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公开(公告)号：US4642335A
公开(公告)日：1987-02-10
申请号：US738352
申请日：1985-05-28
IPC分类号： C07K14/195 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61K35/74 , A61K38/00 , A61P35/00 , C07H15/252 , C07K14/00 , C07K14/41 , C07K17/02 , C07K17/06
CPC分类号： C07H15/252 , Y10S530/812 , Y10S530/825
摘要： This invention relates to an antitumor composition of anthracycline compounds bonded to hydrophilic polypeptides having a molecular weight between 10,000 and 15,000.
摘要翻译： 本发明涉及结合至分子量为10,000至15,000的亲水性多肽的蒽环类化合物的抗肿瘤组合物。
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公开(公告)号：US4560748A
公开(公告)日：1985-12-24
申请号：US500908
申请日：1983-06-03
申请人： Shigezo Udaka , Shigeyoshi Miyashiro , Kazuo Hirayama , Toshihiko Ando , Asao Murai , Tsuyoshi Shiio , Takao Kida , Hiroshiro Shibai
发明人： Shigezo Udaka , Shigeyoshi Miyashiro , Kazuo Hirayama , Toshihiko Ando , Asao Murai , Tsuyoshi Shiio , Takao Kida , Hiroshiro Shibai
IPC分类号： C12P21/02 , A61K31/70 , A61K31/7042 , A61K31/7052 , A61P31/04 , A61P31/12 , A61P35/00 , C07H17/02 , C12P19/28 , C07H17/00
摘要： A streptothricin-group compound having the formula: ##STR1## in which R represents ##STR2## is disclosed along with methods for producing this compound and a microorganism useful in its production.
摘要翻译： 公开了具有下式的其中R表示
+ TR 的下式的链霉菌素基化合物以及用于生产该化合物的方法和用于其生产的微生物。 -
公开(公告)号：US4452891A
公开(公告)日：1984-06-05
申请号：US300041
申请日：1981-09-08
申请人： Takao Kida , Takehiko Ishikawa , Hiroshiro Shibai
发明人： Takao Kida , Takehiko Ishikawa , Hiroshiro Shibai
CPC分类号： C12P17/04 , Y10S435/934
摘要： Mycophenolic acid is produced by aerobically culturing in a culture medium a mutant of the genus Penicillium capable of producing mycophenolic acid, said mutant being resistant to clofibrat, and recovering the mycophenolic acid which accumulates in the culture medium.
摘要翻译： 霉酚酸通过在培养基中有条不紊地培养，能够产生霉酚酸的青霉属的突变体，所述突变体对clofibrat具有抗性，并且回收积累在培养基中的霉酚酸。
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4.发明授权Human T or B cell lines and a process for producing immunologically active substances using the same 失效人T或B细胞系和使用其的免疫活性物质的制备方法
公开(公告)号：US4758513A
公开(公告)日：1988-07-19
申请号：US736376
申请日：1985-05-21
CPC分类号： C07K14/555 , C07K14/55 , Y10S435/948
摘要： This invention relates to a human T or B cell line carrying at least one Ela human adenovirus 12-type gene or fragment thereof; said cell line being capable of spontaneously producing an immmunologically active substance. This invention also relates to a process for producing an immunologically active substance comprising culturing a human B- or T- cell line carrying at least one human Ela adenovirus 12-type gene or fragment thereof in a culture medium capable of supporting growth thereof for a period of time effective to attain a spontaneous production of the substance thereof.
摘要翻译： 本发明涉及携带至少一种Ela人腺病毒12型基因或其片段的人T或B细胞系; 所述细胞系能够自发产生免疫活性物质。 本发明还涉及一种生产免疫活性物质的方法，包括在能够支持其生长的培养基中培养携带至少一种人Ela腺病毒12型基因或其片段的人B或T-细胞系一段时间 的时间有效地实现其物质的自发生产。
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5.发明授权
公开(公告)号：US5847078A
公开(公告)日：1998-12-08
申请号：US400194
申请日：1995-03-03
申请人： Yuzuru Eto , Tomoko Tsuji , Satoshi Takano , Misako Takezawa , Yasunori Yokogawa , Hiroshiro Shibai
发明人： Yuzuru Eto , Tomoko Tsuji , Satoshi Takano , Misako Takezawa , Yasunori Yokogawa , Hiroshiro Shibai
IPC分类号： C07K14/52 , A61K38/00 , A61P7/06 , A61P35/02 , C07K14/00 , C07K14/575 , C12P21/02 , C12R1/91 , C07K4/12
CPC分类号： C07K14/575 , A61K38/00 , Y10S930/26
摘要： A physiologically active polypeptide, BUF-3, having the ability to differentiate and maturate human leukemia cells into normal cells and of accelerating the formation of erythroblasts is disclosed. The polypeptide has a molecular weight of 16.+-.1 Kd as determined by SDS-electrophoresis in the presence of 1% mercaptoethanol, or 25.+-.1 Kd, as determined by SDS-electrophoresis in the absence of mercaptoethanol.
