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    Porous polymer scaffolds for neural tissue engineering and methods of producing the same
    2.
    发明授权
    Porous polymer scaffolds for neural tissue engineering and methods of producing the same 有权
    用于神经组织工程的多孔聚合物支架及其制备方法

    公开(公告)号：US08877498B2

    公开(公告)日：2014-11-04

    申请号：US13309280

    申请日：2011-12-01

    申请人： Ulrike G.K. Wegst ,  Margaret Wheatley ,  Benjamin W. Riblett ,  Nicola Francis ,  Amalie Elizabeth Donius

    发明人： Ulrike G.K. Wegst ,  Margaret Wheatley ,  Benjamin W. Riblett ,  Nicola Francis ,  Amalie Elizabeth Donius

    IPC分类号： C12N5/00 ,  C12N5/0793

    CPC分类号： C12N5/0619 ,  C12N2533/32 ,  C12N2533/52 ,  C12N2533/54 ,  C12N2533/72 ,  C12N2533/74 ,  C12N2537/00

    摘要： The present invention relates to scaffolds that can physically guide cells, e.g. neurons, while best matching the material properties of native tissue. The present invention also relates to methods of generating such scaffolds, and for the use of such scaffolds, e.g. in spinal cord and peripheral nerve injury repair. The methods of the present invention include a uniquely controlled freeze casting process to generate highly porous, linearly oriented scaffolds. The scaffolds of the present invention not only comprise a highly aligned porosity, but also contain secondary guidance structures in the form of ridges running parallel to the pores to create a series of microstructured and highly aligned channels. This hierarchy of structural guidance aligns and guides neurite outgrowth down the channels created by the ridges, and keep neurites from branching perpendicular to the inter-ridge grooves.

    摘要翻译： 本发明涉及能够物理引导细胞的支架，例如， 神经元，同时最好地匹配天然组织的材料性质。 本发明还涉及产生这种支架的方法，以及用于这种支架的使用。 在脊髓和周围神经损伤修复。 本发明的方法包括独特控制的冷冻铸造方法以产生高度多孔的，线性定向的支架。 本发明的支架不仅包括高度对准的孔隙率，而且还包含平行于孔的脊的形式的次级引导结构，以产生一系列微结构和高度排列的通道。 这种结构指导层次结构使脊突产生的神经突向下生长，从而使脊突产生的通道向下延伸，并保持神经突不垂直于脊间沟槽分支。

    Gas-filled polymeric microbubbles for ultrasound imaging
    3.
    发明授权
    Gas-filled polymeric microbubbles for ultrasound imaging 失效
    用于超声成像的气体填充聚合物微泡

    公开(公告)号：US5487390A

    公开(公告)日：1996-01-30

    申请号：US182216

    申请日：1994-01-14

    申请人： Smadar Cohen ,  Alexander K. Andrianov ,  Margaret Wheatley ,  Harry R. Allcock ,  Robert S. Langer

    发明人： Smadar Cohen ,  Alexander K. Andrianov ,  Margaret Wheatley ,  Harry R. Allcock ,  Robert S. Langer

    IPC分类号： A61K9/127 ,  A61K9/16 ,  A61K9/50 ,  A61K49/22 ,  A61K51/12 ,  B01J13/14 ,  C08G79/02 ,  C12N11/04 ,  A61B8/14

    CPC分类号： A61K9/1271 ,  A61K49/223 ,  A61K49/225 ,  A61K49/226 ,  A61K51/1258 ,  A61K9/1641 ,  A61K9/5031 ,  B01J13/14 ,  C08G79/025 ,  C12N11/04 ,  A61K2123/00 ,  Y10S977/753 ,  Y10S977/929 ,  Y10T428/2987

    摘要： Compositions, methods for preparing and methods of using air-filled polymeric microcapsules for ultrasound imaging are disclosed. Air-encapsulating microcapsules are formed by ionotropically gelling synthetic polyelectrolytes such as poly(carboxylatophenoxy)phosphazene, poly(acrylic acid), poly(methacrylic acid) and methacrylic acid copolymers (Eudragit's) by contact with multivalent ions such as calcium ions. In the preferred embodiment, the average size of the microcapsules is less than seven .mu.m so that they are suitable for injection intravenously. The polymeric microcapsules are stable to imaging and display high echogenicity, both in vitro and in vivo. Due to their in vivo stability their potential application is extended beyond vascular imaging to liver and renal diseases, fallopian tube diseases, detecting and characterizing tumor masses and tissues, and measuring peripheral blood velocity. The microcapsules can optionally be linked with ligands that minimize tissue adhesion or that target the microcapsules to specific regions.

