公开(公告)号：US20100311070A1

公开(公告)日：2010-12-09

申请号：US12843552

申请日：2010-07-26

申请人： Kwang-wook OH ,  Jin-tae KIM ,  Kak NAMKOONG ,  Chin-sung PARK ,  Yoon-kyoung CHO

发明人： Kwang-wook OH ,  Jin-tae KIM ,  Kak NAMKOONG ,  Chin-sung PARK ,  Yoon-kyoung CHO

IPC分类号： C12Q1/68 ,  C12M1/34

CPC分类号： B01L7/52 ,  B01L3/502715 ,  B01L3/50851 ,  B01L2300/0627 ,  B01L2300/18

摘要： Provided are a PCR module and a multiple PCR system using the same. More particularly, provided are a PCR module with a combined PCR thermal cycler and PCR product detector, and a multiple PCR system using the same.

摘要翻译： 提供了PCR模块和使用该PCR模块的多重PCR系统。 更具体地，提供了具有组合的PCR热循环仪和PCR产物检测器的PCR模块，以及使用其的多重PCR系统。

公开(公告)号：US20120168016A1

公开(公告)日：2012-07-05

申请号：US13402271

申请日：2012-02-22

申请人： Kwang-wook OH ,  Kak NAMKOONG ,  Chin-sung PARK

发明人： Kwang-wook OH ,  Kak NAMKOONG ,  Chin-sung PARK

IPC分类号： F15C1/04 ,  F15C1/06 ,  F15C7/00 ,  F16K31/66

CPC分类号： F15C5/00 ,  F16K99/0001 ,  F16K99/0032 ,  F16K99/0044 ,  F16K99/0046 ,  F16K2099/0084 ,  F16K2099/0086 ,  F16K2099/0092 ,  Y10T137/0391 ,  Y10T137/2191 ,  Y10T137/2196 ,  Y10T137/2224 ,  Y10T137/4643

摘要： Provided is a microvalve having a magnetic wax plug which includes a micro fluidic structure having an inlet portion and an outlet portion, a magnetic wax plug provided at a predetermined 5 section where the inlet portion and the outlet portion meet, existing in a solid state, melted at a temperature higher than a predetermined temperature, and reversibly moving along a magnetic field, so as to control flux of a fluid through the micro fluidic structure, a heating portion provided corresponding to the section and heating the magnetic wax plug to be melted, and a magnetic field 10 application portion selectively applying a magnetic field to a position where the melted magnetic wax plug arrives.

摘要翻译： 本发明提供一种具有磁性蜡塞的微型阀，其包括具有入口部和出口部的微流体结构，以固态存在的入口部和出口部相遇的规定5部设置的磁性蜡塞， 在高于预定温度的温度下熔化，并且沿着磁场可逆地移动，以便控制通过微流体结构的流体的流量，对应于该部分设置的加热部分并加热待熔化的磁性蜡塞， 以及选择性地将磁场施加到熔融的磁性蜡塞到达的位置的磁场10施加部。

公开(公告)号：US20110079289A1

公开(公告)日：2011-04-07

申请号：US12968752

申请日：2010-12-15

申请人： Kwang-wook OH ,  Kak NAMKOONG ,  Chin-sung PARK

发明人： Kwang-wook OH ,  Kak NAMKOONG ,  Chin-sung PARK

IPC分类号： F15D1/00

CPC分类号： F15C5/00 ,  F16K99/0001 ,  F16K99/0032 ,  F16K99/0044 ,  F16K99/0046 ,  F16K2099/0084 ,  F16K2099/0086 ,  F16K2099/0092 ,  Y10T137/0391 ,  Y10T137/2191 ,  Y10T137/2196 ,  Y10T137/2224 ,  Y10T137/4643

摘要： Provided is a microvalve having a magnetic wax plug which includes a micro fluidic structure having an inlet portion and an outlet portion, a magnetic wax plug provided at a predetermined section where the inlet portion and the outlet portion meet, existing in a solid state, melted at a temperature higher than a predetermined temperature, and reversibly moving along a magnetic field, so as to control flux of a fluid through the micro fluidic structure, a heating portion provided corresponding to the section and heating the magnetic wax plug to be melted, and a magnetic field application portion selectively applying a magnetic field to a position where the melted magnetic wax plug arrives.

