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    PEPTIDE HAVING CANCER SELECTIVE TRANSLOCATION FUNCTION AND USE THEREOF
    1.
    发明申请
    PEPTIDE HAVING CANCER SELECTIVE TRANSLOCATION FUNCTION AND USE THEREOF 审中-公开
    具有癌症选择性转录功能的肽和其使用

    公开(公告)号：US20150165060A1

    公开(公告)日：2015-06-18

    申请号：US14395807

    申请日：2013-09-16

    申请人： SNU R&DB Foundation ,  Nano Intelligent Biomedical Engineering Corporation Co., Ltd.

    发明人： Yoon Jeong Park ,  Chong-Pyoung Chung ,  Jin Sook Suh ,  Yoon Jung Choi

    IPC分类号： A61K47/48 ,  A61K49/00 ,  A61K31/704 ,  C07K7/08 ,  A61K38/46

    CPC分类号： A61K47/64 ,  A61K31/704 ,  A61K38/00 ,  A61K49/0056 ,  C07K7/08 ,  C07K14/47 ,  C07K2319/10 ,  C12Q1/26 ,  C12Q1/58 ,  C12Q1/66 ,  C12Y301/13 ,  G01N33/574

    摘要： The present invention relates a peptide having cancer selective translocation function, and the use thereof, and more particularly to a VEGF-binding protein transduction domain (VPTD) represented as SEQ ID NO: 1 or a heparin-binding protein transduction domain (HPTD) represented as SEQ ID NO: 2, which bind specifically to VEGF and heparin, which are overexpressed specifically in tumor cells or tumor tissues, and to a conjugate comprising a drug linked to the peptide.The peptide and the peptide-drug conjugate bind specifically to VEGF and heparin in tumor cells or tumor tissue and accumulate in the tumor cells or tumor tissue, and thus can be used for the accurate diagnosis and treatment of cancer. Also, the non-specific distribution of the peptide or the conjugate in the body after administration is inhibited, and thus the side effects thereof can be minimized. Accordingly, the peptide or the conjugate is useful for the diagnosis and treatment of cancer.

    摘要翻译： 本发明涉及具有癌症选择性易位功能的肽及其用途，更具体地涉及以SEQ ID NO：1表示的VEGF结合蛋白转导结构域（VPTD）或代表的肝素结合蛋白转导结构域（HPTD） 如SEQ ID NO：2，其特异性结合VEGF和肝素，其特异性地在肿瘤细胞或肿瘤组织中过表达，以及包含与肽连接的药物的缀合物。 肽和肽 - 药物缀合物在肿瘤细胞或肿瘤组织中特异性结合VEGF和肝素并积聚在肿瘤细胞或肿瘤组织中，因此可用于癌症的准确诊断和治疗。 此外，肽或结合物在给药后体内的非特异性分布被抑制，因此其副作用可以最小化。 因此，肽或缀合物可用于癌症的诊断和治疗。

    PEPTIDE HAVING CANCER SELECTIVE TRANSLOCATION FUNCTION AND USE THEREOF
    3.
    发明申请
    PEPTIDE HAVING CANCER SELECTIVE TRANSLOCATION FUNCTION AND USE THEREOF 审中-公开
    具有癌症选择性转录功能的肽和其使用

    公开(公告)号：US20160367694A1

    公开(公告)日：2016-12-22

    申请号：US15234396

    申请日：2016-08-11

    申请人： SNU R&DB FOUNDATION ,  Nano Intelligent Biomedical Engineering Corporation Co. Ltd

    发明人： Yoon Jeong Park ,  Chong-Pyoung Chung ,  Jin Sook Suh ,  Yoon Jung Choi

    IPC分类号： A61K47/48 ,  A61K31/704 ,  A61K38/46

    CPC分类号： A61K47/64 ,  A61K31/704 ,  A61K38/00 ,  A61K49/0056 ,  C07K7/08 ,  C07K14/47 ,  C07K2319/10 ,  C12Q1/26 ,  C12Q1/58 ,  C12Q1/66 ,  C12Y301/13 ,  G01N33/574

    摘要： The present invention relates a peptide having cancer selective translocation function, and the use thereof, and more particularly to a VEGF-binding protein transduction domain (VPTD) represented as SEQ ID NO: 1 or a heparin-binding protein transduction domain (HPTD) represented as SEQ ID NO: 2, which bind specifically to VEGF and heparin, which are overexpressed specifically in tumor cells or tumor tissues, and to a conjugate comprising a drug linked to the peptide.The peptide and the peptide-drug conjugate bind specifically to VEGF and heparin in tumor cells or tumor tissue and accumulate in the tumor cells or tumor tissue, and thus can be used for the accurate diagnosis and treatment of cancer. Also, the non-specific distribution of the peptide or the conjugate in the body after administration is inhibited, and thus the side effects thereof can be minimized. Accordingly, the peptide or the conjugate is useful for the diagnosis and treatment of cancer.

    摘要翻译： 肽和肽 - 药物缀合物在肿瘤细胞或肿瘤组织中特异性结合VEGF和肝素并积聚在肿瘤细胞或肿瘤组织中，因此可用于癌症的准确诊断和治疗。 此外，肽或结合物在给药后体内的非特异性分布被抑制，因此其副作用可以最小化。 因此，肽或缀合物可用于癌症的诊断和治疗。