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    Hybrid tissues for tissue engineering
    2.
    发明申请
    Hybrid tissues for tissue engineering 审中-公开
    组织工程杂交组织

    公开(公告)号：US20050002982A1

    公开(公告)日：2005-01-06

    申请号：US10726072

    申请日：2003-12-01

    申请人： David Mooney ,  Charles Vacanti ,  Craig Halberstadt ,  Andrea Ferguson ,  Jennifer Marler ,  Byung-Soo Kim

    发明人： David Mooney ,  Charles Vacanti ,  Craig Halberstadt ,  Andrea Ferguson ,  Jennifer Marler ,  Byung-Soo Kim

    IPC分类号： A61K35/12 ,  A61K48/00 ,  A61L27/38 ,  C12N5/071

    CPC分类号： A61L27/3886 ,  A61K35/12 ,  A61K48/00 ,  A61L27/3817 ,  A61L27/3821 ,  A61L27/3826 ,  A61L27/383 ,  A61L27/3847 ,  A61L27/3852 ,  A61L27/3895 ,  C12N5/0697 ,  C12N2502/1317 ,  C12N2502/28 ,  C12N2533/40

    摘要： The present invention comprises an implantable device that provides artificial tissues for repair, augmentation and reconstructive surgery which have mechanical properties comparable to the natural tissues that they supplement or replace. Such devices can be produced by a tissue engineering method comprising seeding a polymer matrix with a first cell type and a second cell type and culturing the seeded matrix under conditions suitable for cell growth or maintenance, whereby a tissue comprising a mixed cell population containing both the first and second cell types is produced. The tissue produced by this method contains a mixed population in which the two cell types are intimately associated without apparent stratification and has mechanical properties which are intermediate between similarly produced tissues containing either one of the two cell types. This invention is particularly useful in forming implantable structural members.

    摘要翻译： 本发明包括可植入装置，其提供用于修复，增加和重建手术的人造组织，其具有与其补充或替代的天然组织相当的机械性能。 这样的装置可以通过组织工程方法来生产，包括将具有第一种细胞类型和第二种细胞类型的聚合物基质接种，并在适于细胞生长或维持的条件下培养接种的基质，由此将包含混合细胞群的组织 产生第一和第二细胞类型。 通过该方法产生的组织包含混合群体，其中两种细胞类型密切相关而没有明显的分层，并且具有在含有两种细胞类型之一的类似产生的组织之间中间的机械性质。 本发明特别可用于形成可植入结构构件。

    Production of a biological factor and creation of an immunologically privileged environment using genetically altered Sertoli cells
    3.
    发明授权
    Production of a biological factor and creation of an immunologically privileged environment using genetically altered Sertoli cells 有权
    使用遗传改变的Sertoli细胞生产生物因子和创造免疫特性环境

    公开(公告)号：US07399751B2

    公开(公告)日：2008-07-15

    申请号：US10219804

    申请日：2002-08-15

    申请人： Shaun A. Kirkpatrick ,  Paul Gores ,  Craig Halberstadt

    发明人： Shaun A. Kirkpatrick ,  Paul Gores ,  Craig Halberstadt

    IPC分类号： A61K31/711

    CPC分类号： A61K38/28 ,  A61K38/4846 ,  A61K48/00 ,  A61K2035/122 ,  C12N5/0683 ,  C12N9/1051 ,  C12N9/644 ,  C12Y304/21022

    摘要： The present invention provides a method of providing an individual with a biological factor or intermediate thereof which comprises introducing into the individual Sertoli cells genetically altered to produce the biological factor or intermediate thereof. The genetically altered Sertoli cells are administered in an amount effective to produce the desired effect. Aside from producing the biological factor or intermediate thereof, the engineered Sertoli cells also create an immunologically privileged site. Vectors comprising a promoter which functions in Sertoli cells operably linked to coding sequence for a desired biological factor are also provided as are Sertoli cells comprising such vectors. A pharmaceutical composition comprising Sertoli cells genetically altered to produce a biological factor is also provided.

    摘要翻译： 本发明提供了向个体提供生物因子或其中间体的方法，其包括向遗传改变以产生生物因子或其中间体的各个Sertoli细胞中引入。 以有效产生所需效果的量施用遗传改变的Sertoli细胞。 除了产生生物因子或其中间体之外，工程化的Sertoli细胞还产生免疫特异性位点。 包含与可操作地连接到所需生物因子的编码序列的Sertoli细胞中起作用的启动子的载体也是包含这种载体的Sertoli细胞。 还提供了包含遗传改变以产生生物因子的Sertoli细胞的药物组合物。

    Bioreactor for cell growth and associated methods
    4.
    发明授权
    Bioreactor for cell growth and associated methods 有权
    生物反应器用于细胞生长和相关方法

