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18 条记录 (耗时 0.026 秒)

    Use of Aptamers in Liquid Chromatography and Liquid Chromatography - Mass Spectrometry
    1.
    发明申请
    Use of Aptamers in Liquid Chromatography and Liquid Chromatography - Mass Spectrometry 审中-公开
    在液相色谱和液相色谱中使用适配子 - 质谱

    公开(公告)号：US20140162248A1

    公开(公告)日：2014-06-12

    申请号：US14101624

    申请日：2013-12-10

    申请人： Steven A. Cohen ,  Martin Gilar

    发明人： Steven A. Cohen ,  Martin Gilar

    IPC分类号： C12N15/115 ,  C12Q1/68

    CPC分类号： C12Q1/6876 ,  B01D15/08 ,  B01D15/362 ,  B01J20/24 ,  B01J20/285 ,  C07K1/22 ,  G01N33/54306 ,  G01N33/6842 ,  G01N33/6848 ,  G01N2030/085

    摘要： The present disclosure relates to the use of aptamers in solid phase extraction, chromatography and chromatography-mass spectrometry systems. More specifically, the present disclosure relates to the use of aptamers in SPE and chromatography systems to selectively retain, extract and/or pre-concentrate target molecule(s) having a specific affinity for the particular aptamer(s). The target molecule(s) can be further analyzed by mass spectrometry with limited interferences and/or enhanced sensitivity.

    摘要翻译： 本公开涉及在固相萃取，色谱和色谱 - 质谱系统中使用适体。 更具体地说，本公开内容涉及在SPE和色谱系统中适体的选择性保留，提取和/或预浓缩对于特定适体具有特异性亲和力的靶分子的用途。 目标分子可以通过质谱进一步分析，有限的干扰和/或增强的灵敏度。

    Vessel, dispensing devices, kits and methods for containing fluids
    5.
    发明授权
    Vessel, dispensing devices, kits and methods for containing fluids 有权
    容器，分配装置，用于容纳流体的试剂盒和方法

    公开(公告)号：US08409443B2

    公开(公告)日：2013-04-02

    申请号：US12595344

    申请日：2008-04-10

    申请人： Martin Gilar ,  Christopher C. Benevides ,  Jennifer Fournier

    发明人： Martin Gilar ,  Christopher C. Benevides ,  Jennifer Fournier

    IPC分类号： B01D15/08 ,  B01D21/26 ,  B04B15/00 ,  B65D51/18

    CPC分类号： B01L3/50825 ,  B01L3/5021 ,  B01L2200/026 ,  B01L2200/142 ,  B01L2300/0858 ,  Y10T137/0318 ,  Y10T137/7869 ,  Y10T137/86187 ,  Y10T436/25375 ,  Y10T436/255

    摘要： A device for limiting sample evaporation. The device has a vessel body having a body exterior surface and at least one body interior surface. The at least one body interior surface has one or more walls defining a first chamber, a second chamber and a conduit means. The first chamber has a first chamber opening for receiving at least one of the groups selected from a sample and a sample dispensing device. The first chamber opening defines the border of the body exterior surface and the body interior surface. The conduit means is in communication with the first chamber and the second chamber for receiving at least one of the group consisting of sample from said first chamber, a sample from a sample dispensing device and a sample dispensing device passing through or into the conduit means for placing the sample in the conduit means or into the second chamber. The second chamber is in communication with the conduit means for receiving and containing the sample from at least one of the group selected from the sample dispensing device and conduit means. The conduit means is arranged such that the sample in the second chamber is substantially isolated from the atmosphere to limit sample evaporation in the second chamber as the sample is contained therein.

    摘要翻译： 用于限制样品蒸发的装置。 该装置具有容器主体，其具有主体外表面和至少一个主体内表面。 所述至少一个主体内表面具有限定第一室，第二室和导管装置的一个或多个壁。 第一室具有用于接收从样品和样品分配装置中选择的至少一个组的第一室开口。 第一腔室开口限定身体外表面和身体内表面的边界。 导管装置与第一腔室和第二腔室连通，用于接收来自所述第一腔室的样品，来自样品分配装置的样品和通过或进入导管装置的样品分配装置中的至少一个， 将样品放置在导管装置中或进入第二室。 第二室与用于从选自样品分配装置和导管装置中的组中的至少一个接收和容纳样品的导管装置连通。 管道装置被布置成使得第二室中的样品基本上与大气隔离，以在样品被包含在第二室中时限制第二室中的样品蒸发。

    Apparatus and methods for mass-spectrometric directed purification of biopolymers
    7.
    发明授权
    Apparatus and methods for mass-spectrometric directed purification of biopolymers 有权
    用于生物聚合物质谱定向纯化的装置和方法

    公开(公告)号：US08153009B2

    公开(公告)日：2012-04-10

    申请号：US11912047

    申请日：2006-04-21

    申请人： Martin Gilar ,  John C. Gebler ,  Fang Xia

    发明人： Martin Gilar ,  John C. Gebler ,  Fang Xia

    IPC分类号： B01D15/08

    CPC分类号： G01N30/34

    摘要： A method for extracting at least one target compound from a sample includes injecting an overloaded amount of the sample into a chromatographic conduit (110), and flowing a solvent having a time-varying composition through the conduit (110). An apparatus for extracting at least one target compound from a sample includes a chromatography module, a mass-spectrometry module in fluid communication with the chromatography module to receive a portion of an eluent from the chromatography module, and a control unit in communication with the chromatography module and the mass-spectrometry module.

    摘要翻译： 从样品中提取至少一种目标化合物的方法包括将过量的样品注入色谱管道（110）中，并使具有时变组成的溶剂流经导管（110）。 用于从样品中提取至少一种目标化合物的装置包括色谱模块，与色谱模块流体连通以从色谱模块接收一部分洗脱液的质谱模块，以及与色谱法连通的控制单元 模块和质谱模块。