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    System and method for enabling selection of an image registration transformation
    1.
    发明授权
    System and method for enabling selection of an image registration transformation 有权
    允许选择图像配准变换的系统和方法

    公开(公告)号：US08380007B2

    公开(公告)日：2013-02-19

    申请号：US12096648

    申请日：2006-12-05

    申请人： Raymond C. Chan ,  Robert Manzke ,  Shunmugavelu Sokka ,  Volker Rasche ,  Vivek Reddy

    发明人： Raymond C. Chan ,  Robert Manzke ,  Shunmugavelu Sokka ,  Volker Rasche ,  Vivek Reddy

    IPC分类号： G06K9/32

    CPC分类号： G06T7/38 ,  G06T7/35 ,  G06T2207/30004

    摘要： System and method for enabling intra-operative selection of an image registration transformation for use in displaying a first image dataset and a second image dataset in correspondence with one another. Image dataset acquisition devices (12, 14) obtain the first and second image datasets. A similarity function indicative of a likelihood that the first and second image datasets are in correspondence with one another is computed by a processor (16) and then a ranking of each of a plurality of local maxima of the similarity function is determined. Registration transformations derived from a plurality of the local maxima are displayed on a display (18), and using a user-interface (22), a physician can select each registration transformation to ascertain visually whether it is the clinically-optimal registration transformation for subsequent use.

    摘要翻译： 用于使得能够在操作中选择图像配准变换以用于相互对应地显示第一图像数据集和第二图像数据集的系统和方法。 图像数据集获取装置（12,14）获得第一和第二图像数据集。 由处理器（16）计算指示第一和第二图像数据集彼此对应的可能性的相似度函数，然后确定相似度函数的多个局部最大值中的每一个的等级。 从多个本地最大值导出的登记变换被显示在显示器（18）上，并且使用用户界面（22），医师可以选择每个注册变换以在视觉上确定是否是用于后续的临床优化注册变换 使用。

    System and Method for Enabling Selection of an Image Registration Transformation
    2.
    发明申请
    System and Method for Enabling Selection of an Image Registration Transformation 有权
    用于启用图像注册转换选​​择的系统和方法

    公开(公告)号：US20080279430A1

    公开(公告)日：2008-11-13

    申请号：US12096648

    申请日：2006-12-05

    申请人： Raymond C. Chan ,  Robert Manzke ,  Shunmugavelu Sokka ,  Volker Rasche ,  Vivek Reddy

    发明人： Raymond C. Chan ,  Robert Manzke ,  Shunmugavelu Sokka ,  Volker Rasche ,  Vivek Reddy

    IPC分类号： G06T7/00

    CPC分类号： G06T7/38 ,  G06T7/35 ,  G06T2207/30004

    摘要： System and method for enabling intra-operative selection of an image registration transformation for use in displaying a first image dataset and a second image dataset in correspondence with one another. Image dataset acquisition devices (12, 14) obtain the first and second image datasets. A similarity function indicative of a likelihood that the first and second image datasets are in correspondence with one another is computed by a processor (16) and then a ranking of each of a plurality of local maxima of the similarity function is determined. Registration transformations derived from a plurality of the local maxima are displayed on a display (18), and using a user-interface (22), a physician can select each registration transformation to ascertain visually whether it is the clinically-optimal registration transformation for subsequent use.

