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公开(公告)号：US09447400B2
公开(公告)日：2016-09-20
申请号：US13510902
申请日：2010-11-19
申请人： Richard R. Bott , Thijs Kaper , Bradley Kelemen , Frits Goedegebuur , Ronaldus Wilhelmus Hommes , Slavko Kralj , Paulien Kruithof , Igor Nikolaev , Wilhelmus Antonious Hendricus Van Der Kley , Johannes Franciscus Thomas Van Lieshout , Sander Van Stigt Thans , Gudrun Vogtentanz , Mats Sandgren
发明人： Richard R. Bott , Thijs Kaper , Bradley Kelemen , Frits Goedegebuur , Ronaldus Wilhelmus Hommes , Slavko Kralj , Paulien Kruithof , Igor Nikolaev , Wilhelmus Antonious Hendricus Van Der Kley , Johannes Franciscus Thomas Van Lieshout , Sander Van Stigt Thans , Gudrun Vogtentanz , Mats Sandgren
CPC分类号： C12N9/2445 , C12N15/52 , C12P19/02 , C12P19/14 , C12Y302/01021
摘要： The present disclosure is generally directed to enzymes and in particular beta-glucosidase variants. Also described are nucleic acids encoding beta-glucosidase variants, compositions comprising beta-glucosidase variants, methods of using beta-glucosidase variants, and methods of identifying additional useful beta-glucosidase variants.
摘要翻译： 本公开通常涉及酶，特别是β-葡糖苷酶变体。 还描述了编码β-葡糖苷酶变体的核酸，包含β-葡糖苷酶变体的组合物，使用β-葡糖苷酶变体的方法和鉴定另外有用的β-葡糖苷酶变体的方法。
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2.发明授权Cellulase variants with improved expression, activity and stability, and use thereof 有权具有改善的表达，活性和稳定性的纤维素酶变体及其用途公开(公告)号：US08679816B2
公开(公告)日：2014-03-25
申请号：US13321928
申请日：2010-06-03
申请人： Wolfgang Aehle , Richard R. Bott , Benjamin Bower , Jonathan Caspi , David A. Estell , Frits Goedegebuur , Ronaldus W. J. Hommes , Thijs Kaper , Bradley Kelemen , Slavko Kralj , Johan Van Lieshout , Igor Nikolaev , Sander Van Stigt Thans , Louise Wallace , Gudrun Vogtentanz , Mats Sandgren
发明人： Wolfgang Aehle , Richard R. Bott , Benjamin Bower , Jonathan Caspi , David A. Estell , Frits Goedegebuur , Ronaldus W. J. Hommes , Thijs Kaper , Bradley Kelemen , Slavko Kralj , Johan Van Lieshout , Igor Nikolaev , Sander Van Stigt Thans , Louise Wallace , Gudrun Vogtentanz , Mats Sandgren
CPC分类号： C12N9/2437 , C12Y302/01091 , Y02E50/17
摘要： The present disclosure relates to cellulase variants. In particular the present disclosure relates to cellulase variants having improved expression, activity and/or stability. Also described are nucleic acids encoding the cellulase variants, compositions comprising the cellulase variants, and methods of use thereof.
摘要翻译： 本公开涉及纤维素酶变体。 特别地，本公开涉及具有改善的表达，活性和/或稳定性的纤维素酶变体。 还描述了编码纤维素酶变体的核酸，包含纤维素酶变体的组合物及其使用方法。
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3.发明申请CELLULASE VARIANTS WITH IMPROVED EXPRESSION, ACTIVITY AND STABILITY, AND USE THEREOF 有权具有改进的表达，活性和稳定性的纤维素酶变体及其用途公开(公告)号：US20120135500A1
公开(公告)日：2012-05-31
申请号：US13321928
申请日：2010-06-03
申请人： Wolfgang Aehle , Richard R. Bott , Benjamin Bower , Jonathan Caspi , David A. Estell , Frits Goedegebuur , Ronaldus W.J. Hommes , Thijs Kaper , Bradley Kelemen , Slavko Kralj , Johan Van Lieshout , Igor Nikolaev , Sander Van Stigt Thans , Louise Wallace , Gudrun Vogtentanz , Mats Sandgren
发明人： Wolfgang Aehle , Richard R. Bott , Benjamin Bower , Jonathan Caspi , David A. Estell , Frits Goedegebuur , Ronaldus W.J. Hommes , Thijs Kaper , Bradley Kelemen , Slavko Kralj , Johan Van Lieshout , Igor Nikolaev , Sander Van Stigt Thans , Louise Wallace , Gudrun Vogtentanz , Mats Sandgren
IPC分类号： C12N9/42
CPC分类号： C12N9/2437 , C12Y302/01091 , Y02E50/17
摘要： The present disclosure relates to cellulase variants. In particular the present disclosure relates to cellulase variants having improved expression, activity and/or stability. Also described are nucleic acids encoding the cellulase variants, compositions comprising the cellulase variants, and methods of use thereof.
