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公开(公告)号：US08404198B2
公开(公告)日：2013-03-26
申请号：US12549311
申请日：2009-08-27
申请人： Joseph Amshey , Daniel Bezdek , Espir Kahatt , Alexander Khorlin , Lance Parsons , Todd Peterson , Timothy Powers , Michael Thacker , Timothy Updyke , Korneija Zgonc
发明人： Joseph Amshey , Daniel Bezdek , Espir Kahatt , Alexander Khorlin , Lance Parsons , Todd Peterson , Timothy Powers , Michael Thacker , Timothy Updyke , Korneija Zgonc
IPC分类号： B01L9/00
CPC分类号： B01L3/502715 , B01L3/50273 , B01L7/00 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/0689 , B01L2200/10 , B01L2200/16 , B01L2300/0636 , B01L2300/0681 , B01L2300/0867 , B01L2300/088 , B01L2300/123 , B01L2400/0481 , B01L2400/0487 , B01L2400/0605 , B01L2400/0655 , G01N2035/00306 , G01N2035/1037 , Y10T436/2575
摘要： The present invention provides systems, devices, apparatuses and methods for automated bioprocessing. Examples of protocols and bioprocessing procedures suitable for the present invention include but are not limited to: immunoprecipitation, chromatin immunoprecipitation, recombinant protein isolation, nucleic acid separation and isolation, protein labeling, separation and isolation, cell separation and isolation, food safety analysis and automatic bead based separation. In some embodiments, the invention provides automated systems, automated devices, automated cartridges and automated methods of western blot processing. Other embodiments include automated systems, automated devices, automated cartridges and automated methods for separation, preparation and purification of nucleic acids, such as DNA or RNA or fragments thereof, including plasmid DNA, genomic DNA, bacterial DNA, viral DNA and any other DNA, and for automated systems, automated devices, automated cartridges and automated methods for processing, separation and purification of proteins, peptides and the like.
摘要翻译： 本发明提供了用于自动化生物处理的系统，装置，装置和方法。 适用于本发明的方案和生物处理方法的实例包括但不限于：免疫沉淀，染色质免疫沉淀，重组蛋白分离，核酸分离和分离，蛋白标记，分离和分离，细胞分离和分离，食品安全分析和自动 珠基分离。 在一些实施方案中，本发明提供自动化系统，自动化装置，自动化盒和western印迹处理的自动化方法。 其他实施方案包括自动化系统，自动化装置，自动化盒和用于分离，制备和纯化核酸例如DNA或RNA或其片段的自动化方法，包括质粒DNA，基因组DNA，细菌DNA，病毒DNA和任何其它DNA， 以及用于自动化系统，自动化设备，自动化盒和用于处理，分离和纯化蛋白质，肽等的自动化盒和自动化方法。
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公开(公告)号：US08845984B2
公开(公告)日：2014-09-30
申请号：US13615500
申请日：2012-09-13
申请人： Joseph Amshey , Daniel Bezdek , Espir Kahatt , Alexander Khorlin , Lance Parsons , Todd Peterson , Timothy Powers , Michael Thacker , Timothy Updyke , Kornelija Zgonc
发明人： Joseph Amshey , Daniel Bezdek , Espir Kahatt , Alexander Khorlin , Lance Parsons , Todd Peterson , Timothy Powers , Michael Thacker , Timothy Updyke , Kornelija Zgonc
CPC分类号： B01L3/502715 , B01L3/50273 , B01L7/00 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/0689 , B01L2200/10 , B01L2200/16 , B01L2300/0636 , B01L2300/0681 , B01L2300/0867 , B01L2300/088 , B01L2300/123 , B01L2400/0481 , B01L2400/0487 , B01L2400/0605 , B01L2400/0655 , G01N2035/00306 , G01N2035/1037 , Y10T436/2575
摘要： The present invention provides systems, devices, apparatuses and methods for automated bioprocessing. Examples of protocols and bioprocessing procedures suitable for the present invention include but are not limited to: immunoprecipitation, chromatin immunoprecipitation, recombinant protein isolation, nucleic acid separation and isolation, protein labeling, separation and isolation, cell separation and isolation, food safety analysis and automatic bead based separation. In some embodiments, the invention provides automated systems, automated devices, automated cartridges and automated methods of western blot processing. Other embodiments include automated systems, automated devices, automated cartridges and automated methods for separation, preparation and purification of nucleic acids, such as DNA or RNA or fragments thereof, including plasmid DNA, genomic DNA, bacterial DNA, viral DNA and any other DNA, and for automated systems, automated devices, automated cartridges and automated methods for processing, separation and purification of proteins, peptides and the like.
