公开(公告)号：US20100191305A1

公开(公告)日：2010-07-29

申请号：US12359830

申请日：2009-01-26

申请人： Mir Imran ,  Lu Wang ,  Paren Shah ,  Joel Harris

发明人： Mir Imran ,  Lu Wang ,  Paren Shah ,  Joel Harris

IPC分类号： A61N1/36 ,  A61B5/0478 ,  A61M5/00

CPC分类号： A61B5/04001 ,  A61B5/04004 ,  A61B5/0478 ,  A61B5/0531 ,  A61B5/4094 ,  A61N1/0529 ,  A61N1/0539 ,  A61N1/36017 ,  A61N1/36025 ,  A61N1/36064 ,  A61N1/36082

摘要： Embodiments provide an apparatus and method for detection of aberrant neural-electric activity (ANEA) in the brain causing an epileptic seizure or other neurologic condition. One embodiment provides an apparatus for detection of ANEA comprising an introducer having at least one lumen. The introducer is introduced into brain tissue through an opening in the skull. A reference electrode is positioned at an introducer distal portion. A plurality of electrode members are advanceable within the at least one lumen with each member having an insulated portion and an exposed distal portion. The members have a non-deployed state in the introducer and a deployed state when outwardly advanced out of the introducer. In the deployed state, the members are substantially orthogonal to each other with the exposed distal portions defining a detection volume capable of determining an electric field vector produced by the ANEA and the direction of a foci of the ANEA.

摘要翻译： 实施例提供了用于检测脑中异常神经电活动（ANEA）的装置和方法，其引起癫痫发作或其他神经病症。 一个实施例提供了一种用于检测ANEA的装置，包括具有至少一个内腔的导引器。 导引器通过头骨中的开口引入脑组织。 参考电极位于导引器远端部分。 多个电极构件可在至少一个内腔内前进，每个构件具有绝缘部分和暴露的远端部分。 这些构件在导引器中具有非展开状态，并且当向外推进导引器时处于展开状态。 在展开状态下，构件基本上彼此正交，暴露的远侧部分限定能够确定由ANEA产生的电场矢量和ANEA焦点方向的检测体积。

公开(公告)号：US09095503B2

公开(公告)日：2015-08-04

申请号：US13430662

申请日：2012-03-26

申请人： Mir Imran ,  Mir Hashim ,  Glen McLaughlin ,  Huma Arastu ,  Rekha Vaidyanathan ,  Joel Harris ,  Radhika Korupolu ,  Andrew Mangogna ,  Chang Ong ,  Sanjay Patel ,  Lu Wang ,  Timothy Williams

发明人： Mir Imran ,  Mir Hashim ,  Glen McLaughlin ,  Huma Arastu ,  Rekha Vaidyanathan ,  Joel Harris ,  Radhika Korupolu ,  Andrew Mangogna ,  Chang Ong ,  Sanjay Patel ,  Lu Wang ,  Timothy Williams

IPC分类号： A61N1/30 ,  A61K9/00 ,  A61N1/04 ,  A61K31/4178 ,  A61K31/4468 ,  A61K31/454 ,  A61K31/5415 ,  A61N1/32

CPC分类号： A61N1/325 ,  A61K9/0009 ,  A61K9/0014 ,  A61K31/4178 ,  A61K31/4468 ,  A61K31/454 ,  A61K31/5415 ,  A61N1/0436 ,  A61N1/044 ,  A61N1/0448 ,  A61N1/30 ,  A61N1/303

摘要： Various embodiments provide methods and systems for the biphasic iontophoretic transdermal delivery of therapeutic agents. An embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into the skin. A dose of agent is delivered from the assembly into the skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel the agent out of the assembly. During a second period, a second current having a characteristic to attract the agent is used to retain the agent in the assembly such that delivery of agent into skin is minimized. A dose of agent may be delivered on demand by an input from the patient. Embodiments may be used for delivery of agents which cause adverse effects from unwanted passive diffusion.

摘要翻译： 各种实施方案提供了用于治疗剂的双相离子电渗透皮递送的方法和系统。 用于这种传送的方法的实施例包括将至少一个电极组件定位成与患者的皮肤电连通。 组合件包括包含被动地扩散入皮肤的治疗剂的溶液。 使用具有例如极性和大小的特性的第一电流，在第一时段期间，将剂量的药剂从组合物输送到皮肤中，以将药剂排斥出组合体。 在第二时段期间，使用具有吸引剂的特性的第二电流将试剂保持在组合中，使得药剂递送到皮肤中最小化。 可以根据患者的输入要求递送剂量。 实施方案可以用于递送由不希望的被动扩散引起不利影响的试剂。