摘要翻译： 本公开涉及纤维素酶变体。 特别地，本公开涉及具有改善的表达，活性和/或稳定性的纤维素酶变体。 还描述了编码纤维素酶变体的核酸，包含纤维素酶变体的组合物及其使用方法。
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公开(公告)号：US20130143301A1
公开(公告)日：2013-06-06
申请号：US13510902
申请日：2010-11-19
申请人： Richard R. Bott , Thijs Kaper , Bradley Kelemen , Frits Goedegebuur , Ronaldus Hommes , Slavko Kralj , Paulien Kruithof , Igor Nikolaev
发明人： Richard R. Bott , Thijs Kaper , Bradley Kelemen , Frits Goedegebuur , Ronaldus Hommes , Slavko Kralj , Paulien Kruithof , Igor Nikolaev
IPC分类号： C12N9/24
CPC分类号： C12N9/2445 , C12N15/52 , C12P19/02 , C12P19/14 , C12Y302/01021
摘要： The present disclosure is generally directed to enzymes and in particular beta-glucosidase variants. Also described are nucleic acids encoding beta-glucosidase variants, compositions comprising beta-glucosidase variants, methods of using beta-glucosidase variants, and methods of identifying additional useful beta-glucosidase variants.
摘要翻译： 本公开通常涉及酶，特别是β-葡糖苷酶变体。 还描述了编码β-葡糖苷酶变体的核酸，包含β-葡糖苷酶变体的组合物，使用β-葡糖苷酶变体的方法和鉴定另外有用的β-葡糖苷酶变体的方法。
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5.发明申请CELLULASE COMPOSITIONS AND METHODS OF USING THE SAME FOR IMPROVED CONVERSION OF LIGNOCELLULOSIC BIOMASS INTO FERMENTABLE SUGARS 审中-公开纤维素组合物和使用它们的方法将改良的细菌生物质转化成可食用糖公开(公告)号：US20140073017A1
公开(公告)日：2014-03-13
申请号：US14004872
申请日：2012-03-16
IPC分类号： C12N9/42
CPC分类号： C12N9/2437 , C12N9/2445 , C12N15/80 , C12P19/14 , C12Y302/01021 , D06M16/003 , Y02P20/52
摘要： The present invention relates to compositions that can be used in hydrolyzing biomass such as compositions comprising a polypeptide having β-glucosidase activity, methods for hydrolyzing biomass material, and methods for improving the stability and saccharification efficacy of a composition comprising such β-glucosidase polypeptides and/or activity.
摘要翻译： 本发明涉及可用于水解生物质的组合物，例如包含具有β-葡糖苷酶活性的多肽的组合物，用于水解生物质材料的方法，以及用于提高包含此类β-葡糖苷酶多肽的组合物的稳定性和糖化功效的方法，以及 /或活动。
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公开(公告)号：US20130177947A1
公开(公告)日：2013-07-11
申请号：US13498069
申请日：2010-09-22
申请人： Benjamin Bower , Megan Yee Hsi , Thijs Kaper , Bradley R. Keleman , Suzanne E. Lantz , Edmund A. Larenas , Colin Mitchinson , Steven Kim , William D. Hitz , Mark Emptage , Keith Dumont Wing
发明人： Benjamin Bower , Megan Yee Hsi , Thijs Kaper , Bradley R. Keleman , Suzanne E. Lantz , Edmund A. Larenas , Colin Mitchinson , Steven Kim , William D. Hitz , Mark Emptage , Keith Dumont Wing
CPC分类号： C12N9/248 , C12N9/0006 , C12N9/0065 , C12N9/16 , C12N9/20 , C12N9/2402 , C12N9/2437 , C12N9/2445 , C12N9/2485 , C12P19/00 , C12P19/02 , C12P19/14 , C12Y302/01 , C12Y302/01004 , C12Y302/01008 , C12Y302/01021 , C12Y302/01037 , C12Y302/01055 , Y02E50/343
摘要： The present disclosure is generally directed to glycosyl hydrolase enzymes, compositions comprising such enzymes, and methods of using the enzymes and compositions, for example for the saccharification of cellulosic and hemicellulosic materials into sugars.
摘要翻译： 本公开一般涉及糖基水解酶，包含这些酶的组合物，以及使用酶和组合物的方法，例如将纤维素和半纤维素材料糖化为糖。
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公开(公告)号：US07935494B2
公开(公告)日：2011-05-03
申请号：US12040524
申请日：2008-02-29
申请人： Thijs Kaper , Michael Platten , Lawrence Steinman , Wolf Frommer
发明人： Thijs Kaper , Michael Platten , Lawrence Steinman , Wolf Frommer
IPC分类号： G01N33/53
CPC分类号： G01N33/6872 , G01N33/5008 , G01N2333/70596 , G01N2800/24
摘要： The present invention provides methods for detecting changes in tryptophan concentrations in a cell and methods for identifying agents that modulate cellular tryptophan concentrations. In particular, the present invention provides methods for detecting cellular exchange between tryptophan and kynurenine, and methods for identifying agents that modulate this exchange. The present invention also provides methods for treating a disease associated with immunosuppression in a subject in need thereof. In particular, the present invention is directed toward a method of treating a disease associated with immunosuppression comprising contacting the disease with an agent that modulates cellular Trp/kynurenine exchange. Furthermore, the present invention provides methods for identifying an agent that modulates an immunosuppression.
