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19 条记录 (耗时 0.026 秒)

    HYDROPHILIC POLYMER-CONJUGATED LIPIDS FOR PEPTIDE AND PROTEIN FOLDING DISORDERS
    2.
    发明申请
    HYDROPHILIC POLYMER-CONJUGATED LIPIDS FOR PEPTIDE AND PROTEIN FOLDING DISORDERS 审中-公开
    用于肽和蛋白折叠病的亲水性聚合物脂肪

    公开(公告)号：US20100062969A1

    公开(公告)日：2010-03-11

    申请号：US12296238

    申请日：2007-04-06

    申请人： Hayat Onyuksel ,  Israel Rubinstein

    发明人： Hayat Onyuksel ,  Israel Rubinstein

    IPC分类号： A61K38/00 ,  A61K31/685

    CPC分类号： A61K47/6907 ,  A61K47/544 ,  A61K47/60

    摘要： The present invention provides a method of correcting peptide or protein misfolding, which can be used to treat peptide and protein disorder in a mammalian subject. The method comprises administering to the mammalian subject, preferably a human subject, an effective amount of a composition comprising sterically stabilized simple micelles (SSM) of a hydrophilic polymer-conjugated lipid or sterically stabilized mixed micelles (SSMM) of a hydrophilic polymer-conjugated lipid and a water-insoluble lipid. The composition may further comprise a biologically active compound, such as but not limited to vasoactive intestinal peptide (VIP), associated with the SSM or SSMM.

    摘要翻译： 本发明提供了一种校正肽或蛋白质错误折叠的方法，其可用于治疗哺乳动物受试者中的肽和蛋白质紊乱。 该方法包括向哺乳动物受试者，优选人受试者施用有效量的包含亲水性聚合物共轭脂质的亲水性聚合物共轭脂质或空间稳定的混合胶束（SSMM）的空间稳定的简单胶束（SSM）的组合物 和水不溶性脂质。 组合物还可包含与SSM或SSMM相关的生物活性化合物，例如但不限于血管活性肠肽（VIP）。

    Morphology in electrochemically grown conducting polymer films
    4.
    发明授权
    Morphology in electrochemically grown conducting polymer films 失效
    电化学生长导电聚合物膜中的形态

    公开(公告)号：US5108573A

    公开(公告)日：1992-04-28

    申请号：US533551

    申请日：1990-06-05

    申请人： Israel Rubinstein ,  Shimshon Gottesfeld ,  Eyal Sabatani

    发明人： Israel Rubinstein ,  Shimshon Gottesfeld ,  Eyal Sabatani

    IPC分类号： H01B1/12 ,  H01M4/60

    CPC分类号： B82Y30/00 ,  H01B1/127 ,  H01B1/128 ,  H01M4/60

    摘要： A conducting polymer film with an improved space filling is formed on a metal electrode surface. A self-assembling monolayer is formed directly on the metal surface where the monolayer has a first functional group that binds to the metal surface and a second chemical group that forms a chemical bonding site for molecules forming the conducting polymer. The conducting polymer is then conventioonally deposited by electrochemical deposition. In one example, a conducting film of polyaniline is formed on a gold electrode surface with an intermediate monolayer of p-aminothiophenol.

    摘要翻译： 在金属电极表面上形成具有改善的空间填充的导电聚合物膜。 直接在金属表面上形成自组装单层，其中单层具有结合金属表面的第一官能团和形成导电聚合物分子的化学键合位点的第二化学基团。 然后通过电化学沉积将导电聚合物固化沉积。 在一个实例中，聚苯胺的导电膜在金电极表面上形成有中间单层对氨基苯硫酚。

    Electrochemical method for visual detection of nonmetallic surface inclusions in metallic substrates
    5.
    发明授权
    Electrochemical method for visual detection of nonmetallic surface inclusions in metallic substrates 失效
    用于金属基体中非金属表面夹杂物的视觉检测的电化学方法

    公开(公告)号：US4498960A

    公开(公告)日：1985-02-12

    申请号：US438116

    申请日：1982-11-01

    申请人： Israel Rubinstein

    发明人： Israel Rubinstein

    IPC分类号： G01N21/91 ,  G01N27/00 ,  B01D59/40

    CPC分类号： G01N21/91

    摘要： An electrochemical method for fast and non-destructive visual detection of nonmetallic surface inclusions in metallic substrates is provided. The method uses electrode modification techniques, wherein, for example, a monomer is electrochemically polymerized, to form a dark film on the metallic substrate, thus causing any nonconductive inclusions, which will not be coated with the film, to appear bright and highly visible.

    摘要翻译： 提供了一种用于金属基底中非金属表面夹杂物的快速和非破坏性视觉检测的电化学方法。 该方法使用电极改性技术，其中例如单体被电化学聚合，以在金属基材上形成暗膜，从而导致任何不会被膜涂覆的非导电夹杂物显现出明亮和高度可见。

    Method and apparatus for detecting and quantifying a chemical substance employing an optical transmission property of metallic islands on a transparent substrate
    9.
    发明授权
    Method and apparatus for detecting and quantifying a chemical substance employing an optical transmission property of metallic islands on a transparent substrate 有权
    在透明基板上使用金属岛的透光性检测和定量化学物质的方法和装置

    公开(公告)号：US08071391B2

    公开(公告)日：2011-12-06

    申请号：US09922220

    申请日：2001-08-03

    申请人： Israel Rubinstein ,  Alexander Vaskevich ,  Gregory Kalyuzhny

    发明人： Israel Rubinstein ,  Alexander Vaskevich ,  Gregory Kalyuzhny

    IPC分类号： G01N33/553

    CPC分类号： B82Y30/00 ,  G01N21/553 ,  G01N21/554 ,  G01N21/75

    摘要： This invention seeks to provide methods and apparatus for analysis. Electromagnetic radiation is transmitted through a plurality of metallic islands on a transparent substrate. A resultant optical property of the plurality of metallic islands is measured. Thereafter a chemical substance is adsorbed onto the plurality of metallic islands so as to produce a chemical substance-metallic islands moiety.Electromagnetic radiation is transmitted through the chemical substance-metallic islands moiety and a resultant optical property of metallic islands in the chemical substance-metallic islands moiety is measured. The resultant optical property of the metallic islands in chemical substance-metallic islands moiety and the resultant optical property of the plurality of metallic islands are employed so as to provide at least one of a quantitative indication and a qualitative indication of at least one of: the chemical substance-metallic islands moiety, a functionality of the chemical substance-metallic islands moiety, the plurality of metallic islands, a functionality of the plurality of metallic islands, the chemical substance and a functionality of the chemical substance.

    摘要翻译： 本发明寻求提供用于分析的方法和装置。 电磁辐射通过透明基板上的多个金属岛传播。 测量多个金属岛的合成光学特性。 此后，化学物质被吸附到多个金属岛上，以便产生化学物质 - 金属岛部分。 电磁辐射通过化学物质 - 金属岛部分传输，并测量化学物质 - 金属岛部分中金属岛的合成光学性质。 采用化学物质 - 金属岛部分中的金属岛的所得光学性质和多个金属岛的所得光学性质，以提供以下至少一个的定量指示和定性指示中的至少一个： 化学物质 - 金属岛部分，化学物质 - 金属岛部分的功能，多个金属岛，多个金属岛的官能团，化学物质和化学物质的功能。