    摘要翻译： 公开了组合物，制备方法和使用空气填充的聚合物微胶囊用于超声成像的方法。 通过与多价离子如钙离子接触，通过离子交换胶凝聚合电解质如聚（羧基苯氧基）磷腈，聚（丙烯酸），聚（甲基丙烯酸）和甲基丙烯酸共聚物（Eudragit's））形成空气封装的微胶囊。 在优选的实施方案中，微胶囊的平均尺寸小于7μm，使得它们适合静脉内注射。 聚合物微胶囊在体外和体内都能稳定成像并显示高回波性。 由于其体内稳定性，其潜在应用范围超出血管成像，肝肾疾病，输卵管疾病，检测和表征肿瘤块和组织，并测量外周血速度。 微胶囊可以任选地与使组织粘附最小化或将微胶囊靶向特定区域的配体连接。

    Polymeric microparticles containing agents for imaging
    4.
    发明授权
    Polymeric microparticles containing agents for imaging 失效
    含有成像剂的聚合物微粒

    公开(公告)号：US5562099A

    公开(公告)日：1996-10-08

    申请号：US292522

    申请日：1994-08-18

    申请人： Smadar Cohen ,  Alexander K. Andrianov ,  Margaret Wheatley ,  Harry R. Allcock ,  Robert S. Langer

    发明人： Smadar Cohen ,  Alexander K. Andrianov ,  Margaret Wheatley ,  Harry R. Allcock ,  Robert S. Langer

    IPC分类号： A61K9/127 ,  A61K9/16 ,  A61K9/50 ,  A61K49/22 ,  A61K51/12 ,  B01J13/14 ,  C08G79/02 ,  C12N11/04 ,  A61K49/00

    CPC分类号： B82Y5/00 ,  A61K49/223 ,  A61K49/225 ,  A61K49/226 ,  A61K51/1258 ,  A61K9/1271 ,  A61K9/1641 ,  A61K9/5031 ,  B01J13/14 ,  C08G79/025 ,  C12N11/04 ,  A61K2123/00 ,  Y10S977/753

    摘要： Compositions, methods for preparing and methods of using contrast agent-filled polymeric microparticles for imaging are disclosed. In a preferred embodiment, air-encapsulating microparticles are formed by ionotropically gelling synthetic polyelectrolytes such as poly(carboxylatophenoxy)phosphazene, poly(acrylic acid), poly(methacrylic acid) and methacrylic acid copolymers (Eudragit's) by contact with multivalent ions such as calcium ions. In the preferred embodiment, the average size of the microparticles is less than seven .mu.m so that they are suitable for injection intravenously. The polymeric microparticles are stable to imaging and display high echogenicity, both in vitro and in vivo. Due to their in vivo stability their potential application is extended beyond vascular imaging to liver and renal diseases, fallopian tube diseases, detecting and characterizing tumor masses and tissues, and measuring peripheral blood velocity. The microparticles can optionally be linked with ligands that minimize tissue adhesion or that target the microparticles to specific regions.

    摘要翻译： 公开了组合物，制备方法和使用造影剂填充的聚合物微粒用于成像的方法。 在一个优选的实施方案中，空气封装的微粒通过与多价离子例如钙的接触通过离子交换胶凝合成聚合电解质如聚（羧基苯氧基）磷腈，聚（丙烯酸），聚（甲基丙烯酸）和甲基丙烯酸共聚物（Eudragit's） 离子。 在优选的实施方案中，微粒的平均尺寸小于7μm，使得它们适于静脉内注射。 聚合物微粒对于成像是稳定的，并且在体外和体内均显示出高回波性。 由于其体内稳定性，其潜在应用范围超出血管成像，肝肾疾病，输卵管疾病，检测和表征肿瘤块和组织，并测量外周血速度。 微粒可任选地与使组织粘附最小化或将微粒靶向特定区域的配体连接。