公开(公告)号：US20130023815A1

公开(公告)日：2013-01-24

申请号：US13430662

申请日：2012-03-26

申请人： Mir Imran ,  Mir Hashim ,  Glen McLaughlin ,  Huma Arastu ,  Rekha Vaidyanathan ,  Joel Harris ,  Radhika Korupolu ,  Andrew Mangogna ,  Chang Ong ,  Sanjay Patel ,  Lu Wang ,  Timothy Williams

发明人： Mir Imran ,  Mir Hashim ,  Glen McLaughlin ,  Huma Arastu ,  Rekha Vaidyanathan ,  Joel Harris ,  Radhika Korupolu ,  Andrew Mangogna ,  Chang Ong ,  Sanjay Patel ,  Lu Wang ,  Timothy Williams

IPC分类号： A61N1/30

CPC分类号： A61N1/325 ,  A61K9/0009 ,  A61K9/0014 ,  A61K31/4178 ,  A61K31/4468 ,  A61K31/454 ,  A61K31/5415 ,  A61N1/0436 ,  A61N1/044 ,  A61N1/0448 ,  A61N1/30 ,  A61N1/303

摘要： Various embodiments provide methods and systems for the biphasic iontophoretic transdermal delivery of therapeutic agents. An embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into the skin. A dose of agent is delivered from the assembly into the skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel the agent out of the assembly. During a second period, a second current having a characteristic to attract the agent is used to retain the agent in the assembly such that delivery of agent into skin is minimized. A dose of agent may be delivered on demand by an input from the patient. Embodiments may be used for delivery of agents which cause adverse effects from unwanted passive diffusion.

公开(公告)号：US10046085B2

公开(公告)日：2018-08-14

申请号：US13261054

申请日：2010-06-01

申请人： Mir Imran ,  Sanjay Patel ,  Joel Harris

发明人： Mir Imran ,  Sanjay Patel ,  Joel Harris

IPC分类号： A61L27/14 ,  A61F2/82 ,  A61L27/26 ,  A61L27/58 ,  A61L31/04 ,  A61L31/14 ,  A61F2/04 ,  A61F2/06 ,  A61F2/07

摘要： Embodiments of the invention provide compositions include bio degradable polymers, medical implants fabricated from these compositions and methods of using such implants. Many embodiments provide medical implants including a first polymer backbone having a first rate of biodegradation and a second polymer backbone having a second rate of biodegradation faster than the first rate. In some embodiments, the second backbone is configured to be replaced by a natural tissue layer. The first backbone provides a scaffold for the implant while the second backbone degrades. This scaffold can enhance mechanical properties of the implant including various aspects of mechanical strength such as tensile, bending, hoop and yield strength; and elasticity. The scaffold also serves to maintain a minimum level of structural support of the implant during the period of degradation of the second backbone or for the entire life of the implant so that the implant does not mechanically fail.

公开(公告)号：US20100268295A1

公开(公告)日：2010-10-21

申请号：US12427733

申请日：2009-04-21

申请人： Mir Imran ,  Joel Harris

发明人： Mir Imran ,  Joel Harris

IPC分类号： A61N1/365

CPC分类号： A61N1/36514 ,  A61B5/046 ,  A61N1/056 ,  A61N1/0573 ,  A61N1/3621 ,  A61N1/3622 ,  A61N1/3624 ,  A61N1/36578 ,  A61N1/3684 ,  A61N1/3702 ,  A61N1/395

摘要： An embodiment of the invention provides an apparatus for the detection and treatment of atrial arrhythmia comprising an electrical lead having proximal and distal portions. The distal portion is positionable in an atrial chamber and the end of the proximal portion is configured to be coupled to a pacemaker. The lead comprises a plurality of conductive wires clad with an insulative coating and has sufficient flexibility to be positioned in the atria from a percutaneous introductory site. The conductive wires are coupled to a plurality of pairs of bipolar electrodes positioned on a membrane attachable to an endocardial wall. The electrode pairs are distributed in a pattern defining an area for detecting a location of a foci of aberrant electrical activity located within or adjacent the area and sending a pacing signal to that location to prevent or stop an occurrence of atrial fibrillation caused by that foci.

