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    Large-volume bolus patient controlled drug administration device
    1.
    发明授权
    Large-volume bolus patient controlled drug administration device 有权
    大体积推注患者控制药物给药装置

    公开(公告)号：US08308688B2

    公开(公告)日：2012-11-13

    申请号：US12968988

    申请日：2010-12-15

    申请人： Moises Valle ,  Giuseppe Sacca

    发明人： Moises Valle ,  Giuseppe Sacca

    IPC分类号： A61M1/00

    CPC分类号： A61M5/16813 ,  A61M5/14216 ,  A61M5/16809 ,  A61M39/28 ,  A61M2005/1405

    摘要： A patient controlled liquid drug administration device is provided that enables either or both of a continuous flow of a liquid drug, as well as successive, large-volume boluses thereof, to be self-administered to and by a patient while avoiding bolus refill during bolus delivery or after bolus delivery but before an intake stroke of the pump occurs. The device includes an elongated housing having an axial cavity extending through it with a reciprocating pump mounted at a bottom end thereof. The pump defines a closed internal reservoir and includes a first wall, or seat, that is fixed in the cavity, and a second, flexible wall that is axially movable in the cavity in relation to the fixed wall between reservoir-full and reservoir-empty positions. The pump includes an inlet port that is connectable to a source of a pressurized liquid drug by an inlet conduit, and an outlet port subcutaneously connectable to the patient by an outlet conduit, both conduits extending out the bottom end of the housing. An outlet clamp is mounted in the cavity to move between a closed position constricting the outlet conduit of the pump, thereby preventing the flow of the liquid drug through the outlet conduit, and an open position. An inlet clamp is mounted in the cavity to move between a closed position constricting the inlet conduit and thereby preventing the flow of liquid through it, and an open position disengaged from the inlet conduit, thereby allowing the flow of liquid through it.

    摘要翻译： 提供一种患者控制的液体药物给药装置，其使液体药物的连续流动以及连续的大体积推注中的任一种或两者能够自动施用于患者并且由患者自发施用，同时避免在推注期间弹丸补充 输送或推料后，但在泵的进气冲程发生之前。 该装置包括细长壳体，其具有延伸穿过其的轴向空腔，其具有安装在其底端的往复泵。 泵限定了一个封闭的内部储存器，并且包括固定在空腔中的第一壁或座，以及第二柔性壁，所述第二壁柔性壁可相对于在储液器和储存器空间之间的固定壁在空腔中轴向移动 职位 该泵包括通过入口导管连接到加压液体药物源的入口端口，以及通过出口导管皮下可连接到患者的出口端口，两个延伸出外壳底端的管道。 出口夹具安装在空腔中以在限制泵的出口导管的闭合位置之间移动，从而防止液体药物流过出口导管和打开位置。 入口夹具安装在空腔中，以在限制入口管道的封闭位置之间移动，从而防止液体流过其中，并且打开位置与入口导管脱开，从而允许液体流过其中。

    Large-Volume Bolus Patient Controlled Drug Administration Device
    2.
    发明申请
    Large-Volume Bolus Patient Controlled Drug Administration Device 有权
    大容积螺栓患者控制药物管理装置

    公开(公告)号：US20120157918A1

    公开(公告)日：2012-06-21

    申请号：US12968988

    申请日：2010-12-15

    申请人： Moises Valle ,  Giuseppe Sacca

    发明人： Moises Valle ,  Giuseppe Sacca

    IPC分类号： A61M5/168

    CPC分类号： A61M5/16813 ,  A61M5/14216 ,  A61M5/16809 ,  A61M39/28 ,  A61M2005/1405

    摘要： A patient controlled liquid drug administration device is provided that enables either or both of a continuous flow of a liquid drug, as well as successive, large-volume boluses thereof, to be self-administered to and by a patient while avoiding bolus refill during bolus delivery or after bolus delivery but before an intake stroke of the pump occurs. The device includes an elongated housing having an axial cavity extending through it with a reciprocating pump mounted at a bottom end thereof. The pump defines a closed internal reservoir and includes a first wall, or seat, that is fixed in the cavity, and a second, flexible wall that is axially movable in the cavity in relation to the fixed wall between reservoir-full and reservoir-empty positions. The pump includes an inlet port that is connectable to a source of a pressurized liquid drug by an inlet conduit, and an outlet port subcutaneously connectable to the patient by an outlet conduit, both conduits extending out the bottom end of the housing. An outlet clamp is mounted in the cavity to move between a closed position constricting the outlet conduit of the pump, thereby preventing the flow of the liquid drug through the outlet conduit, and an open position. An inlet clamp is mounted in the cavity to move between a closed position constricting the inlet conduit and thereby preventing the flow of liquid through it, and an open position disengaged from the inlet conduit, thereby allowing the flow of liquid through it.