摘要翻译： 提供一种具有磁性蜡塞的微型阀，其包括具有入口部分和出口部分的微流体结构，设置在入口部分和出口部分相遇的预定部分处的固体状态的熔融蜡 在高于预定温度的温度下，并且沿着磁场可逆地移动，以便控制通过微流体结构的流体的通量;对应于该部分设置的加热部分，并加热待熔化的磁性蜡塞;以及 选择性地将磁场施加到熔融的磁性蜡塞到达的位置的磁场施加部。

公开(公告)号：US20090071542A1

公开(公告)日：2009-03-19

申请号：US12277780

申请日：2008-11-25

申请人： Kwang-wook OH ,  Kak NAMKOONG ,  Chin-sung PARK

发明人： Kwang-wook OH ,  Kak NAMKOONG ,  Chin-sung PARK

IPC分类号： F17D1/16

CPC分类号： F15C5/00 ,  F16K99/0001 ,  F16K99/0032 ,  F16K99/0044 ,  F16K99/0046 ,  F16K2099/0084 ,  F16K2099/0086 ,  F16K2099/0092 ,  Y10T137/0391 ,  Y10T137/2191 ,  Y10T137/2196 ,  Y10T137/2224 ,  Y10T137/4643

摘要： Provided is a microvalve having a magnetic wax plug which includes a micro fluidic structure having an inlet portion and an outlet portion, a magnetic wax plug provided at a predetermined section where the inlet portion and the outlet portion meet, existing in a solid state, melted at a temperature higher than a predetermined temperature, and reversibly moving along a magnetic field, so as to control flux of a fluid through the micro fluidic structure, a heating portion provided corresponding to the section and heating the magnetic wax plug to be melted, and a magnetic field application portion selectively applying a magnetic field to a position where the melted magnetic wax plug arrives.

摘要翻译： 提供一种具有磁性蜡塞的微型阀，其包括具有入口部分和出口部分的微流体结构，设置在入口部分和出口部分相遇的预定部分处的固体状态的熔融蜡 在高于预定温度的温度下，并且沿着磁场可逆地移动，以便控制通过微流体结构的流体的通量;对应于该部分设置的加热部分，并加热待熔化的磁性蜡塞;以及 选择性地将磁场施加到熔融的磁性蜡塞到达的位置的磁场施加部。

公开(公告)号：US20070152206A1

公开(公告)日：2007-07-05

申请号：US11617978

申请日：2006-12-29

申请人： Yoon-kyoung CHO ,  Sung-young JEONG ,  Kak NAMKOONG ,  Chin-sung PARK

发明人： Yoon-kyoung CHO ,  Sung-young JEONG ,  Kak NAMKOONG ,  Chin-sung PARK

IPC分类号： H01L29/06

CPC分类号： B03C5/005 ,  B03C5/026

摘要： A device and method for manipulating particles using dielectrophoresis are disclosed. The device comprises a chamber comprising an inlet port, an outlet port, and metal post electrodes, and a power supply, wherein the metal post electrodes are arranged in at least two rows in a vertical position with respect to the flow of fluids, each row comprises at least two metal post electrodes, each odd row is wired to a metal pad through a metal line, and each even row is wired to another metal pad through a metal line, and the power supply is connected to the metal pads.