摘要翻译： 本发明的一个实施方案提供了用于检测和治疗心房心律失常的装置，其包括具有近端部分和远端部分的电引线。 远侧部分可定位在心房中，并且近端部分的端部被配置为联接到起搏器。 引线包括用绝缘涂层包覆的多个导线，并且具有足够的灵活性，以便从经皮引导位置定位在心房中。 导电线耦合到多个双极电极对，其位于可附接到心内膜壁的膜上。 电极对以限定用于检测位于该区域内或邻近该区域的异常电活动焦点的位置的区域的图案分布，并向该位置发送起搏信号以防止或停止由该焦点引起的心房颤动的发生。

公开(公告)号：US20100114225A1

公开(公告)日：2010-05-06

申请号：US12265690

申请日：2008-11-05

申请人： Mir Imran ,  Dean Andersen ,  Joel Harris

发明人： Mir Imran ,  Dean Andersen ,  Joel Harris

IPC分类号： H05K5/06 ,  A61N1/00

CPC分类号： A61N5/0622 ,  A61N1/0529 ,  A61N1/0536 ,  A61N1/36 ,  A61N1/36064 ,  A61N1/37 ,  A61N1/375 ,  A61N1/3754 ,  A61N5/0601 ,  A61N2005/063 ,  H01R13/5224 ,  H01R2201/12

摘要： Embodiments described herein provide lid structures for medical implant (MI) housing. In one embodiment, the invention provides a lid structure for a MI housing comprising a substrate comprising a dielectric material, a conductive portion fabricated on a substrate surface or interior, a frame at least partially surrounding the substrate perimeter, a plurality of vias projecting at least partially through the substrate, a plurality of conductive pins with at least one pin projecting through a via. The frame is hermetically joined to the substrate and can be hermetically joined to the housing. The conductive portion allows electrical components, including capacitors, inductors, resistor and antennas to be fabricated on or coupled to the substrate surface or interior. The antenna comprises a conductive trace positioned on a substrate top surface and is configured to send and receive signals between an implant within a patient's body and a communication device external to the body.

摘要翻译： 本文描述的实施例提供用于医疗植入物（MI）壳体的盖结构。 在一个实施例中，本发明提供了一种用于MI壳体的盖结构，其包括基底，其包括电介质材料，制造在基底表面或内部的导电部分，至少部分围绕基底周边的框架，至少突出的多个通孔 部分地穿过衬底，具有至少一个销突出通过通孔的多个导电销。 框架气密地接合到基板上并且可以气密地接合到壳体。 导电部分允许包括电容器，电感器，电阻器和天线的电气部件制造在衬底表面或内部上或耦合到衬底表面或内部。 天线包括位于衬底顶表面上的导电迹线，并被配置为在患者体内的植入物和身体外部的通信装置之间发送和接收信号。

公开(公告)号：US20120184894A1

公开(公告)日：2012-07-19

申请号：US13342948

申请日：2012-01-03

申请人： Mir Imran ,  Phil Morgan ,  Mir Hashim ,  Joel Harris

发明人： Mir Imran ,  Phil Morgan ,  Mir Hashim ,  Joel Harris

IPC分类号： A61N1/30

CPC分类号： A61K8/0208 ,  A61K8/19 ,  A61K9/0009 ,  A61K9/0021 ,  A61K9/7046 ,  A61K33/26 ,  A61K33/42 ,  A61K2800/83 ,  A61Q7/00

摘要： Embodiments of the invention provide patches for the transdermal delivery of compositions to treat an individual suffering from hair loss. Many embodiments provide an iontophoretic patch for the transdermal delivery hair growth stimulating agents for the treatment of hair loss by stimulating the growth of new hair in areas of the scalp exhibiting hair loss. The patch comprises an electrode and a reservoir containing a composition comprising iron containing compound, such as a chelated iron compound for the delivery of the therapeutically effective amount of iron. The patch can be shaped to be placed and remain on the head. Various embodiments provide methods of using embodiments of the iontophoretic patch for delivering a hair growth stimulating agent such as a chelated iron compound, minoxidil and finasteride to the scalp and other areas exhibiting hair loss. Such methods can be used for re-growing hair, and/or preventing or slowing hair loss.

摘要翻译： 本发明的实施方案提供了用于透皮递送组合物以治疗患有脱发的个体的贴剂。 许多实施方案提供用于透皮递送毛发生长刺激剂的离子电渗贴剂，用于通过在头皮表现出脱发的区域中刺激新毛发的生长来治疗脱发。 贴片包括电极和储存器，其含有包含含铁化合物的组合物，例如用于递送治疗有效量的铁的螯合铁化合物。 该贴片的形状可被放置并保留在头部上。 各种实施方案提供了使用离子电渗贴剂的实施方案将头发生长刺激剂如螯合铁化合物，米诺地尔和非那雄胺递送至头皮和其它出现脱发的区域的方法。 这种方法可用于再生长毛发和/或预防或减缓脱发。

公开(公告)号：US20130325108A1

公开(公告)日：2013-12-05

申请号：US13261054

申请日：2010-06-01

申请人： Mir Imran ,  Sanjay Patel ,  Joel Harris

发明人： Mir Imran ,  Sanjay Patel ,  Joel Harris

IPC分类号： A61L27/14 ,  A61F2/04 ,  A61F2/82

CPC分类号： A61L27/14 ,  A61F2/04 ,  A61F2/06 ,  A61F2/07 ,  A61F2/82 ,  A61F2210/0004 ,  A61L27/26 ,  A61L27/58 ,  A61L31/041 ,  A61L31/148