    摘要翻译： 提供一种患者控制的液体药物给药装置，其使液体药物的连续流动以及连续的大体积推注中的任一种或两者能够自动施用于患者并且由患者自发施用，同时避免在推注期间弹丸补充 输送或推料后，但在泵的进气冲程发生之前。 该装置包括细长壳体，其具有延伸穿过其的轴向空腔，其具有安装在其底端的往复泵。 泵限定了一个封闭的内部储存器，并且包括固定在空腔中的第一壁或座，以及第二柔性壁，所述第二壁柔性壁可相对于在储液器和储存器空间之间的固定壁在空腔中轴向移动 职位 该泵包括通过入口导管连接到加压液体药物源的入口端口，以及通过出口导管皮下可连接到患者的出口端口，两个延伸出外壳底端的管道。 出口夹具安装在空腔中以在限制泵的出口导管的闭合位置之间移动，从而防止液体药物流过出口导管和打开位置。 入口夹具安装在空腔中，以在限制入口管道的封闭位置之间移动，从而防止液体流过其中，并且打开位置与入口导管脱开，从而允许液体流过其中。

    Decontamination system for use with a rapid transfer port
    5.
    发明授权
    Decontamination system for use with a rapid transfer port 失效
    用于快速转运港口的净化系统

    公开(公告)号：US06969497B2

    公开(公告)日：2005-11-29

    申请号：US10190860

    申请日：2002-07-08

    申请人： Giuseppe Sacca

    发明人： Giuseppe Sacca

    IPC分类号： A61L2/00 ,  A61L2/20 ,  A61L2/26

    CPC分类号： A61L2/20 ,  A61L2/0005 ,  A61L2/26 ,  A61L2202/14 ,  A61L2202/23

    摘要： The system includes an enclosure for providing a closed volume for bactericide vapor. The enclosure has a container access opening formed therein for providing vapor communication between a container and the closed volume. A container interface assembly at the container access opening positions, locks and seals the container to the enclosure. A container door removal system is partially contained within the enclosure and is operably engaged with the enclosure and attachable to a container door of the container for separating the container door from the container. The container door removal system includes an actuator element located external to the enclosure. A vapor injection system is included having an inlet and an outlet for the bactericide vapor. During operation, a container is attached to the container interface assembly and the container door is separated from the container by operating the actuator element of the container door removal system providing vapor communication between the closed volume and the volume within the container. The bactericide vapor may be introduced into the enclosure and the container via the vapor injection system.

    摘要翻译： 该系统包括用于为杀菌剂蒸气提供封闭体积的外壳。 外壳具有形成在其中的容器进入开口，用于在容器和封闭容积之间提供蒸气连通。 在容器进入开口处的容器接口组件，将容器锁定并密封到外壳。 容器门移除系统部分地容纳在外壳内并且可操作地与外壳接合并且可附接到容器的容器门，用于将容器门与容器分离。 集装箱门移除系统包括位于外壳外部的致动器元件。 包括具有用于杀菌剂蒸气的入口和出口的蒸气喷射系统。 在操作期间，容器附接到容器接口组件，并且通过操作容器门去除系统的致动器元件，使容器门与容器分离，从而在封闭容积和容器内的体积之间提供蒸气连通。 杀菌剂蒸气可以通过蒸气喷射系统引入外壳和容器。

    Pressure-activated medication transfer system
    8.
    发明授权
    Pressure-activated medication transfer system 失效
    压力激活药物转移系统

    公开(公告)号：US5526853A

    公开(公告)日：1996-06-18

    申请号：US292232

    申请日：1994-08-17

    申请人： Charles J. McPhee ,  C. Kenneth Lovejoy ,  Giuseppe Sacca

    发明人： Charles J. McPhee ,  C. Kenneth Lovejoy ,  Giuseppe Sacca

    IPC分类号： A61J1/00 ,  A61J1/20

    CPC分类号： A61J1/2089 ,  A61J1/10 ,  A61J1/1475 ,  A61J1/201 ,  A61J1/2013 ,  A61J2200/10

    摘要： A binary connector intercouples a plugged drug vial and a plugged, flexible-walled diluent container so that the diluent can pass to the vial from the container only after the latter has been pressurized by squeezing. Sharp-tipped, hollow spikes with intercommunicating axial bores extend in diametrically opposite directions from a disk-shaped base, with jaws having circularly arrayed flexible arms extending in diametrically opposite directions from the base, coaxially around respective ones of the spikes. A compressible rubber plug is wedged in one of the bores. A vial is engaged to a container for liquid communication by snapping the connectors' jaws around their respective inlets, causing the connectors' hollow spikes to pierce their respective plugs. However, not until the container is squeezed is the plug expelled from the blocked bore and communication established between vial and container.

