07D213/55 , C07D213/71 , C12N9/99
CPC分类号： C07D213/53 , C07D213/55 , C07D213/71
摘要： The compounds according to the invention can be prepared by reaction of the corresponding amines with sulphonic acid derivatives, or in the case of the aminooxy compounds by reaction of ketones with aminooxy compounds or alkylation of hydroxylamines, or in the case of the alkene compounds by reaction of ketones with phosphorusylides. The phenylsulphonamide substituted pyridinealkene- and -aminooxyalkenecarboxylic acid derivatives can be used for the treatment of thromboembolic disorders, ischaemias, arteriosclerosis, allergies and asthma.
摘要翻译： 根据本发明的化合物可以通过相应的胺与磺酸衍生物的反应或在氨基氧化合物的情况下通过酮与氨基氧化合物的反应或羟胺的烷基化反应来制备，或者在烯烃化合物的情况下通过反应 的含有二酰亚胺的酮。 苯基磺酰胺取代的吡啶亚烷基 - 和 - 氨基氧代羧酸衍生物可用于治疗血栓栓塞障碍，局部缺血，动脉硬化，过敏和哮喘。
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7.发明授权Processes for preparing acarviosyl transferase and for using it in the conversion of acarbose homologues into acarbose, for the preparation of acarbose homologues 失效用于制备阿卡波糖转移酶并用于将阿卡波糖同系物转化成阿卡波糖的方法，用于制备阿卡波糖同系物
公开(公告)号：US5989882A
公开(公告)日：1999-11-23
申请号：US816105
申请日：1997-03-14
申请人： Anneliese Crueger , Hans-Georg Dellweg , Jurgen Georg Lenz , Werner Schroder , Hermann Pape , Klaus Goeke , Beate Schaper , Michael Hemker , Wolfgang Piepersberg , Jurgen Distler , Ansgar Stratmann
发明人： Anneliese Crueger , Hans-Georg Dellweg , Jurgen Georg Lenz , Werner Schroder , Hermann Pape , Klaus Goeke , Beate Schaper , Michael Hemker , Wolfgang Piepersberg , Jurgen Distler , Ansgar Stratmann
IPC分类号： C12N15/09 , C07H3/06 , C07H15/00 , C07H21/04 , C12N9/10 , C12N15/00 , C12N15/11 , C12N15/31 , C12N15/52 , C12N15/54 , C12N15/76 , C12P19/12 , C12P19/18 , C12P19/26 , C12R1/045 , C12R1/19 , C12N1/20
CPC分类号： C12P19/26 , C12N9/1048
摘要： The invention relates to acarviosyl transferase from actinomycetes, mainly from Actinoplanes sp. SE 50/110 and its mutants, to a process for isolating, purifying and characterizing the enzyme, to the isolation and characterization of the acbD gene encoding the acarviosyl transferase, to the expression of the acarviosyl transferase in a heterologous host organism, to the use of the acarviosyl transferase for converting acarbose minor constituents into acarbose or for preparing acarbose homologues, to the use of the acarviosyl transferase in acarbose purification, and also to the preparation of production mutants in which formation of minor constituents is reduced by means of inactivation of the acarviosyl transferase gene.
摘要翻译： 本发明涉及来自放线菌的主要来自Actinoplanes sp。的acarviosyl转移酶。 SE 50/110及其突变体，用于分离，纯化和表征酶的过程，分离和表征编码α-乙酰氧基转移酶的acbD基因到异源宿主生物体中的阿卡非糖转移酶的表达，使用 的阿卡波糖转移酶用于将阿卡波糖次要成分转化成阿卡波糖或用于制备阿卡波糖同系物，以及在阿卡波糖纯化中使用阿卡波糖转移酶，以及制备生产突变体，其中通过灭活 阿维生素转移酶基因。
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公开(公告)号：US5328931A
公开(公告)日：1994-07-12
申请号：US917565
申请日：1992-07-21
IPC分类号： A61K31/435 , A61K31/44 , A61P25/18 , A61P25/28 , C07D211/90 , C07D213/55 , A61K31/455
CPC分类号： C07D211/90
摘要： N-alkylated 1,4-dihydropyridinedicarboxylic acid esters can be prepared either by reaction of aldehydes with acetoacetic esters and amines, optionally with isolation of the corresponding ylidene compounds, or by reaction of aminocrotonic acid esters with ylidene compounds and subsequent alkylation of the NH function. The N-alkylated 1,4-dihydropyridinedicarboxylic acid esters can be employed as active compounds in medicaments, in particular as cerebral therapeutics.
