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公开(公告)号：US20110189292A1
公开(公告)日：2011-08-04
申请号：US12883139
申请日：2010-09-15
申请人： Pierre F. Lebreton , Sebastien Pierre , Adam L. Collette , Rebecca L. Horan , Jingsong Chen , Gregory H. Altman
发明人： Pierre F. Lebreton , Sebastien Pierre , Adam L. Collette , Rebecca L. Horan , Jingsong Chen , Gregory H. Altman
CPC分类号： A61K8/64 , A61K9/0019 , A61K9/06 , A61K31/167 , A61K38/17 , A61K47/42 , A61L27/227 , A61L27/3604 , A61L27/3641 , A61Q19/08 , A61K2300/00
摘要： The present specification provides compositions useful as dermal fillers and methods using such compositions to treat a condition of skin.
摘要翻译： 本说明书提供了可用作真皮填料的组合物和使用这种组合物治疗皮肤病症的方法。
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公开(公告)号：US08900571B2
公开(公告)日：2014-12-02
申请号：US13398674
申请日：2012-02-16
申请人： Dennis E. Van Epps , Guang-Liang Jiang , Adam L. Collette , Rebecca L. Horan , Jingsong Chen , Gregory H. Altman , Wha Bin Im
发明人： Dennis E. Van Epps , Guang-Liang Jiang , Adam L. Collette , Rebecca L. Horan , Jingsong Chen , Gregory H. Altman , Wha Bin Im
IPC分类号： A01N63/00 , A61F2/20 , A61K8/49 , A61K8/64 , A61K31/5377 , A61K31/519 , A61K31/4025 , A61K8/98 , A61Q19/00 , A61K38/17 , A61K35/12
CPC分类号： A61K31/4025 , A61K8/49 , A61K8/4913 , A61K8/4926 , A61K8/4986 , A61K8/64 , A61K8/981 , A61K31/519 , A61K31/5377 , A61K35/35 , A61K38/1767 , A61Q19/00 , A61K2300/00
摘要： The invention relates to compositions comprising a silk fibroin material, adipose tissue and a compound of the structure where X1 and X5 are independently CH or N; X7 is NH, O or S; X8 and X9 are independently CH or N; R13 is an optionally substituted aryl or optionally substituted heteroaryl and R14 is C1-6 alkyl, optionally substituted aryl or optionally substituted heteroaryl. The composition is administered to a site of a soft tissue condition including those of breast tissue. The silk fibroin material can be in the form of a silk hydrogel, a silk film, a silk scaffold, a silk sheet, a silk porous material or a silk fiber. The silk fibroin material can be substantially sericin free.
摘要翻译： 本发明涉及包含丝素蛋白材料，脂肪组织和其中X1和X5独立地为CH或N的结构的化合物的组合物; X7是NH，O或S; X8和X9独立地为CH或N; R13是任选取代的芳基或任选取代的杂芳基，R 14是C 1-6烷基，任选取代的芳基或任选取代的杂芳基。 将组合物施用于包括乳房组织的组织状况的部位。 丝素蛋白材料可以是丝素水凝胶，丝膜，丝绸支架，丝绸片，丝多孔材料或丝纤维的形式。 丝素蛋白材料可以基本上不含丝胶蛋白。
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公开(公告)号：US20120269777A1
公开(公告)日：2012-10-25
申请号：US13398667
申请日：2012-02-16
申请人： Dennis E. Van Epps , Guang-Liang Jiang , Adam L. Collette , Rebecca L. Horan , Jingsong Chen , Gregory H. Altman , Wha Bin Im
发明人： Dennis E. Van Epps , Guang-Liang Jiang , Adam L. Collette , Rebecca L. Horan , Jingsong Chen , Gregory H. Altman , Wha Bin Im
CPC分类号： A61K8/49 , A61K8/4913 , A61K8/4926 , A61K8/4986 , A61K8/64 , A61K8/981 , A61K31/192 , A61K31/215 , A61K31/4015 , A61K31/4025 , A61K31/421 , A61K35/35 , A61K35/63 , A61K38/00 , A61K38/1767 , A61K2800/91 , A61Q19/08 , A61K2300/00
摘要： The specification discloses compositions and methods for treating a soft tissue defect of an individual.