摘要： Embodiments of the invention provide compositions comprising bio degradable polymers, medical implants fabricated from these compositions and methods of using such implants. Many embodiments provide medical implants comprising a first polymer backbone having a first rate of biodegradation and a second polymer backbone having a second rate of biodegradation faster than the first rate. In some embodiments, the second backbone is configured to be replaced by a natural tissue layer. The first backbone provides a scaffold for the implant while the second backbone degrades. This scaffold can enhance mechanical properties of the implant including various aspects of mechanical strength such as tensile, bending, hoop and yield strength; and elasticity. The scaffold also serves to maintain a minimum level of structural support of the implant during the period of degradation of the second backbone or for the entire life of the implant so that the implant does not mechanically fail.

摘要翻译： 本发明的实施方案提供了包含生物可降解聚合物，由这些组合物制造的医疗植入物和使用这种植入物的方法的组合物。 许多实施方案提供医学植入物，其包含具有第一生物降解速率的第一聚合物主链和具有比第一速率快的第二生物降解速率的第二聚合物主链。 在一些实施例中，第二主干被配置为由天然组织层代替。 第一个骨架提供植入物的支架，而第二个骨架降解。 该支架可以增强植入物的机械性能，包括机械强度的各个方面，例如拉伸，弯曲，箍和屈服强度; 和弹性。 支架还用于在第二主骨架的退化期间或植入物的整个寿命期间保持植入物的最小结构支撑水平，使得植入物不会机械地失效。

公开(公告)号：US20080070892A1

公开(公告)日：2008-03-20

申请号：US11854623

申请日：2007-09-13

申请人： Joel Harris ,  Bernard Neustadt ,  Stephen Sorota ,  Andrew Stamford ,  Deen Tulshian ,  Brian McKittrick

发明人： Joel Harris ,  Bernard Neustadt ,  Stephen Sorota ,  Andrew Stamford ,  Deen Tulshian ,  Brian McKittrick

IPC分类号： A61K31/439 ,  A61P3/06

CPC分类号： A61K31/438 ,  A61K31/444 ,  A61K31/495 ,  A61K31/497 ,  A61K31/513 ,  A61K45/06

摘要： Disclosed is a method of treating a disease or condition (e.g., pain, diabetes or disorders of lipid metabolism) comprising administering an azetidine derivative of the formula I selected from the group consisting of the compounds defined by Tables 1, 2, 3a, 3b, 3c, 3d and 4a.

摘要翻译： 公开了治疗疾病或病症（例如，疼痛，糖尿病或脂质代谢紊乱）的方法，包括给予式I的氮杂环丁烷衍生物，其选自表1,2,3,2a，3b， 3c，3d和4a。

公开(公告)号：US20070066620A1

公开(公告)日：2007-03-22

申请号：US11522221

申请日：2006-09-15

申请人： Bernard Neustadt ,  Craig Boyle ,  Samuel Chackalamannil ,  Joel Harris ,  Claire Lankin ,  Hong Liu ,  Unmesh Shah ,  Andrew Stamford

发明人： Bernard Neustadt ,  Craig Boyle ,  Samuel Chackalamannil ,  Joel Harris ,  Claire Lankin ,  Hong Liu ,  Unmesh Shah ,  Andrew Stamford

IPC分类号： A61K31/519 ,  C07D487/14

CPC分类号： C07D487/14

摘要： Compounds having the structural formula I or a pharmaceutically acceptable salt thereof, wherein R is R1-isoxazolyl, R1-oxadiazolyl, R1-dihydrofuranyl, R1-pyrazolyl, R1-imidazolyl, R1-pyrazinyl or R1-pyrimidinyl; R1 is 1, 2 or 3 substituents selected from H, alkyl, alkoxy and halo; Z is optionally substituted-aryl, or optionally substituted-heteroaryl; are disclosed, as well as their use in the treatment of central nervous system diseases, in particular Parkinson's disease and Extra Pyramidal Syndrome, pharmaceutical compositions comprising them, and combinations with other agents.

摘要翻译： 具有结构式I的化合物或其药学上可接受的盐，其中R为R 1 - 异恶唑基，R 1 - 恶二唑基，R 1 - 二氢呋喃基，R 1 - 吡唑基，R 1 - 咪唑基，R 1 - 吡嗪基或R 1 - 嘧啶基; R 1是1,2或3个选自H，烷基，烷氧基和卤素的取代基; Z是任选取代的 - 芳基或任选取代的杂芳基; 以及它们在治疗中枢神经系统疾病，特别是帕金森病和额外锥体综合征，包含它们的药物组合物以及与其它药剂的组合中的用途。