    摘要翻译： 用于使得能够在操作中选择图像配准变换以用于相互对应地显示第一图像数据集和第二图像数据集的系统和方法。 图像数据集获取装置（12,14）获得第一和第二图像数据集。 由处理器（16）计算指示第一和第二图像数据集彼此对应的可能性的相似度函数，然后确定相似度函数的多个局部最大值中的每一个的等级。 从多个本地最大值导出的登记变换被显示在显示器（18）上，并且使用用户界面（22），医师可以选择每个注册变换以在视觉上确定是否是用于后续的临床优化注册变换 使用。

    MRI-guided HIFU marking to guide radiotherapy and other procedures
    4.
    发明授权
    MRI-guided HIFU marking to guide radiotherapy and other procedures 有权
    MRI指导HIFU标记指导放疗等手术

    公开(公告)号：US09486651B2

    公开(公告)日：2016-11-08

    申请号：US12531495

    申请日：2008-03-07

    申请人： Gregory Karczmar ,  Shunmugavelu Sokka ,  Charles A. Pelizzari

    发明人： Gregory Karczmar ,  Shunmugavelu Sokka ,  Charles A. Pelizzari

    IPC分类号： A61N7/00 ,  A61B5/00 ,  A61B5/055 ,  A61N7/02 ,  A61N5/10

    CPC分类号： A61N7/02 ,  A61B90/39 ,  A61B2090/374 ,  A61B2090/376 ,  A61N5/1049 ,  A61N2005/1061

    摘要： The present disclosure provides for effective systems and methods for increasing target tissue conspicuity within a particular anatomy of a particular patient. In an exemplary embodiment, a system associated with the present disclosure includes: (a) a MRI-guided HIFU system for generating ablation markings on a target tissue region, the MRI-guided HIFU system including a transducer for delivering HIFU to the target tissue region, the delivered HIFU generating the ablation markings on the target tissue and an MRI imaging system adapted to generate a three dimensional image of the target tissue region during HIFU delivery for guiding the delivery of the HIFU to the target tissue region; (b) a radiotherapy delivery system for delivering radiotherapy treatment to the target tissue region; and (c) a CT imaging system operable within the radiotherapy delivery system for generating a three dimensional image of the target tissue region. The markings generated on the target tissue region by the MRI-guided HIFU are visible in the image generated by the CT imaging system. The image generated by the CT imaging system guides the location of the radiotherapy treatment delivered to the target tissue region.

    摘要翻译： 本公开提供了用于增加特定患者的特定解剖结构内的目标组织显着性的有效系统和方法。 在示例性实施例中，与本公开相关联的系统包括：（a）用于在目标组织区域上产生消融标记的MRI引导的HIFU系统，所述MRI引导的HIFU系统包括用于将HIFU传送到目标组织区域的换能器 所传送的HIFU在靶组织上产生消融标记，以及MRI成像系统，其适于在HIFU递送期间产生目标组织区域的三维图像，用于将HIFU传送到目标组织区域; （b）放射治疗递送系统，用于向目标组织区域递送放射治疗; 和（c）可在放射治疗递送系统内操作的用于产生目标组织区域的三维图像的CT成像系统。 通过MRI引导的HIFU在靶组织区域上产生的标记在CT成像系统产生的图像中是可见的。 由CT成像系统产生的图像引导放射治疗治疗传送到目标组织区域的位置。

    THERAPY SYSTEM WITH TEMPERATURE CONTROL
    8.
    发明申请
    THERAPY SYSTEM WITH TEMPERATURE CONTROL 有权
    具有温度控制的治疗系统

    公开(公告)号：US20100280356A1

    公开(公告)日：2010-11-04

    申请号：US12812240

    申请日：2009-01-09

    申请人： Max Oskar Kohler ,  Shunmugavelu Sokka

    发明人： Max Oskar Kohler ,  Shunmugavelu Sokka

    IPC分类号： A61N7/02 ,  A61B5/055

    CPC分类号： A61N7/02 ,  A61B5/015 ,  A61B5/055 ,  A61B2017/00084 ,  A61B2090/374

    摘要： A therapy system comprises a therapy module to direct a therapeutic action to a target along successive trajectories in a target region that includes the target. A thermometry module is provided to measure temperature a measurement field and in particular to compute a thermal dose. A control module to controls the therapy module to apply the therapeutic action along the respective trajectories on the basis of the measured temperature and/or thermal dose. The successive trajectories are located in the target zone outward or inward relative to one another within the target zone. In particular the therapeutic action subsists in application a focused ultrasound beam to the target. Temperature measurement is done on the basis of magnetic resonance signals.