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公开(公告)号：US20120213853A1
公开(公告)日：2012-08-23
申请号：US13398674
申请日：2012-02-16
申请人： Dennis E. Van Epps , Guang-Liang Jiang , Adam L. Collette , Rebecca L. Horan , Jingsong Chen , Gregory H. Altman , Wha Bin Im
发明人： Dennis E. Van Epps , Guang-Liang Jiang , Adam L. Collette , Rebecca L. Horan , Jingsong Chen , Gregory H. Altman , Wha Bin Im
IPC分类号： A61K9/00 , A61P1/00 , A61P13/00 , A61K35/12 , A61K8/49 , A61Q19/00 , A61P15/00 , A61P17/00 , A61P1/02
CPC分类号： A61K31/4025 , A61K8/49 , A61K8/4913 , A61K8/4926 , A61K8/4986 , A61K8/64 , A61K8/981 , A61K31/519 , A61K31/5377 , A61K35/35 , A61K38/1767 , A61Q19/00 , A61K2300/00
摘要： The specification discloses compositions and methods for treating a soft tissue defect of an individual.
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公开(公告)号：US08288347B2
公开(公告)日：2012-10-16
申请号：US12906777
申请日：2010-10-18
CPC分类号： A61K8/64 , A61K9/0019 , A61K9/06 , A61K31/167 , A61K38/17 , A61K47/42 , A61L27/227 , A61L27/3604 , A61L27/3641 , A61Q19/08 , A61K2300/00
摘要： The present specification provides compositions useful as dermal fillers and methods using such compositions to treat a condition of skin.
摘要翻译： 本说明书提供了可用作真皮填料的组合物和使用这种组合物治疗皮肤病症的方法。
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公开(公告)号：US20120172317A1
公开(公告)日：2012-07-05
申请号：US13420182
申请日：2012-03-14
IPC分类号： A61K38/17 , C09D189/00 , A61P17/00 , C12N5/02 , A61K47/42
CPC分类号： A61F2/12 , A61K8/64 , A61K38/1767 , A61K47/42 , A61K2800/5922 , A61K2800/91 , A61L27/227 , A61L27/26 , A61L27/52 , A61L2430/34 , A61Q19/00 , C08B37/0072 , C08L89/00
摘要： The present specification provides for methods for purifying fibroins, purified fibroins, methods of conjugating biological and synthetic molecules to fibroins, fibroins conjugated to such molecules, methods of making fibroin hydrogels, fibroin hydrogels and fibroin hydrogel formulations useful for a variety of medical uses, including, without limitation uses as bulking agents, tissue space fillers, templates for tissue reconstruction or regeneration, cell culture scaffolds for tissue engineering and for disease models, surface coating to improve medical device function, or drug delivery devices.
摘要翻译： 本说明书提供了用于纯化丝心蛋白，纯化的丝心蛋白，将生物和合成分子与丝心蛋白缀合的方法，与此类分子缀合的丝心蛋白，制备丝心蛋白水凝胶的方法，丝心蛋白水凝胶和用于各种医疗用途的丝心蛋白水凝胶制剂的方法，包括 ，但不限于用作填充剂，组织空间填充剂，用于组织重建或再生的模板，用于组织工程和疾病模型的细胞培养支架，用于改善医疗装置功能的表面涂层或药物递送装置。
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公开(公告)号：US09005606B2
公开(公告)日：2015-04-14
申请号：US13420334
申请日：2012-03-14
IPC分类号： A61F2/10 , A61K35/12 , A61P43/00 , C08B37/08 , A61K38/17 , A61K47/42 , A61L27/22 , A61L27/26 , A61L27/52 , A61K8/64 , A61Q19/00 , A61F2/12
CPC分类号： A61F2/12 , A61K8/64 , A61K38/1767 , A61K47/42 , A61K2800/5922 , A61K2800/91 , A61L27/227 , A61L27/26 , A61L27/52 , A61L2430/34 , A61Q19/00 , C08B37/0072 , C08L89/00
摘要： The present specification provides for methods for purifying fibroins, purified fibroins, methods of conjugating biological and synthetic molecules to fibroins, fibroins conjugated to such molecules, methods of making fibroin hydrogels, fibroin hydrogels and fibroin hydrogel formulations useful for a variety of medical uses, including, without limitation uses as bulking agents, tissue space fillers, templates for tissue reconstruction or regeneration, cell culture scaffolds for tissue engineering and for disease models, surface coating to improve medical device function, or drug delivery devices.
