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    Pyrimidinedione derivatives and antiarrythmic agents containing the same
    1.
    发明授权
    Pyrimidinedione derivatives and antiarrythmic agents containing the same 失效
    嘧啶二酮衍生物和含有它们的抗焦虑剂

    公开(公告)号：US5308848A

    公开(公告)日：1994-05-03

    申请号：US927738

    申请日：1992-08-12

    申请人： Michihiko Miyamoto ,  Tsutomu Katakami ,  Nobuya Kawauchi ,  Tadahito Nobori ,  Joji Kamiya ,  Masaaki Ishii

    发明人： Michihiko Miyamoto ,  Tsutomu Katakami ,  Nobuya Kawauchi ,  Tadahito Nobori ,  Joji Kamiya ,  Masaaki Ishii

    IPC分类号： C07D239/54 ,  C07D239/545 ,  C07D401/12 ,  A61K31/505 ,  C07D239/10

    CPC分类号： C07D239/545 ,  C07D401/12

    摘要： A pyrimidinedione derivative compound has a basic backbone in which a phenyl group part and a pyrimidinedione part are linked by a linking structure comprising an alkyl chain containing two nitrogen atoms. This linking structure is represented by ##STR1## [wherein A is --(CH.sub.2).sub.n --, --CO-- or --O--(CH.sub.2).sub.m --; each of R.sup.1 and R.sup.2 is independently a hydrogen atom or a lower alkyl group which may be substituted by a hydroxyl group, or R.sup.1 and R.sup.2 may be so linked with each other as to make an alkylene chain and thus form a heterocyclic structure; R.sup.5 is a halogen atom, a hydroxyl group, a lower alkyloxycarbonyl group, a lower alkyloxy group which may be substituted by a lower alkyloxy group, or a lower alkyl group which may be substituted by a hydroxyl group, or R.sup.5 may be so linked with R.sup.1 as to make an alkylene chain and thus form a heterocyclic structure; n is 0, 1, 2 or 3 (when R.sup.5 is the hydroxyl group, n.noteq.0); m is 0, 1, 2 or 3; and k is 0, 1, 2 or 3 (however, a compound in which A is --O--(CH.sub.2).sub.m -- and R.sup.5 is the hydroxyl group is excluded from the pyrimidinedione derivative)]. The pyrimidinedione derivative and its acid addition salt are useful for a medical treatment of cardiac arrhythmias.

    摘要翻译： 嘧啶二酮衍生物化合物具有其中苯基部分和嘧啶二酮部分通过包含含有两个氮原子的烷基链的连接结构连接的碱性主链。 该连接结构由表示，其中A是 - （CH 2）n - ， - CO-或-O-（CH 2）m - ; R 1和R 2各自独立地为氢原子或可以被羟基取代的低级烷基，或者R 1和R 2可以相互连接形成亚烷基链，从而形成杂环结构; R5是卤素原子，羟基，低级烷氧基羰基，可被低级烷氧基取代的低级烷氧基或可被羟基取代的低级烷基，或R5可以与 R1形成亚烷基链，从而形成杂环结构; n是0,1,2或3（当R5是羟基时，n是等于0）; m为0,1,2或3; 并且k为0,1,2或3（然而，其中A为-O-（CH 2）m - 且R 5为羟基的化合物不包括在嘧啶二酮衍生物中]]。 嘧啶二酮衍生物及其酸加成盐可用于治疗心律失常。

    Epoxy-resin composition and use thereof
    5.
    发明授权
    Epoxy-resin composition and use thereof 有权
    环氧树脂组合物及其用途

    公开(公告)号：US06297332B1

    公开(公告)日：2001-10-02

    申请号：US09295592

    申请日：1999-04-22

    申请人： Tatsuhiro Urakami ,  Kenichi Sugimoto ,  Keisuke Takuma ,  Tadahito Nobori ,  Usaji Takaki

    发明人： Tatsuhiro Urakami ,  Kenichi Sugimoto ,  Keisuke Takuma ,  Tadahito Nobori ,  Usaji Takaki

    IPC分类号： C08F28300

    CPC分类号： H01B3/40 ,  C08G59/688 ,  Y10T428/12528

    摘要： An epoxy-resin composition comprising (A) an at least bifunctional epoxy compound and/or an at least bifunctional epoxy resin, (B) a curing agent, and (C) an accelerating agent, the accelerating agent essentially containing a phosphine oxide represented by general formula (1); where R1 to R6 all of which may be the same or not are hydrogen, straight, branched or cyclic alkyl having 1 to 10 carbons or aryl or aralkyl having 6 to 10 carbons.

