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公开(公告)号:US08551714B2
公开(公告)日:2013-10-08
申请号:US13367326
申请日:2012-02-06
CPC分类号: B01L3/50273 , B01F11/0071 , B01F13/0059 , B01J2219/005 , B01L3/502715 , B01L3/502738 , B01L3/502761 , B01L7/52 , B01L9/527 , B01L2200/027 , B01L2200/028 , B01L2200/0647 , B01L2200/0668 , B01L2200/10 , B01L2200/12 , B01L2300/0654 , B01L2300/0803 , B01L2300/0806 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/1822 , B01L2300/1844 , B01L2400/0409 , B01L2400/0421 , B01L2400/043 , B01L2400/0487 , B01L2400/0638 , B01L2400/0655 , B01L2400/086 , C12Q2565/629 , G01N1/34 , G01N27/44721 , G01N27/44743 , G01N27/44791 , G01N35/0098
摘要: Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such as DNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense.
摘要翻译: 公开了用于将微芯片连接到各种类型的模块的方法和装置。 所公开的技术可用作各种应用的样品制备和分析系统,如DNA测序和基因分型,蛋白质组学,病原体检测,诊断和生物防治。
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公开(公告)号:US08431390B2
公开(公告)日:2013-04-30
申请号:US13287398
申请日:2011-11-02
CPC分类号: B01L3/50273 , B01F11/0071 , B01F13/0059 , B01J2219/005 , B01L3/502715 , B01L3/502738 , B01L3/502761 , B01L7/52 , B01L9/527 , B01L2200/027 , B01L2200/028 , B01L2200/0647 , B01L2200/0668 , B01L2200/10 , B01L2200/12 , B01L2300/0654 , B01L2300/0803 , B01L2300/0806 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/1822 , B01L2300/1844 , B01L2400/0409 , B01L2400/0421 , B01L2400/043 , B01L2400/0487 , B01L2400/0638 , B01L2400/0655 , B01L2400/086 , C12Q2565/629 , G01N1/34 , G01N27/44721 , G01N27/44743 , G01N27/44791 , G01N35/0098
摘要: Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such as DNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense.
摘要翻译: 公开了用于将微芯片连接到各种类型的模块的方法和装置。 所公开的技术可用作各种应用的样品制备和分析系统,如DNA测序和基因分型,蛋白质组学,病原体检测,诊断和生物防治。
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公开(公告)号:US20110039303A1
公开(公告)日:2011-02-17
申请号:US12526015
申请日:2008-02-05
申请人: Stevan Bogdan Jovanovich , Iuliu Ioan Blaga , Allen Boronkay , Joanne Horn , Michael Van Nguyen , William D. Nielsen , Mattias Vangbo
发明人: Stevan Bogdan Jovanovich , Iuliu Ioan Blaga , Allen Boronkay , Joanne Horn , Michael Van Nguyen , William D. Nielsen , Mattias Vangbo
CPC分类号: C12Q1/686 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L7/52 , B01L7/525 , B01L2200/028 , B01L2200/0668 , B01L2200/10 , B01L2300/0816 , B01L2300/0867 , B01L2300/0874 , B01L2300/088 , B01L2300/0887 , B01L2300/0896 , B01L2300/1827 , B01L2400/0481 , B01L2400/0655 , B33Y80/00 , B82Y30/00 , F16K99/0001
摘要: The present invention discloses the integration of programmable microfluidic circuits to achieve practical applications to process biochemical and chemical reactions and to integrate these reactions. In some embodiments workflows for biochemical reactions or chemical workflows are combined. Microvalves such as programmable microfluidic circuit with Y valves and flow through valves are disclosed. In some embodiments microvalves of the present invention are used for mixing fluids, which may be part of an integrated process. These processes include mixing samples and moving reactions to an edge or reservoir for modular microfluidics, use of capture regions, and injection into analytical devices on separate devices. In some embodiments star and nested star designs, or bead capture by change of cross sectional area of a channel in a microvalve are used. Movement of samples between temperature zones are further disclosed using fixed temperature and movement of the samples by micropumps.