摘要翻译： 本说明书提供了用于纯化丝心蛋白，纯化的丝心蛋白，将生物和合成分子与丝心蛋白缀合的方法，与此类分子缀合的丝心蛋白，制备丝心蛋白水凝胶的方法，丝心蛋白水凝胶和用于各种医疗用途的丝心蛋白水凝胶制剂的方法，包括 ，但不限于用作填充剂，组织空间填充剂，用于组织重建或再生的模板，用于组织工程和疾病模型的细胞培养支架，用于改善医疗装置功能的表面涂层或药物递送装置。
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公开(公告)号：US08894992B2
公开(公告)日：2014-11-25
申请号：US13398680
申请日：2012-02-16
申请人： Dennis E. Van Epps , Guang-Liang Jiang , Adam L. Collette , Rebecca L. Horan , Jingsong Chen , Gregory H. Altman , Wha Bin Im
发明人： Dennis E. Van Epps , Guang-Liang Jiang , Adam L. Collette , Rebecca L. Horan , Jingsong Chen , Gregory H. Altman , Wha Bin Im
IPC分类号： A61F2/20 , A01N63/00 , A61K8/44 , A61K8/64 , A61K35/12 , A61Q19/00 , A61K31/195 , A61K8/98 , A61K31/4025 , A61L27/40 , A61K35/64
CPC分类号： A61K31/4025 , A61K8/44 , A61K8/64 , A61K8/981 , A61K31/195 , A61K35/35 , A61K35/63 , A61K38/1767 , A61L27/40 , A61Q19/00 , A61K2300/00
摘要： The invention relates to compositions comprising adipose tissue, a silk fibroin material and a compound of the structure The composition is administered to a site of a soft tissue condition including those of breast tissue. The silk fibroin material can be in the form of a silk hydrogel, a silk film, a silk scaffold, a silk sheet, a silk porous material, a silk fiber or a combination of those materials. The silk material may be substantially sericin free.
摘要翻译： 本发明涉及包含脂肪组织，丝素蛋白材料和结构化合物的组合物。将组合物施用于包括乳腺组织的软组织病症的部位。 丝素蛋白材料可以是丝素水凝胶，丝膜，丝绸支架，丝
绸，丝绸多孔材料，丝纤维或这些材料的组合的形式。 丝质材料可以基本上不含丝氨酸。-
公开(公告)号：US20120213852A1
公开(公告)日：2012-08-23
申请号：US13398661
申请日：2012-02-16
申请人： Dennis E. Van Epps , Guang-Liang Jiang , Adam L. Collette , Rebecca L. Horan , Jingsong Chen , Gregory H. Altman , Wha Bin Im
发明人： Dennis E. Van Epps , Guang-Liang Jiang , Adam L. Collette , Rebecca L. Horan , Jingsong Chen , Gregory H. Altman , Wha Bin Im
CPC分类号： A61K31/381 , A61K8/49 , A61K8/4913 , A61K8/4926 , A61K8/4986 , A61K8/64 , A61K8/981 , A61K31/4015 , A61K31/4025 , A61K31/45 , A61K35/35 , A61K38/1767 , A61K45/06 , A61Q19/00 , A61K2300/00
摘要： The specification discloses compositions and methods for treating a soft tissue defect of an individual.
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公开(公告)号：US20110020409A1
公开(公告)日：2011-01-27
申请号：US12764043
申请日：2010-04-20
CPC分类号： A61F2/12 , A61K8/64 , A61K38/1767 , A61K47/42 , A61K2800/5922 , A61K2800/91 , A61L27/227 , A61L27/26 , A61L27/52 , A61L2430/34 , A61Q19/00 , C08B37/0072 , C08L89/00
摘要： The present specification provides for methods for purifying fibroins, purified fibroins, methods of conjugating biological and synthetic molecules to fibroins, fibroins conjugated to such molecules, methods of making fibroin hydrogels, fibroin hydrogels and fibroin hydrogel formulations useful for a variety of medical uses, including, without limitation uses as bulking agents, tissue space fillers, templates for tissue reconstruction or regeneration, cell culture scaffolds for tissue engineering and for disease models, surface coating to improve medical device function, or drug delivery devices.
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