摘要翻译： 公开了一种使用介电电泳操作颗粒的装置和方法。 该装置包括一个包括入口端口，出口端口和金属柱状电极以及电源的腔室，其中金属柱状电极相对于流体流沿垂直位置布置成至少两排，每排 包括至少两个金属柱电极，每个奇数行通过金属线连接到金属焊盘，并且每个偶数行通过金属线连接到另一个金属焊盘，并且电源连接到金属焊盘。

公开(公告)号：US20090057599A1

公开(公告)日：2009-03-05

申请号：US12023197

申请日：2008-01-31

申请人： Kak NAMKOONG ,  Chin-sung PARK ,  Jin-tae KIM ,  Joo-won RHEE

发明人： Kak NAMKOONG ,  Chin-sung PARK ,  Jin-tae KIM ,  Joo-won RHEE

IPC分类号： F16K31/00 ,  F16K7/00

CPC分类号： F16K99/0001 ,  Y10T137/87434 ,  Y10T137/877

摘要： An elastic valve and a microfluidic device including the same are provided. The elastic valve includes a channel dented by external pressure so as to be elastically restituted; and a plurality of channel closing protrusions, which comprise elastomer as a material, which are protruded from at least one inner side surface of the channel toward an opposite inner side surface, and which are separated from each other so as not to interrupt a flow of fluids, wherein, when external pressure is applied in order to dent the channel, the plurality of channel closing protrusions are deformed so as to be elastically restituted, thereby closing the channel.

摘要翻译： 提供弹性阀和包括该弹性阀的微流体装置。 弹性阀包括通过外部压力凹陷以便被弹性恢复的通道; 以及多个通道闭合突起，其包括弹性体作为材料，其从所述通道的至少一个内侧表面突出到相对的内侧表面，并且彼此分离，以便不会中断流动 流体，其中当施加外部压力以凹陷通道时，多个通道关闭突起变形以便被弹性地恢复，从而关闭通道。

公开(公告)号：US20110033919A1

公开(公告)日：2011-02-10

申请号：US12904557

申请日：2010-10-14

申请人： Kak NAMKOONG ,  Su-hyeon KIM ,  Jin-tae KIM ,  Chin-sung PARK ,  Young-sun LEE

发明人： Kak NAMKOONG ,  Su-hyeon KIM ,  Jin-tae KIM ,  Chin-sung PARK ,  Young-sun LEE

IPC分类号： C12M1/40

CPC分类号： B81B3/0081 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/00873 ,  B01L3/5027 ,  B01L7/5255 ,  B01L2200/14 ,  B01L2200/147 ,  B01L2300/1805 ,  B01L2300/1827 ,  B81B2201/051 ,  F28F21/02 ,  F28F2013/006

摘要： A method of reducing a temperature difference between a high-temperature and a low-temperature substrate includes interposing a heat transfer facilitating layer which has a higher thermal conductivity than air and can hold particles between the substrates, and maintaining close contact between the high-temperature substrate, the heat transfer facilitating layer, and the low-temperature substrate, wherein formation of an air layer can be at least substantially prevented between the high-temperature substrate and the heat transfer facilitating layer, and between the low-temperature substrate and the heat transfer facilitating layer. A fluid reaction device includes a microfluidic reaction chip which accommodates a fluid, a heater, and a heat transfer facilitating layer which is interposed between the microfluidic reaction chip and the heater, the heat transfer facilitating layer has a higher thermal conductivity than air and can hold particles, wherein formation of an air layer can be prevented.

摘要翻译： 降低高温和低温基板之间的温度差的方法包括：介于热传导率高于空气的传热促进层，并且可以在基板之间保持颗粒，并且保持高温 基板，传热促进层和低温基板，其中至少可以在高温基板和传热促进层之间以及在低温基板和热量之间基本上防止空气层的形成 转移促进层。 流体反应装置包括容纳流体的微流体反应芯片，加热器和介于微流体反应芯片和加热器之间的传热促进层，传热促进层具有比空气更高的导热性并且可以保持 颗粒，其中可以防止空气层的形成。

公开(公告)号：US20100015695A1

公开(公告)日：2010-01-21

申请号：US12504213

申请日：2009-07-16

申请人： Yoon-kyoung CHO ,  Joon-ho KIM ,  Kak NAMKOONG ,  Geun-bae LIM ,  Jun-hong Min

发明人： Yoon-kyoung CHO ,  Joon-ho KIM ,  Kak NAMKOONG ,  Geun-bae LIM ,  Jun-hong Min

