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    High throughput multi-dimensional sample analysis
    1.
    发明授权
    High throughput multi-dimensional sample analysis 有权
    高通量多维样本分析

    公开(公告)号：US07132650B1

    公开(公告)日：2006-11-07

    申请号：US10951255

    申请日：2004-09-25

    申请人： Ronald C. Gamble ,  Stephen D. O'Connor ,  Bruce Wilcox ,  Matthew M. Gregori

    发明人： Ronald C. Gamble ,  Stephen D. O'Connor ,  Bruce Wilcox ,  Matthew M. Gregori

    IPC分类号： H01J49/42

    CPC分类号： G01N30/7233 ,  G01N30/466 ,  G01N30/80 ,  G01N2030/8447 ,  H01J49/0018 ,  H01J49/0431 ,  H01J49/107 ,  Y10T137/86863 ,  Y10T137/86871 ,  Y10T436/115831

    摘要： High throughput analytical systems and methods employing multiple liquid phase separation process regions coupled to a common mass spectrometer are provided. Disclosed systems and methods permits parallel separation and parallel storage of discrete eluate fractions, followed by sequential discharge and ionization of previously stored eluate portions to yield a composite ion stream containing the sequential series of eluate portions, followed by mass analysis of the ion stream. A common manifold may receive ions and utilize pressurized gas or ion gating to direct ions within the manifold toward the mass spectrometer inlet.

    摘要翻译： 提供了使用耦合到共同的质谱仪的多个液相分离工艺区域的高通量分析系统和方法。 公开的系统和方法允许离散洗脱液级分的并行分离和平行存储，随后顺序地排出和离子化先前储存的洗脱液部分，以产生含有顺序一系列洗脱液部分的复合离子流，随后对离子流进行质量分析。 常见的歧管可以接收离子并利用加压气体或离子门控来将歧管内的离子引向质谱仪入口。

    Systems and methods for high-throughput microfluidic sample analysis
    3.
    发明授权
    Systems and methods for high-throughput microfluidic sample analysis 有权
    用于高通量微流体样品分析的系统和方法

    公开(公告)号：US06812458B2

    公开(公告)日：2004-11-02

    申请号：US10637234

    申请日：2003-08-08

    申请人： Matthew M. Gregori ,  Joseph F. Covington ,  Steven E. Hobbs

    发明人： Matthew M. Gregori ,  Joseph F. Covington ,  Steven E. Hobbs

    IPC分类号： H01J4900

    CPC分类号： G01N30/466 ,  B01L3/5027 ,  G01N30/7266 ,  G01N30/84 ,  G01N2030/628 ,  G01N2030/8411 ,  H01J49/04

    摘要： Systems and methods for collecting the output of multiple simultaneously operated chromatography columns and providing the outputs to a single mass spectrometer are provided. Such systems utilize predetermined lengths of microfluidic tubing that act as storage buffers for the substantially all of the output of each column, preserving all data and, because the storage buffers are microfluidic, there is minimal diffusion between sample bands and solvent and signal clarity is preserved.

    摘要翻译： 提供了用于收集多个同时操作的色谱柱的输出并将输出提供给单个质谱仪的系统和方法。 这样的系统使用预定长度的微流体管，其用作用于每个柱的基本上所有输出的储存缓冲液，保留所有数据，并且由于存储缓冲液是微流体，所以在样品带和溶剂之间存在最小的扩散，并保持信号的清晰度 。

    Systems and methods for high throughput sample analysis
    4.
    发明授权
    Systems and methods for high throughput sample analysis 有权
    用于高通量样品分析的系统和方法

    公开(公告)号：US07214320B1

    公开(公告)日：2007-05-08

    申请号：US10979946

    申请日：2004-11-01

    申请人： Matthew M. Gregori ,  Joseph F. Covington ,  Steven E. Hobbs

    发明人： Matthew M. Gregori ,  Joseph F. Covington ,  Steven E. Hobbs

    IPC分类号： B01D15/08

    CPC分类号： B01L3/502753 ,  B01L3/0268 ,  B01L2300/0864 ,  B01L2300/0887 ,  B01L2400/0421 ,  B01L2400/0487 ,  G01N30/466 ,  G01N30/6095 ,  G01N30/7266 ,  H01J49/0409 ,  H01J49/0431 ,  H01J49/0463

    摘要： Systems and methods for analyzing a plurality of samples in parallel include a plurality of liquid phase separation regions, a plurality of microfluidic storage regions, and a common mass spectrometer. Samples are separated in parallel in the separation regions to yield a plurality of output streams that are stored in the storage regions. The contents of each storage region, or at least a representative portion thereof, are sequentially discharged, ionized, and directed to the inlet of a mass spectrometer. In this manner, multiple separations are conducted in parallel with outputs provided serially to a common mass spectrometer without any loss of data. Microfluidic storage regions minimize diffusion between bands of separated samples. Portions of separated samples may be directed to fraction collectors.

    摘要翻译： 用于并行分析多个样品的系统和方法包括多个液相分离区域，多个微流体存储区域和共同的质谱仪。 在分离区域中并行地分离样品以产生存储在存储区域中的多个输出流。 每个存储区域的内容物，或其至少其代表部分被依次排出，离子化并被引导到质谱仪的入口。 以这种方式，与输出提供的共同进行多次分离，而不会丢失任何数据。 微流体存储区域最小化分离样品的条带之间的扩散。 分离的样品的部分可以被引导到级分收集器。