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公开(公告)号：US5856503A
公开(公告)日：1999-01-05
申请号：US762867
申请日：1996-12-06
申请人： Johannes Aebi , Henrietta Dehmlow , Jacques Himber , Hans-Peter Marki , Hans Lengsfeld , Olivier Morand , Gerard Schmid , Yu-Hua Ji
发明人： Johannes Aebi , Henrietta Dehmlow , Jacques Himber , Hans-Peter Marki , Hans Lengsfeld , Olivier Morand , Gerard Schmid , Yu-Hua Ji
IPC分类号： A61K31/34 , A61K31/343 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/415 , A61K31/42 , A61K31/423 , A61K31/425 , A61K31/428 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/50 , A61K31/502 , A61K31/505 , A61K31/517 , A61P3/06 , A61P9/10 , A61P31/04 , C07D209/10 , C07D209/12 , C07D209/14 , C07D215/20 , C07D217/14 , C07D217/16 , C07D231/56 , C07D237/30 , C07D239/74 , C07D239/82 , C07D261/20 , C07D265/02 , C07D275/04 , C07D275/06 , C07D307/79 , C07D307/80 , C07D307/81 , C07D311/58 , C07D333/54 , C07D333/56 , C07D333/58
CPC分类号： C07D333/54 , C07D215/20 , C07D217/14 , C07D231/56 , C07D237/30 , C07D239/74 , C07D239/82 , C07D261/20 , C07D265/02 , C07D275/04 , C07D275/06 , C07D307/79 , C07D311/58
摘要： Aminoalkyl-substituted benzo-heterocyclic compounds of the formula ##STR1## wherein M, Q, R and T are as defined in the specification, as well as acid addition salts thereof. These compounds are useful as cholesterol level lowering agents and as antimycotic agents.
摘要翻译： 其中M，Q，R和T如说明书中所定义的氨基烷基取代的苯并杂环化合物及其酸加成盐。 这些化合物可用作胆固醇水平降低剂和抗真菌剂。
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公开(公告)号：US06441177B1
公开(公告)日：2002-08-27
申请号：US09464435
申请日：1999-12-16
申请人： Johannes Aebi , Henrietta Dehmlow , Jacques Himber , Synèse Jolidon , Hans Lengsfeld , Olivier Morand , Gérard Schmid , Yu-Hua Ji
发明人： Johannes Aebi , Henrietta Dehmlow , Jacques Himber , Synèse Jolidon , Hans Lengsfeld , Olivier Morand , Gérard Schmid , Yu-Hua Ji
IPC分类号： C07D40100
CPC分类号： C07C323/25 , C07C217/20 , C07C217/46 , C07C217/52 , C07C235/78 , C07C235/84 , C07C255/56 , C07C311/04 , C07C323/22 , C07C2601/02 , C07D211/46 , C07D211/58 , C07D213/64 , C07D333/22
摘要： Tertiary amines of the formula wherein A1, A2, A3, A4, M, p, T and Q are as defined herein, and acid addition salts thereof, have antimycotic and cholesterol-lowering activity.
摘要翻译： 式Al，A2，A3，A4，M，p，T和Q的叔胺如本文所定义，并且其酸加成盐具有抗真菌和降低胆固醇的活性。
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公开(公告)号：US6034275A
公开(公告)日：2000-03-07
申请号：US762827
申请日：1996-12-06
申请人： Johannes Aebi , Henrietta Dehmlow , Jacques Himber , Synese Jolidon , Hans Lengsfeld , Olivier Morand , Gerard Schmid , Ku-Hua Ji
发明人： Johannes Aebi , Henrietta Dehmlow , Jacques Himber , Synese Jolidon , Hans Lengsfeld , Olivier Morand , Gerard Schmid , Ku-Hua Ji
IPC分类号： C07D249/08 , A61K31/135 , A61K31/15 , A61K31/165 , A61K31/275 , A61K31/35 , A61K31/351 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/44 , A61K31/4402 , A61K31/4418 , A61K31/445 , A61P3/06 , A61P9/00 , A61P31/04 , A61P31/10 , C07C211/08 , C07C211/15 , C07C211/16 , C07C217/20 , C07C217/46 , C07C217/52 , C07C217/76 , C07C225/22 , C07C235/78 , C07C235/84 , C07C237/06 , C07C255/56 , C07C255/58 , C07C311/04 , C07C317/16 , C07C323/10 , C07C323/22 , C07C323/25 , C07D207/08 , C07D211/46 , C07D211/58 , C07D213/64 , C07D233/60 , C07D257/04 , C07D309/12 , C07D333/20 , C07D333/22 , C07C213/00
CPC分类号： C07C323/25 , C07C217/20 , C07C217/46 , C07C217/52 , C07C235/78 , C07C235/84 , C07C255/56 , C07C311/04 , C07C323/22 , C07D211/46 , C07D211/58 , C07D213/64 , C07D333/22 , C07C2101/02
摘要： Tertiary amines of the formula ##STR1## wherein A.sup.1, A.sup.2, A.sup.3, A.sup.4, L, M, p, T, and Q are as defined herein, have antimycotic and cholesterol-lowering activity.