摘要翻译: 本发明公开了可编程微流体电路的集成,以实现处理生化和化学反应的实际应用并整合这些反应。 在一些实施方案中,组合用于生化反应或化学工作流程的工作流程。 公开了诸如具有Y阀和流过阀的可编程微流体电路的微型阀。 在一些实施方案中,本发明的微型阀用于混合流体,其可以是整合过程的一部分。 这些过程包括将样品和移动反应混合到用于模块化微流体的边缘或储存器,使用捕获区域以及将其注入到分离设备上的分析装置中。 在一些实施例中,使用星形和嵌套星形设计,或者通过微通道中的通道的横截面积的改变来进行珠捕获。 使用固定温度和通过微型泵将样品移动进一步公开了温度区之间样品的移动。
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公开(公告)号:US20130344475A1
公开(公告)日:2013-12-26
申请号:US13896581
申请日:2013-05-17
CPC分类号: C12Q1/6869 , B01F11/0071 , B01F13/0059 , B01L3/5025 , B01L3/5027 , B01L3/502715 , B01L3/502738 , B01L3/502753 , B01L3/502761 , B01L7/52 , B01L9/527 , B01L2200/027 , B01L2200/028 , B01L2200/0668 , B01L2200/10 , B01L2300/0627 , B01L2300/0636 , B01L2300/0654 , B01L2300/0803 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/1822 , B01L2300/1827 , B01L2300/1844 , B01L2400/0415 , B01L2400/0421 , B01L2400/0481 , B01L2400/0655 , C12N15/1003 , C12N15/1013 , C12Q1/24 , C12Q1/6806 , C12Q1/6844 , C12Q1/686 , C12Q1/70 , G01N2035/00514 , Y10T436/163333 , Y10T436/25875
摘要: Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such as DNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense.
摘要翻译: 公开了用于将微芯片连接到各种类型的模块的方法和装置。 所公开的技术可用作各种应用的样品制备和分析系统,如DNA测序和基因分型,蛋白质组学,病原体检测,诊断和生物防治。
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公开(公告)号:US08476063B2
公开(公告)日:2013-07-02
申请号:US12815685
申请日:2010-06-15
CPC分类号: C12Q1/6869 , B01F11/0071 , B01F13/0059 , B01L3/5025 , B01L3/5027 , B01L3/502715 , B01L3/502738 , B01L3/502753 , B01L3/502761 , B01L7/52 , B01L9/527 , B01L2200/027 , B01L2200/028 , B01L2200/0668 , B01L2200/10 , B01L2300/0627 , B01L2300/0636 , B01L2300/0654 , B01L2300/0803 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/1822 , B01L2300/1827 , B01L2300/1844 , B01L2400/0415 , B01L2400/0421 , B01L2400/0481 , B01L2400/0655 , C12N15/1003 , C12N15/1013 , C12Q1/24 , C12Q1/6806 , C12Q1/6844 , C12Q1/686 , C12Q1/70 , G01N2035/00514 , Y10T436/163333 , Y10T436/25875
摘要: Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such as DNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense.
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公开(公告)号:US20160053314A1
公开(公告)日:2016-02-25
申请号:US14824333
申请日:2015-08-12
CPC分类号: C12Q1/6869 , B01F11/0071 , B01F13/0059 , B01L3/5025 , B01L3/5027 , B01L3/502715 , B01L3/502738 , B01L3/502753 , B01L3/502761 , B01L7/52 , B01L9/527 , B01L2200/027 , B01L2200/028 , B01L2200/0668 , B01L2200/10 , B01L2300/0627 , B01L2300/0636 , B01L2300/0654 , B01L2300/0803 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/1822 , B01L2300/1827 , B01L2300/1844 , B01L2400/0415 , B01L2400/0421 , B01L2400/0481 , B01L2400/0655 , C12N15/1003 , C12N15/1013 , C12Q1/24 , C12Q1/6806 , C12Q1/6844 , C12Q1/686 , C12Q1/70 , G01N2035/00514 , Y10T436/163333 , Y10T436/25875
摘要: Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such as DNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense.
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公开(公告)号:US08431340B2
公开(公告)日:2013-04-30
申请号:US12605217
申请日:2009-10-23
CPC分类号: B01L3/50273 , B01F11/0071 , B01F13/0059 , B01J2219/005 , B01L3/502715 , B01L3/502738 , B01L3/502761 , B01L7/52 , B01L9/527 , B01L2200/027 , B01L2200/028 , B01L2200/0647 , B01L2200/0668 , B01L2200/10 , B01L2200/12 , B01L2300/0654 , B01L2300/0803 , B01L2300/0806 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/1822 , B01L2300/1844 , B01L2400/0409 , B01L2400/0421 , B01L2400/043 , B01L2400/0487 , B01L2400/0638 , B01L2400/0655 , B01L2400/086 , C12Q2565/629 , G01N1/34 , G01N27/44721 , G01N27/44743 , G01N27/44791 , G01N35/0098
摘要: Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such as DNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense.
