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    Apparatus for measuring a decomposable compound in solution
    1.
    发明授权
    Apparatus for measuring a decomposable compound in solution 失效
    用于测量溶液中可分解化合物的装置

    公开(公告)号：US06521184B1

    公开(公告)日：2003-02-18

    申请号：US09589011

    申请日：2000-06-07

    申请人： Raymond Edgson ,  Arfon Goodman-Jones ,  Bo Olde ,  Lars-Fride Olsson

    发明人： Raymond Edgson ,  Arfon Goodman-Jones ,  Bo Olde ,  Lars-Fride Olsson

    IPC分类号： G01N2706

    CPC分类号： C12Q1/58 ,  G01N27/021 ,  G01N33/493 ,  Y10T436/171538 ,  Y10T436/25

    摘要： Methods and apparatus for measuring the concentration of decomposable substances, such as urea, are disclosed. The disclosed methods include adding a gaseous buffer, such as CO2, to the solution containing the decomposable compound, measuring the conductivity of the solution, decomposing the decomposable compound, measuring the conductivity of the thus-decomposed compound solution, and calculating the differential conductivities between the two measured solutions. The apparatus for carrying out these methods are also disclosed.

    摘要翻译： 公开了用于测量可分解物质如尿素的浓度的方法和装置。 所公开的方法包括向含有可分解化合物的溶液中加入气态缓冲液，例如CO 2，测量溶液的电导率，分解可分解化合物，测量这样分解的化合物溶液的电导率，并计算 两个测量的解决方案。 还公开了用于实施这些方法的装置。

    Methods and devices for monitoring the integrity of a fluid connection
    4.
    发明授权
    Methods and devices for monitoring the integrity of a fluid connection 有权
    用于监测流体连接完整性的方法和装置

    公开(公告)号：US09442036B2

    公开(公告)日：2016-09-13

    申请号：US13001314

    申请日：2009-06-26

    申请人： Martin Furmanski ,  Anders Roslund ,  Bo Olde ,  Kristian Solem ,  Thomas Hertz ,  Jan Sternby

    发明人： Martin Furmanski ,  Anders Roslund ,  Bo Olde ,  Kristian Solem ,  Thomas Hertz ,  Jan Sternby

    IPC分类号： G01L27/00 ,  G01N33/49 ,  G01M3/28 ,  A61M1/36

    CPC分类号： G01M3/2846 ,  A61M1/3653 ,  A61M1/3656 ,  A61M1/3659 ,  A61M1/3661 ,  G01L27/002 ,  G01M3/2815 ,  G01N33/49

    摘要： A method of monitoring the integrity of a fluid connection between first and second fluid containing systems based on at least one time-dependent measurement signal from a pressure sensor in the first fluid containing system. The pressure sensor detects first pulses originating from a first pulse generator in the first fluid containing system and second pulses originating from a second pulse generator in the second fluid containing system. A parameter value representing a distribution of signal values within a time window is calculated by analyzing the measurement signal in the time domain and/or by using information on the timing of the second pulses in the measurement signal. The parameter value may be calculated as a statistical dispersion measure of the signal values, or from matching the signal to a predicted temporal signal profile of the second pulse. The integrity of the fluid connection is determined from the parameter value.

    摘要翻译： 基于来自第一流体容纳系统中的压力传感器的至少一个与时间相关的测量信号来监测第一和第二流体容纳系统之间的流体连接的完整性的方法。 压力传感器检测来自第一流体容纳系统中的第一脉冲发生器的第一脉冲和源自第二流体容纳系统中的第二脉冲发生器的第二脉冲。 通过在时域中分析测量信号和/或通过使用关于测量信号中的第二脉冲的定时的信息来计算表示时间窗内的信号值分布的参数值。 可以将参数值计算为信号值的统计色散测量值，或者将信号与第二脉冲的预测时间信号分布匹配。 根据参数值确定流体连接的完整性。

