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    System for the analysis of liquid samples
    3.
    发明授权
    System for the analysis of liquid samples 有权
    液体样品分析系统

    公开(公告)号：US08940249B2

    公开(公告)日：2015-01-27

    申请号：US12850934

    申请日：2010-08-05

    申请人： Rainer D. Jaeggi ,  Oliver Gutmann ,  Michael Glauser ,  Heinz-Michael Hein ,  Edwin Oosterbroek ,  Michael Andreas Heinrich

    发明人： Rainer D. Jaeggi ,  Oliver Gutmann ,  Michael Glauser ,  Heinz-Michael Hein ,  Edwin Oosterbroek ,  Michael Andreas Heinrich

    IPC分类号： G01N35/08 ,  G01N35/10 ,  G01N35/00

    CPC分类号： G01N35/1095 ,  B01L2200/027 ,  G01N35/085 ,  G01N2035/00158 ,  G01N2035/1034

    摘要： A system for the automated analysis of liquid samples having one or more processing units for reaction between the samples and one or more reagents to thereby obtain reaction products is disclosed. Disclosed also are a sample unit for supplying the samples to the one or more processing units; a reagent unit equipped with plural reagent vessels containing one or more reagents for mixing with the samples; a distribution unit for distributing fluids including the one or more reagents provided with plural distribution lines, at least some of which are connected to the reagent vessels and the one or more processing units; and at least one analytical unit for analyzing the samples based on the reaction products, in which the analytical unit may include at least one detector for detecting the reaction products.

    摘要翻译： 公开了一种用于自动分析液体样品的系统，该液体样品具有一个或多个处理单元，用于样品与一种或多种试剂之间的反应，从而获得反应产物。 还公开了一种用于将样本提供给一个或多个处理单元的采样单元; 配备有多个试剂容器的试剂单元，所述试剂容器含有一种或多种用于与样品混合的试剂; 用于分配流体的分配单元，所述流体包括具有多个分配管线的一种或多种试剂，其中至少一些连接到所述试剂容器和所述一个或多个处理单元; 以及用于基于反应产物分析样品的至少一个分析单元，其中分析单元可以包括用于检测反应产物的至少一个检测器。

    System For The Analysis Of Liquid Samples
    4.
    发明申请
    System For The Analysis Of Liquid Samples 有权
    液体样品分析系统

    公开(公告)号：US20110189052A1

    公开(公告)日：2011-08-04

    申请号：US12850934

    申请日：2010-08-05

    申请人： Rainer D. Jaeggi ,  Oliver Gutmann ,  Michael Glauser ,  Heinz-Michael Hein ,  Edwin Oosterbroek ,  Michael Andreas Heinrich

    发明人： Rainer D. Jaeggi ,  Oliver Gutmann ,  Michael Glauser ,  Heinz-Michael Hein ,  Edwin Oosterbroek ,  Michael Andreas Heinrich

    IPC分类号： G01N33/00

    CPC分类号： G01N35/1095 ,  B01L2200/027 ,  G01N35/085 ,  G01N2035/00158 ,  G01N2035/1034

    摘要： A system for the automated analysis of liquid samples having one or more processing units for reaction between the samples and one or more reagents to thereby obtain reaction products is disclosed. Disclosed also are a sample unit for supplying the samples to the one or more processing units; a reagent unit equipped with plural reagent vessels containing one or more reagents for mixing with the samples; a distribution unit for distributing fluids including the one or more reagents provided with plural distribution lines, at least some of which are connected to the reagent vessels and the one or more processing units; and at least one analytical unit for analyzing the samples based on the reaction products, in which the analytical unit may include at least one detector for detecting the reaction products.

    摘要翻译： 公开了一种用于自动分析液体样品的系统，该液体样品具有一个或多个处理单元，用于样品与一种或多种试剂之间的反应，从而获得反应产物。 还公开了一种用于将样本提供给一个或多个处理单元的采样单元; 配备有多个试剂容器的试剂单元，所述试剂容器含有一种或多种用于与样品混合的试剂; 用于分配流体的分配单元，所述流体包括具有多个分配管线的一种或多种试剂，其中至少一些连接到所述试剂容器和所述一个或多个处理单元; 以及用于基于反应产物分析样品的至少一个分析单元，其中分析单元可以包括用于检测反应产物的至少一个检测器。

