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    Process for preparing 2-(p-fluorophenyl)-2 methyl-propionic acid and 3-(p-fluorophenyl)-2-methylpropionic acid derivatives
    1.
    发明授权
    Process for preparing 2-(p-fluorophenyl)-2 methyl-propionic acid and 3-(p-fluorophenyl)-2-methylpropionic acid derivatives 失效
    制备2-（对氟苯基）-2甲基 - 丙酸和3-（对氟苯基）-2-甲基丙酸衍生物的方法

    公开(公告)号：US5675034A

    公开(公告)日：1997-10-07

    申请号：US581757

    申请日：1996-01-02

    申请人： Matthias Beller ,  Hartmut Fischer ,  Heinz Strutz

    发明人： Matthias Beller ,  Hartmut Fischer ,  Heinz Strutz

    IPC分类号： B01J31/16 ,  C07B61/00 ,  C07C67/303 ,  C07C67/343 ,  C07C67/347 ,  C07C69/65 ,  C07C69/76

    CPC分类号： C07C69/65 ,  C07C67/303 ,  C07C67/343

    摘要： Process for preparing 3-(p-fluorophenyl)-2-methylpropionic acid and derivatives thereof of the formula (I), ##STR1## in which R is a hydroxy group, a linear or branched (C.sub.1 -C.sub.8)-alkoxy group, an aryloxygroup, an amino group or a (C.sub.1 -C.sub.8)-alkylamino group or a (C.sub.1 -C.sub.8)-dialkylamino group, by a) converting p-fluoroaniline into the p-fluorophenyldiazonium salt of the formula (II) ##STR2## in which X is the equivalent of an anion of an organic or inorganic acid having a pKa value of less than 7, b) reacting the diazonium salt of the formula (II) with a methacrylic acid derivative of the formula (III) ##STR3## in which R is as defined above in the presence of a palladium catalyst, if desired in the presence of a base and/or a solvent, to give the compounds of the formulae (IV) and (V) in which R is as defined above, ##STR4## and c) hydrogenating the resulting compounds of the formulae (IV) and (V) in the presence of a palladium catalyst with hydrogen.

    摘要翻译： 制备式（I）的3-（对氟苯基）-2-甲基丙酸及其衍生物的方法，其中R是羟基，直链或支链（C1-C8） - 烷氧基 基团，芳氧基，氨基或（C1-C8） - 烷基氨基或（C1-C8） - 二烷基氨基，通过a）将对氟苯胺转化为式（II）的对氟苯基重氮盐

    Halogenated cinnamic acids and esters thereof, processes for the preparation thereof and halogenated aryldiazonium salts
    2.
    发明授权
    Halogenated cinnamic acids and esters thereof, processes for the preparation thereof and halogenated aryldiazonium salts 失效
    卤化肉桂酸​​及其酯，其制备方法和卤代芳基重氮盐

    公开(公告)号：US5516932A

    公开(公告)日：1996-05-14

    申请号：US178089

    申请日：1994-01-06

    申请人： Matthias Beller ,  Hartmut Fischer ,  Laurent Weisse ,  Klaus Forstinger ,  Ralf Pfirmann ,  Heinz Strutz

    发明人： Matthias Beller ,  Hartmut Fischer ,  Laurent Weisse ,  Klaus Forstinger ,  Ralf Pfirmann ,  Heinz Strutz

    IPC分类号： B01J23/44 ,  C07B61/00 ,  C07C57/60 ,  C07C67/333 ,  C07C67/343 ,  C07C69/65 ,  C07C245/20 ,  C07C69/76

    CPC分类号： C07C245/20 ,  C07C57/60 ,  C07C67/343 ,  C07C69/65

    摘要： The present invention relates to compounds of the formula ##STR1## in which R.sup.1 and R.sup.2 are identical or different and are hydrogen or an alkyl radical having 1 to 18 carbon atoms and optionally containing oxygen, nitrogen or halogen, the radicals X, Y and Z are identical and are a fluorine, bromine or iodine atom or if two of the radicals X, Y or Z are identical or all of the radicals X, Y, Z are different from each other, X, Y and Z are a fluorine, chlorine, bromine or iodine atom. The invention further relates to a process for the preparation of the compounds, by reacting an aryldiazonium salt of the formula ##STR2## in which the radicals X, Y and Z are identical and are a fluorine, bromine or iodine atom or, if two of the radicals X, Y and Z are identical or all of the radicals X, Y, Z are different from each other, X, Y and Z are a fluorine, chlorine, bromine or iodine atom and A.sup.(-) is an anion of an acid having a pK.sub.a