摘要翻译： 本发明提供了用于自动化生物处理的系统，装置，装置和方法。 适用于本发明的方案和生物处理方法的实例包括但不限于：免疫沉淀，染色质免疫沉淀，重组蛋白分离，核酸分离和分离，蛋白标记，分离和分离，细胞分离和分离，食品安全分析和自动 珠基分离。 在一些实施方案中，本发明提供自动化系统，自动化装置，自动化盒和western印迹处理的自动化方法。 其他实施方案包括自动化系统，自动化装置，自动化盒和用于分离，制备和纯化核酸例如DNA或RNA或其片段的自动化方法，包括质粒DNA，基因组DNA，细菌DNA，病毒DNA和任何其它DNA， 以及用于自动化系统，自动化设备，自动化盒和用于处理，分离和纯化蛋白质，肽等的自动化盒和自动化方法。
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公开(公告)号：US20100120129A1
公开(公告)日：2010-05-13
申请号：US12549311
申请日：2009-08-27
申请人： Joseph Amshey , Daniel Bezdek , Espir Kahatt , Alexander Khorlin , Lance Parsons , Todd Peterson , Timothy Powers , Michael Thacker , Timothy Updyke , Kornelija Zgonc
发明人： Joseph Amshey , Daniel Bezdek , Espir Kahatt , Alexander Khorlin , Lance Parsons , Todd Peterson , Timothy Powers , Michael Thacker , Timothy Updyke , Kornelija Zgonc
CPC分类号： B01L3/502715 , B01L3/50273 , B01L7/00 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/0689 , B01L2200/10 , B01L2200/16 , B01L2300/0636 , B01L2300/0681 , B01L2300/0867 , B01L2300/088 , B01L2300/123 , B01L2400/0481 , B01L2400/0487 , B01L2400/0605 , B01L2400/0655 , G01N2035/00306 , G01N2035/1037 , Y10T436/2575
摘要： The present invention provides systems, devices, apparatuses and methods for automated bioprocessing. Examples of protocols and bioprocessing procedures suitable for the present invention include but are not limited to: immunoprecipitation, chromatin immunoprecipitation, recombinant protein isolation, nucleic acid separation and isolation, protein labeling, separation and isolation, cell separation and isolation, food safety analysis and automatic bead based separation. In some embodiments, the invention provides automated systems, automated devices, automated cartridges and automated methods of western blot processing. Other embodiments include automated systems, automated devices, automated cartridges and automated methods for separation, preparation and purification of nucleic acids, such as DNA or RNA or fragments thereof, including plasmid DNA, genomic DNA, bacterial DNA, viral DNA and any other DNA, and for automated systems, automated devices, automated cartridges and automated methods for processing, separation and purification of proteins, peptides and the like.
