Device for cellular electrophysiology sensor, cellular electrophysiology sensor using the device, and method for manufacturing the cellular electrophysiology sensor device
    3.
    发明授权
    Device for cellular electrophysiology sensor, cellular electrophysiology sensor using the device, and method for manufacturing the cellular electrophysiology sensor device 有权
    用于细胞电生理学传感器的装置,使用该装置的细胞电生理学传感器以及用于制造细胞电生理学传感器装置的方法

    公开(公告)号:US08445263B2

    公开(公告)日:2013-05-21

    申请号:US12301307

    申请日:2007-06-27

    IPC分类号: C12M1/34

    CPC分类号: G01N33/48728

    摘要: A leakage current on a side surface of a sensor chip of a cell electrophysiological sensor is reduced. In order to do so, a sensor chip having a continuity hole and a chip holding part covering the side surface of the sensor chip are provided. The sensor chip includes silicon as a main component, and the chip holding part is made of glass. The chip holding part is adhesively bonded to the side surface of the sensor chip by glass welding. Thus, in the cell electrophysiological sensor device of the present invention, the airtightness between the side surface of the sensor chip and the chip holding part is improved, so that a leakage current can be reduced.

    摘要翻译: 细胞电生理传感器的传感器芯片的侧表面的漏电流减少。 为了这样做,提供了具有连续孔的传感器芯片和覆盖传感器芯片的侧表面的芯片保持部分。 传感器芯片包括硅作为主要部件,芯片保持部分由玻璃制成。 通过玻璃焊接将芯片保持部粘合到传感器芯片的侧面。 因此,在本发明的细胞电生理传感器装置中,传感器芯片的侧面与芯片保持部之间的气密性提高,能够降低漏电流。

    PROCESS FOR PRODUCING CELL ELECTROPHYSIOLOGICAL SENSOR AND APPARATUS FOR PRODUCING THE CELL ELECTROPHYSIOLOGICAL SENSOR
    4.
    发明申请
    PROCESS FOR PRODUCING CELL ELECTROPHYSIOLOGICAL SENSOR AND APPARATUS FOR PRODUCING THE CELL ELECTROPHYSIOLOGICAL SENSOR 有权
    用于生产细胞电生理传感器的方法和用于生产细胞电生理传感器的装置

    公开(公告)号:US20110126590A1

    公开(公告)日:2011-06-02

    申请号:US12808499

    申请日:2008-11-28

    CPC分类号: G01N33/48728

    摘要: A process including holding sensor chip; holding glass tube surrounding the outer periphery of the side surface of sensor chip; applying a wind pressure to the side surface of glass tube from the outside of glass tube and melting glass tube to be glass-welded to the side surface of sensor chip. Thereby, the outer periphery of sensor chip can be surrounded by a highly hydrophilic glass tube. Thus, a cell electrophysiological sensor with high measurement accuracy can be produced.

    摘要翻译: 一种包括保持传感器芯片的过程; 围绕传感器芯片侧面外周的玻璃管; 从玻璃管的外侧将玻璃管的侧面施加风压并将玻璃熔融的玻璃管玻璃焊接到传感器芯片的侧面。 因此,传感器芯片的外周可被高度亲水性的玻璃管包围。 因此,可以制造具有高测量精度的细胞电生理传感器。

    BIOSENSOR
    5.
    发明申请
    BIOSENSOR 有权
    生物传感器

    公开(公告)号:US20100170790A1

    公开(公告)日:2010-07-08

    申请号:US12668538

    申请日:2008-07-08

    IPC分类号: G01N33/487 G01N27/26

    摘要: A sensor includes a diaphragm having a through-hole (1), and includes a frame supporting a diaphragm and having a cavity. Kerfs are formed in a frame so as to extend from an end surface of the frame, and the wall surfaces of the kerfs are made hydrophilic. This structure can suppress the occurrence of bubbles in the vicinity of the through-hole, and efficiently remove the remaining bubbles. As a result, the bubbles adhering to the vicinity of the through-hole can be removed, and the measuring reliability of the sensor can be improved.

    摘要翻译: 传感器包括具有通孔(1)的隔膜,并且包括支撑隔膜并具有空腔的框架。 齿框形成在框架中以从框架的端面延伸,并且切口的壁表面被制成亲水性。 该结构可以抑制通孔附近的气泡的产生,有效地除去残留的气泡。 结果,可以去除附着在通孔附近的气泡,并且可以提高传感器的测量可靠性。

    COMPONENT SEPARATION DEVICE
    6.
    发明申请
    COMPONENT SEPARATION DEVICE 有权
    组件分离装置

    公开(公告)号:US20100126922A1

    公开(公告)日:2010-05-27

    申请号:US12532908

    申请日:2008-05-14

    IPC分类号: B01D21/28

    摘要: A component separating device includes a flow channel, an acoustic wave generator for generating an acoustic wave in the flow channel, a first inlet channel for introducing a fist solution containing solid particles into the flow channel, a second inlet channel for introducing a second solution, and outlet channels for discharging a solution from the flow channel. A density grade generator is provided at the first inlet channel for forming a density grade of the solid particles. This component separating device extracts the solid particles into a high-purity solution at a high collecting rate.