    摘要翻译： 本发明涉及式（I）的化合物，其中R 1和R 2相同或不同并且是氢或具有1至18个碳原子并且任选地含有氧，氮或卤素的烷基，基团X， Y和Z相同并且是氟，溴或碘原子，或者如果基团X，Y或Z中的两个相同或基团X，Y，Z的全部彼此不同，则X，Y和Z是 氟，氯，溴或碘原子。 本发明还涉及通过使基团X，Y和Z相同且为氟，溴或碘原子的式（II）的芳基重氮盐与式 如果基团X，Y和Z中的两个相同或全部基团X，Y，Z彼此不同，X，Y和Z是氟，氯，溴或碘原子，并且A（ - ）是 具有pKa <7的酸的阴离子与式（III）的化合物反应，其中R 1和R 2相同或不同，并且是氢或具有1至18个碳原子的烷基，并且任选地含有氧，氮 或卤素，在含钯催化剂的存在下，如果合适，加入碱，和式（II）的芳基重氮盐。

    Process for preparing vinyl-substituted aromatic compounds from arylamines
    3.
    发明授权
    Process for preparing vinyl-substituted aromatic compounds from arylamines 失效
    从芳基胺制备乙烯基取代的芳族化合物的方法

    公开(公告)号：US5475176A

    公开(公告)日：1995-12-12

    申请号：US222325

    申请日：1994-04-04

    申请人： Matthias Beller ,  Heinz Strutz

    发明人： Matthias Beller ,  Heinz Strutz

    IPC分类号： B01J23/44 ,  B01J31/28 ,  C07B37/04 ,  C07B61/00 ,  C07C2/86 ,  C07C15/44 ,  C07C15/58 ,  C07C15/60 ,  C07C41/30 ,  C07C1/00 ,  C07C2/66 ,  C07C15/46

    CPC分类号： C07C41/30 ,  C07B37/04 ,  C07C2/86

    摘要： The present invention relates to a process for preparing vinyl-substituted aromatic compounds of the formula (I) Ar--CH.dbd.CH.sub.2, where Ar is a phenyl group that may bear 1 to 5 substituents, naphthyl or anthryl or a naphthyl radical bearing 1 to 7 substituents or an anthryl radical bearing 1 to 8 substituents, or a mononuclear five-, six- or seven-membered heterocyclic aromatic group which contains an oxygen atom and/or one or two nitrogen atoms in the ring and may bear 1 to 5 substituents, wherein an arylamine of the formula (II) Ar--NH.sub.2, where Ar has the aforementioned meaning, is reacted in an organic acid with an organic nitrite of the formula (III) R--ONO, where R is an alkyl group having 1 to 18 carbon atoms, a phenyl radical which may bear 1 to 3 alkyl groups each having 1 to 4 carbon atoms, or is an alkylcarbonyl group having 2 to 5 carbon atoms, and ethylene in an organic solvent in the presence of a palladium(0) of palladium(II) compound at temperatures of 0.degree. to 35.degree. C.

    摘要翻译： 本发明涉及制备式（I）所示的乙烯基取代的芳族化合物的方法Ar-CH = CH 2，其中Ar是可以带有1至5个取代基的苯基，含有1至5个取代基的萘基或蒽基或萘基 7个取代基或含有1至8个取代基的蒽基，或在环中含有氧原子和/或一个或两个氮原子的单核五，六或七元杂环芳族基团，并且可以具有1至5个取代基 其中式（II）Ar-NH 2的芳基胺（其中Ar具有上述含义）在有机酸与式（III）的有机亚硝酸酯R-ONO反应，其中R是具有1〜 18个碳原子，可具有1至3个具有1至4个碳原子的烷基或者是具有2至5个碳原子的烷基羰基的苯基，以及在有机溶剂中的钯（0）存在下的乙烯， 的钯（II）化合物在0℃至35℃的温度下进行。

    Process for preparing aromatic olefins
    4.
    发明授权
    Process for preparing aromatic olefins 失效
    芳烃烯烃的制备方法

    公开(公告)号：US5360924A

    公开(公告)日：1994-11-01

    申请号：US177945

    申请日：1994-01-06

    申请人： Matthias Beller ,  Hartmut Fischer ,  Heinz Strutz

    发明人： Matthias Beller ,  Hartmut Fischer ,  Heinz Strutz

    IPC分类号： B01J23/44 ,  C07B37/04 ,  C07B61/00 ,  C07C37/11 ,  C07C39/19 ,  C07C47/542 ,  C07C47/55 ,  C07C67/343 ,  C07C69/76 ,  C07C69/86 ,  C07C69/92 ,  C07C201/12 ,  C07C205/06 ,  C07C233/05 ,  C07C233/11 ,  C07C233/20 ,  C07C235/34 ,  C07C237/06 ,  C07C253/30 ,  C07C255/32 ,  C07C255/50 ,  C07C255/51 ,  C07C255/54 ,  C07C255/55 ,  C07C255/57 ,  C07C255/58

