公开(公告)号：US20050070692A1

公开(公告)日：2005-03-31

申请号：US10503504

申请日：2003-02-20

申请人： John Beals ,  Lihua Huang ,  Jirong Lu ,  Derrick Witcher

发明人： John Beals ,  Lihua Huang ,  Jirong Lu ,  Derrick Witcher

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61P19/02 ,  A61P19/04 ,  A61P29/00 ,  C07K16/24 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12P21/08 ,  C07K16/44

CPC分类号： C07K16/245 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/76

摘要： The present invention encompasses analogs of humanized antibody Hu007 that neutralize IL-1β activity in vivo. These antibodies can be used to treat various diseases such as rheumatoid arthritis and osteoarthritis.

摘要翻译： 本发明包括在体内中和IL-1β活性的人源化抗体Hu007的类似物。 这些抗体可用于治疗各种疾病，例如类风湿性关节炎和骨关节炎。

公开(公告)号：US20080269467A1

公开(公告)日：2008-10-30

申请号：US12095398

申请日：2006-12-05

申请人： Barrett Allan ,  Chi-Kin Chow ,  Lihua Huang ,  Ling Liu ,  Jirong Lu ,  Kingman Ng ,  Jonathan Wendell Tetreault ,  Andrew Gordon Werner

发明人： Barrett Allan ,  Chi-Kin Chow ,  Lihua Huang ,  Ling Liu ,  Jirong Lu ,  Kingman Ng ,  Jonathan Wendell Tetreault ,  Andrew Gordon Werner

IPC分类号： C07K16/24

CPC分类号： C07K16/244 ,  A61K2039/505 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92

摘要： Anti-IL-17 antibodies are identified that are characterized as having a high affinity and slow off rate for human IL-17. The antibodies of the invention may be chimeric, humanized or fully human antibodies, immunoconjugates of the antibodies or antigen-binding fragments thereof. The antibodies of the invention are useful in particular for treating autoimmune, inflammatory, cell proliferative and developmental disorders.

摘要翻译： 鉴定出抗IL-17抗体的特征在于对人IL-17具有高亲和力和缓慢的速率。 本发明的抗体可以是嵌合，人源化或完全人抗体，抗体的免疫偶联物或其抗原结合片段。 本发明的抗体特别用于治疗自身免疫性，炎症性，细胞增殖性和发育性疾病。

公开(公告)号：USD930314S1

公开(公告)日：2021-09-07

申请号：US29712292

申请日：2019-11-07

申请人： Lihua Huang

设计人： Lihua Huang

公开(公告)号：US07655627B2

公开(公告)日：2010-02-02

申请号：US11718636

申请日：2005-12-07

申请人： Christopher Carl Frye ,  Lihua Huang ,  Radmila Micanovic

发明人： Christopher Carl Frye ,  Lihua Huang ,  Radmila Micanovic

IPC分类号： C07K14/50 ,  A61K38/18

CPC分类号： C07K14/50 ,  A61K38/00

摘要： The present invention relates to novel muteins of human fibroblast growth factor 21 with reduced deamidation compared to wild-type human FGF-21. Both protein and the respective encoding nucleic acid species are disclosed. The invention also embodies vectors and host cells for the propagation of said nucleic acid sequences and the production of said muteins. Also disclosed are methods for treating type 2 diabetes, obesity, or metabolic syndrome.

摘要翻译： 本发明涉及与野生型人FGF-21相比，减少脱酰胺的人成纤维细胞生长因子21的新颖突变蛋白。 公开了蛋白质和各自编码的核酸物质。 本发明还体现了用于扩增所述核酸序列和产生所述突变蛋白的载体和宿主细胞。 还公开了治疗2型糖尿病，肥胖症或代谢综合征的方法。

公开(公告)号：US20060105106A1

公开(公告)日：2006-05-18

申请号：US11055936

申请日：2005-02-11

申请人： Mihaela Balseanu ,  Kee Jung ,  Lihua Huang ,  Li-Qun Xia ,  Rongping Wang ,  Derek Witty ,  Lewis Stern ,  Martin Seamons ,  Hichem M'Saad ,  Michael Kwan

发明人： Mihaela Balseanu ,  Kee Jung ,  Lihua Huang ,  Li-Qun Xia ,  Rongping Wang ,  Derek Witty ,  Lewis Stern ,  Martin Seamons ,  Hichem M'Saad ,  Michael Kwan

IPC分类号： C23C16/00 ,  B05D3/00 ,  H05H1/24

CPC分类号： H01L21/0217 ,  C23C16/345 ,  C23C16/5096 ,  C23C16/56 ,  H01J37/32082 ,  H01L21/02274 ,  H01L21/3105 ,  H01L21/3185 ,  H01L2924/0002 ,  H01L2924/00

摘要： A stressed film is formed on a substrate. The substrate is placed in a process zone and a plasma is formed of a process gas provided in the process zone, the process gas having silicon-containing gas and nitrogen-containing gas. A diluent gas such as nitrogen can also be added. The as-deposited stressed material can be exposed to ultraviolet radiation or electron beams to increase the stress value of the deposited material. In addition or in the alternative, a nitrogen plasma treatment can be used to increase the stress value of the material during deposition. Pulsed plasma methods to deposit stressed materials are also described.