    Method for the automated analysis of liquid samples using centrifugal force in a microfluidic structure
    5.
    发明授权
    Method for the automated analysis of liquid samples using centrifugal force in a microfluidic structure 有权
    在微流体结构中使用离心力自动分析液体样品的方法

    公开(公告)号：US08580567B2

    公开(公告)日：2013-11-12

    申请号：US12903492

    申请日：2010-10-13

    申请人： Emad Sarofim ,  Edwin Oosterbroek ,  Claudio Cherubini ,  Nenad Milicevic

    发明人： Emad Sarofim ,  Edwin Oosterbroek ,  Claudio Cherubini ,  Nenad Milicevic

    IPC分类号： G01N21/07

    CPC分类号： G01N35/00029 ,  B01L3/502738 ,  B01L7/52 ,  B01L2200/0642 ,  B01L2200/0673 ,  B01L2300/0829 ,  B01L2300/0864 ,  B01L2400/0409 ,  B01L2400/0677 ,  G01N21/07 ,  G01N2021/0325 ,  G01N2035/00099 ,  G01N2035/00495

    摘要： A method for the automated analysis of liquid samples using at least one microfluidic structure is disclosed as well as microfluidic structures, a device having at least one of the microfluidic structures, a kit and a system including such microfluidic device. In one embodiment, the method may comprise: transferring a sample into a first fluid reservoir which is in fluid communication with a second fluid reservoir by a flow channel; spinning the microfluidic structure so as to transport the sample into one or more dead-end recesses or chambers; transferring a control fluid into the structure which generates a barrier to flow and diffusion of the sample contained in the one or more dead-end recesses or chambers; and analyzing the sample contained in the one or more dead-end recesses or chambers.

    摘要翻译： 公开了使用至少一个微流体结构自动分析液体样品的方法，以及微流体结构，具有至少一个微流体结构的装置，试剂盒和包括这种微流体装置的系统。 在一个实施例中，该方法可以包括：将样品转移到通过流动通道与第二流体储存器流体连通的第一流体储存器中; 旋转微流体结构以将样品输送到一个或多个死端凹部或腔室中; 将控制流体转移到所述结构中，所述结构产生包含在所述一个或多个死端凹部或腔室中的样品的流动和扩散的阻挡层; 并分析包含在一个或多个死端凹部或腔室中的样品。

    MULTI-WELL PLATE WITH TAILORED CHAMBERS
    6.
    发明申请
    MULTI-WELL PLATE WITH TAILORED CHAMBERS 有权
    多层板，配有定制座椅

    公开(公告)号：US20100064781A1

    公开(公告)日：2010-03-18

    申请号：US12556925

    申请日：2009-09-10

    申请人： Claudio Cherubini ,  Nicole Gwerder ,  Martin Kopp ,  Edwin Oosterbroek ,  Emad Sarofim

    发明人： Claudio Cherubini ,  Nicole Gwerder ,  Martin Kopp ,  Edwin Oosterbroek ,  Emad Sarofim

    IPC分类号： G01N21/00 ,  B01L3/00 ,  G01N1/44

    CPC分类号： B01L3/50851 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/0858

    摘要： Systems, methods and multi-well plates comprising an array of wells for thermal treatment of chemical or biological samples are disclosed. Each of the wells comprises a bottom opening, an upper opening, inner side walls extending from the bottom opening to the upper opening, a protrusion extending from the inner side walls into the well with a first cross-sectional area and located at a height from the bottom opening which is smaller than the height from the upper opening. A sample chamber with a second cross-sectional area is formed between the bottom opening and the protrusion. An upper chamber with a third cross-sectional area is formed between the protrusion and the upper opening, and in which the first cross-sectional area is smaller than the third cross-sectional area and smaller than or equal to the second cross-sectional area.

    摘要翻译： 公开了包括用于化学或生物样品的热处理的孔阵列的系统，方法和多孔板。 每个孔包括底部开口，上部开口，从底部开口延伸到上部开口的内侧壁，从内侧壁延伸进入井的突起，其具有第一横截面积并且位于与 底部开口小于从上部开口的高度。 具有第二横截面积的样品室形成在底部开口和突起之间。 在所述突起与所述上部开口之间形成具有第三横截面积的上部腔室，其中，所述第一横截面积小于所述第三横截面积，并且小于或等于所述第二横截面积 。

    Multi-well plate with tailored chambers
    7.
    发明授权
    Multi-well plate with tailored chambers 有权
    多孔板与定制的房间