    CPC分类号： C07C67/343

    摘要： Process for preparing aromatic olefins of the formula (1) ##STR1## in which R.sup.1 -R.sup.3 are hydrogen, alkyl (C.sub.1 -C.sub.8) , alkoxy-(C.sub.1 -C.sub.5), phenyl, fluorine, chlorine, bromine, --OH, --NO.sub.2, --CN, --CHO, --COalkyl(C.sub.1 -C.sub.4) , --COphenyl, --COOalkyl (C.sub.1 -C.sub.4) , --OCOalkyl(C.sub.1 -C.sub.4), --NHCOalkyl(C.sub.1 -C.sub.4) , --CF.sub.3, --NH.sub.2, --NH--alkyl(C.sub.1 -C.sub.4) or --N(alkyl(C.sub.1 -C.sub.4)).sub.2 and R.sup.4 is hydrogen, alkyl(C.sub.1 -C.sub.8), phenyl, fluorine, chlorine, bromine, --OH, --NO.sub.2, --CN, --CHO or --OCOalkyl (C.sub.1 -C.sub.4) , and X is, inter alia, alkenyl(C.sub.2 -C.sub.12) or cycloalkenyl(C.sub.4 -C.sub.8) or the group ##STR2## in which R.sup.5 and R.sup.6 are, independently of one another, hydrogen or methyl, and Y is --phenyl, --CN, --COOH, --COOalkyl(C.sub.1 -C.sub.12), --COOphenyl, ##STR3## --CON (phenyl).sub.2, --COalkyl(C.sub.1 -C.sub.12), --COphenyl, --Oalkyl(C.sub.1 -C.sub.12) , --Ophenyl or the radical ##STR4## in which R.sup.1 -R.sup.4 are as defined above, by reacting an aryldiazonium salt of the formula (2) ##STR5## in which R.sup.1 -R.sup.4 are as defined and Z is the equivalent of an anion of an acid having a pK.sub.a of less than 7, with an olefin of the formula (3)HX (3)

    摘要翻译： 制备式（1）的芳族烯烃的方法其中R1-R3是氢，烷基（C1-C8），烷氧基 - （C1-C5），苯基，氟，氯，溴，-OH ，-NO 2，-CN，-CHO，-CO烷基（C1-C4），-CO苯基，-COO烷基（C1-C4），-OCO烷基（C1-C4），-NHCO烷基（C1-C4） ，-NH-烷基（C1-C4）或-N（烷基（C1-C4））2，R4是氢，烷基（C1-C8），苯基，氟，氯，溴，-OH，-NO2，-CN ，-CHO或-OCO烷基（C1-C4），X特别是链烯基（C2-C12）或环烯基（C4-C8）或其中R5和R6彼此独立的基团 氢或甲基，Y是 - 苯基，-CN，-COOH，-COO烷基（C1-C12），-COO苯基，-CON（苯基）2，-CO-烷基（C1-C12） （2）的芳基重氮盐（其中R1-R4如上所定义）的基团（C1-C12）， - 苯基或其中R1-R4如上所定义的基团 Z是相当于pKa小于7的酸的阴离子与下式的烯烃 （3）HX（3）

    Process for catalytically preparing aromatic or heteroaromatic nitriles
    8.
    发明授权
    Process for catalytically preparing aromatic or heteroaromatic nitriles 有权
    用于催化制备芳族或杂芳族腈的方法

    公开(公告)号：US08314243B2

    公开(公告)日：2012-11-20

    申请号：US11986398

    申请日：2007-11-21

    申请人： Nikolaus Müller ,  Wolfgang Mägerlein ,  Alain Cotté ,  Matthias Beller ,  Thomas Schareina ,  Alexander Zapf

    发明人： Nikolaus Müller ,  Wolfgang Mägerlein ,  Alain Cotté ,  Matthias Beller ,  Thomas Schareina ,  Alexander Zapf

    IPC分类号： C07D211/78 ,  A01N43/38

    CPC分类号： C07B37/04 ,  C07C1/26 ,  C07C17/10 ,  C07C2529/40 ,  C07D213/61 ,  C07C9/00 ,  C07C19/075

    摘要： A process is described for catalytically preparing optionally substituted aromatic or heteroaromatic nitrites of the general formula (I) Ar—CN  (I) by reacting the corresponding aryl halides of the general formula (II) Ar—X  (II) in which X is chlorine, bromine, iodine, triflate, nonaflate, mesylate or tosylate and Ar is an optionally substituted aromatic or heteroaromatic radical, characterized in that the reaction is performed in the presence of a palladium compound, a phosphine of the general formula (III) or (IV) where R is an alkyl radical and R′, R″ and R′″ are each an alkyl radical or an aryl radical or heteroaryl radical and A is an alkylene or arylene radical, and potassium hexacyanoferrate(II) or potassium hexacyanoferrate(III), optionally in a solvent and optionally with addition of a base.

    摘要翻译： 描述了通过使通式（II）Ar-X（II）的相应芳基卤反应其中X为氯的方法催化制备通式（I）Ar-CN（I）的任选取代的芳族或杂芳族亚硝酸盐的方法 溴，碘，三氟甲磺酸酯，壬酸酯，甲磺酸酯或甲苯磺酸酯，Ar是任选取代的芳族或杂芳族基团，其特征在于反应在钯化合物，通式（III）或（IV） ）其中R是烷基，R'，R“和R”“各自是烷基或芳基或杂芳基，A是亚烷基或亚芳基，六氰基铁酸钾（II）或六氰基铁酸钾（III） ，任选地在溶剂中和任选地加入碱。