    Method and device for detecting a configuration of withdrawal and return devices
    5.
    发明授权
    Method and device for detecting a configuration of withdrawal and return devices 有权
    用于检测退出和退回装置的配置的方法和装置

    公开(公告)号：US09289544B2

    公开(公告)日：2016-03-22

    申请号：US13519146

    申请日：2010-12-22

    申请人： Bo Olde ,  Kristian Solem

    发明人： Bo Olde ,  Kristian Solem

    IPC分类号： A61M1/30 ,  A61M1/36 ,  A61M5/168

    CPC分类号： A61M1/30 ,  A61M1/3653 ,  A61M1/3656 ,  A61M1/3659 ,  A61M1/3661 ,  A61M5/16859 ,  A61M2205/13 ,  A61M2205/3331 ,  A61M2230/04

    摘要： A device is arranged to detect a configuration of withdrawal and return devices (1, 14, 111, 112, 211, 212, 702, 703, 802, 803) coupling an extracorporeal blood flow circuit (20) to a cardiovascular system of a subject. The device comprises a signal processor (29), which is configured to receive a primary measurement signal obtained by a primary pressure sensor (4a, 4b, 4c) in the extracorporeal blood flow circuit (20). The device is further configured to process the primary measurement signal for extraction of primary pressure data originating from a subject pulse generator (3′) in the cardiovascular system or extracorporeal blood flow circuit (20), the primary pressure data comprising at least a part of a first pulse from the subject pulse generator (3′). The device is also configured to calculate a parameter value from the primary pressure data and to determine the configuration based at least partly on the parameter value.

    摘要翻译： 一种装置被布置成检测将体外血流回路（20）耦合到对象的心血管系统的撤回和返回装置（1,14,111,112,211,212,702,702,802,803）的构造 。 该装置包括信号处理器（29），其被配置为接收由体外血流回路（20）中的一次压力传感器（4a，4b，4c）获得的主测量信号。 该装置还被配置为处理主要测量信号以提取源自心血管系统或体外血流回路（20）中的受检者脉冲发生器（3'）的主要压力数据，所述主要压力数据包括至少一部分 来自对象脉冲发生器（3'）的第一脉冲。 该装置还被配置为从主压力数据计算参数值，并且至少部分地基于参数值来确定配置。

    APPARATUS AND METHOD FOR PREDICTION OF RAPID SYMPTOMATIC BLOOD PRESSURE DECREASE
    6.
    发明申请
    APPARATUS AND METHOD FOR PREDICTION OF RAPID SYMPTOMATIC BLOOD PRESSURE DECREASE 审中-公开
    用于预测快速症状性血压降低的装置和方法

    公开(公告)号：US20130274570A9

    公开(公告)日：2013-10-17

    申请号：US13519067

    申请日：2010-12-22

    申请人： Bo Olde ,  Kristian Solem

    发明人： Bo Olde ,  Kristian Solem

    IPC分类号： A61B5/00 ,  A61M1/30 ,  A61B5/0205

    CPC分类号： A61B5/4836 ,  A61B5/0205 ,  A61B5/021 ,  A61B5/02108 ,  A61B5/02416 ,  A61B5/053 ,  A61M1/30 ,  A61M1/36 ,  A61M2230/30

    摘要： A monitoring arrangement 100 is configured to predict a rapid syruptomatic drop in a subject's blood pressure, e.g. during a medical treatment or when operating aircraft. To this aim, a pulse shape parameter (pps) with respect to a peripheral body part (105) of the subject (P) is repeatedly registered by means of a pulse oximetry instrument (110) adapted to detect light response variations in blood vessels. A respective pulse magnitude measure is calculated based on each of a number of received pulse shape parameters (pps), and a statistical dispersion measure is calculated based on the thus-calculated pulse magnitude measure. It is investigated whether or not the statistical dispersion measure fulfils a decision criterion relative to a reference measure. An output signal (α) is generated if the decision criterion is found to be fulfilled.