    摘要翻译： 一种环氧树脂组合物，其包含（A）至少双官能环氧化合物和/或至少双官能环氧树脂，（B）固化剂和（C）促进剂，所述促进剂基本上含有由 通式（1）;其中R 1至R 6全部可以相同或不同，为氢，具有1至10个碳的直链，支链或环状烷基或具有6至10个碳的芳基或芳烷基。

    Phosphine sulfide, a manufacturing process therefor and use thereof
    6.
    发明授权
    Phosphine sulfide, a manufacturing process therefor and use thereof 有权
    硫化磷，其制造方法及其用途

    公开(公告)号：US6153794A

    公开(公告)日：2000-11-28

    申请号：US348586

    申请日：1999-07-07

    申请人： Katsuhiko Funaki ,  Isao Hara ,  Takaomi Hayashi ,  Shinji Kiyono ,  Atsushi Shibahara ,  Kazumi Mizutani ,  Tadahito Nobori ,  Usaji Takaki

    发明人： Katsuhiko Funaki ,  Isao Hara ,  Takaomi Hayashi ,  Shinji Kiyono ,  Atsushi Shibahara ,  Kazumi Mizutani ,  Tadahito Nobori ,  Usaji Takaki

    IPC分类号： C07F9/53 ,  C07F9/06 ,  C07F9/22 ,  C08G65/26 ,  C07C43/11 ,  C07C69/76

    CPC分类号： C07F9/224 ,  C07F9/065 ,  C08G65/2675

    摘要： An organic compound which is basic and soluble in an organic solvent, does not have a problem in preparation or handling and exhibits catalytic activity as a basic compound, i.e., a phosphine sulfide represented by formula (1), and a manufacturing process therefor, i.e., manufacturing a phosphine sulfide represented by formula (1), by reacting one molecule of thiophosphoryl chloride with three molecules of a phosphorane represented by formula (2). The phosphine sulfide can be used in a process for effectively manufacturing a poly(alkylene oxide) by polymerizing an alkylene oxide in the presence of the phosphine sulfide or of the phosphine sulfide and an active hydrogen compound selected from water and organic compounds having a partial structure of --OH or --NH--; and 2) a process for manufacturing a 1,2-dioxyethane derivative from an epoxy compound, i.e, manufacturing a 1,2-dioxyethane derivative by reacting an epoxy compound with a carboxylate, carboxylic anhydride, carbonate or phenol compound, respectively, in the presence of the phosphine sulfide.

    摘要翻译： 碱性且可溶于有机溶剂的有机化合物在制备或处理中没有问题，并且表现出作为碱性化合物的催化活性，即由式（1）表示的硫化膦及其制备方法，即 制备由式（1）表示的硫化膦，通过使一分子的硫代磷酰氯与由式（2）表示的三价分子的三分子反应。 所述硫化膦可用于通过在硫化膦或硫化氢存在下聚合烯化氧和选自水和具有部分结构的有机化合物的活性氢化合物来有效制造聚（环氧烷）的方法 的-OH或-NH-; 和2）由环氧化合物制造1,2-二氧乙烷衍生物的方法，即分别通过使环氧化合物与羧酸酯，羧酸酐，碳酸酯或酚化合物反应制备1,2-二氧乙烷衍生物 硫化磷的存在。

    Curing agent composition for epoxy resins, epoxy resin composition and use thereof
    9.
    发明授权
    Curing agent composition for epoxy resins, epoxy resin composition and use thereof 有权
    环氧树脂固化剂组合物，环氧树脂组合物及其应用

    公开(公告)号：US06911503B2

    公开(公告)日：2005-06-28

    申请号：US10432368

    申请日：2002-09-27

    申请人： Sunao Maeda ,  Tatsuhiro Urakami ,  Tomoyuki Kawabata ,  Koutarou Suzuki ,  Tadahito Nobori

    发明人： Sunao Maeda ,  Tatsuhiro Urakami ,  Tomoyuki Kawabata ,  Koutarou Suzuki ,  Tadahito Nobori

    IPC分类号： C08G59/62 ,  C08G59/68 ,  H01L23/29 ,  C08L61/10 ,  C08L61/14 ,  C08L63/04 ,  C09K3/10

    CPC分类号： H01L23/293 ,  C08G59/621 ,  C08G59/688 ,  H01L2924/0002 ,  H01L2924/00

    摘要： An epoxy resin composition comprising an epoxy resin (A), a curing agent (B) and a curing accelerator (C), wherein the curing agent (B) is a phenol compound having two or more hydroxyl functional groups or a compound obtained by esterification of the phenol compound or a mixture of these compounds, and the curing accelerator (C) is a salt of a phosphazenium compound represented by a formula (I): (wherein R1s each represent a hydrogen atom, a linear, branched or cyclic alkyl group having 1 to 10 carbon atoms or an aryl or aralkyl group having 6 to 10 carbon atoms and may be all the same or different from one another; and Z− represents a halogen anion, hydroxy anion, alkoxy anion, aryloxy anion or carboxy anion).

    摘要翻译： 包含环氧树脂（A），固化剂（B）和固化促进剂（C）的环氧树脂组合物，其中固化剂（B）是具有两个或多个羟基官能团的酚化合物或通过酯化获得的化合物 的酚化合物或这些化合物的混合物，固化促进剂（C）是式（I）表示的磷氮杂鎓化合物的盐：（其中R 1〜4各自表示氢原子 ，具有1至10个碳原子的直链，支链或环状烷基或具有6至10个碳原子的芳基或芳烷基，并且可以彼此相同或不同;且Z代表 卤素阴离子，羟基阴离子，烷氧基阴离子，芳氧基阴离子或羧基阴离子）。