摘要翻译： 本发明提供了用于自动化生物处理的系统，装置，装置和方法。 适用于本发明的方案和生物处理方法的实例包括但不限于：免疫沉淀，染色质免疫沉淀，重组蛋白分离，核酸分离和分离，蛋白标记，分离和分离，细胞分离和分离，食品安全分析和自动 珠基分离。 在一些实施方案中，本发明提供自动化系统，自动化装置，自动化盒和western印迹处理的自动化方法。 其他实施方案包括自动化系统，自动化装置，自动化盒和用于分离，制备和纯化核酸例如DNA或RNA或其片段的自动化方法，包括质粒DNA，基因组DNA，细菌DNA，病毒DNA和任何其它DNA， 以及用于自动化系统，自动化设备，自动化盒和用于处理，分离和纯化蛋白质，肽等的自动化盒和自动化方法。
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公开(公告)号：US20130040376A1
公开(公告)日：2013-02-14
申请号：US13615500
申请日：2012-09-13
申请人： Joseph AMSHEY , Daniel Bezdek , Espir Kahatt , Alexander Khorlin , Lance Parsons , Todd Peterson , Timothy Powers , Michael Tacher , Timothy Updyke , Kornelija Zgonc
发明人： Joseph AMSHEY , Daniel Bezdek , Espir Kahatt , Alexander Khorlin , Lance Parsons , Todd Peterson , Timothy Powers , Michael Tacher , Timothy Updyke , Kornelija Zgonc
CPC分类号： B01L3/502715 , B01L3/50273 , B01L7/00 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/0689 , B01L2200/10 , B01L2200/16 , B01L2300/0636 , B01L2300/0681 , B01L2300/0867 , B01L2300/088 , B01L2300/123 , B01L2400/0481 , B01L2400/0487 , B01L2400/0605 , B01L2400/0655 , G01N2035/00306 , G01N2035/1037 , Y10T436/2575
摘要： The present invention provides systems, devices, apparatuses and methods for automated bioprocessing. Examples of protocols and bioprocessing procedures suitable for the present invention include but are not limited to: immunoprecipitation, chromatin immunoprecipitation, recombinant protein isolation, nucleic acid separation and isolation, protein labeling, separation and isolation, cell separation and isolation, food safety analysis and automatic bead based separation. In some embodiments, the invention provides automated systems, automated devices, automated cartridges and automated methods of western blot processing. Other embodiments include automated systems, automated devices, automated cartridges and automated methods for separation, preparation and purification of nucleic acids, such as DNA or RNA or fragments thereof, including plasmid DNA, genomic DNA, bacterial DNA, viral DNA and any other DNA, and for automated systems, automated devices, automated cartridges and automated methods for processing, separation and purification of proteins, peptides and the like.
摘要翻译： 本发明提供了用于自动化生物处理的系统，装置，装置和方法。 适用于本发明的方案和生物处理方法的实例包括但不限于：免疫沉淀，染色质免疫沉淀，重组蛋白分离，核酸分离和分离，蛋白标记，分离和分离，细胞分离和分离，食品安全分析和自动 珠基分离。 在一些实施方案中，本发明提供自动化系统，自动化装置，自动化盒和western印迹处理的自动化方法。 其他实施方案包括自动化系统，自动化装置，自动化盒和用于分离，制备和纯化核酸例如DNA或RNA或其片段的自动化方法，包括质粒DNA，基因组DNA，细菌DNA，病毒DNA和任何其它DNA， 以及用于自动化系统，自动化设备，自动化盒和用于处理，分离和纯化蛋白质，肽等的自动化盒和自动化方法。
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公开(公告)号：US20120196304A1
公开(公告)日：2012-08-02
申请号：US13311519
申请日：2011-12-05
申请人： Robert DEES , Dale Dembrow , Brent Henry , Espir Kahatt , James Meegan , Timothy Powers , Steven Roman , Jeffrey Rossio
发明人： Robert DEES , Dale Dembrow , Brent Henry , Espir Kahatt , James Meegan , Timothy Powers , Steven Roman , Jeffrey Rossio
CPC分类号： G01N33/54373
摘要： The present invention relates to, in part, methods, reagents and apparatuses for the detection of agents. The present invention also relates, in part, to compositions including, but not limited to, flow cells, assay chambers, reagent reservoir delivery units and devices for holding an assay chamber. The present invention also provides various components and combinations of components for various detection apparatuses. The present invention also relates to a portable agent detection apparatus that can be used in the field or at a point of care and is not limited to specialized laboratories or limited to use by highly skilled users.