摘要翻译： 下式的叔胺其中A1，A2，A3，A4，L，M，p，T和Q如本文所定义，具有抗真菌和降低胆固醇的活性。
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公开(公告)号：US20070099985A1
公开(公告)日：2007-05-03
申请号：US11634573
申请日：2006-12-06
IPC分类号： A61K31/381 , C07D333/72
CPC分类号： C07D417/12 , C07D231/12 , C07D233/56 , C07D249/08 , C07D275/04 , C07D275/06 , C07D333/54 , C07D409/12
摘要： The present invention relates to heteroaromate OSC inhibitors. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
摘要翻译： 本发明涉及异离子OSC抑制剂。 该化合物可用于治疗和/或预防与2,3-氧化山梨醇 - 羊毛甾醇环化酶如高胆固醇血症，高脂血症，动脉硬化，血管疾病，霉菌病，胆结石，肿瘤和/或过度增殖性疾病相关的疾病，以及治疗和 /或预防糖耐量异常和糖尿病。
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公开(公告)号：US06858651B2
公开(公告)日：2005-02-22
申请号：US09925188
申请日：2001-08-09
申请人： Jean Ackermann , Johannes Aebi , Denise Blum , Alexander Chucholowski , Henrietta Dehmlow , Hans-Peter Maerki , Olivier Morand , Rene Trussardi , Elisabeth von der Mark , Sabine Wallbaum , Thomas Weller
发明人： Jean Ackermann , Johannes Aebi , Denise Blum , Alexander Chucholowski , Henrietta Dehmlow , Hans-Peter Maerki , Olivier Morand , Rene Trussardi , Elisabeth von der Mark , Sabine Wallbaum , Thomas Weller
IPC分类号： C07D295/08 , A61K31/135 , A61K31/16 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/18 , A61K31/223 , A61K31/255 , A61K31/27 , A61K31/277 , A61K31/341 , A61K31/351 , A61K31/36 , A61K31/381 , A61K31/397 , A61K31/40 , A61K31/404 , A61K31/4164 , A61K31/42 , A61K31/44 , A61K31/4402 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/5375 , A61K31/54 , A61P1/16 , A61P3/06 , A61P3/10 , A61P9/10 , A61P31/10 , A61P33/00 , A61P35/00 , C07C233/23 , C07C233/74 , C07C235/54 , C07C235/84 , C07C255/57 , C07C269/04 , C07C271/24 , C07C271/52 , C07C271/56 , C07C275/26 , C07C275/28 , C07C275/30 , C07C275/34 , C07C275/38 , C07C275/40 , C07C291/04 , C07C303/38 , C07C307/08 , C07C307/10 , C07C311/07 , C07C311/13 , C07C311/20 , C07C335/14 , C07C335/16 , C07C335/18 , C07C335/22 , C07D205/04 , C07D207/12 , C07D209/42 , C07D211/14 , C07D211/22 , C07D211/44 , C07D211/70 , C07D213/81 , C07D215/36 , C07D233/84 , C07D261/10 , C07D295/092 , C07D295/135 , C07D295/14 , C07D307/38 , C07D309/12 , C07D317/58 , C07D333/24 , C07D333/34 , C07D333/40 , A61K31/14 , C07C43/20
CPC分类号： C07D295/088 , C07C233/23 , C07C233/74 , C07C235/54 , C07C235/84 , C07C255/57 , C07C271/52 , C07C271/56 , C07C275/26 , C07C275/28 , C07C275/30 , C07C275/34 , C07C275/38 , C07C275/40 , C07C291/04 , C07C307/08 , C07C307/10 , C07C311/07 , C07C311/13 , C07C311/20 , C07C335/14 , C07C335/16 , C07C335/18 , C07C335/22 , C07C2601/02 , C07C2601/14 , C07D295/135
摘要： The present invention relates to aminocyclohexanol derivatives useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
摘要翻译： 本发明涉及可用于治疗和/或预防与2,3-氧化山梨醇 - 羊毛甾醇环化酶如高胆固醇血症，高脂血症，动脉硬化，血管疾病，真菌病，胆结石，肿瘤和/或过度增殖性疾病相关的疾病的氨基环己醇衍生物 ，以及治疗和/或预防糖耐量异常和糖尿病。
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公开(公告)号：US06706751B2
公开(公告)日：2004-03-16
申请号：US10014959
申请日：2001-12-11
申请人： Johannes Aebi , Jean Ackermann , Alexander Chucholowski , Henrietta Dehmlow , Olivier Morand , Sabine Wallbaum , Thomas Weller , Narendra Panday
发明人： Johannes Aebi , Jean Ackermann , Alexander Chucholowski , Henrietta Dehmlow , Olivier Morand , Sabine Wallbaum , Thomas Weller , Narendra Panday
IPC分类号： A61P4300
CPC分类号： C07D215/20 , C07D209/08
摘要： The present invention relates to novel dihydroindole and tetrahydroquinoline derivatives and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