    摘要翻译： 治疗系统包括治疗模块，用于在包括目标的目标区域中沿着连续轨迹将治疗作用指向靶。 提供测温模块以测量测量场的温度，特别是计算热剂量。 控制模块，用于控制治疗模块，基于测量的温度和/或热剂量，沿着相应的轨迹施加治疗作用。 连续轨迹在目标区域内相对于彼此向外或向内位于目标区域中。 特别地，治疗作用在应用中存在聚焦超声波束到目标。 温度测量是基于磁共振信号进行的。

    Method and Apparatus for Ultrasound Drug Delivery and Thermal Therapy with Phase-Convertible Fluids
    9.
    发明申请
    Method and Apparatus for Ultrasound Drug Delivery and Thermal Therapy with Phase-Convertible Fluids 有权
    用于超声药物递送和相可转换液体治疗的方法和装置

    公开(公告)号：US20080200845A1

    公开(公告)日：2008-08-21

    申请号：US11914777

    申请日：2006-05-25

    申请人： Shunmugavelu Sokka ,  Christopher Stephen Hall ,  Marcel Rene Bohmer

    发明人： Shunmugavelu Sokka ,  Christopher Stephen Hall ,  Marcel Rene Bohmer

    IPC分类号： A61N7/02 ,  A61M37/00

    CPC分类号： A61M37/0092 ,  A61B8/12 ,  A61B8/546 ,  A61B2017/22008 ,  A61K41/0033 ,  A61K49/223 ,  A61N7/00 ,  A61N7/02

    摘要： An ultrasound treatment comprises applying ultrasound at a first energy level (32) to a region of interest (20) in a subject for activating a cavitation nucleation agent during a first portion of a treatment cycle (t1-t2). Ultrasound at a second energy level (34) is applied to the region of interest (20) during a second portion of the treatment cycle (t2-t3) for implementing a desired thermal therapy in the presence of the cavitation nucleation agent activated during the first portion of the treatment cycle. The second energy level is at an energy level different from the first energy level.

    摘要翻译： 超声处理包括将第一能级（32）的超声波施用于受试者的感兴趣区域（20），以在治疗周期（t 1 -t 2）的第一部分期间激活空化成核剂。 在治疗周期（t 2 -t 3）的第二部分期间，在第二能量水平（34）处的超声被施加到感兴趣区域（20），以在存在激活的空化成核剂的情况下实现期望的热疗法 治疗周期的第一部分。 第二能级处于与第一能级不同的能级。

    Therapy system with temperature control
    10.
    发明授权
    Therapy system with temperature control 有权

    公开(公告)号：US09687681B2

    公开(公告)日：2017-06-27

    申请号：US12812240

    申请日：2009-01-09

    申请人： Max Oskar Kohler ,  Shunmugavelu Sokka

    发明人： Max Oskar Kohler ,  Shunmugavelu Sokka

    IPC分类号： A61N7/02 ,  A61B5/01 ,  A61B5/055 ,  A61B17/00 ,  A61B90/00

    CPC分类号： A61N7/02 ,  A61B5/015 ,  A61B5/055 ,  A61B2017/00084 ,  A61B2090/374

    摘要： A therapy system comprises a therapy module to direct a therapeutic action to a target along successive trajectories in a target zone that includes the target. A thermometry module is provided to measure temperature in a measurement field and to compute a thermal dose. The measurement field at least partially covers the target zone. A control module controls the therapy module to switch the therapeutic action to a next successive trajectory on the basis of the measured temperature or thermal dose. The successive trajectories are located inside of or outside of one another within the target zone. The therapeutic action comprises application of a focused ultrasound beam to the target. Temperature measurement is done on the basis of magnetic resonance signals.