摘要翻译： 本发明部分涉及用于检测试剂的方法，试剂和装置。 本发明还部分涉及包括但不限于流动池，测定室，试剂储存器输送单元和用于保持测定室的装置的组合物。 本发明还提供了用于各种检测装置的各种部件和组件的组合。 本发明还涉及一种便携式检测装置，其可以在现场使用或在一个关注点处使用，并且不限于专门的实验室或被高技能用户使用。
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公开(公告)号：US20100285490A1
公开(公告)日：2010-11-11
申请号：US11966747
申请日：2007-12-28
申请人： Robert Dees , Dale Dembrow , Brent Henry , Espir Kahatt , James Meegan , Timothy Powers , Steven Roman , Jeffrey Rossio
发明人： Robert Dees , Dale Dembrow , Brent Henry , Espir Kahatt , James Meegan , Timothy Powers , Steven Roman , Jeffrey Rossio
CPC分类号： G01N33/54373
摘要： The present invention relates to, in part, methods, reagents and apparatuses for the detection of agents. The present invention also relates, in part, to compositions including, but not limited to, flow cells, assay chambers, reagent reservoir delivery units and devices for holding an assay chamber. The present invention also provides various components and combinations of components for various detection apparatuses. The present invention also relates to a portable agent detection apparatus that can be used in the field or at a point of care and is not limited to specialized laboratories or limited to use by highly skilled users.
摘要翻译： 本发明部分涉及用于检测试剂的方法，试剂和装置。 本发明还部分涉及包括但不限于流动池，测定室，试剂储存器输送单元和用于保持测定室的装置的组合物。 本发明还提供了用于各种检测装置的各种部件和组件的组合。 本发明还涉及一种便携式检测装置，其可以在现场使用或在一个关注点处使用，并且不限于专门的实验室或被高技能用户使用。
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公开(公告)号：US20140064456A1
公开(公告)日：2014-03-06
申请号：US13602080
申请日：2012-08-31
申请人： Yun Zou , Scott Stephen Zelakiewicz , Floribertus P. M. Heukensfeldt Jansen , Jeffrey Wayne Eberhard , Fengfeng Tao , Timothy Powers , Thomas Edmund Sjoberg
发明人： Yun Zou , Scott Stephen Zelakiewicz , Floribertus P. M. Heukensfeldt Jansen , Jeffrey Wayne Eberhard , Fengfeng Tao , Timothy Powers , Thomas Edmund Sjoberg
IPC分类号： H01J35/30
CPC分类号： H01J35/28 , H01J35/025 , H01J35/14
摘要： A motion correction system and method for motion correction for an x-ray tube is presented. One embodiment of the motion correction system includes a sensing unit coupled to an x-ray tube to determine a distance with which an impingement location of an electron beam generated by the x-ray tube deviates from a determined location due to motion of the x-ray tube. The motion correction system further includes a control unit coupled to the sensing unit to generate a control signal corresponding to the distance with which the impingement location of the electron beam deviates. Also, the motion correction system includes a deflection unit coupled to the control unit to steer the electron beam to the determined location based on the generated control signal.
摘要翻译： 提出了用于X射线管的运动校正系统和运动校正方法。 运动校正系统的一个实施例包括耦合到X射线管的感测单元，以确定由x射线管产生的电子束的冲击位置由于X射线管的运动而偏离确定的位置的距离， 射线管。 运动校正系统还包括耦合到感测单元的控制单元，以产生对应于电子束的冲击位置偏离的距离的控制信号。 此外，运动校正系统包括耦合到控制单元的偏转单元，以基于所生成的控制信号将电子束转向确定的位置。
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公开(公告)号：US20070155739A1
公开(公告)日：2007-07-05
申请号：US11646650
申请日：2006-12-28
申请人： Irving Sucholeiki , Timothy Powers , Christian Gege , Harald Bluhm , Rory Dodd , Hongbo Deng , Xinyuan Wu , Christoph Steeneck
发明人： Irving Sucholeiki , Timothy Powers , Christian Gege , Harald Bluhm , Rory Dodd , Hongbo Deng , Xinyuan Wu , Christoph Steeneck
IPC分类号： A61K31/5383 , A61K31/5377 , A61K31/506 , C07D491/02 , C07D413/02 , C07D403/02
CPC分类号： C07D403/12 , C07D239/28 , C07D409/12 , C07D417/12
摘要： This invention relates to substituted bis-amide pyrimidine compounds of Formula (I), which are useful for the treatment of metalloprotease mediated diseases, in particular MMP-13 related diseases.