    摘要翻译: 元件分离装置包括流路,用于在流路中产生声波的声波发生器,用于将含有固体粒子的第一溶液引入流路的第一入口通道,用于引入第二溶液的第二入口通道, 以及用于从流动通道排出溶液的出口通道。 在第一入口通道处设置密度级发生器,用于形成固体颗粒的密度等级。 该组分分离装置以高收集速率将固体颗粒提取成高纯度溶液。

    COMPONENT SEPARATING DEVICE AND CHEMICAL ANALYSIS DEVICE USING THE SAME
    7.
    发明申请
    COMPONENT SEPARATING DEVICE AND CHEMICAL ANALYSIS DEVICE USING THE SAME 有权
    组分分离装置和使用该组分分析装置的化学分析装置

    公开(公告)号:US20100078323A1

    公开(公告)日:2010-04-01

    申请号:US12444485

    申请日:2007-11-15

    IPC分类号: G01N35/08 B01D21/28

    摘要: A vibrator has a large strength of a standing wave even with a low driving voltage, thereby improving the accuracy of component separation. A device according to the present invention includes a substrate having a channel groove provided in an upper surface of the substrate, a seal provided above the substrate so as to cover an upper opening of the channel groove, a projection provided on an outer side wall opposite to the channel groove, and a vibrator causing the projection to warp and vibrate in a depth direction of the channel groove. The warping vibration of the projection is amplified due to effect of leverage, and generates a large stress on the outer wall of the channel groove having the projection provided thereon. Consequently, the strength of a standing wave in the channel groove increases even for a low driving voltage, thereby improving the accuracy of component separation.

    摘要翻译: 振动器即使具有低驱动电压也具有大的驻波强度,从而提高了元件分离的精度。 根据本发明的装置包括:衬底,其具有设置在衬底的上表面中的沟槽;密封件,设置在衬底上方以覆盖通道槽的上开口;突出部,设置在相对的外侧壁上 并且使振动器沿着沟槽的深度方向翘曲而振动。 突起的翘曲振动由于杠杆作用而被放大,并且在其上设置有突起的通道槽的外壁上产生大的应力。 因此,即使对于低驱动电压,通道槽中驻波的强度也增加,从而提高部件分离的精度。

    Process for producing cell electrophysiological sensor and apparatus for producing the cell electrophysiological sensor
    8.
    发明授权
    Process for producing cell electrophysiological sensor and apparatus for producing the cell electrophysiological sensor 有权
    用于生产细胞电生理传感器和用于产生细胞电生理传感器的装置的方法

    公开(公告)号:US08375745B2

    公开(公告)日:2013-02-19

    申请号:US12808499

    申请日:2008-11-28

    IPC分类号: C03B23/043 C03B23/09

    CPC分类号: G01N33/48728

    摘要: A process including holding sensor chip; holding glass tube surrounding the outer periphery of the side surface of sensor chip; applying a wind pressure to the side surface of glass tube from the outside of glass tube and melting glass tube to be glass-welded to the side surface of sensor chip. Thereby, the outer periphery of sensor chip can be surrounded by a highly hydrophilic glass tube. Thus, a cell electrophysiological sensor with high measurement accuracy can be produced.

    摘要翻译: 一种包括保持传感器芯片的过程; 围绕传感器芯片侧面外周的玻璃管; 从玻璃管的外侧将玻璃管的侧面施加风压并将玻璃熔融的玻璃管玻璃焊接到传感器芯片的侧面。 因此,传感器芯片的外周可以被高度亲水性的玻璃管包围。 因此,可以制造具有高测量精度的细胞电生理传感器。

    Component separation device
    9.
    发明授权
    Component separation device 有权
    元件分离装置

    公开(公告)号:US08273302B2

    公开(公告)日:2012-09-25

    申请号:US12532908

    申请日:2008-05-14

    IPC分类号: B01D21/28

    摘要: A component separating device includes a flow channel, an acoustic wave generator for generating an acoustic wave in the flow channel, a first inlet channel for introducing a fist solution containing solid particles into the flow channel, a second inlet channel for introducing a second solution, and outlet channels for discharging a solution from the flow channel. A density grade generator is provided at the first inlet channel for forming a density grade of the solid particles. This component separating device extracts the solid particles into a high-purity solution at a high collecting rate.

    摘要翻译: 元件分离装置包括流路,用于在流路中产生声波的声波发生器,用于将含有固体粒子的第一溶液引入流路的第一入口通道,用于引入第二溶液的第二入口通道, 以及用于从流动通道排出溶液的出口通道。 在第一入口通道处设置密度级发生器,用于形成固体颗粒的密度等级。 该组分分离装置以高收集速率将固体颗粒提取成高纯度溶液。