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    Method Of Differentiation From Stem Cells To Hepatocytes
    6.
    发明申请
    Method Of Differentiation From Stem Cells To Hepatocytes 审中-公开
    从干细胞分化为肝细胞的方法

    公开(公告)号：US20120231490A1

    公开(公告)日：2012-09-13

    申请号：US13504149

    申请日：2010-10-22

    申请人： Hiroyuki Mizuguchi ,  Kenji Kawabata ,  Mitsuru Inamura ,  Miho Furue

    发明人： Hiroyuki Mizuguchi ,  Kenji Kawabata ,  Mitsuru Inamura ,  Miho Furue

    IPC分类号： C12N15/861 ,  C12Q1/02 ,  C12N5/10

    CPC分类号： C12N5/067 ,  C12N2500/25 ,  C12N2500/36 ,  C12N2500/44 ,  C12N2500/46 ,  C12N2501/115 ,  C12N2501/119 ,  C12N2501/155 ,  C12N2501/16 ,  C12N2501/60 ,  C12N2501/91 ,  C12N2506/02 ,  C12N2506/45 ,  C12N2510/00

    摘要： Disclosed are: a gene transduction method for use in the induction of the differentiation of stem cells such as ES cells or iPS cells into hepatocytes effectively; stem cells into each of which a gene useful for the induction of the differentiation into hepatocytes is introduced; and hepatocytes produced from stem cells each having the gene introduced therein. A specific gene can be introduced into stem cells such as ES cells or iPS cells using an adenovirus vector. The effective induction of the differentiation into hepatocytes can be achieved by introducing the gene. Specifically, the effective induction of the differentiation of stem cells such as ES cells or iPS cells into hepatocytes can be achieved by introducing at least one gene selected from HEX gene, HNF4A gene, HNF6 gene and SOX17 gene into the stem cells.

    摘要翻译： 公开的是：用于诱导干细胞如ES细胞或iPS细胞分化成肝细胞的基因转导方法; 引入干细胞，其中每一种可用于诱导分化成肝细胞的基因; 和从其中引入基因的干细胞产生的肝细胞。 可以使用腺病毒载体将特定基因导入干细胞如ES细胞或iPS细胞。 可以通过引入基因来实现分化成肝细胞的有效诱导。 具体地说，通过将至少一种选自HEX基因，HNF4A基因，HNF6基因和SOX17基因的基因导入干细胞，可以有效诱导干细胞如ES细胞或iPS细胞分化成肝细胞。

    Simulation apparatus, simulation method and non-transitory computer readable recording medium
    9.
    发明授权
    Simulation apparatus, simulation method and non-transitory computer readable recording medium 有权
    仿真设备，仿真方法和非暂时性计算机可读记录介质

    公开(公告)号：US09183673B2

    公开(公告)日：2015-11-10

    申请号：US13705667

    申请日：2012-12-05

    申请人： Ai Omodaka ,  Yoshiyuki Shioyama ,  Kenji Kawabata

    发明人： Ai Omodaka ,  Yoshiyuki Shioyama ,  Kenji Kawabata

    IPC分类号： G06F9/455 ,  G06F11/22 ,  G06T17/10 ,  G06F17/50

    CPC分类号： G06T17/10 ,  G06F17/5009

    摘要： In accordance with an embodiment, a simulation apparatus includes a two-dimensional section dividing processing unit, a two-dimensional simulator, a one-dimensional combining processing unit, and a three-dimensional shape combining processing unit. The two-dimensional section dividing processing unit divides a three-dimensional shape as a simulation target into at least one set of two-dimensional sections intersecting with each other and defines the three-dimensional shape as the two-dimensional sections. The two-dimensional simulator runs a two-dimensional shape simulation in each time step for each of the two-dimensional sections obtained by the dividing and acquires a two-dimensional shape. The one-dimensional combining processing unit extracts a film configuration for each intersection of the two-dimensional sections from the acquired two-dimensional shape and combines the film configurations to acquire one-dimensional film configurations. The three-dimensional shape combining processing unit creates a three-dimensional structure from the acquired one-dimensional film configurations on the basis of information on the intersection.

    摘要翻译： 根据实施例，模拟装置包括二维部分分割处理单元，二维模拟器，一维组合处理单元和三维形状组合处理单元。 二维部分分割处理部将作为模拟对象的三维形状分割为相互交叉的至少一组二维部，并将三维形状定义为二维部。 二维模拟器在通过分割获得的每个二维部分的每个时间步长中进行二维形状模拟，并获得二维形状。 一维组合处理单元从获取的二维形状中提取二维部分的每个交点的胶片配置，并组合胶片配置以获得一维胶片配置。 三维形状组合处理单元根据所获得的一维胶片配置，基于交叉点的信息创建三维结构。