摘要翻译: 公开了用于将微芯片连接到各种类型的模块的方法和装置。 所公开的技术可用作各种应用的样品制备和分析系统,如DNA测序和基因分型,蛋白质组学,病原体检测,诊断和生物防治。
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公开(公告)号:US20130029338A1
公开(公告)日:2013-01-31
申请号:US13367326
申请日:2012-02-06
CPC分类号: B01L3/50273 , B01F11/0071 , B01F13/0059 , B01J2219/005 , B01L3/502715 , B01L3/502738 , B01L3/502761 , B01L7/52 , B01L9/527 , B01L2200/027 , B01L2200/028 , B01L2200/0647 , B01L2200/0668 , B01L2200/10 , B01L2200/12 , B01L2300/0654 , B01L2300/0803 , B01L2300/0806 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/1822 , B01L2300/1844 , B01L2400/0409 , B01L2400/0421 , B01L2400/043 , B01L2400/0487 , B01L2400/0638 , B01L2400/0655 , B01L2400/086 , C12Q2565/629 , G01N1/34 , G01N27/44721 , G01N27/44743 , G01N27/44791 , G01N35/0098
摘要: Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such as DNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense.
摘要翻译: 公开了用于将微芯片连接到各种类型的模块的方法和装置。 所公开的技术可用作各种应用的样品制备和分析系统,如DNA测序和基因分型,蛋白质组学,病原体检测,诊断和生物防治。
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公开(公告)号:US20050150765A1
公开(公告)日:2005-07-14
申请号:US11076571
申请日:2005-03-09
申请人: David Roach , Jing Ni , Iuliu-Ioan Blaga , Owe Salven , Stevan Bogdan Jovanovich
发明人: David Roach , Jing Ni , Iuliu-Ioan Blaga , Owe Salven , Stevan Bogdan Jovanovich
CPC分类号: B01L3/502738 , B01L3/502715 , B01L2200/027 , B01L2200/10 , B01L2300/0861 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644 , B01L2400/065 , G01N27/44743 , G01N27/44791
摘要: Structures and methods that facilitate integration and/or isolation of various functions in a microchip system are disclosed. In one embodiment, the integration of the functions is by a multi-chip, sliding linear valve approach. The chips are in continued physical contact. In a second embodiment, the chips are separated and rejoined when they are moved to the preferred position. Surface coating of the joining edges helps prevent leakage and keeps liquid in the capillary channels for both embodiments. Another embodiment relates to miniature valves. Several designs were disclosed, including the linear, edge-contact sliding valve approach. Method to fabricate very small, high aspect ratio holes in glass was also disclosed, which facilitates the above embodiments.
摘要翻译: 公开了促进微芯片系统中各种功能的集成和/或隔离的结构和方法。 在一个实施例中,功能的集成是通过多芯片滑动线性阀方法。 这些芯片是持续的身体接触。 在第二实施例中,当芯片移动到优选位置时,芯片被分离并重新接合。 对于两个实施例,接合边缘的表面涂层有助于防止泄漏并将液体保持在毛细通道中。 另一实施例涉及微型阀。 公开了几种设计,包括线性边缘接触滑阀方法。 还公开了在玻璃中制造非常小的高纵横比孔的方法,这有助于上述实施例。
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公开(公告)号:US20100068723A1
公开(公告)日:2010-03-18
申请号:US12605217
申请日:2009-10-23
IPC分类号: C12Q1/68 , G01N33/543 , G01N1/14
CPC分类号: B01L3/50273 , B01F11/0071 , B01F13/0059 , B01J2219/005 , B01L3/502715 , B01L3/502738 , B01L3/502761 , B01L7/52 , B01L9/527 , B01L2200/027 , B01L2200/028 , B01L2200/0647 , B01L2200/0668 , B01L2200/10 , B01L2200/12 , B01L2300/0654 , B01L2300/0803 , B01L2300/0806 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/1822 , B01L2300/1844 , B01L2400/0409 , B01L2400/0421 , B01L2400/043 , B01L2400/0487 , B01L2400/0638 , B01L2400/0655 , B01L2400/086 , C12Q2565/629 , G01N1/34 , G01N27/44721 , G01N27/44743 , G01N27/44791 , G01N35/0098
摘要: Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such asDNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense.
摘要翻译: 公开了用于将微芯片连接到各种类型的模块的方法和装置。 所公开的技术可用作各种应用的样品制备和分析系统,如DNA测序和基因分型,蛋白质组学,病原体检测,诊断和生物防治。
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