摘要翻译： 本发明涉及新的二氢吲哚和四氢喹啉衍生物及其药学上可接受的盐和/或其药学上可接受的酯。 该化合物可用于治疗和/或预防与2,3-氧化山梨醇 - 羊毛甾醇环化酶如高胆固醇血症，高脂血症，动脉硬化，血管疾病，霉菌病，胆结石，肿瘤和/或过度增殖性疾病相关的疾病，以及治疗和 /或预防糖耐量异常和糖尿病。
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公开(公告)号：US06683201B2
公开(公告)日：2004-01-27
申请号：US09906214
申请日：2001-07-16
申请人： Jean Ackermann , Johannes Aebi , Alexander Chucholowski , Henrietta Dehmlow , Olivier Morand , Sabine Wallbaum , Thomas Weller
发明人： Jean Ackermann , Johannes Aebi , Alexander Chucholowski , Henrietta Dehmlow , Olivier Morand , Sabine Wallbaum , Thomas Weller
IPC分类号： C07C22900
CPC分类号： C07D213/75 , C07C233/29 , C07C233/75 , C07C235/56 , C07C235/84 , C07C255/57 , C07C271/28 , C07C271/58 , C07C275/34 , C07C275/38 , C07C307/10 , C07C311/13 , C07C311/21 , C07C311/29 , C07C323/44 , C07C335/18 , C07C335/22 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/42 , C07C2603/18 , C07D207/14 , C07D207/20 , C07D209/42 , C07D211/22 , C07D211/42 , C07D211/46 , C07D211/70 , C07D213/81 , C07D213/82 , C07D215/36 , C07D239/42 , C07D261/10 , C07D295/088 , C07D307/14 , C07D307/52 , C07D317/58 , C07D319/18 , C07D333/24 , C07D333/34 , C07D333/38
摘要： The present invention relates to compounds of formula (I) wherein U, Y, V, W, L, X, A1, A2, A3, A4, A5 and A6 are as defined in the description and claims and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, parasite infections, gallstones, tumors and/or hyperproliferative disorders, and/or treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
摘要翻译： 本发明涉及式（I）化合物，其中U，Y，V，W，L，X，A 1，A 2，A 3，A 4，A 5和A <6>如说明书和权利要求及其药学上可接受的盐和/或其药学上可接受的酯所定义。 该化合物可用于治疗和/或预防与2,3-氧化山梨醇 - 羊毛甾醇环化酶相关的疾病，例如高胆固醇血症，高脂血症，动脉硬化，血管疾病，真菌病，寄生虫感染，胆结石，肿瘤和/或过度增殖性疾病， 和/或治疗和/或预防糖耐量异常和糖尿病。
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公开(公告)号：US06503907B2
公开(公告)日：2003-01-07
申请号：US09998882
申请日：2001-11-20
申请人： Jean Ackermann , Johannes Aebi , Henrietta Dehmlow , Olivier Morand , Narendra Panday , Thomas Weller
发明人： Jean Ackermann , Johannes Aebi , Henrietta Dehmlow , Olivier Morand , Narendra Panday , Thomas Weller
IPC分类号： A61K31535
CPC分类号： C07D401/12 , C07D209/08 , C07D403/12 , C07D417/12
摘要： The present invention relates to indole derivatives, dihydroindole derivatives and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
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公开(公告)号：US07173043B2
公开(公告)日：2007-02-06
申请号：US11178164
申请日：2005-07-08
IPC分类号： A61K31/4453 , A61K31/428 , A61K31/381 , C07D417/10 , C07D275/04 , C07D333/58
CPC分类号： C07D417/12 , C07D231/12 , C07D233/56 , C07D249/08 , C07D275/04 , C07D275/06 , C07D333/54 , C07D409/12
摘要： The present invention relates to heteroaromate OSC inhibitors. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
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公开(公告)号：US07102007B2
公开(公告)日：2006-09-05
申请号：US10648451
申请日：2003-08-26
申请人： Johannes Aebi , Jean Ackermann , Alexander Chucholowski , Henrietta Dehmlow , Olivier Morand , Sabine Wallbaum , Thomas Weller , Narendra Panday
发明人： Johannes Aebi , Jean Ackermann , Alexander Chucholowski , Henrietta Dehmlow , Olivier Morand , Sabine Wallbaum , Thomas Weller , Narendra Panday
IPC分类号： C07D215/02 , A61K31/47
CPC分类号： C07D215/20 , C07D209/08
摘要： The present invention relates to novel dihydroindole and tetrahydroquinoline derivatives and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
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