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    Collagen-based injectable drug delivery system and its use
    5.
    发明授权
    Collagen-based injectable drug delivery system and its use 失效
    基于胶原的可注射药物递送系统及其用途

    公开(公告)号：US5807581A

    公开(公告)日：1998-09-15

    申请号：US537073

    申请日：1995-09-29

    申请人： Joel S. Rosenblatt ,  Richard A. Berg

    发明人： Joel S. Rosenblatt ,  Richard A. Berg

    IPC分类号： A61K9/00 ,  A61K9/20 ,  A61K38/00 ,  A61K38/22 ,  A61K38/43 ,  A61K47/34 ,  A61K47/42 ,  A61K9/08

    CPC分类号： A61K9/0024 ,  A61K9/205 ,  A61K9/2063

    摘要： Drugs are delivered in a sustained manner from an in vivo depot which is formed from a collagen-based injectable composition. The injectable composition is fluid when injected but undergoes crosslinking in situ to form a crosslinked collagen matrix which encloses the drug to be released. The composition also includes a flexible chain polymer which is similarly charged to the precrosslinked collagen. This flexible chain polymer is enclosed in the matrix as well when the matrix forms and alters the effective porosity of the matrix. The drug diffuses out of the matrix at a rate which depends upon the matrix's effective porosity.

    摘要翻译： 药物以持续的方式从由基于胶原的可注射组合物形成的体内贮库递送。 可注射组合物在注射时是流体，但是在原位进行交联以形成包封要释放的药物的交联胶原蛋白基质。 该组合物还包括类似地装入预交联胶原的柔性链聚合物。 当基质形成和改变基质的有效孔隙率时，该柔性链聚合物也被包封在基质中。 药物以取决于基质的有效孔隙率的速率从基质中扩散出来。

    Method and composition for deforming soft tissues
    8.
    发明授权
    Method and composition for deforming soft tissues 有权
    软组织变形的方法和组成

    公开(公告)号：US06423332B1

    公开(公告)日：2002-07-23

    申请号：US09579214

    申请日：2000-05-26

    申请人： Shawn T. Huxel ,  Ram L. Kataria ,  Joel S. Rosenblatt

    发明人： Shawn T. Huxel ,  Ram L. Kataria ,  Joel S. Rosenblatt

    IPC分类号： A61F1300

    CPC分类号： A61L27/52

    摘要： The present invention provides a composition and method for augmenting soft tissue, which composition includes a continuous phase that is a solid at temperatures less than about 10° C. or greater than about 30° C. and is a fluid at temperatures between about 10° C. and about 30° C., and which contains an aqueous solvent having dissolved therein a hydrogel and a dehydrating agent, and a discontinuous phase containing a plurality of hydrophilic hydrogel particles that are swellable in the aqueous solvent, that are not biodegradable for periods of time in excess of one year, and that have a hydrated diameter of greater than about 25 microns upon hydration by physiologic fluid; wherein the final volume of the hydrophilic hydrogel particles upon hydration by physiologic fluid is substantially the same as the initial volume of the composition used to augment the soft tissue.

    摘要翻译： 本发明提供了一种用于增加软组织的组合物和方法，该组合物包括在低于约10℃或大于约30℃的温度下为固体的连续相，并且为约10℃ 并且含有其中溶解有水凝胶和脱水剂的水性溶剂，以及包含在水性溶剂中可溶胀的多个亲水性水凝胶颗粒的不连续相，其不能在时间段内生物降解 的时间超过一年，并且通过生理液体水合时具有大于约25微米的水合直径; 其中亲水性水凝胶颗粒在生理液体水合时的最终体积基本上与用于增加软组织的组合物的初始体积相同。