摘要翻译： 公开了具有将人白血病细胞分化和成熟为正常细胞并促进成红细胞形成的能力的生理活性多肽BUF-3。 如果在不存在巯基乙醇的条件下通过SDS-电泳测定，该多肽在1％巯基乙醇或25 +/- 1Kd存在下通过SDS-电泳测定的分子量为16 +/- 1Kd。
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6.发明授权Modified microbially-produced cellulose gel with human epidermal cells adsorbed thereon for use as a skin graft or vulnerary cover 失效修饰的微生物生产的纤维素凝胶，其上吸附有人表皮细胞，用作皮肤移植物或漏药盖
公开(公告)号：US5558861A
公开(公告)日：1996-09-24
申请号：US567212
申请日：1995-12-05
IPC分类号： A61L27/60 , C08B11/145 , C08L1/02 , C12N5/00 , A01N63/00 , A61F2/10 , A61F13/00 , A61K9/14 , A61K35/36 , A61L15/00 , C08B1/00 , C12N1/02
CPC分类号： A61L27/60 , C08B11/145 , C08L1/02 , C12N5/0068 , C12N2533/78 , Y10S435/948
摘要： Disclosed is a gel of microbially-produced cellulose, characterized in that the microbially-produced cellulose is modified by (1) physically or chemically bonding an animal cell adhesive protein to the cellulose, and/or (2) substituting hydrogen atoms of at least parts of hydroxyl groups of the cellulose with a positively or negatively charged organic group. This gel is valuable as a carrier for mass culture of animal cells or as a medical vulnerary cover.
摘要翻译： 公开了一种微生物纤维素的凝胶，其特征在于，通过（1）将动物细胞粘附蛋白物理或化学键合到纤维素上，和/或（2）用至少部分的氢原子代替微生物纤维素 的带有正或负电荷的有机基团的纤维素的羟基。 该凝胶作为动物细胞大规模培养的载体或作为医疗漏洞覆盖物是有价值的。
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公开(公告)号：US5023079A
公开(公告)日：1991-06-11
申请号：US403033
申请日：1989-09-01
申请人： Yasuo Komoda , Yasunori Yokogawa , Masahiko Okunishi , Koichi Ishii , Hiroshiro Shibai , Ryosaku Noumi
发明人： Yasuo Komoda , Yasunori Yokogawa , Masahiko Okunishi , Koichi Ishii , Hiroshiro Shibai , Ryosaku Noumi
IPC分类号： C12P1/04 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61K35/74 , A61P31/04 , A61P31/10 , C07G11/00 , C07H17/08 , C12P1/06 , C12P19/62 , C12R1/465
CPC分类号： C12P1/06
摘要： An antimycotic agent having a high degree of antimicrobial activity towards Eumycetes and with a level of toxicity lower than that of heptaene antibiotic V-28-3 is disclosed. This compound is a methyl ester derivative of heptaene antibiotic V-28-3.
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公开(公告)号：US5240911A
公开(公告)日：1993-08-31
申请号：US410402
申请日：1989-09-21
申请人： Yasuo Totsuka , Itaru Kojima , Etsuro Ogata , Makoto Shiozaki , Shigeru Shioya , Hiroshiro Shibai , Yuzuru Eto
发明人： Yasuo Totsuka , Itaru Kojima , Etsuro Ogata , Makoto Shiozaki , Shigeru Shioya , Hiroshiro Shibai , Yuzuru Eto
IPC分类号： C12P21/02 , A61K38/00 , A61K38/22 , A61P3/08 , A61P3/10 , C07K1/20 , C07K14/52 , C07K14/575 , C12N15/09 , C12R1/91
CPC分类号： A61K38/22
摘要： Pharmaceutical compositions containing the polypeptides BUF-3, BUF-4 and BUF-5 have hypoglycemic activity. BUF-3 is a homodimer of monomer A shown in FIG. 1. The monomer has a molecular weight of 16.+-.1 kd. BUF-4 is a heterodimer of monomer A and monomer B (FIG. 2). These products can be produced by cell culture of malignant leukemia cells or by recombinant DNA engineering.
摘要翻译： 含有多肽BUF-3，BUF-4和BUF-5的药物组合物具有降血糖活性。 BUF-3是图1所示的单体A的同二聚体。 单体的分子量为16 +/- 1kd。 BUF-4是单体A和单体B的异二聚体（图2）。 这些产品可以通过恶性白血病细胞的细胞培养或通过重组DNA工程产生。
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9.发明授权Composition containing buf-3 and superoxide dismutase as a cell cleavage promoting agent 失效含有BUF-3和超氧化物歧化酶作为细胞清除促进剂的组合物
公开(公告)号：US5206160A
公开(公告)日：1993-04-27
申请号：US580876
申请日：1990-09-11
申请人： Michio Takahashi , Kunio Shioda , Hiroshiro Shibai
发明人： Michio Takahashi , Kunio Shioda , Hiroshiro Shibai
IPC分类号： A01N43/38 , A61K38/00 , C07K14/575 , C12N5/02 , C12N5/073
CPC分类号： C07K14/575 , C12N5/0604 , A61K38/00 , C12N2501/16
摘要： A cleavage promoting agent comprising as an effective ingredient at least one of the polypeptides BUF-3, BUF-4 and BUF-5 is useful for the treatment of fertilized or unfertilized ova in order to promote cell division and improve reproduction efficiency.
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公开(公告)号：US5200395A
公开(公告)日：1993-04-06
申请号：US784685
申请日：1991-10-29
申请人： Yuzuru Eto , Naoto Koyama , Daisuke Ejima , Masayo Washitake , Hiroshiro Shibai
发明人： Yuzuru Eto , Naoto Koyama , Daisuke Ejima , Masayo Washitake , Hiroshiro Shibai
IPC分类号： A61K38/22
CPC分类号： A61K38/22
摘要： The polypeptides BUF-4 and BUF-5 may be used to treat osteoporosis, cancer, and anemia, and pharmaceutical compositions containing BUF-4 and/or BUF-5 are disclosed.
摘要翻译： 多肽BUF-4和BUF-5可用于治疗骨质疏松症，癌症和贫血，并且公开了含有BUF-4和/或BUF-5的药物组合物。
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