    摘要翻译： 二进制连接器将封闭的药物小瓶和堵塞的柔性壁稀释剂容器相互连接，使得稀释剂只有在通过挤压加压后才能从容器中通过小瓶。 具有相互连通的轴向孔的尖锐的，中空的钉与盘形基部沿径向相反的方向延伸，钳口具有圆形排列的柔性臂，其从基部沿径向相反的方向延伸，同轴地围绕相应的尖峰。 一个可压缩橡胶塞楔入其中一个孔。 通过将连接器的夹爪卡在它们各自的入口周围，将小瓶接合到容器以进行液体连通，使得连接器的空心钉刺穿它们各自的塞子。 然而，直到容器被挤压才能将塞子从阻塞的孔中排出并且在瓶和容器之间建立通信。

    System and method for leak detection
    9.
    发明申请
    System and method for leak detection 失效
    泄漏检测系统和方法

    公开(公告)号：US20060179922A1

    公开(公告)日：2006-08-17

    申请号：US11057724

    申请日：2005-02-12

    申请人： Giuseppe Sacca

    发明人： Giuseppe Sacca

    IPC分类号： G01M3/04

    CPC分类号： G01M3/3281 ,  G01M3/3218 ,  G01M3/3236

    摘要： A leak testing control assembly for a leak testing system of a type that cooperates with a test part interface that is coupled with a test part. In a broad aspect the leak testing control assembly includes a working fluid generator for applying a working fluid having a fluidic pressure to a test part. A flow controller assembly is coupled to the working fluid generator. The flow controller assembly includes a flow controller element for controlling the flow rate of the working fluid. A pressure level measuring element is positioned relative to the test part for measuring the fluidic pressure. A control system is coupled to the flow controller assembly and the pressure level measuring element. A user interface is coupled to the control system for providing user interaction with the leak testing control assembly. During operation, the control system 1) facilitates application of the fluidic pressure at a selected relatively constant flow rate; and, 2) interprets the value of the fluidic pressure, after the application of the fluidic pressure at the selected relatively constant flow rate, to determine whether the test part is free of leaks.

    摘要翻译： 一种用于与测试部件接口耦合的测试部件接口类型的泄漏测试系统的泄漏测试控制组件。 在广泛的方面，泄漏测试控制组件包括用于将具有流体压力的工作流体施加到测试部件的工作流体发生器。 流量控制器组件联接到工作流体发生器。 流量控制器组件包括用于控制工作流体的流量的流量控制器元件。 压力水平测量元件相对于测试部件定位以测量流体压力。 控制系统耦合到流量控制器组件和压力水平测量元件。 用户界面耦合到控制系统，以提供与泄漏测试控制组件的用户交互。 在操作期间，控制系统1）有助于以选定的相对恒定的流速施加流体压力; 以及2）在以所选择的相对恒定的流速施加流体压力之后，解释流体压力的值，以确定测试部件是否没有泄漏。

    System and method for leak detection
    10.
    发明授权
    System and method for leak detection 失效
    泄漏检测系统和方法

    公开(公告)号：US07174772B2

    公开(公告)日：2007-02-13

    申请号：US11057724

    申请日：2005-02-12

    申请人： Giuseppe Sacca

    发明人： Giuseppe Sacca

    IPC分类号： G01M3/04

    CPC分类号： G01M3/3281 ,  G01M3/3218 ,  G01M3/3236

    摘要： A leak testing control assembly for a leak testing system of a type that cooperates with a test part interface that is coupled with a test part. In a broad aspect the leak testing control assembly includes a working fluid generator for applying a working fluid having a fluidic pressure to a test part. A flow controller assembly is coupled to the working fluid generator. The flow controller assembly includes a flow controller element for controlling the flow rate of the working fluid. A pressure level measuring element is positioned relative to the test part for measuring the fluidic pressure. A control system is coupled to the flow controller assembly and the pressure level measuring element. A user interface is coupled to the control system for providing user interaction with the leak testing control assembly. During operation, the control system 1) facilitates application of the fluidic pressure at a selected relatively constant flow rate; and, 2) interprets the value of the fluidic pressure, after the application of the fluidic pressure at the selected relatively constant flow rate, to determine whether the test part is free of leaks.

    摘要翻译： 一种用于与测试部件接口耦合的测试部件接口类型的泄漏测试系统的泄漏测试控制组件。 在广泛的方面，泄漏测试控制组件包括用于将具有流体压力的工作流体施加到测试部件的工作流体发生器。 流量控制器组件联接到工作流体发生器。 流量控制器组件包括用于控制工作流体的流量的流量控制器元件。 压力水平测量元件相对于测试部件定位以测量流体压力。 控制系统耦合到流量控制器组件和压力水平测量元件。 用户界面耦合到控制系统，以提供与泄漏测试控制组件的用户交互。 在操作期间，控制系统1）有助于以选定的相对恒定的流速施加流体压力; 以及2）在以所选择的相对恒定的流速施加流体压力之后，解释流体压力的值，以确定测试部件是否没有泄漏。