摘要翻译： 在基板上形成应力膜。 将基板放置在处理区中，并且等离子体由设置在处理区中的工艺气体形成，工艺气体具有含硅气体和含氮气体。 还可以加入稀释气体如氮气。 沉积的应力材料可以暴露于紫外线辐射或电子束以增加沉积材料的应力值。 另外或替代地，可以使用氮等离子体处理来增加沉积期间材料的应力值。 还描述了用于沉积应力材料的脉冲等离子体方法。

公开(公告)号：US08173974B2

公开(公告)日：2012-05-08

申请号：US12869788

申请日：2010-08-27

申请人： Yan Zheng ,  Jingyu Bian ,  Shufan Geng ,  Ruifu Yang ,  Lei Zhou ,  Huijie Huang ,  Youbao Zhang ,  Lihua Huang

发明人： Yan Zheng ,  Jingyu Bian ,  Shufan Geng ,  Ruifu Yang ,  Lei Zhou ,  Huijie Huang ,  Youbao Zhang ,  Lihua Huang

IPC分类号： G01J1/58

CPC分类号： G01N21/6428 ,  B82Y15/00 ,  B82Y20/00 ,  G01N2021/6441 ,  G01N2201/06193

摘要： A method of indirect emission by nano-materials includes providing an infrared up-conversion phosphor 1 (weight ratio) and a long-wave ultraviolet phosphor 0.01-10 (weight ratio); treating both surfaces of the infrared up-conversion phosphor and the long-wave ultraviolet phosphor; mixing the infrared up-conversion phosphor and the long-wave ultraviolet phosphor; exciting the infrared up-conversion phosphor by a near-infrared laser with a wavelength of 980 mn to emit blue light as a secondary excitation lightsource; exciting the long-wave ultraviolet phosphor by the blue light to emit a visible light. Biological reactions can be conveniently detected by detecting the visible light.

摘要翻译： 纳米材料间接发射的方法包括提供红外线上转换荧光体1（重量比）和长波紫外线荧光粉0.01-10（重量比）; 处理红外线上变换荧光体和长波紫外线荧光体的两面; 混合红外线上转换荧光体和长波紫外线荧光体; 通过波长980nm的近红外激光激发红外上转换荧光体，发射蓝光作为次级激发光源; 通过蓝光激发长波紫外线荧光体发出可见光。 通过检测可见光可以方便地检测生物反应。

公开(公告)号：US08063188B2

公开(公告)日：2011-11-22

申请号：US12376390

申请日：2007-08-23

申请人： Robert Owen Sayers ,  Lihua Huang

发明人： Robert Owen Sayers ,  Lihua Huang

IPC分类号： C07K16/24 ,  C07K16/00 ,  A61K39/395

CPC分类号： C07K16/22 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92

摘要： Monoclonal anti-myostatin antibodies that preferentially bind myostatin over GDF-11, have strong binding affinity to myostatin and are resistant to chemical degradation. The antibodies of the invention are useful for increasing muscle mass, increasing bone density, or for the treatment or prevention of various disorders in mammalian and avian species.

摘要翻译： 优先结合肌肉生长抑制素的GDF-11单克隆抗肌生成抑制素抗体对肌生成抑制素具有强烈的结合亲和力，并且对化学降解具有抗性。 本发明的抗体可用于增加肌肉质量，增加骨密度，或用于治疗或预防哺乳动物和禽类物种中的各种疾病。

公开(公告)号：US20100270176A1

公开(公告)日：2010-10-28

申请号：US12667507

申请日：2007-07-04

申请人： Guangxin Xiang ,  Liangbin Pan ,  Wanli Xing ,  Lihua Huang ,  Zhongyao Yu ,  Jing Zhu ,  Yuxiang Zhou ,  Jing Cheng

发明人： Guangxin Xiang ,  Liangbin Pan ,  Wanli Xing ,  Lihua Huang ,  Zhongyao Yu ,  Jing Zhu ,  Yuxiang Zhou ,  Jing Cheng

IPC分类号： G01N33/50 ,  G01N27/26

CPC分类号： G01N33/4836 ,  B01J2219/00653 ,  B01J2219/00743 ,  B01L3/502707 ,  B01L2300/0645 ,  B01L2400/0421 ,  B01L2400/0424

摘要： A microelectrode sensing device includes a substrate and an array of microelectrode sensors. Each sensor includes a first conductive layer that at least partially conducts electricity. The first conductive layer is formed above the substrate and patterned to include a recording electrode that measures electrical activities of target cells. Each sensor also includes a second conductive layer that at least partially conducts electricity. The second conductive layer is elevated above the first layer and patterned to include multiple positioning electrodes arranged to define a sensing region above the recording electrode. The positioning electrodes are designed to generate an electric field pattern in the sensing region to move and confine the target cells to a sub-region of the sensing region that at least partially overlaps the recording electrode.