    公开(公告)号：US08852925B2

    公开(公告)日：2014-10-07

    申请号：US11957747

    申请日：2007-12-17

    申请人： Craig Halberstadt ,  Richard Peindl

    发明人： Craig Halberstadt ,  Richard Peindl

    IPC分类号： C12M1/00 ,  C12M3/00 ,  C12M1/12 ,  C12N5/02 ,  C12N5/00 ,  C12M1/34

    CPC分类号： C12N5/0655 ,  C12M21/08 ,  C12M23/34 ,  C12M23/58 ,  C12M25/14 ,  C12M29/04 ,  C12M35/04 ,  C12M35/08 ,  C12M41/00 ,  C12M41/32 ,  C12N5/0068 ,  C12N2539/00

    摘要： Apparatuses, systems, and methods are provided for growing and maintaining cells. A three-dimensional matrix, such as a hydrogel material, is seeded with cells and placed in a bioreactor having two compartments. The matrix is supported between the two compartments by first and second porous materials, which engage opposing surfaces of the matrix. A first media stream having certain properties is propagated through the first compartment, where it contacts one surface of the matrix via the first porous material. A second media stream having different properties is propagated through the second compartment such that it contacts the opposite surface of the matrix via the second porous material. Through migration of each stream at least partially into the matrix, various controlled gradients may be established within the matrix, encouraging growth of the cells. Such gradients include osmotic pressure, oscillating osmotic pressure, hydrostatic pressure, oxygen tension, and/or nutrient gradients.

    摘要翻译： 提供了用于生长和维持细胞的装置，系统和方法。 将诸如水凝胶材料的三维基质接种细胞并置于具有两个隔室的生物反应器中。 基体由第一和第二多孔材料支撑在两个隔室之间，第一和第二多孔材料接合基体的相对表面。 具有某些性质的第一介质流通过第一隔室传播，其中它经由第一多孔材料接触基体的一个表面。 具有不同性质的第二介质流传播通过第二隔室，使得其经由第二多孔材料接触基体的相对表面。 通过将每个流的至少部分迁移到基质中，可以在基质内建立各种受控梯度，促进细胞生长。 这种梯度包括渗透压，振荡渗透压，静水压力，氧气压力和/或营养梯度。

    PRODUCTION OF A BIOLOGICAL FACTOR AND CREATION OF AN IMMUNOLOGICALLY PRIVILEGED ENVIRONMENT USING GENETICALLY ALTERED SERTOLI CELLS
    7.
    发明申请
    PRODUCTION OF A BIOLOGICAL FACTOR AND CREATION OF AN IMMUNOLOGICALLY PRIVILEGED ENVIRONMENT USING GENETICALLY ALTERED SERTOLI CELLS 审中-公开
    生物因子的生成和使用遗传改良的丝氨酸细胞创建免疫特异性环境

    公开(公告)号：US20080145348A1

    公开(公告)日：2008-06-19

    申请号：US12034305

    申请日：2008-02-20

    申请人： Shaun A. Kirkpatrick ,  Paul Gores ,  Craig Halberstadt

    发明人： Shaun A. Kirkpatrick ,  Paul Gores ,  Craig Halberstadt

    IPC分类号： A61K35/12 ,  C12N15/63 ,  C12N5/08 ,  A61P3/10

    CPC分类号： A61K38/28 ,  A61K38/4846 ,  A61K48/00 ,  A61K2035/122 ,  C12N5/0683 ,  C12N9/1051 ,  C12N9/644 ,  C12Y304/21022

    摘要： The present invention provides a method of providing an individual with a biological factor or intermediate thereof which comprises introducing into the individual Sertoli cells genetically altered to produce the biological factor or intermediate thereof. The genetically altered Sertoli cells are administered in an amount effective to produce the desired effect. Aside from producing the biological factor or intermediate thereof, the engineered Sertoli cells also create an immunologically privileged site. Vectors comprising a promoter which functions in Sertoli cells operably linked to coding sequence for a desired biological factor are also provided as are Sertoli cells comprising such vectors. A pharmaceutical composition comprising Sertoli cells genetically altered to produce a biological factor is also provided.

    摘要翻译： 本发明提供了向个体提供生物因子或其中间体的方法，其包括向遗传改变以产生生物因子或其中间体的各个Sertoli细胞中引入。 以有效产生所需效果的量施用遗传改变的Sertoli细胞。 除了产生生物因子或其中间体之外，工程化的Sertoli细胞还产生免疫特异性位点。 包含与可操作地连接到所需生物因子的编码序列的Sertoli细胞中起作用的启动子的载体也是包含这种载体的Sertoli细胞。 还提供了包含遗传改变以产生生物因子的Sertoli细胞的药物组合物。