摘要翻译： 本发明提供了用于检测细胞中色氨酸浓度变化的方法以及鉴定调节细胞色氨酸浓度的试剂的方法。 特别地，本发明提供了检测色氨酸和犬尿氨酸之间的细胞交换的方法，以及用于鉴定调节该交换的试剂的方法。 本发明还提供了在有需要的受试者中治疗与免疫抑制相关的疾病的方法。 特别地，本发明涉及一种治疗与免疫抑制相关的疾病的方法，其包括将疾病与调节细胞Trp /犬尿苷交换的药物接触。 此外，本发明提供了鉴定调节免疫抑制的药剂的方法。
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8.发明授权Compositions and methods comprising cellulase variants with reduced affinity to non-cellulosic materials 有权包含对非纤维素材料具有降低的亲和力的纤维素酶变体的组合物和方法公开(公告)号：US08236542B2
公开(公告)日：2012-08-07
申请号：US12477887
申请日：2009-06-03
CPC分类号： C12N9/2437 , C12P19/02 , C12P19/14 , C12Y302/01004 , C12Y302/01091 , Y02E50/16 , Y02E50/17
摘要： The present disclosure relates to cellulase variants. In particular the present disclosure relates to cellulase variants having reduced binding to non-cellulosic materials. Also described are nucleic acids encoding the cellulase, compositions comprising said cellulase, methods of identifying cellulose variants and methods of using the compositions.
摘要翻译： 本公开涉及纤维素酶变体。 特别地，本公开涉及具有减少的与非纤维素材料结合的纤维素酶变体。 还描述了编码纤维素酶的核酸，包含所述纤维素酶的组合物，鉴定纤维素变体的方法和使用该组合物的方法。
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公开(公告)号：US20080227140A1
公开(公告)日：2008-09-18
申请号：US12040524
申请日：2008-02-29
申请人： Thijs Kaper , Michael Platten , Lawrence Steinman , Wolf Frommer
发明人： Thijs Kaper , Michael Platten , Lawrence Steinman , Wolf Frommer
CPC分类号： G01N33/6872 , G01N33/5008 , G01N2333/70596 , G01N2800/24
摘要： The present invention provides methods for detecting changes in tryptophan concentrations in a cell and methods for identifying agents that modulate cellular tryptophan concentrations. In particular, the present invention provides methods for detecting cellular exchange between tryptophan and kynurenine, and methods for identifying agents that modulate this exchange. The present invention also provides methods for treating a disease associated with immunosuppression in a subject in need thereof. In particular, the present invention is directed toward a method of treating a disease associated with immunosuppression comprising contacting the disease with an agent that modulates cellular Trp/kynurenine exchange. Furthermore, the present invention provides methods for identifying an agent that modulates an immunosuppression.
摘要翻译： 本发明提供了用于检测细胞中色氨酸浓度变化的方法以及鉴定调节细胞色氨酸浓度的试剂的方法。 特别地，本发明提供了检测色氨酸和犬尿氨酸之间的细胞交换的方法，以及用于鉴定调节该交换的试剂的方法。 本发明还提供了在有需要的受试者中治疗与免疫抑制相关的疾病的方法。 特别地，本发明涉及一种治疗与免疫抑制相关的疾病的方法，其包括将疾病与调节细胞Trp /犬尿苷交换的药物接触。 此外，本发明提供了鉴定调节免疫抑制的药剂的方法。
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10.发明授权Compositions and methods comprising cellulase variants with reduced affinity to non-cellulosic materials 有权包含对非纤维素材料具有降低的亲和力的纤维素酶变体的组合物和方法公开(公告)号：US08999692B2
公开(公告)日：2015-04-07
申请号：US13543627
申请日：2012-07-06
IPC分类号： C12N9/42
CPC分类号： C12N9/2437 , C12P19/02 , C12P19/14 , C12Y302/01004 , C12Y302/01091 , Y02E50/16 , Y02E50/17
摘要： The present disclosure relates to cellulase variants. In particular the present disclosure relates to cellulase variants having reduced binding to non-cellulosic materials. Also described are nucleic acids encoding the cellulase, compositions comprising said cellulase, methods of identifying cellulose variants and methods of using the compositions.
摘要翻译： 本公开涉及纤维素酶变体。 特别地，本公开涉及具有减少的与非纤维素材料结合的纤维素酶变体。 还描述了编码纤维素酶的核酸，包含所述纤维素酶的组合物，鉴定纤维素变体的方法和使用该组合物的方法。
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