    摘要翻译： 监测装置100被配置为预测受试者的血压中的快速糖尿病下降。 在医疗或运营飞机时。 为此目的，相对于被检体（P）的周边主体部分（105）的脉冲形状参数（pps）通过适于检测血管中的光反应变化的脉搏血氧仪（110）重复记录。 基于接收的脉冲形状参数（pps）中的每一个来计算相应的脉冲幅度测量，并且基于由此计算的脉冲幅度测量值来计算统计色散测量。 调查统计色散测量是否满足参考测量的决策标准。 如果发现满足判定标准，则产生输出信号（α）。

    METHOD AND DEVICE FOR DETECTING A FAULT CONDITION
    7.
    发明申请
    METHOD AND DEVICE FOR DETECTING A FAULT CONDITION 有权
    用于检测故障条件的方法和装置

    公开(公告)号：US20130204174A1

    公开(公告)日：2013-08-08

    申请号：US13519248

    申请日：2010-12-22

    申请人： Bo Olde ,  Kristian Solem

    发明人： Bo Olde ,  Kristian Solem

    IPC分类号： G01N11/02

    CPC分类号： G01N11/02 ,  A61M1/3639 ,  A61M1/3653 ,  A61M1/3656 ,  A61M1/3661 ,  A61M5/16859 ,  A61M2205/13 ,  A61M2205/15 ,  A61M2205/3331 ,  A61M2230/04

    摘要： A device is configured to detect a fault condition in a fluid connection system between a first (e.g. extracorporeal blood circuit) and second (e.g. vascular system of a patient) fluid containing systems. The first and second fluid containing systems comprise a first and second pulse generator, respectively. A pressure sensor is arranged in the first fluid containing system to detect pulses originating from the first and second pulse generator. The device operates according to a detection method, by generating a time-dependent monitoring signal based on measurement data obtained from said at least one pressure sensor, such that the monitoring signal at least comprises one or more first pulses; processing (42) the monitoring signal to calculate a parameter value which is indicative of the shape of at least part of a first pulse in the monitoring signal, and evaluating (44) the parameter value for detection of the fault condition.

    摘要翻译： 设备被配置为检测流体连接系统中的第一（例如体外血液回路）和第二（例如患者的血管系统）流体容纳系统之间的故障状况。 第一和第二流体容纳系统分别包括第一和第二脉冲发生器。 压力传感器布置在第一流体容纳系统中以检测源自第一和第二脉冲发生器的脉冲。 该装置根据检测方法，通过基于从所述至少一个压力传感器获得的测量数据产生与时间相关的监视信号，使得监视信号至少包括一个或多个第一脉冲; 处理（42）监视信号以计算指示监视信号中的第一脉冲的至少一部分的形状的参数值，并评估（44）用于检测故障状况的参数值。

    Controlling an apparatus for fluid transfer to and/or from a subject
    9.
    发明授权
    Controlling an apparatus for fluid transfer to and/or from a subject 有权
    控制用于流体转移到和/或从受试者的装置

    公开(公告)号：US09289545B2

    公开(公告)日：2016-03-22

    申请号：US13519148

    申请日：2010-12-22

    申请人： Bo Olde ,  Kristian Solem ,  Thomas Hertz ,  Jan Sternby ,  Anders Wieslander

    发明人： Bo Olde ,  Kristian Solem ,  Thomas Hertz ,  Jan Sternby ,  Anders Wieslander

    IPC分类号： A61M1/30 ,  A61B5/0215 ,  A61B5/024 ,  A61B5/00 ,  A61M1/36

    CPC分类号： A61M1/3656 ,  A61B5/02125 ,  A61B5/0215 ,  A61B5/02405 ,  A61B5/4836 ,  A61M1/30 ,  A61M1/3643 ,  A61M1/3644 ,  A61M1/3653 ,  A61M1/3659 ,  A61M2205/3331 ,  A61M2205/6018