IPC分类号： C12M1/00

CPC分类号： G01N35/08 ,  B01F5/0646 ,  B01F5/0647 ,  B01F5/0654 ,  B01F13/0071 ,  B01F2015/0221 ,  B01J2219/00783 ,  B01J2219/00824 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00837 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00891 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2300/0809 ,  B01L2300/0861 ,  B01L2300/0883 ,  G01N2035/00366 ,  G01N2035/00514

摘要： A method and apparatus for amplifying nucleic acids. The method includes introducing into a reaction vessel via different inlet channels a reactant aqueous solution containing reactants for nucleic acid amplification and a fluid that is phase-separated from the reactant aqueous solution and does not participate in amplification reaction, creating a plurality of reactant aqueous solution droplets surrounded by the fluid by contacting the reactant aqueous solution with the fluid in the reaction vessel, and amplifying the nucleic acids in the reactant aqueous solution droplets. The apparatus includes a substrate, a reaction vessel formed inside of the substrate, at least one first inlet channel formed inside the substrate, connected to an end of the reaction vessel, and allowing introduction of a reactant aqueous solution containing reactants for nucleic acid amplification into the reaction vessel, a second inlet channel formed inside the substrate, connected to the end of the reaction vessel, and allowing introduction of a fluid that is phase-separated from the reactant aqueous solution and does not participate in amplification reaction into the reaction vessel, and a heating unit installed on the substrate in such a way to thermally contact with the substrate and heating the substrate.

公开(公告)号：US20090074623A1

公开(公告)日：2009-03-19

申请号：US12056311

申请日：2008-03-27

申请人： Chin-sung PARK ,  Kak NAMKOONG ,  Young-sun LEE ,  Joo-won RHEE

发明人： Chin-sung PARK ,  Kak NAMKOONG ,  Young-sun LEE ,  Joo-won RHEE

IPC分类号： B01L3/00

CPC分类号： B01L3/502707 ,  B01L7/52 ,  B01L2200/12 ,  B01L2300/0851 ,  B01L2300/16 ,  B01L2300/1827

摘要： Provided is a microfluidic device including a substrate; a chamber formed by a groove in a bottom surface of the substrate, whereby a fluid can be accommodated in the chamber; and an adhesive tape adhered to the bottom surface of the substrate, wherein the adhesive tape includes a polymer film and a silicone adhesive agent coated on the polymer film.

摘要翻译： 提供了一种包括基板的微流体装置; 由衬底的底面中的凹槽形成的腔室，由此可将流体容纳在腔室中; 以及粘附到基材的底表面的粘合带，其中胶带包括聚合物膜和涂覆在聚合物膜上的硅氧烷粘合剂。

公开(公告)号：US20130137165A1

公开(公告)日：2013-05-30

申请号：US13608533

申请日：2012-09-10

申请人： Won-jong JUNG ,  Sun-ok JUNG ,  Won-seok CHUNG ,  Chin-sung PARK ,  Joon-ho KIM ,  Kak NAMKOONG

发明人： Won-jong JUNG ,  Sun-ok JUNG ,  Won-seok CHUNG ,  Chin-sung PARK ,  Joon-ho KIM ,  Kak NAMKOONG

IPC分类号： C12M1/42

CPC分类号： B01L3/502715 ,  B01L2300/0654 ,  B01L2300/0816 ,  G01N21/6452 ,  G01N2021/0314 ,  G01N2021/0325 ,  G01N2021/058 ,  G01N2021/6463

摘要： A gene analysis device including an illumination optical system radiating exciting light onto a sample solution; a microfluidic device for forming a bio-reaction space of the sample solution and including at least one micro-chamber in which a reflection pattern is formed; and a detection optical system for detecting a fluorescence signal generated by a bio-reaction in the micro-chamber and comprising a photodetector.

摘要翻译： 一种基因分析装置，包括将激发光照射到样品溶液上的照明光学系统; 微流体装置，用于形成样品溶液的生物反应空间，并且包括至少一个其中形成有反射图案的微室; 以及检测光学系统，用于检测由微室中的生物反应产生的荧光信号，并包括光电检测器。