摘要翻译： 微电极感测装置包括基板和微电极传感器阵列。 每个传感器包括至少部分地导电的第一导电层。 第一导电层形成在衬底上并被图案化以包括测量靶细胞的电活动的记录电极。 每个传感器还包括至少部分地传导电的第二导电层。 第二导电层在第一层之上被升高并且被图案化以包括布置成限定记录电极上方的感测区域的多个定位电极。 定位电极被设计成在感测区域中产生电场图案以移动并将目标单元限制在至少部分地与记录电极重叠的感测区域的子区域上。

公开(公告)号：US20050202685A1

公开(公告)日：2005-09-15

申请号：US10801190

申请日：2004-03-15

申请人： Lihua Huang ,  Tzu-Fang Huang ,  Dian Sugiarto ,  Li-Qun Xia ,  Peter Lee ,  Hichem M'Saad ,  Zhenjiang Cui ,  Sohyun Park ,  Jerry Sugiarto

发明人： Lihua Huang ,  Tzu-Fang Huang ,  Dian Sugiarto ,  Li-Qun Xia ,  Peter Lee ,  Hichem M'Saad ,  Zhenjiang Cui ,  Sohyun Park ,  Jerry Sugiarto

IPC分类号： C23C16/02 ,  C23C16/32 ,  C23C16/40 ,  H01L21/316 ,  H01L21/768 ,  H01L21/31 ,  H01L21/469

CPC分类号： H01L21/31633 ,  C23C16/02 ,  C23C16/325 ,  C23C16/401 ,  H01L21/02126 ,  H01L21/02274 ,  H01L21/02304 ,  H01L21/76801 ,  H01L21/7681 ,  H01L21/76826 ,  H01L21/76832

摘要： Methods are provided for processing a substrate for depositing an adhesion layer having a low dielectric constant between two low k dielectric layers. In one aspect, the invention provides a method for processing a substrate including introducing an organosilicon compound and an oxidizing gas at a first ratio of organosilicon compound to oxidizing gas into the processing chamber, generating a plasma of the oxidizing gas and the organosilicon compound to form an initiation layer on a barrier layer comprising at least silicon and carbon, introducing the organosilicon compound and the oxidizing gas at a second ratio of organosilicon compound to oxidizing gas greater than the first ratio into the processing chamber, and depositing a first dielectric layer adjacent the dielectric initiation layer.

摘要翻译： 提供了用于处理用于沉积在两个低k电介质层之间具有低介电常数的粘合层的衬底的方法。 一方面，本发明提供一种处理基板的方法，包括以有机硅化合物的第一比例将有机硅化合物和氧化气体与氧化气体导入处理室，产生氧化气体的等离子体和有机硅化合物，形成 在至少包含硅和碳的阻挡层上的起始层，以有机硅化合物的第二比例将有机硅化合物和氧化气体与大于第一比例的氧化气体引入到处理室中，以及沉积与第 电介质起始层。

公开(公告)号：US08784633B2

公开(公告)日：2014-07-22

申请号：US12667507

申请日：2007-07-04

申请人： Guangxin Xiang ,  Liangbin Pan ,  Wanli Xing ,  Lihua Huang ,  Zhongyao Yu ,  Jing Zhu ,  Yuxiang Zhou ,  Jing Cheng

发明人： Guangxin Xiang ,  Liangbin Pan ,  Wanli Xing ,  Lihua Huang ,  Zhongyao Yu ,  Jing Zhu ,  Yuxiang Zhou ,  Jing Cheng

IPC分类号： G01N27/447 ,  G01N27/453

CPC分类号： G01N33/4836 ,  B01J2219/00653 ,  B01J2219/00743 ,  B01L3/502707 ,  B01L2300/0645 ,  B01L2400/0421 ,  B01L2400/0424

摘要： A microelectrode sensing device includes a substrate and an array of microelectrode sensors. Each sensor includes a first conductive layer that at least partially conducts electricity. The first conductive layer is formed above the substrate and patterned to include a recording electrode that measures electrical activities of target cells. Each sensor also includes a second conductive layer that at least partially conducts electricity. The second conductive layer is elevated above the first layer and patterned to include multiple positioning electrodes arranged to define a sensing region above the recording electrode. The positioning electrodes are designed to generate an electric field pattern in the sensing region to move and confine the target cells to a sub-region of the sensing region that at least partially overlaps the recording electrode.

摘要翻译： 微电极感测装置包括基板和微电极传感器阵列。 每个传感器包括至少部分地导电的第一导电层。 第一导电层形成在衬底上并被图案化以包括测量靶细胞的电活动的记录电极。 每个传感器还包括至少部分地传导电的第二导电层。 第二导电层在第一层之上被升高并且被图案化以包括布置成限定记录电极上方的感测区域的多个定位电极。 定位电极被设计成在感测区域中产生电场图案以移动并将目标单元限制在至少部分地与记录电极重叠的感测区域的子区域上。