摘要翻译： 本发明涉及式（I）的取代双酰胺嘧啶化合物，其可用于治疗金属蛋白酶介导的疾病，特别是MMP-13相关疾病。
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公开(公告)号：US20060293345A1
公开(公告)日：2006-12-28
申请号：US11440087
申请日：2006-05-22
申请人： Christoph Steeneck , Christian Gege , Frank Richter , Matthias Hochguertel , Tim Feuerstein , Harald Bluhm , Irving Sucholeiki , Jurgen Boer , Xinyuan Wu , Matthias Schneider , Bert Nolte , Brian Gallagher , Joshua Van Veldhuizen , Hongbo Dong , Michael Essers , Heiko Kroth , Andrew Kiely , Timothy Powers , Arthur Taveras
发明人： Christoph Steeneck , Christian Gege , Frank Richter , Matthias Hochguertel , Tim Feuerstein , Harald Bluhm , Irving Sucholeiki , Jurgen Boer , Xinyuan Wu , Matthias Schneider , Bert Nolte , Brian Gallagher , Joshua Van Veldhuizen , Hongbo Dong , Michael Essers , Heiko Kroth , Andrew Kiely , Timothy Powers , Arthur Taveras
IPC分类号： A61K31/519 , C07D491/04 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of heterobicyclic MMP-13 inhibiting compounds, that exhibit an increased potency in relation to currently known MMP-13 inhibitors.
摘要翻译： 本发明一般涉及含酰胺基的药剂，特别涉及含酰胺的杂双环金属蛋白酶抑制剂化合物。 更具体地说，本发明提供了一类新型的杂双环MMP-13抑制化合物，其表现出与目前已知的MMP-13抑制剂有关的效力。
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公开(公告)号：US6030917A
公开(公告)日：2000-02-29
申请号：US898715
申请日：1997-07-22
申请人： W. Henry Weinberg , Eric McFarland , Isy Goldwasser , Thomas Boussie , Howard Turner , Johannes A. M. Van Beek , Vince Murphy , Timothy Powers
发明人： W. Henry Weinberg , Eric McFarland , Isy Goldwasser , Thomas Boussie , Howard Turner , Johannes A. M. Van Beek , Vince Murphy , Timothy Powers
IPC分类号： B01J19/00 , C07B61/00 , C07F15/00 , C07F15/04 , C08F4/70 , C08F10/00 , C40B30/08 , C40B40/14 , C40B40/18 , C40B50/14 , C40B60/14 , G01J4/00 , G01N21/64 , G01N29/036 , G01N29/24 , G01N29/34 , G01N29/44 , B01J31/00 , B01J37/00 , C08F4/02
CPC分类号： G01N21/6402 , B01J19/0046 , B82Y30/00 , C07F15/0066 , C07F15/045 , C08F10/00 , G01J4/00 , G01N29/036 , G01N29/2425 , G01N29/348 , G01N29/4427 , B01J2219/00315 , B01J2219/00317 , B01J2219/00364 , B01J2219/00378 , B01J2219/0043 , B01J2219/00443 , B01J2219/00497 , B01J2219/005 , B01J2219/00511 , B01J2219/00515 , B01J2219/0052 , B01J2219/00527 , B01J2219/00536 , B01J2219/00583 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00637 , B01J2219/00644 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00702 , B01J2219/00722 , B01J2219/00738 , B01J2219/00745 , B01J2219/00747 , B01J2219/0075 , B01J2219/00754 , C40B30/08 , C40B40/14 , C40B40/18 , C40B50/14 , C40B60/14 , G01N2291/02818 , G01N2291/0423 , G01N2291/106
摘要： The present invention relates, inter alia, to methodologies for the synthesis, screening and characterization of organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention provide for the combinatorial synthesis, screening and characterization of libraries of supported and unsupported organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention can be applied to the preparation and screening of large numbers of organometallic compounds which can be used not only as catalysts (e.g., homogeneous catalysts), but also as additives and therapeutic agents.
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