    摘要： A control system (23) is arranged to control the operation of an apparatus (200) for extracorporeal blood treatment. The apparatus (200) comprises an extracorporeal blood circuit (20) and a connection system (C) for connecting the blood circuit (20) to the vascular system of a patient. The blood circuit (20) comprises a blood processing device (6), and at least one pumping device (3). The control system is operable to switch between a pre-treatment mode and a blood treatment mode. The blood treatment mode involves operating the blood circuit (20) to pump blood from the vascular system via the connection system (C) through the blood processing device (6) and back to the vascular system via the connection system (C). The control system (23) is operable to obtain measurement data from at least one energy transfer sensor (40) arranged to sense a transfer of energy between the patient and the connection system (C) or between the patient and the blood circuit (20). The control system (23) is configured to, in the pre-treatment mode, process the measurement data for identification of a characteristic change indicating a connection of the blood circuit (20) to the vascular system of the patient, and, upon such identification, take dedicated action. The action may involve activating at least part of a patient protection system and/or enabling entry into the blood treatment mode. The control system may be included in an apparatus (200) for blood treatment, such as a dialysis machine.

    摘要翻译： 控制系统（23）被布置成控制用于体外血液处理的装置（200）的操作。 装置（200）包括用于将血液回路（20）连接到患者血管系统的体外血液回路（20）和连接系统（C）。 血液回路（20）包括血液处理装置（6）和至少一个泵送装置（3）。 控制系统可操作以在预处理模式和血液处理模式之间切换。 血液处理模式包括操作血液回路（20），以经由连接系统（C）从血管系统通过血液处理装置（6）泵送血液，并通过连接系统（C）返回血管系统。 控制系统（23）可操作以从至少一个能量传递传感器（40）获得测量数据，所述能量传递传感器（40）布置成感测患者和连接系统（C）之间或患者与血液回路（20）之间的能量传递， 。 控制系统（23）被配置为在预处理模式下处理用于识别指示血液回路（20）与患者的血管系统的连接的特征变化的测量数据，并且在这种识别 ，采取专门的行动。 该动作可以涉及激活患者保护系统的至少一部分和/或使得能够进入血液处理模式。 控制系统可以包括在用于血液处理的装置（200）中，例如透析机。

    APPARATUS AND METHOD FOR PREDICTION OF RAPID SYMPTOMATIC BLOOD PRESSURE DECREASE
    10.
    发明申请
    APPARATUS AND METHOD FOR PREDICTION OF RAPID SYMPTOMATIC BLOOD PRESSURE DECREASE 审中-公开

    公开(公告)号：US20130096402A1

    公开(公告)日：2013-04-18

    申请号：US13519067

    申请日：2010-12-22

    申请人： Bo Olde ,  Kristian Solem

    发明人： Bo Olde ,  Kristian Solem

    IPC分类号： A61B5/00 ,  A61M1/30 ,  A61B5/0205

    CPC分类号： A61B5/4836 ,  A61B5/0205 ,  A61B5/021 ,  A61B5/02108 ,  A61B5/02416 ,  A61B5/053 ,  A61M1/30 ,  A61M1/36 ,  A61M2230/30

    摘要： A monitoring arrangement 100 is configured to predict a rapid syruptomatic drop in a subject's blood pressure, e.g. during a medical treatment or when operating aircraft. To this aim, a pulse shape parameter (pps) with respect to a peripheral body part (105) of the subject (P) is repeatedly registered by means of a pulse oximetry instrument (110) adapted to detect light response variations in blood vessels. A respective pulse magnitude measure is calculated based on each of a number of received pulse shape parameters (pps), and a statistical dispersion measure is calculated based on the thus-calculated pulse magnitude measure. It is investigated whether or not the statistical dispersion measure fulfils a decision criterion relative to a reference measure. An output signal (α) is generated if the decision criterion is found to be fulfilled.