    公开(公告)号：US08808647B2

    公开(公告)日：2014-08-19

    申请号：US12556925

    申请日：2009-09-10

    申请人： Claudio Cherubini ,  Nicole Gwerder ,  Martin Kopp ,  Edwin Oosterbroek ,  Emad Sarofim

    发明人： Claudio Cherubini ,  Nicole Gwerder ,  Martin Kopp ,  Edwin Oosterbroek ,  Emad Sarofim

    IPC分类号： B01L3/00

    CPC分类号： B01L3/50851 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/0858

    摘要： Systems, methods and multi-well plates comprising an array of wells for thermal treatment of chemical or biological samples are disclosed. Each of the wells comprises a bottom opening, an upper opening, inner side walls extending from the bottom opening to the upper opening, a protrusion extending from the inner side walls into the well with a first cross-sectional area and located at a height from the bottom opening which is smaller than the height from the upper opening. A sample chamber with a second cross-sectional area is formed between the bottom opening and the protrusion. An upper chamber with a third cross-sectional area is formed between the protrusion and the upper opening, and in which the first cross-sectional area is smaller than the third cross-sectional area and smaller than or equal to the second cross-sectional area.

    摘要翻译： 公开了包括用于化学或生物样品的热处理的孔阵列的系统，方法和多孔板。 每个孔包括底部开口，上部开口，从底部开口延伸到上部开口的内侧壁，从内侧壁延伸进入井的突起，其具有第一横截面积并且位于与 底部开口小于从上部开口的高度。 具有第二横截面积的样品室形成在底部开口和突起之间。 在所述突起与所述上部开口之间形成具有第三横截面积的上部腔室，其中，所述第一横截面积小于所述第三横截面积，并且小于或等于所述第二横截面积 。

    METHOD, STRUCTURE, DEVICE, KIT AND SYSTEM FOR THE AUTOMATED ANALYSIS OF LIQUID SAMPLES
    8.
    发明申请
    METHOD, STRUCTURE, DEVICE, KIT AND SYSTEM FOR THE AUTOMATED ANALYSIS OF LIQUID SAMPLES 有权
    液体样品自动分析的方法，结构，装置，工具包和系统

    公开(公告)号：US20110250695A1

    公开(公告)日：2011-10-13

    申请号：US12903492

    申请日：2010-10-13

    申请人： Emad Sarofim ,  Edwin Oosterbroek ,  Claudio Cherubini ,  Nenad Milicevic

    发明人： Emad Sarofim ,  Edwin Oosterbroek ,  Claudio Cherubini ,  Nenad Milicevic

    IPC分类号： G01N35/00 ,  G01N33/00 ,  C12M1/34 ,  B01L3/00

    CPC分类号： G01N35/00029 ,  B01L3/502738 ,  B01L7/52 ,  B01L2200/0642 ,  B01L2200/0673 ,  B01L2300/0829 ,  B01L2300/0864 ,  B01L2400/0409 ,  B01L2400/0677 ,  G01N21/07 ,  G01N2021/0325 ,  G01N2035/00099 ,  G01N2035/00495

    摘要： A method for the automated analysis of liquid samples using at least one microfluidic structure is disclosed as well as microfluidic structures, a device having at least one of the microfluidic structures, a kit and a system including such microfluidic device. In one embodiment, the method may comprise: transferring said sample into a first fluid reservoir which is in fluid communication with a second fluid reservoir by a flow channel; spinning said microfluidic structure so as to transport said sample into one or more dead-end recesses or chambers; transferring a control fluid into the structure which generates a barrier to flow and diffusion of said sample contained in said one or more dead-end recesses or chambers; and analyzing said sample contained in said one or more dead-end recesses or chambers.

    摘要翻译： 公开了使用至少一个微流体结构自动分析液体样品的方法，以及微流体结构，具有至少一个微流体结构的装置，试剂盒和包括这种微流体装置的系统。 在一个实施例中，该方法可以包括：将所述样品转移到通过流动通道与第二流体储存器流体连通的第一流体储存器中; 旋转所述微流体结构以将所述样品输送到一个或多个死端凹部或腔室中; 将控制流体转移到所述结构中，所述结构产生所述一个或多个死端凹部或室中容纳的所述样品的流动和扩散的阻挡层; 并分析包含在所述一个或多个死端凹部或腔室中的所述样品。