摘要翻译： N-烷基化的1,4-二氢吡啶二羧酸酯可以通过醛与乙酰乙酸酯和胺的反应制备，任选地分离相应的亚基化合物，或通过氨基巴豆酸酯与亚基化合物的反应和随后NH官能团的烷基化 。 N-烷基化的1,4-二氢吡啶二羧酸酯可以用作药物中的活性化合物，特别是作为脑治疗剂。
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9.发明授权Substituted dibenz-oxa-thiocinones, -12-oxides and -12,12-dioxides, a process for their preparation and their use in medicaments 失效取代的二苯氧基 - 氧杂环己烷，-12-氧化物和-12,12-二氧化物，其制备方法及其在药物中的用途
公开(公告)号：US5190971A
公开(公告)日：1993-03-02
申请号：US798386
申请日：1991-11-26
申请人： Peter Fey , Klaus Frobel , Jan-Bernd Lenfers , Andreas Knorr , Johannes-Peter Stasch , Erwin Bischoff , Hans-Georg Dellweg , Martin Beuck
发明人： Peter Fey , Klaus Frobel , Jan-Bernd Lenfers , Andreas Knorr , Johannes-Peter Stasch , Erwin Bischoff , Hans-Georg Dellweg , Martin Beuck
IPC分类号： A61K31/39 , A61P9/00 , C07D327/02
CPC分类号： C07D327/02
摘要： The invention relates to substituted dibenz-oxa-thiocinone-12-oxides and -12,12-dioxides of the general formula I ##STR1## in which R.sup.1 to R.sup.6 and Y have the meaning indicated in the description, to processes for their preparation and to their use in medicaments, in particular in circulation-influencing medicaments.
摘要翻译： 本发明涉及通式Ⅰ的取代二苄氧羰硫酮12-氧化物和-12,12-二氧化物，其中R1至R6和Y具有说明书中所示的含义， 其制剂和用于药物，特别是在循环影响药物中的用途。
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10.发明授权Phenylsulphonamide substituted pyridinealkene- and -aminooxyalkanecarboxylic acid derivatives 失效苯磺酰胺取代的吡啶烯基 - 和 - 氨基氧烷基羧酸衍生物
公开(公告)号：US5185348A
公开(公告)日：1993-02-09
申请号：US887208
申请日：1992-05-21
IPC分类号： C07D213/53 , C07D213/55 , C07D213/71
CPC分类号： C07D213/53 , C07D213/55 , C07D213/71
摘要： The compounds according to the invention can be prepared by reaction of the corresponding amines with sulphonic acid derivatives, or in the case of the aminooxy compounds by reacton of ketones with aminooxy compounds or alkylation of hydroxylamines, or in the case of the alkene compounds by reaction of ketones with phosphorusylides. The phenylsulphonamide substituted pyridinealkene- and -aminooxyalkencarboxylic acid derivatives can be used for the treatment of thromboembolic disorders, ischaemias, arteriosclerosis, allergies and asthma.
摘要翻译： 根据本发明的化合物可以通过相应的胺与磺酸衍生物反应来制备，或者在氨基氧化合物的情况下通过酮与氨氧基化合物的反应或羟胺的烷基化反应，或在烯烃化合物的情况下通过反应 的含有二酰亚胺的酮。 苯基磺酰胺取代的吡啶基烯基 - 和 - 氨基氧代羧酸衍生物可用于治疗血栓栓塞性疾病，局部缺血，动脉硬化，过敏和哮喘。
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